UP4 Probiotics Now Available at Target

by Rebecca @ UP4 Probiotics

Tue Apr 19 11:24:06 PDT 2016

We are proud to announce that UP4™ Probiotics are now available at Target stores nationwide!  Visit our Store Locator to find a location near you. 

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How to Fix Hemorrhoids

by John Brisson @ Fix Your Gut

Fri Dec 08 12:13:22 PST 2017

Many people are suffering from the side effects of having chronic constipation and sitting while defecating, hemorrhoids might be the worst. I remember when I had an external hemorrhoid years ago. Severe pain when I sat, and itching so bad I felt like a bear who rubs

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Atlantic Fresh Food Savings!! Feb 15-21

by Eliane @ I Love Savings | Coupons | Grocery | Health | Beauty | Household

Sun Feb 11 09:44:46 PST 2018

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The post Atlantic Fresh Food Savings!! Feb 15-21 appeared first on I Love Savings | Coupons | Grocery | Health | Beauty | Household.

Nootropics in human trials (Intro)

by @ Articles - Articles

Sat Sep 09 06:57:38 PDT 2017

The word "nootropic" derives from the Greek words nous, or "mind", and trepein meaning "to bend or turn". It was first coined by Romanian psychologist and chemist, Corneliu E. Giurgea after synthesizing Piracetam.
For Giurgea a nootropic drug should have the following characteristics:
1. They should enhance learning and memory.
2. They should enhance the resistance of learned behaviors/memories to conditions which tend to disrupt them (e.g. electroconvulsive shock, hypoxia).
3. They should protect the brain against various physical or chemical injuries (e.g. barbiturates, scopalamine).
4. They should increase the efficacy of the tonic cortical/subcortical control mechanisms.
5. They should lack the usual pharmacology of other psychotropic drugs (e.g. sedation, motor stimulation) and possess very few side effects and extremely low toxicity.

In fact, most drugs commonly labelled as nootropics do not fulfill all of these requirements. Some of the best known (e.g. Adderall, Modafinil) seem to not fulfill any, as discussed later. Instead, other characteristics like (reputed increased alertness, focus or motivation) seem to be key to their popularity.
Because of deviating definitions nootropics are more broadly defined (e.g. in wikipedia) as drugs, supplements, or other substances that improve cognitive function, particularly executive functions, memory, creativity, or motivation, in healthy individuals. 

Some nootropics from the very common to the :

Caffeine
Caffeine is the world’s most widely used stimulant (Nawrot, et al., 2003). It is used by over 90 % of North Americans every day (Mednick et al., 2008). It is widely used because of its positive effects on mood and alertness (Lorist & Tops, 2003)and vigilance and attention (Lieberman et al., 1987). However, these effects do not seem applicable / transferable to motor learning and verbal memory and are unable to reverse effects of sleep deprivation, with a dose of 200mg in low to moderate users (< than 2 cups a day) (Mednick et al., 2008). It is also shown to be ineffective in higher cognitive tasks involving working memory (Battig et al., 1984). Overall conclusions regarding the relation of caffeine and memory have been mixed. Positive effects might stem from caffeine withdrawal in high dosage users (Mednick et al., 2008).

Nicotine
With about 1,1 billion smokers worldwide in the year 2015 (WHO 2015) nicotine takes second place as the most widely used stimulant. It was shown that the application of nicotine in non-smoking males enhances performance in continuous performance tasks and therefore is said to improve attention and working-memory (Kumari, et al., 2003), which is in line with other studies suggesting that nicotine affects short-term memory in delayed free recall tasks (Sarah & Fox, 1998)
Another study examined nicotine’s effects on alertness and performance on a covert orienting task were measured. While nicotine decreased overall reaction times in the covert orienting task, there was no change in the validity effect, the reaction time difference between validly and invalidly cued targets. However, nicotine significantly improved both EEG and self-rated measures of alertness. Nicotine seems to increases alertness in non-smokers, with no improvement in spatial attention using a covert orienting task (Griesar et al., 2002). Furthermore Nicotine seems to reduce distraction under low perceptual load by acting as a stimulus filter that prevents irrelevant stimuli entering awareness (Behler et al., 2015).

Methylphenidate/ Ritalin
Most college students I know will immediately think of Ritalin or Modafinil if they are asked to name a cognitive enhancer. Studies have found that 4.1% to 10.8% of college students in the US reported using prescription stimulants non-medically during the past year (Garnier-Dykstra, et al., 2012).
Methylphenidate (MPH - common brand name ‘Ritalin’) is used in treatment of attention deficit hyperactivity disorder (ADHD) and narcolepsy. Most studies focused on the its effects on Attention, Mood, Memory and executive functions. A single dose of MPH showed a positive effect on memory. Repeated doses of MPH had a mood elevating effect but also enhanced anxiety. No statistically significant effect was found in the outcomes attention, mood and executive functions. MPH had no significant effect on sleep-deprived individuals (Repantis et al., 2010). In a 2015 review the authors found some ‘publication bias’, relating to long-term and working memory and conclude that the effect in healthy subject is probably modest overall and that healthy users resort to stimulants to enhance their energy and motivation more than their cognition (Ilieva et al., 2015). 

Modafinil
Modafinil is used in treatment of disorders such as narcolepsy, shift work sleep disorder, and excessive daytime sleepiness associated with obstructive sleep apnea. Most studies focused on its effects on attention, mood, memory, wakefulness and executive functions and motivation. A single dose showed positive effects on attention only. On sleep deprived individuals it was shown to have an impact on executive functions, on memory and wakefulness but there was an insignificant effect on mood and attention (Repantis et al., 2010). A 2012 meta-analysis found that Modafinil was likely effective but criticised the gaps in the literature. (Kelley et al., 2012) 
A recent study on chess players found significantly enhanced performance with Modafinil or Ritalin but only when the players were not under time pressure (Franke et al. 2017). 

Adderall
Mixed Amphetamine Salts also known under the brand Name Adderall became increasingly popular in recent years as an athletic performance enhancer and cognitive enhancer. Like Ritalin, it is also used to treat ADHD and narcolepsy.
Overall effects of Adderall on cognition have been reviewed as very modest, while having a huge effect on perception. It was found to enhance performance in word recall, embedded figures and Raven's Progressive Matrices, but only for lower performing individuals (Ilieva et al., 2013). Adderall might also impair creativity in high performing individuals (Farah et al., 2009).

L-theanine & Caffeine
L- theanine is primarily found in plants (e.g. in the leaves of green and black tea) and fungus. Results evidently demonstrated that L-theanine clearly has a pronounced effect on attention performance and reaction time response in normal healthy subjects susceptible to having high anxiety (Higashiyama et al., 2011).
A dose of L-theanine equivalent to eight cups of black tea improves cognitive and neurophysiological measures of selective attention, to a degree that is comparable with that of caffeine. The combination of Theanine and caffeine seem to have additive effects on attention in high doses (Kahathuduwa et al.,2016).
Studies suggest that 97 mg of L-theanine in combination with 40 mg of caffeine helps to focus attention during a demanding cognitive task (Giesbrecht 2010).

Bacopa Monnieri
Bacopa Monnieri is an herb which has been used in Ayurvedic medicine for centuries. Bacopa's primary mechanism of action is still unclear, it seems to be an anti-oxidant, a weak acetylcholinesterase inhibitor and a cerebral blood flow activator (Aguiar & Borowski , 2013).
There is some evidence to suggest that Bacopa Monnieri improves memory with little evidence of enhancement in any other cognitive domains (Pase et al., 2012).

Piracetam
Closing the circle to the beginning of this short introduction to the topic: Giurgea first coined the term "nootropic" when he synthesized Piracetam in 1964. Since it is not approved by the US FDA, it is primarily used in Europe, Asia, and South America. It is commonly prescribed for cognitive impairment and dementia in several countries of Europe. Research suggests that Piracetam might also have a positive effect on healthy individuals. Subjects were given 3×4 capsules at 400 mg per day, in a double blind study. Each subject learned series of words presented as stimuli upon a memory drum. No effects were observed after 7 days but after 14 days verbal learning had significantly increased (Dimond & Brouwers, 1976). It might also be beneficial for cognitive decline associated with age. Aging subjects did significantly better in a computerized perceptual-motor tasks when on piracetam than on a placebo. (Mindus et al. 1976). While these old studies may not be that reliable, it is still held that Piracetam's “efficacy is documented in cognitive disorders and dementia, vertigo, cortical myoclonus, dyslexia, and sickle cell anemia. While high doses are sometimes necessary, piracetam is well tolerated” (Winblad, 2005). Since Piracetam was first synthesized many structurally similar compounds have emerged. These so called Racetams have poorly understood mechanisms of action; however, piracetam and aniracetam are known to act as positive allosteric modulators of AMPA receptors and appear to modulate cholinergic systems (Gualtieri et al., 2002).

References
* Aguiar, S., & Borowski , T. (2013). Neuropharmacological review of the nootropic herb Bacopa monnieri. Rejuvenation Research, 313-326. 
* Battig , K., Martin, J. R., & Feierabend , J. M. (1984). The effects of caffeine on physiological functions and mental performance. Experentia, 1218–1223.
* Behler , O., Breckel, T. P., & Thiel , C. M. (2015). Nicotine reduces distraction under low perceptual load. Psychopharmacology, 1269-1277.
* Dimond, S. J., & Brouwers, E. M. (1976). Increase in the power of human memory in normal man through the use of drugs. Psychopharmacology, 307-309.
* Farah , M., Haimm , C., Sankoorikal , G., Smith , M., & Chatterjee , A. (2009). When we enhance cognition with Adderall, do we sacrifice creativity? A preliminary study. Psychopharmacology,541-547.
* Franke, A.G.; Gränsmark, P., Agricola, A., Schühle, K., Rommel, T., Sebastian, A., Balló, H.E., Gorbulev, S., Gerdes, C., Frank, B., Ruckes, C., Tüscher, O., Lieb, K. (2017) "Methylphenidate, modafinil, and caffeine for cognitive enhancement in chess: A double-blind, randomised controlled trial" in: European Neuropsychopharmacology Vol27, Issue 3, 1, pp248-260
* Garnier-Dykstra, L. M., Caldeira, K. M., Vincent, K. B., O’Grady, K. E., & Arria, A. M. (2012).Nonmedical use of prescription stimulants during college: Four-year trends in exposure opportunity, use, motives, and sources. J Am Coll Health, 226-234.
* Giesbrecht, T., Rycroft , J. A., Rowson , M. J., & De Bruin , E. A. (2010). The combination of L-theanine and caffeine improves cognitive performance and increases subjective alertness. Nutritional Neuroscience, 283-290.
* Griesar , W. S., Zajdel , D. P., & Oken , B. (2002). Nicotine effects on alertness and spatial attention in non-smokers. Nicotine & Tobacco Research, 185-194.
* Gualtieri , F., Manetti , D., Romanelli , M. N., & Ghelardini , C. (2002). Design and study of piracetamlike nootropics, controversial members of the problematic class of cognition-enhancing drugs. Current Pharmaceutical Design, 125-138.
* Higashiyama, A., Htay, H. H., Ozeki, M., Juneja, L. R., & Kapoor, M. P. (2011). Effects of l-theanine on attention and reaction time response. Journal of Functional Foods, 171-178.
* Ilieva, I., Boland, J., & Farah, M. (2013). Objective and subjective cognitive enhancing effects of mixed amphetamine salts in healthy people. Neuropharmacology, 496-505.
* Ilieva IP, Hook CJ, Farah MJ. (2015) Prescription Stimulants' Effects on Healthy Inhibitory Control, Working Memory, and Episodic Memory: A Meta-analysis.; J Cogn Neurosci. 2015 Jun;27(6):1069-89. 
* Kahathuduwa, C. N., Dassanayake , T. L., Amarakoon , A. M., & Weerasinghe, V. S. (2016). Acute effects of theanine, caffeine and theanine-caffeine combination on attention. Nutritional Neuroscience.
* Kelley, A.M.; Webb, C.M., Athy, J.R., Ley, S., Gaydos, S. (2012) "Cognition enhancement by modafinil: A meta-analysis" in Aviation Space and Environmental Medicine; Vol83, Issue 7, p685-690
* Kumari, V., Gray, J., H ffytche, D., Mitterschiffthaler, M., Das, M., Zachariah, E., . . . Sharma, T. (2003). Cognitive effects of nicotine in humans: an fMRI study. NeuroImage, 1002-1013.
* Lieberman , H. R., Wurtman, R. J., Emde, G. G., Roberts , C., & Coviella, I. L. (1987). The effects of low doses of caffeine on human performance and mood. Psychopharmacology, 308-312.
* Lorist , M. M., & Tops, M. (2003). Caffeine, fatigue, and cognition. Brain Cognition, 82-94.
* Mednick, S. C., Cai, D. J., Kanady, J., & Drummond, S. P. (2008). Comparing the benefits of Caffeine,Naps and Placebo on Verbal, Motor and Perceptual Memory. Behavioural Brain Research, 79–86.
* Mindus , P., Cronholm , B., Levander , S. E., & Schalling , D. (1976). Piracetam-induced improvement of mental performance. A controlled study on normally aging individuals. Acta Psychiatrica Scandinavia, 150-160.
* Nawrot, P., Jordan, S., Eastwood , J., Rotstein , J., Hugenholtz, A., & Feeley, M. (2003). Effects of caffeine on human health. Food Additives & Contaminants, 1-30.
* Pase, M. P., Kean , J., Sarris , J., Neale , C., Scholey , A. B., & Stough , C. (2012). The cognitive enhancing effects of Bacopa monnieri: a systematic review of randomized, controlled human clinical trials. Journal of Alternative Complementary Medicine, 647-652.
* Repantis , D., Schlattmann , P., Laisney , O., & Heuser, I. (2010). Modafinil and methylphenidate for neuroenhancement in healthy individuals: A systematic review. Pharmacological Research, 187-206.
* Sarah , P., & Fox, P. (1998). An investigation into the effects of nicotine gum on short-term memory.Psychopharmacology, 429-433.
* WHO (2015). WHO global report on trends in tobacco smoking 2000-2025. WHO Library Cataloguing-in Publication Data .
* Winblad, B. (2005). Piracetam: a review of pharmacological properties and clinical uses. CNS Drug reviews, 169-182.

Not for profit people pharmaceutical R&D company

by @ Action

Sun Feb 04 19:26:27 PST 2018

Testing the waters to see if there is any interest in a cooperative research and development company funded by forum members and crowdfunding from other forums reddit etc. The company could provide reliable nmr testing, in vitro and eventually in vivo studies all without the motive of profit. Drug candidates could be sold into the for profit market to expand capabilitiesss. Thoughts?

Western Canada Fresh Food Savings!! Feb 15-21

by Eliane @ I Love Savings | Coupons | Grocery | Health | Beauty | Household

Sun Feb 11 09:48:15 PST 2018

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Itchiness of Summer Heat

by Rebecca @ UP4 Probiotics

Thu Jul 07 10:54:24 PDT 2016

By Lynda Robbins, UP4™ Probiotics Education Specialist As a child, I suffered horribly with skin issues.  I’m going to date myself here and tell you that “back then” probiotics were sitting in a time capsule in the distant future (not too distant…I’m not THAT old!) waiting for the lid to be opened and probiotics supplements […]

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DIY Projects: Knowing When to Call a Professional

by Gary Collins, MS @ Primal Power Method

Sat Dec 02 10:39:25 PST 2017

  Part of living off-the-grid is being self-reliant. Being able to address the different issues you encounter with ease helps you maintain your DIY status. Frankly, sometimes you live too far away to find anyone that will come fix your problems. If problem-solving and taking the steps necessary to fix an issue with your home... Read more »

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The curse of noopept/piracetam/pramiracetam

by @ ImmInst Active Topics

Sun Feb 11 21:47:30 PST 2018

I see a number of newer threads of people on Reddit who have sexual issues after taking these nootropics, years ago no one took it seriously, does anyone have any hard data on how to fix this issue or what is the cause of this.

Reasons You May Have Low Testosterone

by Gary Collins, MS @ Primal Power Method

Sun Mar 26 13:09:35 PDT 2017

I am a regular on the The Survival Podcast, as an expert on Primal/Paleo health, nutrition, exercise, simple living and living off the grid. I share a lot of great information during this question and answer format. I have realized I cover a lot of information that may not be contained on my website or... Read more »

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New CFS Study — but almost nothing new :-(

by lassesen @ CFS Remission

Thu Feb 08 20:19:01 PST 2018

The title sounded grander than what it actually contained Open-label pilot for treatment targeting gut dysbiosis in myalgic encephalomyelitis/chronic fatigue syndrome: neuropsychological symptoms and sex comparisons [2018] – Full text “Conclusions Results support the notion that specific microorganisms interact with some ME/CFS symptoms and offer promise for the therapeutic potential of targeting gut dysbiosis in […]

LongeCityNow_Mantas_Matjusaitis_2017.mp3

by @ Last 10 Submissions RSS Feed

Tue May 09 10:48:32 PDT 2017

In this podcast we hear from one of the more recent entrants into the field of senescent cells - Mantas Matjusaitis, the founder of CellAge. Find out how his start-up company plans to reduce and reverse aspects of aging related to senescent cells.

Artifical Organs + Brain Therapies (Best bet for next 20 years)

by @ Action

Thu Jan 04 03:59:15 PST 2018

Hey there folks.

 

Please:

 

1. share with me any links or posts/lists relating to robot organs in particular, or brain health.

 

2. let me know if you want to work on these.

 

3. challenge me that there's a better thing to work on for the next 10-20 years than artificial organs + brain health

 

I'm assuming it will take at least that long to get the nanobots and DNA repair + all the other stuff figured out that's need to keep bio going long term, and that to go full digital risks losing conscious awareness until we understand more about it.

The 3-Day Detox Plant Paradox Green Smoothie Recipe

by Dr. Steven Gundry @ Gundry MD

Tue Feb 06 03:33:54 PST 2018

If there’s one thing that’s for sure in this world, it’s that you simply cannot get enough greens to satisfy your good gut buddies. And when you begin The Plant Paradox – and start to avoid lectins – you’ll find your cravings for dark leafy greens will skyrocket. But, there are so many good reasons […]

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Lavender. Almost as good as Pregabalin

by @ ImmInst Active Topics

Fri Feb 09 05:41:57 PST 2018

I've been testing a few drops of  lavender essential oil for my sky-high levels of anxiety. This stuff is potent. I took 8 drops today, and it's almost as efficient as 100mg of pregabalin ( I've been taking up to 400 mg of pregabalin daily these last months for anxiety and insomnia ). Make sure it's for oral consumption , some essential oils are for use diluted on skin only. Mix the drops with something fat , or just take it in water . It did create some heartburn though, but I took a very high dosage.

 

I've also taken  Silexan ( an extract of lavender ) before. It's bloody expensive, and cheap lavender oil works just as well.

 

Interestingly, lavender essential oil seems to work the same way as pregabalin :

 

https://www.ncbi.nlm.nih.gov/pubmed/23637742

 

 

 

Lavender oil-potent anxiolytic properties via modulating voltage dependent calcium channels.

Schuwald AM1, Nöldner M, Wilmes T, Klugbauer N, Leuner K, Müller WE.

Author information

 

Abstract

Recent clinical data support the clinical use of oral lavender oil in patients suffering from subsyndromal anxiety. We identified the molecular mechanism of action that will alter the perception of lavender oil as a nonspecific ingredient of aromatherapy to a potent anxiolytic inhibiting voltage dependent calcium channels (VOCCs) as highly selective drug target. In contrast to previous publications where exorbitant high concentrations were used, the effects of lavender oil in behavioral, biochemical, and electrophysiological experiments were investigated in physiological concentrations in the nanomolar range, which correlate to a single dosage of 80 mg/d in humans that was used in clinical trials. We show for the first time that lavender oil bears some similarities with the established anxiolytic pregabalin. Lavender oil inhibits VOCCs in synaptosomes, primary hippocampal neurons and stably overexpressing cell lines in the same range such as pregabalin. Interestingly, Silexan does not primarily bind to P/Q type calcium channels such as pregabalin and does not interact with the binding site of pregabalin, the α2δ subunit of VOCCs. Lavender oil reduces non-selectively the calcium influx through several different types of VOCCs such as the N-type, P/Q-type and T-type VOCCs. In the hippocampus, one brain region important for anxiety disorders, we show that inhibition by lavender oil is mainly mediated via N-type and P/Q-type VOCCs. Taken together, we provide a pharmacological and molecular rationale for the clinical use of the oral application of lavender oil in patients suffering from anxiety.

 

 

List of Public Companies Involved in Rejuvenation Tech

by @ ImmInst Active Topics

Wed Feb 07 12:05:43 PST 2018

Does anyone have a list of public companies (stock symbols) involved in rejuvenation technology? For instance, stem cells, glycation breaking, etc?

How to Make Dream Dust with Evidence-Based Herbs for Sleep

by Heather Dessinger and Dr. Lori Valentine Rose (PhD), Certified Nutrition Professional (CNP), Board Certified in Holistic Nutrition @ Mommypotamus

Thu Feb 08 07:09:33 PST 2018

If you’ve been around here for long, you know that I am 100% dedicated to sleep. I am not afraid to go orange-alien faced to combat sleep-busting blue-light, slather butter on my body if it will increase sleep-promoting magnesium, or even drink bananas (B.A.N.A.N.A.S.). So you can bet I jumped at the chance to work […]

Continue Reading...How to Make Dream Dust with Evidence-Based Herbs for Sleep

Pumpkin Spice Bread Recipe with Cider

by Suja Juice @ Suja Juice

Thu Nov 16 14:20:55 PST 2017

Call us obsessed but we can’t get enough of our new Mulled Apple Cider! When we’re not drinking it straight or mixed up in a fun cocktail, we’re adding it to a tasty treat. This pumpkin cider bread combines our favorite flavors of the season like pumpkin and cardamom, sweetened with maple syrup, and can […]

Inhale Essential Oils, Exhale Anxiety with These Oils & Recipes

by Zoe (Social Media Manager) @ Blog – Well.ca Blog

Fri Feb 02 07:00:16 PST 2018

Bonita Barth | Herbalist & Aromatherapist at The Aromatherapist State of mind is the one thing that can colour every other aspect of our lives – it directly impacts our health and well-being, as well as that of those around us. How can an essential...

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Ginger Lime

by admin @ Pressed Probiotic Waters – Suja Juice

Tue Jan 05 16:38:39 PST 2016

Be good to your guts with this refreshing water that offers a subtle zing of ginger with a hint of citrusy lime and 2 billion vegan probiotic CFUs to aid in digestive and immune health.

How To Make Non-Toxic Granite Cleaner

by Heather @ Mommypotamus

Tue Jan 30 07:12:20 PST 2018

I love the bright, crisp scent of this Lemon & Lavender All-Purpose Cleaner, but vinegar is too acidic for granite and can cause etching over time. Store-bought options often contain problematic ingredients – frequently earning a rating of C or even F from the Environmental Working Group – and can cost anywhere from $7-$27 dollars. […]

Continue Reading...How To Make Non-Toxic Granite Cleaner

Ontario Family Fishing Events

by Heather @ I Love Savings | Coupons | Grocery | Health | Beauty | Household

Mon Feb 12 04:52:48 PST 2018

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Bevnet: Suja to Launch Kombucha at Costco This Month

by Suja Juice @ Suja Juice

Fri Jul 07 12:32:29 PDT 2017

BevNET announced Suja’s new Organic Kombucha drink line which is available now at select Costco stores. “Available in 15.2 oz. glass bottles in Ginger, Berry, Peach and Green varieties, Suja Organic Kombuchas are flavored with the company’s cold-pressed juices and contain 5 billion CFUs of vegan probiotics in each. They contain no added natural flavors […]

How To Build The Perfect Charcuterie Board

by Zoe (Social Media Manager) @ Blog – Well.ca Blog

Mon Feb 12 07:00:43 PST 2018

MANDY KING | HOLISTIC NUTRITIONIST | FOUNDER OF HEAL (HEALTHY EATING AND LIVING) The perfect charcuterie board has an unexplained power to wow any guests that you have over for dinner. Luckily, it’s also a surprisingly easy appetizer to throw together! There’s usually no cooking involved...

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Flourless Pumpkin Protein Pancake Recipe

by Nora Lynch @ Suja Juice

Wed Oct 18 16:48:06 PDT 2017

Fall is finally here and the pumpkin craze has begun! From carving pumpkins to pumpkin spice lattes and beer to pumpkin pie on Thanksgiving – it’s everywhere! Sometimes pumpkins get a bad rep because more often than not, they’re used to make delicious recipes that can unfortunately be loaded with unwanted sugar and calories. In reality, pumpkins are rich with vitamins and nutrients and can have major […]

Ego, here to introduce myself

by @ ImmInst Active Topics

Sun Feb 11 18:46:52 PST 2018

Hey,

For a few years now, I've been more or less regularly reading discussions, learning about a host of interesting topics and exploring all Longecity has to offer while never creating an account for some reason. Personally, I believe that this at least in part may have been rooted in the fact that, even though I might appear knowledgeable and am very interested in a number of topics at home on this site, I never truly felt as if I could add something so substantial that it would warrant me making an account and actively participating. I've now decided to do so anyway and, if we are lucky, I may actually be able to add something to this project.

In terms of interests, I am first and foremost fascinated by technology. Of any kind. The mechanics behind an automated watch are just as interesting to me as the inner working of a heater. A circuit board just as mesmerizing as a well engineered differential. You name it and I will want to understand it. This, being the case since my early childhood, though has lead me to realize that, what fascinates me the most isn't technology itself, as incredible as it is, but rather that we, as humans are able to accomplish so much with so little.

With other words, I've been struck with awe ever since I first looked into the human brain that many years ago. On average around 3lb heavy, is it the most complex thing in the as yet known universe. Despite its diminutive size though, we as a species owe everything to it. So what when, or rather if, there will be a day at which our brains have reached their limit?

The printing press was invented and popularized in the 15th century. It revolutionized the way information was accessible, the way information could be stored and the way information could be stored and the way information could be transferred. Now, not even 600 years later, a large chunk of the Earth's population has free and open access to most everything our species has accomplished. At any point in time and almost anywhere.

Technology is going to progress even further and, depending on whom you ask, may actually advance exponentially. We have been lucky so far that humans are very good at adapting to new scenarios. Though there will come a point, maybe in the not-so-distant future, or maybe 10000 years from now, that this won't be enough. That technology out-paces our monkey-brains. You may disagree, but I personally feel that this is more a question of when, rather than if.

Now, this line of thinking has led me, a few years ago, to consider whether or not it may be a good idea to at least entertain the thought, that science should look into the idea of "enhancing" the human brain. That lead me down a rabbit hole so deep, I'm still falling. The research being done is highly fascinating, so much so that I wrote a "pre-university paper" (part of the Austrian equivalent to the "A-Levels") looking into "Neuro Enhancement", its viability, the science behind it, dangers stemming from it, moral and ethical considerations, as well as much more.

I could get into it in length again, talking about key questions like "How would one measure "cognitive performance" and what does actually fall under that label?" among others. But I'll leave it at this for now.

Now, you may think that this has only a minimal relation to the actual focus of Longecity, as, on first sight, I appear to not really be focused on the main reason this site exists, considering and, perhaps someday, finding ways to make death a choice, rather than a necessity. But for me, this is a matter of perspective. My personal hypothesis, our monkey-brains are to "stupid" to ever find a proper way to immortality among other things, aside, I have a key believe.

Even if, some day, we find a way to stop our telomeres from shortening (or whatever you personally believe is the root cause of ageing), our brains, is my firm belief, are going to become older anyway. Thinking back, the way I was able to connect, understand and learn new information during my childhood is inherently different to what I am experiencing now. For the record, I am currently at the age believed by some to be the "ideal age" for a humans brain. Young enough to still be adaptable, yet already more or less "properly wired up". With other words, around 20. Yet I believe that there are some things that, as a child, I might had been able to more efficiently "learn". That for me, is something I feel we should always keep in mind when it comes to "proper anti-ageing", not just the body, but the mind need to be kept young.

My biggest fear is that there may come a day when I get to test whatever new amazing device the tech-giants release, yet I am unable to properly understand what I'm doing. I may be able to learn operation, I may be able to become proficient, but I may never again be able to explain why and how what I'm doing works.

If you are around my age, you may know this from your (grand-)parents. You might be able to show them how to properly operate their new smartphone, you may even get them to more or less get the hang of social networking, but still, the way they use these devices they never grew up with is inherently different from you. Even if you do not understand what happens in the background, you interact different with the tech you grew up with. That is something I am slightly terrified off.

Anyway, this introduction is already going on for quite a bit longer than almost anybody will care to read so thanks to those who actually managed it. You are either very patient or on Adderall, the latter I personally do not like from a neuroscientific level, as I do detest the "all-or-nothing" approach to Neuro Transmitters substances like it bring to the table. Same goes for Dopamine-Reuptake-Inhibitors and the lot.

By the way, I live in Austria, like salty stuff more than sweets, am somewhat of a Car guy, enjoy Games, as well as Anim(ation of all kind)e and movies, hope to try as much as I can in this lifetime, would kindly ask for criticism of any kind as I feel it is necessary to improve and apparently enjoy writing.

Bye,

Ego

Picamilon Source?

by @ ImmInst Active Topics

Mon Feb 05 18:57:19 PST 2018

I'm looking for a source for Picamilon that is obtainable from the US.

 

I don't use this recreationally.  Basically I'm using it as a rescue dose for extreme anxiety that is the result of protracted withdrawal from years of prescription z-drug use.  Apparently my gaba receptors have not yet normalized 30 months after quitting nightly use of eszopiclone. 

 

When I really get into a high anxiety state it's the only thing that will reliably pull me out of it that I feel isn't a massive threat to undoing whatever recovery I'm managed to build. I'm really trying to stay away from GABA receptor PAMs and don't believe that GABA itself will be as down regulating to these receptors.

 

I use maybe 150mg every week or so.  I've got a bottle from 2015 that will be depleted in another month or two. 

 

So does anyone know a reliable source that can get this material into the US in spite of our idiotic laws?

 

 

 

Raspberry

by admin @ Pressed Probiotic Waters – Suja Juice

Fri Jan 01 16:53:28 PST 2016

Feel refreshed with this naturally enhanced water that has a touch of crushed raspberry and 2 billion vegan probiotic CFUs to aid in digestive and immune health.

3 Reasons Yogurt Isn’t Enough for Good Gut Health

by Rebecca @ UP4 Probiotics

Mon Aug 31 10:39:18 PDT 2015

By now you’ve heard all about how adding probiotics to your diet can be very beneficial to your health. And you’re absolutely right! Unfortunately, when most people think probiotics, they think yogurt. We get it, yogurt is delicious and can be a healthy snack, but it should not be your only go-to product when seeking […]

The post 3 Reasons Yogurt Isn’t Enough for Good Gut Health appeared first on UP4 Probiotics.

Samsung Qi Fast Wireless Charging Kit: Charge Pad, Dual-port Fast Charge Car Charger, USB-C Cable, Micro-USB Cable, and Adaptive Fast Charge Wall Charger

by Eliane @ I Love Savings | Coupons | Grocery | Health | Beauty | Household

Mon Feb 12 05:49:53 PST 2018

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The post Samsung Qi Fast Wireless Charging Kit: Charge Pad, Dual-port Fast Charge Car Charger, USB-C Cable, Micro-USB Cable, and Adaptive Fast Charge Wall Charger appeared first on I Love Savings | Coupons | Grocery | Health | Beauty | Household.

8 Reasons to reach out to 'the public'

by @ Articles

Sun Mar 08 16:35:01 PDT 2015

While the idea that drastic life extension may be an option for humankind in the future has been encountered by many through the media and fiction, the vast majority of the public do not grasp whether and how this could realistically apply to them or their loved ones. 
 
Some argue that since life is an universally desirable good and age-related suffering and death universally feared and avoided, ‘public perception’ is something that will take care of itself. If anything, the inherent attractiveness of the concept will always guarantee media interest perhaps even to the point of generating unwarranted hype and the empty promises that have been the bane of the scientific life extension movement for centuries. 
 
Others argue, with great conviction, that public perception and ‘marketing a life extension movement’ should be a prime objective. Here is a list of eight reasons why:  
 
1. Broaden the pool of ideas. Generally, the more minds are altered to and focused towards a common objective, the greater the chance than innovative or groundbreaking ideas will be generated. If Life Extension is a more broadly known, accepted and prestigious topic of interest, more bright minds will be attracted to it.  
 
2. Increase public sector funding and donations. As businesses tend to fund research only when profitability is close it often falls to the public sector and philanthropists to fund the "starter end" of research that will eventually lead to usable products which business will then want to take up. 
 
3. Reduce opposition.  There is an element of ‘shock’ associated with the concept that aging and death may not be inevitable which can lead to denial or impatient dismissal. Visceral or ideological opposition to life extension translates into less government funding, less scientific interest, less favorable laws and less industry support especially if there is no widely established counter-position.   
 
4. Improve regulation.  Whether we are thinking about laws allowing or prohibiting life extension treatments in general, or the speed and efficiency at which the FDA similar entities conduct their reviews, the support of government agencies is important at every stage of the process of getting treatments to the public. Responsive regulation can be generated through public pressure and media attention. 
 
5. Focus corporate interests towards effective treatments.  Only if there is a clear and well-informed demand for proven and validated treatments will effective products become more profitable to the industry than ineffective ‘snake oil’.
 
6. Build economies of scale.  Given the urgent need for life extension treatments for many people there is an interest in helping to bring costs down as soon as possible. If pent-up public demand becomes more clearly visible, consideration of scale-up will become a part of more business plans and healthcare reforms. 
 
7. Improve public health.  A focus on life extension often comes with increased health consciousness. Prevention is better and cheaper than cures and if more people participate in a wider programme of health-conscious living, this is likely to bring overall healthcare costs down.
 
8. Reduce social unrest and disruption.  Even once society accepts the concept of life extension and associated treatments there will still be people who are unwilling or unable to participate. Moreover, extended lifespans will affect society profoundly. Careful public engagement ensures that social unrest and discrimination can be minimised.  
 
If at least one of these reasons makes sense to you, then you may want to think about how you could help ‘connect’ the LongeCity’s mission with others. Generally, the ‘self-multiplying’ effect of outreach should not be underestimated. People act as role models and influencers of their peers. Beyond all media spin, if a person acts and speaks with conviction, others will take note; and if people realize that their friends and family members could live longer they will be more willing to engage in the idea themselves.  
 
 
-- 
This article is based on an original drafted by Sanhar in response to a LongeCity tender.

Longecity Blog - win$100 for 'best regimen'

by @ LONGECITY Community Blog List

Fri Jun 09 02:08:00 PDT 2017

The forum structure at the heart of LongeCity works well in facilitating a free flow of communication and information exchange.
Other more structured ways of curating information have their own advantages, but their adoption appears to be more difficult.

 

In 2014 we closed the 'regimen' forums for brain enhancement and general supplements in favour of a new 'stacks' function.
aiming to generating a searchable database of combinations as an easily accessible resource.

 

It took some time for the new feature to gain traction. In some areas this worked ok, in others we still don't have any entries.

 

To further promote the feature we are launching a small COMPETITION for the BEST REGIMEN in each category.

 

On Sept.1st LongeCity leadership will draw up a shortlist of the most promising entries for each existing category:

• Life Extension, General Health;
• Alertness, Cognition, Mood
• Sports, Performance, Bodybuilding
• Medical
• Weight Loss
• Beauty, Cosmetics, Skin, Anti-Aging

This shortlist will be based (but not necessarily bound) by the average of the "star ratings" an entry has received from all LongeCity readers!
The Immortality Institute Members will then vote on a winner from each shortlist
The winner in each category* will receive $100 (via paypal) and ₮100.

 

(* yes, that means that the winning chance in the currently empty, or sparsely populated categories might be higher)

 

At least for the duration of the competition, the old 'stacks' forums will re-open. We hope that by now everyone has understood the distinction we are aiming for: the 'regimen' feature is for presenting and discussing structured regimens that can be considered, compared and potentially adopted by others down the ages, the forums are for more free-wheeling conversation that might be more speculative, protracted and less likely to hold a swift take-away message for others.

Even UFC Champion, Georges St-Pierre, Suffers From Ulcerative Colitis

by Jason Hooper @ Fix Your Gut

Mon Feb 12 06:00:02 PST 2018

Many people come to Fix Your Gut frustrated and looking for answers or information to assist them and their doctors with figuring out and solving a gut issue. Often they feel like it is only happening to them. They are ill because of their poor lifestyle choices,

The post Even UFC Champion, Georges St-Pierre, Suffers From Ulcerative Colitis appeared first on Fix Your Gut.

Senescent Cell Blog

by @ ImmInst Active Topics

Mon Feb 12 08:49:59 PST 2018

For some strange reason we do not have a section in bioscience for senescent cells as a major anti-aging target. So I am posting this here.

 

Someone linked this informative blog with a few articles explaining cellular senescence, its causes and possible treatments.

 

https://cellsen.wixsite.com/senescentcell

UP4™ ULTRA FOR HIGH POTENCY PROTECTION

by Rebecca @ UP4 Probiotics

Thu Dec 01 08:42:06 PST 2016

  By Lynda Robbins As the UP4™ Probiotics National Education Specialist, my frequent travel schedule keeps me in the sky, on the road, and in the aisles of retail stores.  My exposure to people and gobs of bad bugs is quite high.  Take for instance, the odd occurrence that 9 times out of 10, as […]

The post UP4™ ULTRA FOR HIGH POTENCY PROTECTION appeared first on UP4 Probiotics.

PORTER-CABLE Oil-Free UMC Pancake Compressor with 13-Piece Accessory Kit

by Eliane @ I Love Savings | Coupons | Grocery | Health | Beauty | Household

Mon Feb 12 05:41:39 PST 2018

...

The post PORTER-CABLE Oil-Free UMC Pancake Compressor with 13-Piece Accessory Kit appeared first on I Love Savings | Coupons | Grocery | Health | Beauty | Household.

Opinions on Weight Loss - Could policy revisions lead to a healthier nation?

by @ LONGECITY Community Blog List

Wed Jul 26 05:52:30 PDT 2017

So, I was reading this over at the FDA and it dawned on me that these safety side effects were only likely to occur in people who are aged. In young people, it would very likely not be an issue. So here's the bigger issue:

 

If you take these away from young people or dissuade them from using them altogether, the young people will lose the opportunity to be healthy. Could it be policies like these that are fattening up America while Japan enjoys the slimmest healthiest lifestyle the world over?

 

Instead, I propose that we put age limits on supplements like these. We have minimum ages for alcohol and tobacco, so why not require carding for maximum ages and put in place a system to allow regulatory authorities to print a max age code on retail boxes and bottles. This of course leaves the looming problem of agism still at play and these regulations may negatively impact those who grow younger, but we can cross that bridge when we get there. For now, we just need to ensure that young people don't get fat and that those who are unfortunate enough to be fat when young can get to their optimum weight and experience that while they are still young.

Find out why water kefir is one of the most beneficial probiotic ferments

by ben @ Obi

Tue Dec 27 15:13:52 PST 2016

You may already be familiar with dairy kefir, which is available in the dairy aisles of a number of national grocers. Water Kefir is a close relative of dairy kefir and contains many of the same strains. Water kefir cultures originate from a variety of different plants in nature in areas where sugar and water... Read more »

3 Benefits of Massage (And How To Make Massage Oil)

by Heather @ Mommypotamus

Sat Feb 10 19:59:32 PST 2018

Did you know that – without even speaking a word or touching – your heartbeat can synchronize with someone you love as you sit near them? It’s true. Powerful physiological bonds have been found between couples, parents and children, and even close friends. (Nikos-Rose,  Dell’Amore) And yet it doesn’t always feel like that, does it?  Our […]

Continue Reading...3 Benefits of Massage (And How To Make Massage Oil)

LongeCity Small Grants

by @ LongeCity - Articles

Sat Jun 09 07:14:53 PDT 2012

With the support of our Members and advertisers LongeCity is able to offer a limited number of small grants and financial prizes. 


The following types of projects can be supported:  

The small grants scheme includes 'micro grants' - up to $180 and 'small grants' - up to $500. 
(Grant applications exceeding $500 would usually be expected to be 'matching fundraisers' discussed above.)

Decisions as part of the small grants programme are usually pretty quick and straightforward. However please contact us with a proposal ahead of time - we will not consider applications where the expenditure has already been incurred!
Proposals can be as short or elaborate as necessary, but normally should be about half a page long.

Only LongeCity Members can apply, but any Member is free to apply on behalf of someone else - thus, non-Members are welcome to find a Member to 'sponsor' their application.  

Apply using the contact form

You can use the ideas forum to discuss and prepare the proposal.

Bourbon Cider Cocktail Recipe

by Suja Juice @ Suja Juice

Mon Nov 06 13:55:05 PST 2017

We’re gearing up for the holidays with a seasonal apple cider cocktail! This delightful drink features our Mulled Apple Cider full of seasonal flavors like cinnamon and clove, plus a healthy dose of bourbon to keep you warm. This cocktail keeps things simple with only two main ingredients, and scales up easily – perfect for […]

Nootropics in human trials (Intro)

by @ Articles

Sat Sep 09 06:57:38 PDT 2017

The word "nootropic" derives from the Greek words nous, or "mind", and trepein meaning "to bend or turn". It was first coined by Romanian psychologist and chemist, Corneliu E. Giurgea after synthesizing Piracetam.
For Giurgea a nootropic drug should have the following characteristics:
1. They should enhance learning and memory.
2. They should enhance the resistance of learned behaviors/memories to conditions which tend to disrupt them (e.g. electroconvulsive shock, hypoxia).
3. They should protect the brain against various physical or chemical injuries (e.g. barbiturates, scopalamine).
4. They should increase the efficacy of the tonic cortical/subcortical control mechanisms.
5. They should lack the usual pharmacology of other psychotropic drugs (e.g. sedation, motor stimulation) and possess very few side effects and extremely low toxicity.

In fact, most drugs commonly labelled as nootropics do not fulfill all of these requirements. Some of the best known (e.g. Adderall, Modafinil) seem to not fulfill any, as discussed later. Instead, other characteristics like (reputed increased alertness, focus or motivation) seem to be key to their popularity.
Because of deviating definitions nootropics are more broadly defined (e.g. in wikipedia) as drugs, supplements, or other substances that improve cognitive function, particularly executive functions, memory, creativity, or motivation, in healthy individuals. 

Some nootropics from the very common to the :

Caffeine
Caffeine is the world’s most widely used stimulant (Nawrot, et al., 2003). It is used by over 90 % of North Americans every day (Mednick et al., 2008). It is widely used because of its positive effects on mood and alertness (Lorist & Tops, 2003)and vigilance and attention (Lieberman et al., 1987). However, these effects do not seem applicable / transferable to motor learning and verbal memory and are unable to reverse effects of sleep deprivation, with a dose of 200mg in low to moderate users (< than 2 cups a day) (Mednick et al., 2008). It is also shown to be ineffective in higher cognitive tasks involving working memory (Battig et al., 1984). Overall conclusions regarding the relation of caffeine and memory have been mixed. Positive effects might stem from caffeine withdrawal in high dosage users (Mednick et al., 2008).

Nicotine
With about 1,1 billion smokers worldwide in the year 2015 (WHO 2015) nicotine takes second place as the most widely used stimulant. It was shown that the application of nicotine in non-smoking males enhances performance in continuous performance tasks and therefore is said to improve attention and working-memory (Kumari, et al., 2003), which is in line with other studies suggesting that nicotine affects short-term memory in delayed free recall tasks (Sarah & Fox, 1998)
Another study examined nicotine’s effects on alertness and performance on a covert orienting task were measured. While nicotine decreased overall reaction times in the covert orienting task, there was no change in the validity effect, the reaction time difference between validly and invalidly cued targets. However, nicotine significantly improved both EEG and self-rated measures of alertness. Nicotine seems to increases alertness in non-smokers, with no improvement in spatial attention using a covert orienting task (Griesar et al., 2002). Furthermore Nicotine seems to reduce distraction under low perceptual load by acting as a stimulus filter that prevents irrelevant stimuli entering awareness (Behler et al., 2015).

Methylphenidate/ Ritalin
Most college students I know will immediately think of Ritalin or Modafinil if they are asked to name a cognitive enhancer. Studies have found that 4.1% to 10.8% of college students in the US reported using prescription stimulants non-medically during the past year (Garnier-Dykstra, et al., 2012).
Methylphenidate (MPH - common brand name ‘Ritalin’) is used in treatment of attention deficit hyperactivity disorder (ADHD) and narcolepsy. Most studies focused on the its effects on Attention, Mood, Memory and executive functions. A single dose of MPH showed a positive effect on memory. Repeated doses of MPH had a mood elevating effect but also enhanced anxiety. No statistically significant effect was found in the outcomes attention, mood and executive functions. MPH had no significant effect on sleep-deprived individuals (Repantis et al., 2010). In a 2015 review the authors found some ‘publication bias’, relating to long-term and working memory and conclude that the effect in healthy subject is probably modest overall and that healthy users resort to stimulants to enhance their energy and motivation more than their cognition (Ilieva et al., 2015). 

Modafinil
Modafinil is used in treatment of disorders such as narcolepsy, shift work sleep disorder, and excessive daytime sleepiness associated with obstructive sleep apnea. Most studies focused on its effects on attention, mood, memory, wakefulness and executive functions and motivation. A single dose showed positive effects on attention only. On sleep deprived individuals it was shown to have an impact on executive functions, on memory and wakefulness but there was an insignificant effect on mood and attention (Repantis et al., 2010). A 2012 meta-analysis found that Modafinil was likely effective but criticised the gaps in the literature. (Kelley et al., 2012) 
A recent study on chess players found significantly enhanced performance with Modafinil or Ritalin but only when the players were not under time pressure (Franke et al. 2017). 

Adderall
Mixed Amphetamine Salts also known under the brand Name Adderall became increasingly popular in recent years as an athletic performance enhancer and cognitive enhancer. Like Ritalin, it is also used to treat ADHD and narcolepsy.
Overall effects of Adderall on cognition have been reviewed as very modest, while having a huge effect on perception. It was found to enhance performance in word recall, embedded figures and Raven's Progressive Matrices, but only for lower performing individuals (Ilieva et al., 2013). Adderall might also impair creativity in high performing individuals (Farah et al., 2009).

L-theanine & Caffeine
L- theanine is primarily found in plants (e.g. in the leaves of green and black tea) and fungus. Results evidently demonstrated that L-theanine clearly has a pronounced effect on attention performance and reaction time response in normal healthy subjects susceptible to having high anxiety (Higashiyama et al., 2011).
A dose of L-theanine equivalent to eight cups of black tea improves cognitive and neurophysiological measures of selective attention, to a degree that is comparable with that of caffeine. The combination of Theanine and caffeine seem to have additive effects on attention in high doses (Kahathuduwa et al.,2016).
Studies suggest that 97 mg of L-theanine in combination with 40 mg of caffeine helps to focus attention during a demanding cognitive task (Giesbrecht 2010).

Bacopa Monnieri
Bacopa Monnieri is an herb which has been used in Ayurvedic medicine for centuries. Bacopa's primary mechanism of action is still unclear, it seems to be an anti-oxidant, a weak acetylcholinesterase inhibitor and a cerebral blood flow activator (Aguiar & Borowski , 2013).
There is some evidence to suggest that Bacopa Monnieri improves memory with little evidence of enhancement in any other cognitive domains (Pase et al., 2012).

Piracetam
Closing the circle to the beginning of this short introduction to the topic: Giurgea first coined the term "nootropic" when he synthesized Piracetam in 1964. Since it is not approved by the US FDA, it is primarily used in Europe, Asia, and South America. It is commonly prescribed for cognitive impairment and dementia in several countries of Europe. Research suggests that Piracetam might also have a positive effect on healthy individuals. Subjects were given 3×4 capsules at 400 mg per day, in a double blind study. Each subject learned series of words presented as stimuli upon a memory drum. No effects were observed after 7 days but after 14 days verbal learning had significantly increased (Dimond & Brouwers, 1976). It might also be beneficial for cognitive decline associated with age. Aging subjects did significantly better in a computerized perceptual-motor tasks when on piracetam than on a placebo. (Mindus et al. 1976). While these old studies may not be that reliable, it is still held that Piracetam's “efficacy is documented in cognitive disorders and dementia, vertigo, cortical myoclonus, dyslexia, and sickle cell anemia. While high doses are sometimes necessary, piracetam is well tolerated” (Winblad, 2005). Since Piracetam was first synthesized many structurally similar compounds have emerged. These so called Racetams have poorly understood mechanisms of action; however, piracetam and aniracetam are known to act as positive allosteric modulators of AMPA receptors and appear to modulate cholinergic systems (Gualtieri et al., 2002).

References
* Aguiar, S., & Borowski , T. (2013). Neuropharmacological review of the nootropic herb Bacopa monnieri. Rejuvenation Research, 313-326. 
* Battig , K., Martin, J. R., & Feierabend , J. M. (1984). The effects of caffeine on physiological functions and mental performance. Experentia, 1218–1223.
* Behler , O., Breckel, T. P., & Thiel , C. M. (2015). Nicotine reduces distraction under low perceptual load. Psychopharmacology, 1269-1277.
* Dimond, S. J., & Brouwers, E. M. (1976). Increase in the power of human memory in normal man through the use of drugs. Psychopharmacology, 307-309.
* Farah , M., Haimm , C., Sankoorikal , G., Smith , M., & Chatterjee , A. (2009). When we enhance cognition with Adderall, do we sacrifice creativity? A preliminary study. Psychopharmacology,541-547.
* Franke, A.G.; Gränsmark, P., Agricola, A., Schühle, K., Rommel, T., Sebastian, A., Balló, H.E., Gorbulev, S., Gerdes, C., Frank, B., Ruckes, C., Tüscher, O., Lieb, K. (2017) "Methylphenidate, modafinil, and caffeine for cognitive enhancement in chess: A double-blind, randomised controlled trial" in: European Neuropsychopharmacology Vol27, Issue 3, 1, pp248-260
* Garnier-Dykstra, L. M., Caldeira, K. M., Vincent, K. B., O’Grady, K. E., & Arria, A. M. (2012).Nonmedical use of prescription stimulants during college: Four-year trends in exposure opportunity, use, motives, and sources. J Am Coll Health, 226-234.
* Giesbrecht, T., Rycroft , J. A., Rowson , M. J., & De Bruin , E. A. (2010). The combination of L-theanine and caffeine improves cognitive performance and increases subjective alertness. Nutritional Neuroscience, 283-290.
* Griesar , W. S., Zajdel , D. P., & Oken , B. (2002). Nicotine effects on alertness and spatial attention in non-smokers. Nicotine & Tobacco Research, 185-194.
* Gualtieri , F., Manetti , D., Romanelli , M. N., & Ghelardini , C. (2002). Design and study of piracetamlike nootropics, controversial members of the problematic class of cognition-enhancing drugs. Current Pharmaceutical Design, 125-138.
* Higashiyama, A., Htay, H. H., Ozeki, M., Juneja, L. R., & Kapoor, M. P. (2011). Effects of l-theanine on attention and reaction time response. Journal of Functional Foods, 171-178.
* Ilieva, I., Boland, J., & Farah, M. (2013). Objective and subjective cognitive enhancing effects of mixed amphetamine salts in healthy people. Neuropharmacology, 496-505.
* Ilieva IP, Hook CJ, Farah MJ. (2015) Prescription Stimulants' Effects on Healthy Inhibitory Control, Working Memory, and Episodic Memory: A Meta-analysis.; J Cogn Neurosci. 2015 Jun;27(6):1069-89. 
* Kahathuduwa, C. N., Dassanayake , T. L., Amarakoon , A. M., & Weerasinghe, V. S. (2016). Acute effects of theanine, caffeine and theanine-caffeine combination on attention. Nutritional Neuroscience.
* Kelley, A.M.; Webb, C.M., Athy, J.R., Ley, S., Gaydos, S. (2012) "Cognition enhancement by modafinil: A meta-analysis" in Aviation Space and Environmental Medicine; Vol83, Issue 7, p685-690
* Kumari, V., Gray, J., H ffytche, D., Mitterschiffthaler, M., Das, M., Zachariah, E., . . . Sharma, T. (2003). Cognitive effects of nicotine in humans: an fMRI study. NeuroImage, 1002-1013.
* Lieberman , H. R., Wurtman, R. J., Emde, G. G., Roberts , C., & Coviella, I. L. (1987). The effects of low doses of caffeine on human performance and mood. Psychopharmacology, 308-312.
* Lorist , M. M., & Tops, M. (2003). Caffeine, fatigue, and cognition. Brain Cognition, 82-94.
* Mednick, S. C., Cai, D. J., Kanady, J., & Drummond, S. P. (2008). Comparing the benefits of Caffeine,Naps and Placebo on Verbal, Motor and Perceptual Memory. Behavioural Brain Research, 79–86.
* Mindus , P., Cronholm , B., Levander , S. E., & Schalling , D. (1976). Piracetam-induced improvement of mental performance. A controlled study on normally aging individuals. Acta Psychiatrica Scandinavia, 150-160.
* Nawrot, P., Jordan, S., Eastwood , J., Rotstein , J., Hugenholtz, A., & Feeley, M. (2003). Effects of caffeine on human health. Food Additives & Contaminants, 1-30.
* Pase, M. P., Kean , J., Sarris , J., Neale , C., Scholey , A. B., & Stough , C. (2012). The cognitive enhancing effects of Bacopa monnieri: a systematic review of randomized, controlled human clinical trials. Journal of Alternative Complementary Medicine, 647-652.
* Repantis , D., Schlattmann , P., Laisney , O., & Heuser, I. (2010). Modafinil and methylphenidate for neuroenhancement in healthy individuals: A systematic review. Pharmacological Research, 187-206.
* Sarah , P., & Fox, P. (1998). An investigation into the effects of nicotine gum on short-term memory.Psychopharmacology, 429-433.
* WHO (2015). WHO global report on trends in tobacco smoking 2000-2025. WHO Library Cataloguing-in Publication Data .
* Winblad, B. (2005). Piracetam: a review of pharmacological properties and clinical uses. CNS Drug reviews, 169-182.

Your first blog post!

by @ Probiotics One: Latest News

Sat Feb 15 03:46:34 PST 2014

Welcome to your blog!
A blog is a great place to share details on your products, business and whatever else you think your shoppers might like to hear from you. You can include photos in your blog posts and even videos. For ideas and inspiration on how to structure your blog, take a look at the Bigcommerce ecommerce blog.

How can I delete this post?
To delete this post and add your own, login to your admin area, click the Content tab at the top of the screen and choose Blog.

Powered by Bigcommerce
Your website, online store and blog are powered by Bigcommerce ecommerce software. It includes everything you need to run a beautiful online store including ecommerce website templates, ecommerce hosting, an online shopping cart and more.

Everything you need to know about Tinctures

by Zoe (Social Media Manager) @ Blog – Well.ca Blog

Wed Feb 07 07:00:11 PST 2018

When you feel a cold or a headache coming on, it’s probably a Tylenol bottle you reach for. But tinctures might actually be a more effective treatment! So why not give them a try? Maybe you’ve heard the word “tinctures”. But you don’t know exactly...

The post Everything you need to know about Tinctures appeared first on Well.ca Blog.

Probiotics Improve Oral Health

by Dr. Rasheed Huma @ MicroBiomePlus

Thu Nov 16 12:08:05 PST 2017

Overview According to a scientific report of 2015, about 46% of the adult U.S. population has some form of tooth disease. This percentage increases with age, affecting about 70% of adults aged 65 years and older. [1] Just like our gut, our mouth is also home to over 700 good and bad bacterial species, collectively […]

The post Probiotics Improve Oral Health appeared first on MicroBiomePlus.

Vitamin D, Colds & The Flu. Oh My!

by Doug Cook @ Doug Cook RD

Fri Dec 15 00:45:41 PST 2017

(DougCookRD.com) Colds are big business. In the United States (and proportionately similar here in Canada no doubt) Americans suffer their way through about 1 billion respiratory infections each year (yup, if you’re doing the math, most people get 2-3 ‘colds/flu’ per year; some poor souls even more). They spend about 2 billion dollars on non-prescription […]

Hello all. Looking for topics to improve myself from CKD

by @ ImmInst Active Topics

Thu Feb 08 05:29:53 PST 2018

Hi Guys,

 

I have had igA nephropaty in the past and lost some kidney function. It seems that the igA issue is under control and kidney function is stable now, but I am looking for some alternative to make my kidney function(Creatinine 2.14) better.

 

Thank you,

Cassio

Post lyme disease treatment advice...diet, bpc 157 and or?

by @ Health

Sun Feb 11 17:35:26 PST 2018

Hey everyone,

Thank you in advance for taking the time to read and respond to my post. I’m a 23 year old (otherwise healthy) male who was diagnosed with lyme disease about two months ago. After undergoing an intense supplement/herbal/energetical therapy cleanse and detox, my docotor confirmed that the lyme had left my body. However, I am still experiencing all of my original symptoms, including random shaking, a neck tremor, intense brain fog, a really infammed gut/liver/kidneys, etc. I’m struggling to determine my next course of action — has anyone reading his post dealt with lyme? — have you tried dietary changes to help heal your system? I’m also curious if bpc 157 would be a good option for me? I already eat a fairly well balanced diet that is exclusively organic/non gmo, as well as taking about 15 relevant supplents a day (including probiotics). I guess, in general, I’m seeking any lyme, dietary, or other advice that you might have for me.

Thanks for your time,

-Braden

Cox Communications Review

by Philip Palermo @ Reviews.com

Fri Feb 02 12:54:57 PST 2018

The curse of noopept/piracetam/pramiracetam

by @ Health

Sun Feb 11 21:47:30 PST 2018

I see a number of newer threads of people on Reddit who have sexual issues after taking these nootropics, years ago no one took it seriously, does anyone have any hard data on how to fix this issue or what is the cause of this.

Is Your Adrenal Fatigue Dragging You Down?

by Doug Cook @ Doug Cook RD

Mon Jan 15 20:12:43 PST 2018

(DougCookRD.com) Tired for no reason? Having trouble getting up in the morning? Struggling to keep up with life’s daily demands? Not having fun anymore? Craving salty or sweet snacks or caffeine? Do you have unexplained fears/anxiety? Do you have asthma, arthritis, or fibromyalgia? Then you might be suffering from adrenal fatigue!, or so says the […]

Cryonics

by @ Articles - Articles

Tue Feb 21 13:06:47 PST 2012

The following is a quick overview on Cryonics.

 

NB: The information below is periodically reviewed for accuracy, but LongeCity makes no representations or gives any warranties whatsoever that the following information is accurate and complete at any point in time. LongeCity accepts no responsibility or liability for information contained on this page. The discussion of cryonics service providers and services in no way entails any endorsement on part of LongeCity. The lead author of this page, its editors and other contributors from time to time may be affiliated with one of the service providers mentioned below. Without qualification to the foregoing disclaimers, LongeCity strives to present the following information in an objective and balanced manner. If you feel that information on this page is inaccurate or imbalanced please contact the LongeCity Support Email.

 

INDEX

• Cryonics Overview
• Existing Cryonics Organizations
• Cryonics Services Offered
• Sizes of the Organizations
• Whole Body/Neuro Options
• Cryopreservation and Yearly Fees
• Human Cryopreservation Procedures
• Funding Cryonics by Insurance

Cryonics Overview

 

Cryonics is based on the idea that future medicine will have capabilities well beyond those of current medicine, including the ability to cure all diseases, rejuvenate and repair damage incurred in the cryopreservation process — through the use of nanotechnology and other technologies. Cryonics can be an ambulance or time capsule to future medicine which can allow us to live many thousands of years or longer in youth and good health. Stored at very low temperatures there will be very little molecular motion in cryonics patients for tens of thousands of years, although most of us do not believe that we will have to wait anywhere near so long for future medicine.

 

Although cryonics patients must be legally dead before cryonics procedures to reduce or eliminate ischemic damage and ice formation can be applied, cryonicists do not believe that cryonics patients are dead in an ultimate sense. Nearly all the cells of the body are alive for quite some time after the heart stops — including neurons. A standby team can be used to minimize the time between pronouncement of death and cooling, cardiopulmonary support, etc. Cryonicists believe that the anatomical basis of mind can survive much longer than six minutes after stoppage of the heart in the absence of cooling — despite the inability of current medicine to revive patients without neurological damage after more than six minutes of cardiac arrest. (See Quantifying Ischemic Damage for Cryonics Rescue for more details.)

 

Existing Cryonics Organizations

 

For most of cryonics history (which began in the mid-1960s), all of the cryonics organizations offering cryonics services have been in the United States. In 2005 a cryonics organization was created in Russia (just northwest of Moscow) and there are plans for another cryonics organization in Australia to offer perfusion and storage of cryonics patients within a few years. LongeCity does not endorse any particular cryonics organization. The data below is taken from the cryonics organizations without LongeCity attempting to verify the accuracy of their claims or the extent of the services they claim to provide. If you are considering utilizing any of these organizations, you should conduct your own investigation.

 

NAME	LOCATION	INCORPORATED	NON-PROFIT ?
Alcor Life Extension Foundation	Scottsdale, Arizona	1972	Yes
American Cryonics Society (ACS)	Cupertino, California	1969	Yes
Cryonics Institute (CI)	Clinton Township, Michigan	1976	Yes
KrioRus	Moscow, Russia	2005	No
Oregon Cryonics	Salem, Oregon	2005*	No
Suspended Animation, Inc (SA)	Boynton Beach, Florida	2002	No
Trans Time, Inc.	San Leandro, California	1972	No

 

Alcor Life Extension Foundation and the American Cryonics Society (ACS) are organized as 501©3 charitable organizations, whereas the Cryonics Institute (CI) is simply a non-profit corporation. Although Suspended Animation, Inc. (SA) is ostensibly a for-profit company, it is mainly engaged in research and development of cryonics capabilities financed by the principals of the Life Extension Foundation. By 2012 KrioRus had relocated to a facility closer to Moscow, but a newer facility is being built midway between Moscow and St. Petersburg.

 

Oregon Cryonics was incorporated in 2005, but accepted its first patient (a pet patient) in May, 2014. Jordan Sparks is the owner/operator, but he has plans for a Board of Directors or other mechanism to out-live him (to allow for the organization to continue).

 

Cryonics Services Offered

 

Not all cryonics services are offered by all cryonics organizations. Patient administration service is offered by cryonics organizations that sign-up Members who are to be cryopreserved upon legal death and maintain responsibility for those Members while they are Patient's in cryopreservation storage. Perfusion is the replacement of normal body fluid with cryoprotective solutions to reduce or prevent ice formation at cryogenic temperatures. Storage is the storage of a cryonics patient in liquid nitrogen. Standby/Stabilization/Transport (SST) involves standing by the bedside of a medically terminal patient destined to be cryopreserved, the application of a heart-lung resuscitator and ice-water cooling as soon as possible after declaration of death,and transport to a perfusion facility while tissues are still being stabilized at low temperature.

 

The following table represents the services which cryonics organizations say they provide.

 

*=simplification, see explanation

NAME	PATIENT ADMINISTRATION	PERFUSION	STORAGE	SST
Alcor	Yes	Yes	Yes	Yes
ACS	Yes	Yes*	No*	Yes*
CI	Yes	Yes	Yes	No*
KrioRus	Yes	Yes	Yes	No
Oregon Cryonics	Yes	Yes	Yes	No
SA	No*	No	No	Yes
Trans Time	Yes	No	Yes	No

 

All standby cases done for Alcor Foundation outside of Arizona, but inside the continental United States are handled by Suspended Animation, Inc (SA). Alcor does standby for Alcor Members who are terminal in Arizona, Hawaii, and Alaska as well as in Canada. SA does not provide SST services outside the continental United States for any organization.

 

The American Cryonics Society (ACS) states that it mainly contracts with Suspended Animation,Inc. (SA) for perfusion and standby/transport, and contracts with the Cryonics Institute (CI) for storage. ACS also states that it has equipment, contractors and volunteers which are available for use in perfusion and standby in California should the need arise, although this is far less sophisticated and formal than what SA provides. ACS creates and manages individual charitable trusts for its patients. ACS regards these trusts as an important feature of the benefit gained by being an ACS Member.

 

Cryonics Institute (CI) Members who reside in the continental United States have the option of contracting directly with SA if they desire professional SST.In some cases volunteers or paid funeral directors have provided these services to CI Members. SA will keep records of CI Members who have arranged to have SA SST, but does not continue any administrative responsibility after the patient has been cryopreserved.

 

Trans Time is currently storing patients, but (despite what their website says) is not currently seeking new Members or Patients.

 

Sizes of the Organizations

 

There are various ways by which organization size could be measured, but for the purposes of this section size is represented by the number of Members in the organization, the number of patients currently being stored in liquid nitrogen and the number of full-time paid staff in the organization. The figures below are for April 2017, and are based on the statements of the organization in question.

 

*=simplification, see explanation

NAME	MEMBERS	FUNDED MEMBERS	PATIENTS	STAFF
Alcor	1,639*	1,132*	150	9*
ACS	?*	?*	20*	1*
CI	1,384*	?*	151*	3*
KrioRus	N/A	N/A	52	7*
Oregon Cryonics	8*	N/A	6	5*
SA	N/A	N/A	N/A	3*
Trans Time	?	?	3	1?

 

The Membership statistics reported above are for living Members only. Both Alcor and CI patients are Members (except for the ACS patients at CI). The American Cryonics Society (ACS) has an organizational policy against publishing the number of Members it has in its organization. As of April 2017 the 20 ACS patients were all in storage at the Cryonics Institute (CI). ACS has had one part-time clerk to do office work and has otherwise relied on volunteers. Alcor has 9 full-time staff, 1 consultant, and 1 regular volunteer. The 151 patients in storage at CI includes 20 ACS patients. KrioRus has no Membership program, and the method of counting patients is odd — a few are not stored by KrioRus. KrioRus has 4 full-time and 3 part-time employees as well as numerous volunteers.

 

CI is a subcontractor for storage of 20 ACS patients. CI has three paid staff (two full-time and one part-time), a few contractors and many volunteers. Accounting is done by CI Treasurer Pat Heller (a CPA) with auditing by another CI Director. Trans Time does not report its Membership numbers. Suspended Animation (SA) is a subcontractor which provides Standby/Stabilization/Transport (SST) only to other cryonics organizations (ACS, Alcor and CI), so it has no Members or Patients — so the reporting of Members or Patients for SA is "Not Applicable" (N/A). SA makes extensive use of subcontractors when needed.

 

As of April 2017, CI reported 136 pets, Alcor reported 58 pets, KrioRus reported 21 pets, and Oregon Cryonics reported 2 pets in cryopreservation.

 

Alcor and CI member numbers are not directly comparable because the word "Member" has different meanings for the two organizations. Membership in CI provides the privilege of obtaining cryopreservation services: pet, DNA or human cryopreservation. Many join CI only to store DNA or pets or to support CI, including some Alcor Members. Some Alcor Members have even made arrangements to use CI as a "back-up". Alcor does not allow its Members to have Alcor as a "back-up". Prior to April, 2012, all Alcor Members had made arrangements (ie, funding and contracts in place) for human cryopreservation and SST, but in April 2012 the Associate Alcor Member program was introduced. Associate Alcor Members do not have any cryopreservation arrangements with Alcor.

 

ForApril 2017, Alcor reported 1,639 living Members, 1,132 of whom had made arrangements for human cryopreservation, and 357 of whom were Associate Members. Of the 1,384 CI Members in April 2017, 212 of those had made arrangements for both human cryopreservation and standby/stabilization/transport (all with SA). In September 2015, CI ceased reporting how many of it Members have funding and contracts for cryopreservation. Historically, less than half of CI Members have been funded (prior CI statistics). Since 2006, CI offers a 'partnership' arrangement for CI Members for SA SST.

 

As noted in the previous section, Trans Time is currently storing patients, but (despite what their website says) is not currently seeking new Members or Patients.

 

In 2011 and 2012 SA reorganized its staff to have more part-time employees and contractors, and for much of 2012 and 2013 SA was re-organizing to have facilities in both California and Florida.

 

Oregon Cryonics has an owner (Jordan Sparks) and four other full-time employees. OC has 9 Members, but is no longer accepting new Members..

 

Accounts of patient histories and membership growth can be found at:
--Cryonics Institute (CI) Patient Details
--Cryonics Institute (CI) Statistics Details
--Complete List of Alcor Cryopreservations
--Alcor Membership Statistics

 

Whole Body/Neuro Options

 

The term neuropreservation (or "neuro") generally refers to the practice of cryopreserving only the head rather than the whole body. A "neuro" is usually a whole head, not just the brain, but sometimes only the brain is cryopreserved. Keeping the whole head to preserve the brain is convenient for both perfusion and storage (the skull protects the brain). In some cases, however, "neuros" are brain-only. The following represent options various organizations say that they offer.

 

*=simplification, see explanation

NAME	WHOLE BODY	NEURO
Alcor	Yes	Yes
ACS	Yes	No*
CI	Yes	No
KrioRus	Yes	Yes
Oregon Cryonics	No	Yes
SA	N/A	N/A
Trans Time	Yes	Yes

 

Alcor states that its Members have the option of having their whole body cryopreserved or only their head ("neuro") — with different fees applicable to each choice. In April 2017, Alcor reported having 93 neuro, 54 whole body, and 4 neuro+whole bodypatients, whereas KrioRus reported 25 neuro and 27 whole-body patients. Trans Time has one whole body and two brains.

 

All CI Members with human cryopreservation arrangments are "whole body". ACS states that it does not have a policy against neuropreservation, but as long as it only uses CI as its subcontract or for storage it cannot offer neuro-cryopreservation as an option. Suspended Animation (SA) is a subcontractor which provides Standby/Stabilization/Transport only to other cryonics organizations, not storage, so the question of storage options with SA is "Not Applicable" (N/A).

 

Oregon Cryonics only stores heads and brains. As of February, 2016 Oregon Cryonics was chemically preserving three human brains, and cryopreserving one dog brain.

 

Cryopreservation and Yearly Fees

 

Comparing fees for human cryopreservation and yearly Membership or Emergency Responsibility is difficult to summarize in table form because the policies, procedures and options between the cryonics organization are so different. A great deal of explanation is required. Note that the high prices for human cryopreservation are generally covered by life insurance policies. The following represent the fees that the following organizations state that they charge.

 

*=simplification,see explanation

NAME	WHOLE BODY	NEURO	YEARLY FEES
Alcor	$200,000*	$80,000*	$620*
ACS	$155,000*	N/A	$376*
CI	$28,000*	N/A	$120*
KrioRus	$36,000*	$12,000	None
Oregon Cryonics	N/A	$25,000*	None
SA	N/A	N/A	None
Trans Time	$150,000	$50,000	$96*

To Alcor's yearly fee of $620 annual dues, those living in the United States and Canada must add $180 yearly SST fees for a total of $800 per year. A lifetime payment plan is also available. SST service is not available to Alcor Members outside of the US and Canada, but a $15,000 surcharge is added to whole body and neuro prices in the United Kingdom, and a $25,000 surcharge is added to the prices paid by those living in other countries. For details on Alcor pricing, see Schedule A: Required Costs and Suspension Funding Minimums.

 

The prices given for the American Cryonics Society (ACS) are intended to reflect comparable service to what Alcor provides. In fact, ACS has a very wide menu of options and prices available, including reference to a "California Procedure" which is intended to be distinguished from the"Michigan Procedure" offered by the Cryonics Institute. The yearly fee for an ACS Member is $376 for the first four years and $300 per year thereafter. For details on ACS options and fees, see:www.americancryonics.org.

 

The Cryonics Institute (CI) charges $28,000 for perfusion and storage of a Lifetime Member and $35,000 for a Yearly Member. These prices do not include funeral director costs or shipment to CI for non-local cases. (When CI was begun it was imagined that every state would have at least one cryonics service provider.) The Lifetime CI Member has paid a one-time $1,250 fee and the Yearly CI Member has paid a $75 initiation fee and is paying a $120 yearly fee. Discounts for additional family members and underage family members apply only to Lifetime Memberships. For service more comparable to what Alcor provides — including Standby/Stabilization/Transport (SST) — a Lifetime Member pays $88,000 and a Yearly Member pays $95,000. For details on CI pricing see Membership andDetails Concerning SA Standby and Transport for CI Members.

 

For $49,000 KrioRus states that it offers Russians (Europeans?) the option of shipment and storage at the Cryonics Institute in the USA.

 

Oregon Cryonics charges $25,000 to cryopreserve a whole head, $18,000 for a brain with braincase, and $14,000 for a brain without the braincase. Oregon Cryonics will chemically preserve a brain for as little as $1,000 (see Oregon Cryonics Service Fees for details).

 

As noted in previous sections, Trans Time is currently storing patients, but (despite what their website says) is not currently seeking new Members or Patients.

 

Suspended Animation (SA) is a subcontractor which provides SST only to other cryonics organizations, not Membership or storage, so the question of these options with SA is "Not Applicable" (N/A).

 

Human Cryopreservation Procedures

 

Human cryopreservation procedures are much too complex to be summarized effectively here.

 

Alcor's procedures are summarized on a page of the Alcor website called Alcor Procedures. But is it also very helpful to read actual case reports of Alcor patients in the Cryopreservation Case Reports section of the Alcor website library.

 

CI has a summary of its procedures on its website calledGuide to Cryonics Procedures. CI procedures do not include Standby/Stabilization/Transport (SST), though CI will advise Members on obtaining assistance through local funeral directors. CI Members residing in the continental United States who wish to obtain SST can do so by subcontracting with Suspended Animation, Inc. (SA).

 

Although the American Cryonics Society (ACS) has equipment and volunteers which could be used if necessary, ACS basically relies on SA for Standby/Transport and CI for Perfusion/Storage.The human cryopreservation procedures of Trans Time and KrioRus are not documented on their websites.

 

Funding Cryonics by Insurance
The cost of cryonics is many thousands of dollars, but most cryonicists cover these costs with life insurance policies that name a cryonics organization as beneficiary. Premiums of life insurance policies are most affordable for those who are young and healthy. It is not prudent to seek life insurance in old age or after a terminal illness (when life insurance may be unobtainable). Nor is it prudent to believe that cryonics arrangements can be made efficiently or successfully when in a terminal condition.

 

Rudi Hoffman sells the great majority of cryonics life insurance policies. It makes good sense to take advantage of Rudi's considerable expertise in matters of cryonics and life insurance. (A sincere and unpaid plug for Rudi.)

hi

by @ ImmInst Active Topics

Mon Feb 05 05:57:10 PST 2018

Hi everyone,  been a lurker for a while now and I finally decided to register and participate.

 

Hi, there. new guy on the block

by @ ImmInst Active Topics

Tue Feb 06 07:01:50 PST 2018

I'm 71 YO.  trying to out run mother nature with exercise, diet and enjoy it more with occasional use of mainly stimulatory, legal supplements.  I mainly use phenylpiracetam, piracetam, coffee.  I am a master's level psychologist (industrial/organizational by occupation).  Retired from that an now teach 5 Intro, Child psych classes at several 2 year colleges in southern New Jersey.

My fitness routine involves resistance work and sprinting.

Recently taken a course of antibiotics? Find out why you should be re-populating your body with probiotics

by ben @ Obi

Sun Jan 15 13:59:31 PST 2017

Antibiotics came into widespread medical use in the 1940s. They give us the ability to deal with emergency infections in a powerful way. Before antibiotics, people were more likely to die because of diarrhea and basic infections – or from simple sickness in old age. However, antibiotics work by indiscriminately killing your body’s bacteria, both... Read more »

Geroprotector Review: Rapamycin and other mTOR...

by @ Articles

Tue Jul 18 14:03:16 PDT 2017

Sven Bulterijs continues his discussion of prominent compounds with potential life extension efficacy by looking not just at rapamycin but also at its target, the mTOR pathway, which has likely a key role in mediating lifespan. ⇒ read the article in "Sven's Science Corner" blog

Local Meetings

by @ Active Goals RSS Feed

Mon Aug 18 12:17:00 PDT 2014

Goal Runtime: 18 August 2014 - 07:17 PM - Continuous Goal
To support local meetings during for the International Longevity Day and beyond.

Did you know that stevia is a natural sweetener that comes from a plant?

by ben @ Obi

Wed Sep 07 08:21:41 PDT 2016

Stevia might taste sweet, but it’s actually known to have the opposite effects of sugar – recent studies have found compelling evidence it might be a powerful tool in combating type II diabetes in humans.  Historical uses for stevia have included gum health and soothing an upset stomach. But if stevia is so great, why... Read more »

Need help making sense of blood glucose readings

by @ ImmInst Active Topics

Sun Feb 11 03:44:28 PST 2018

Hi!

I'm usually only reading at these forums but decided that I need some help to figure out what is going on with my blood glucose.

Fasting in the morning it is 75-83 mg/dL typically. After my typical breakfast (1l yogurt, some cottage cheese and a slice of bread or some oatmeal) the blood glucose looks like this:
Before breakfast 75
15 min post 75
1 hour post 65
2 hour post 65
3 hour post 84

Before lunch 80
45 min after lunch 85
75 min after lunch 78
110 min after lunch 97
2.5 hours after lunch 86

This lunch consisted of gluten free pasta (rice pasta)
Cottage cheese, meatballs

What I'm not getting is why my blood glucose drops to hypo range after breakfast, but not after lunch?

I do 16:8 IF

Supplements are:
Rhodiola,
Zinc carnosine for stomach issuer
Boron 10 mg
Lifeextension two a day multi @1 a day
B-right
Tmg
Omega 3 4g
L-tyrosine 800mg

All taken in the morning before breakfast.

I do heavy weight lifting twice a week.

Please comment and give advice to what is going on.

My suspicion so far is the high amount of dairy in the breakfast. I tried to reduce it bit with little effect. Im considering to omit it from breakfast. Other than that I dont know.

Thanks in advance

Look below for microbiome modifiers added

by lassesen @ CFS Remission

Sat Feb 03 13:55:46 PST 2018

A reader wrote: “Hi Ken, what is your take on reducing, I can only find 3 things that may reduce Proteobacterium, L. taurine, and walnuts from your site and Chris’s pubmed study above which shows L. Reuteri works. It seems to me this would be a great direction. I’m thinking of adding L. Reuteri and […]

Want A More Youthful Brain? Get More Lutein

by Doug Cook @ Doug Cook RD

Wed Nov 08 00:30:00 PST 2017

(DougCookRD.com) Growing up I remember my grandmother giving me little nutrition nuggets taken from Canada’s Food Guide such as “you should always have one dark orange and one dark green vegetable each day”. From a young age, we’re taught about healthy eating and how different foods help to keep us healthy; milk of course has […]

Life Extension Pseudoscience and SENS Plan

by @ Action

Fri Jan 19 06:01:35 PST 2018

Life Extension Pseudoscience and the SENS Plan

 

Quote from the above document:

 

However, given the recent successes and highly emotional nature of life extension research, Aubrey de Grey is not the first, nor will he be the last, to promote a hopelessly insufficient but ably camouflaged pipe-dream to the hopeful many. With this in mind, we hope our list provides a general line of demarcation between increasingly sophisticated life extension pretense, and real science and engineering, so that we can focus honestly on the significant challenges before us.

 

May be when the mission, vision and goals of a company, or in this case a research foundation and public charity in financial distress, sound too good to be true the alarm bell should be ringing.

After 8 years since its foundation (2009) is there any available tested application/therapy coming out from SENS line of research?

 

 

Lyric Hijacking - Fall Out Boy: Immortals (LongeCity Version)

by @ LONGECITY Community Blog List

Tue Oct 17 13:58:00 PDT 2017

 

They say we are what we are
But we don’t have to be
I’m glad to hate you but I do it in the best way
I’ll be the watcher of the eternal flame
I’ll be the guard dog of all your forever dreams
I block the sand from the bottom half of the hourglass (Glass, glass)
I’ll try to picture me without you but I can’t
'Cause we could be immortals, immortals
It won't be long, be long
If we live forever then, pull the blackout curtains down
It won't be long, be long
We will be immor immortals, immor immortals
Immor immortals, immor immortals
Sometimes the only payoff for having any faith
Is when you test it again and again everyday
I’m still improving your model to get to my future
It's never over, they’re not the last sutures

 

I stop the sand from the bottom half of the hourglass (Glass, glass)
I’ll try to picture me without you but I can’t
'Cause we will be immortals, immortals
It won't be long, be long
If we live forever then, pull the blackout curtains down
Just not for long, for long
We will be immor immortals, immor immortals
(Immortals)
And if we live forever then, pull the blackout curtains down
We will be immortals, immortals
It won't be long, be long
We will be immor immortals, immor immortals
Immor immortals, immor immortals
Immortals

Lemon Bread Recipe With Vanilla Glaze (Gluten-Free, Paleo)

by Heather @ Mommypotamus

Wed Jan 10 14:10:16 PST 2018

It’s happened to you, too right? You’re scrolling through Facebook and some divine looking recipe flits across your feed. Before you know it your rummaging through your pantry to check for ingredients, because this recipe needs to happen right. now. (Seriously, not just me, right?) Now, usually I am more of a steak and kale […]

Continue Reading...Lemon Bread Recipe With Vanilla Glaze (Gluten-Free, Paleo)

Significance of Consuming a Vegan Probiotic

by Dr. Rasheed Huma @ MicroBiomePlus

Wed Dec 13 15:47:02 PST 2017

What are vegan probiotics? These are the probiotics that are free of animal products, fish, GMOs, soy, gluten, or harmful additives of any kind. What are the benefits of consuming a Vegan Probiotic? Being entirely vegan makes a probiotic allergy safe. Moreover, it could be an ideal option for the vegans who face a challenge […]

The post Significance of Consuming a Vegan Probiotic appeared first on MicroBiomePlus.

Guten Tag

by @ ImmInst Active Topics

Mon Feb 05 00:09:30 PST 2018

Hi

by @ ImmInst Active Topics

Tue Feb 06 16:21:09 PST 2018

Hello forum,

   I'm 38 and line in Southern California. Supplements I take right now are:

Morning - 1 Pill Resveracel, 1 Pill Crucera-SGS, 1 Scoop BHB Salt, 1 Scoopt MCT Oil, & Veggie Smoothie (or sub spirulena pills)

Nightime - 1 Pill Meriva-SF, Glucosamine (Thorne)

My goal is to stay physically healthy as long as possible. I'm pretty tall, and we don't seem to last as long. 

Right now I'm interested in Fullerene. 

What’s the benefit of natural probiotics found in yogurt, kombucha and kefir versus lab strains found in pills and supplements?

by ben @ Obi

Sun Jul 24 14:28:27 PDT 2016

Fermented cultures occur naturally in foods and beverages like water kefir (used in Obi), milk kefir, kombucha, yogurts, miso, sauerkraut, and tempeh. Every human culture throughout history has taken advantage of fermented cultures for health, food preservation, and recreation. Isolated strains of microorganisms are a relatively recent phenomenon that has only really been an option since... Read more »

Rebecca’s Skin Care Routine – Tips for Vibrant Skin

by nayelle @ NAYELLE Probiotic Skincare – Formulated For Sensitive Skin

Tue May 30 09:09:34 PDT 2017

Rebecca is one of our favourite fitness and lifestyle bloggers. She is a fitness professional helping to connect women on their journey to a happier, healthier lifestyle through her online community at www.BeNaturally.fit . Her goal is to provide knowledge and continuing support so that everyone can create their own unique nutrition and fitness routine [...]

The post Rebecca’s Skin Care Routine – Tips for Vibrant Skin appeared first on NAYELLE Probiotic Skincare - Formulated For Sensitive Skin.

Mucuna Pruriens builds tolerance? Your experiences?

by @ ImmInst Active Topics

Sun Feb 11 21:36:33 PST 2018

I have seen some topics about people who take Mucuna Pruriens... And they say that it is followed by a low/causes dopamine downregulation?

 

I am wondering if that's true, because in the end I am looking for a way to increase my dopamine constantly, not just for an hour or two, and not to increase it for a day and then feel sluggish the next day even if I take it.

 

I have not tried this herb, but I do not want to spend money on something that doesn't work the way I want it to work.

 

So please comment and let me know your experiences with this herb? And perhaps some suggestions on other herbs that would increase my dopamine, since I have been low on dopamine for over a decade now, except for an occassional random high that lasts for like 20 or 30 hours when I get really excited about something...

 

Thanks! 

Erythromycin, carglumic acid, capecitabine, and ivermectin as lifespan extenders

by @ ImmInst Active Topics

Mon Feb 05 06:56:35 PST 2018

Repurposed FDA-approved drugs targeting genes influencing aging can extend lifespan and healthspan in rotifers.

caliban's Blog - Shalots

by @ LONGECITY Community Blog List

Thu May 18 13:42:00 PDT 2017

“Shalot” = a made-up word for a type of person active in life extension, cryonics, artificial intelligence and related fields. Sometimes encountered on LongeCity.

 

The word is a constriction of ‘zealot’ and ‘shallow’ and also a reference to Tennyson’s poem ‘the Lady of Shalott’ (2x’t’) as someone who is removed from the real world, obsessed with images and appearances and likely to disappear suddenly and pointlessly.
“Shallot” (2x’l’) Is a word for a type of onion. A bland yet pungent vegetable that can make you cry when you work with it…

 

Characteristics of a shalot:

 

1) Shalots know little about the history of science and technology, let alone in life-extension. They fail to appreciate how much they risk repeating the past, and moreover, how much they themselves are –hopefully unwittingly– playing the part of a peddler of hype and false promises in the footsteps of hundreds who have come before. Instead, they are usually convinced that it’s all new and unheard of –including their own schemes and fancies.

 

2) Shalots don’t understand a lot about science. Most of the time they obfuscate this fact, sometimes they are quite upfront, even aggressive about it. They make a distinction between scientists as people who do the grunt work and people like themselves who are ‘organisers’. They understand even less about medicine.

 

3) They are interested in media buzz and talk a lot about ‘mass movements’ and ‘marketing’ about ‘policy’ – but usually fail to demonstrate where these factors have ever been truly relevant in producing tangible scientific advances.

 

4) Shalots often lament that different activities are not well-coordinated enough and paint a picture where global innovation would function much more efficiently if only someone would be in charge to co-ordinate.

 

5) They are usually not very successful in their professional life but are fairly sure that they were born to greatness. Even worse, if they have been successful once, they are now convinced that they have all the answers.

 

6) When a shalot accepts a specific, useful, or even important task they often under-perform… which should come as a surprise because the things that they really wanted to do would have been much more demanding.

 

7) Shalots tacitly assume Life Extension is a kind of ‘pill’ – something that will be invented at some stage and then solve all medical issues associated with aging in one go. They therefore talk about things like “before and after” and “until”. Some shalots declare that they realise it is more complicated than that, but their attitudes don’t suggest this is true.

 

8) They come onto the scene with a splash, a rush of activity. Sometimes that is very welcome because you can’t or don’t want to identify them as a shalot straight away. Sometimes, it is clear to most who have been there before that shalot shenanigans are in evidence, but not giving them a minimum of time would look bad and –who knows?– maybe, just maybe, the shalot can make a useful contribution before wandering of. And they will disappear after a while. Sometimes they get a job or a girlfriend.

 

You can tell that my own studies about shalots are as frustrating as they often purport themselves to be. I try to avoid them. Nonetheless I might return to this polemic with more observations as my experience may regrettably inspire.
This is a private rant, in no way related to anything I do at LongeCity or elsewhere.

LongeCity Affiliate Labs

by @ Articles

Sun Jun 19 18:16:58 PDT 2016

The Longecity “Affiliate Labs” are small, research-focused enterprises or independent academic research groups led by a scientists with strong ties to the Longecity community and a proven track record of commitment to scientific inquiry directly relevant to the Longecity mission.
These leaders and their colleagues are not just trailblazers in advancing important areas of regenerative and rejuvenation research, but also incredibly helpful when there is a community need for peer review, when providing advice and training to a young scientist, and in providing the expertise and tools to test the novel, controversial, or promising scientific leads sourced from the Longecity community and beyond.

Community Funding
There is a small support fund that the labs can draw on to flexibly support their research activities. While not a substitute for private investment and public sector grants, the ability to flexibly ‘just try’ out a new idea without needing to ‘pitch’ in lengthy proposals can be an invaluable accelerator to research progress. All Affiliates have an active link to the Longecity community, so there is a level of accountability and responsiveness beyond anything encountered in ‘traditional’ research donations.
By donating to the Affiliate Labs fund, Members can be assured that every penny goes directly to an expert personally and professionally committed to making a difference in the scientific conquest of death.
Donate HERE

Current Affiliate Labs
- Alexandra Stolzing, Loughborough University, UK & Leipzig University, Germany.
- James Clement - Betterhumans, USA
- João Pedro de Magalhães, University of Liverpool, UK
- John Schloendorn – Gene&Cell Technologies, USA
- Kelsey Moody, Ichor Therapeutics, USA.
- Kevin Perrott – Buck Institute, USA
- Matthew O’Connor – SENS Foundation, USA

Beauty Vitamins for Healthy Skin

by nayelle @ NAYELLE Probiotic Skincare – Formulated For Sensitive Skin

Thu Apr 06 09:35:47 PDT 2017

Skin is our biggest organ. That fact alone should prompt us to take care of it. Doctors say that the skin is an indicator not just of our skin health, but our health in general. The skin reflects what's happening inside our bodies, and if we take care of the skin inside and out, [...]

The post Beauty Vitamins for Healthy Skin appeared first on NAYELLE Probiotic Skincare - Formulated For Sensitive Skin.

Free Sample of Mr Hyde Zero Supplement

by Heather @ I Love Savings | Coupons | Grocery | Health | Beauty | Household

Mon Feb 12 05:19:46 PST 2018

...

The post Free Sample of Mr Hyde Zero Supplement appeared first on I Love Savings | Coupons | Grocery | Health | Beauty | Household.

Upper Gut Dysbiosis, Anxiety, Brain Fog, Fatigue, Is Ammonia the Cause?

by John Brisson @ Fix Your Gut

Fri Jan 12 13:17:53 PST 2018

When someone is suffering from dysbiosis, imbalances within the body can readily occur and make people ill. Upper gut dysbiosis is becoming more well-known and is separate from SIBO (small intestinal bacterial overgrowth) and colonic overgrowth. With new research, we get great insight on previously unknown health

The post Upper Gut Dysbiosis, Anxiety, Brain Fog, Fatigue, Is Ammonia the Cause? appeared first on Fix Your Gut.

Your probiotics could be causing thick blood

by lassesen @ CFS Remission

Thu Feb 08 21:36:10 PST 2018

A reader asked: “Do you still think thick blood is a common issue and do you still recommend getting the multiple labs for thick blood? Is there a viscosity test you recommend for seeing that the thickness is at any given time?” Given that I have been focusing on the microbiome  (mainly because it is actionable […]

Causes of Dry and Dehydrated Skin

by nayelle @ NAYELLE Probiotic Skincare – Formulated For Sensitive Skin

Wed Mar 22 18:58:32 PDT 2017

Dry skin can be a temporary condition or a lifelong concern. Dry skin can be genetically determined or a product of an increasingly stressful lifestyle coupled with continual exposure to the sun, wind and chemicals in the environment. It can also be caused by the use of poor quality skin care products. It becomes extremely [...]

The post Causes of Dry and Dehydrated Skin appeared first on NAYELLE Probiotic Skincare - Formulated For Sensitive Skin.

Healthy Cherry Chocolate Smoothie Recipe

by Lauren Bonsell @ Blog – Well.ca Blog

Wed Jan 31 07:00:30 PST 2018

Have a chocolate craving but want to stay away from processed sugar and sweets? We all know the feeling. That’s why we created this craving-busting and healthy cherry chocolate smoothie recipe! It’s creamy and has the same flavours you love in Black Forest cake – but...

The post Healthy Cherry Chocolate Smoothie Recipe appeared first on Well.ca Blog.

Weston A. Price: “Just Thrive Probiotic Podcast is TOP 3 of 2017!”

by Chris @ Thrive Probiotic

Mon Jan 08 09:54:47 PST 2018

We are excited to report that Weston A. Price’s “Best of 2017” Episode is NOW available! Do yourself and your health a BIG favor – kick off 2018 with the best health tips in your back pocket! The episode includes excerpts from the popular Just Thrive Probiotic podcast (episode #84) featuring microbiologist Kiran Krishnan on the […]

The post Weston A. Price: “Just Thrive Probiotic Podcast is TOP 3 of 2017!” appeared first on Thrive Probiotic.

Can Depression Be Helped With Probiotics?

by Doug Cook @ Doug Cook RD

Wed Dec 27 00:45:43 PST 2017

(DougCookRD.com) The human intestines house an astonishing number, and species, of microorganisms (microbiota), most of which live in the colon. The exact number is still being debated but  we have a lot of them and they play an intimate role in well-bring, not the least of which is their role in regulating mental health and […]

Why do some turtles outlive humans?

by @ Articles - Articles

Wed Feb 08 16:45:06 PST 2017

(⇒ write for LongeCity )


The oldest human recorded in modernity was Jeanne Louise Calment, she died in the age of 122 years and 164 days [1] .

There are rumors that the oldest tortoise called Adwaita (Aldabra giant tortoise) died in the age of about 250 years [2] or that it was 188-year-old radiated tortoise named Tui Malila [3] , or that the highest verified age of 177 years had Galapagos giant tortoise Harriet [4] . The oldest currently living turtle is considered to be Jonathan (Seychelles giant tortoise), estimated to be over 180 years old these days [5] . Although all aforementioned numbers are estimations, it seems these turtles were older than human supercentenarians.

All previously mentioned species are terrestrial tortoises, a group with longest lifespans among turtles. The most famous of them, well-researched Galapagos giant tortoise, was observed by Charles Darwin when he was forming his well-known theory of evolution by natural selection [6] . There is only one freshwater turtle known to be able to outlive human, it is the common snapping turtle estimated to live up to more than hundred years [7] . While being considerably less researched, recorded maximal lifespan of sea turtles is usually shorter, not exceeding 80 years, however, it is believed that the green sea turtle can live up to 100 years. [8]

It is a difficult question to answer why these reptiles can outlive us because even to determine the actual age of animals with a long lifespan is complicated – partially due to the fact that it takes such a long time to study. Furthermore, many turtles are endangered species [9] so there may not be as many organisms to hand as needed for proper statistics. Nonetheless, we can still claim that turtles are among the most long-living vertebrates on earth [10] . Why?

Firstly, turtles, like all reptiles, benefit from being ectothermic organisms. They do not maintain body temperature and thus save a lot of energy. But that also means they are less flexible: it is crucial for their lifespan to be in natural temperature environment of daily cycles with night-time temperature drop [11] . If they do not live under these conditions in captivity, metabolic pathways change and turtles die much sooner. [12]

Turtles are well-adapted in other ways: their famous shell – the carapace –is good protection against natural predators. Most of hatchling turtles with a soft shell do not survive the first year [13] . A research of natural populations of freshwater turtles showed that only one per cent of them can celebrate the twentieth birthdays, but once the adulthood is reached, mortality rate drops and remains constant throughout the rest of life [14] .

Some turtles can survive under extreme environmental conditions, such as freezing [15] or lack of oxygen for months [16] . They can even undergo hibernation and anaerobic metabolism and therefore deal with hypoxia and anoxia, it was also proposed that the same genes can play a role in longevity itself [17] and also in oxidative stress resistance [18] that further promotes longer life [19] .

Turtle’s bones and shell are used as lactate buffer lowering metabolic acidosis caused by anaerobic glycolysis during the period of lack of oxygen [20] ; [21] Their organism is protected by strong innate immunity compensating slow acquired immune reactions [22] .

Because turtles have very slow metabolism as well as growth, their bodies do not need to deal with excessive metabolic heat and byproducts as mammals [23] . Their natural diet is very simple but also necessary for their longevity. [24]

According to the evolutionary theories, staying alive is less important after menopause. Galapagos giant tortoises achieve sexual maturity late (around the age of up to forty years in the wild, and between twenty and twenty-five years of life in captivity [25] ), then staying fertile until death [26] .

The Hayflick limit is said to determine how many times a cell can divide [27] . The Hayflick limit of Galapagos giant tortoise was said to be about 110 divisions [28] , approximately twice as many as 50 of human cells [29] . Studies in this context have highlighted the importance of telomeres, the protective end sequences of chromosomes, that get shorter with each cell division [30] , can play at least a partially role in life expectancy. It was observed that telomeres in European freshwater turtle’s cells are of the same length in both embryo and adult organism [31] .

Thus, it was believed that turtles are negligibly senescent organisms [32] . In other words, the cells do not age and no age-related diseases appear, which is very different cell behavior than in human bodies [33] and probably the key to any natural longevity. However, evidence now suggests that turtles may not be really negligibly senescent because of observations of survival and reproductive senescence in late age in the painted turtle population [34]

As we can see, turtles have some advantages in the lifespan field. Some of these might inspire researchers to increase lifespans in humans.

Substances for reversing SSRI induced sexual dysfunction, my theory

by @ ImmInst Active Topics

Wed Feb 07 13:55:40 PST 2018

SSRIs are well known to cause temporary and often even permanent sexual dysfunction. The mechanism is not known for sure but some believe it has to do with downregulating norepinephrine and dopamine receptors. Too much serotonin supposedly does that.

 

Is there a substance, that would do to norepinephrine or dopamine the exact same thing an SSRI does to serotonin (and subsequently the other neurotransmitters)? Like, if an SSRI makes you permanently blunted and way too relaxed because now you have more serotonin or more serotonin receptors, and less dopamine and norepinephrine, is there a substance that would make you more excitable, make your fight or flight system more ready, make you produce less serotonin or downregulate your serotonin receptors and increase permanently norepinephrine and dopamine?

American living in Vienna, Austria

by @ ImmInst Active Topics

Mon Feb 05 13:42:39 PST 2018

38, high-functioning with depression and anxiety since the age of 13 or 14.

 

Currently on:

-150mg/day Venlafaxine (morning)

-30mg/day Mirtazapin (evening)

-Heavy exercise 2-4x/week (rugby, gym)

 

These keep me with one foot in the land of the living, but I'm desperate for some kind of lived experience beyond just surviving.

 

A little birdie told me some interesting things about NSI-189, so I'm here to investigate.

 

Also, I've been irregularly using tDCS on a depression montage for a few months.

 

Cryonics Hardship Fund

by @ LongeCity - Articles

Fri Jul 18 16:26:34 PDT 2014

Cryonics is a method of ‘medical time travel’ - placing the body in biostasis after legal death with the hope that future technology will be invented which can revive the body. To most people who share LongeCity’s mission cryonics is the ‘second worst thing’ that can happen to you, but nonetheless a viable alternative to burial or creation.

Cryonics prices vary (an overview can be found on this page maintained by Cryonics expert and LongeCity Advisor Ben Best) but it is affordable to nearly everyone via life insurance… nearly everyone. A few people who really want cryonics cannot get life insurance: After an accident, LongeCity Member James Swayze found himself quadriplegic and unable to get insurance. The life of LongeCity Member William O’Rights took a turn for the worst when he was diagnosed with aggressive throat cancer after having been suddenly deprived of all funds. Kim Suozzi was 23 and had not yet heard about cryonics when she was diagnosed with terminal brain cancer. Aaron Winborn heard of her case - and cryonics- only when the debilitating effects of Lou Gehrig's Disease had already begun to paralyse him. All these people were eventually offered a cryonics provision through the generous donations of others in our community.
We want to continue this proud tradition, looking out for those who share our common dream in unlimited lifespans, in the shadow of imminent death and despair.

However, this needs to be done carefully. It cannot be stressed enough that cryonics is affordable to most people if they only have the foresight to act early and arrange affordable life insurance. This element of personal responsibility is at the heart not just of cryonics. If we establish a hardship scheme, it must not create a moral hazard, and incentive to put things off as too unpleasant and complicated to think about until it is too late. Of course, we must also ward against fraud and abuse. An element of careful analysis and due diligence is therefore required, looking into the circumstances of each individual case.

The LongeCity cryonics hardship fund has two purposes:
1) To support a (volunteer based) infrastructure for maintaining the scheme and exercising the due diligence mentioned above
2) When a hardship case has been endorsed by LongeCity, we will use the hardship fund to help to fundraise for that individual by matching further donations. All these donations will go to a dedicated account for that person’s cryopreservation, never to the individual directly.

Applicants to our cryonics hardship fund must
- co-operate fully with LongeCity appointed auditors and reviewers
- genuinely be unable to not fully fund their cryosuspension and not have a reasonable chance of doing so prior to their likely death
- help to fundraise for their cause and help raise public awareness for cryonics

In the past, we have partnered with our friend in the Venturist community on cryonic hardship cases. We hoping to do so again on future occasions.



Click HERE to make a contribution to the fund

To apply email the full details of your case: contact@longecity.org

User Agreement

by @ LongeCity - Articles

Sat Dec 17 15:11:18 PST 2011

Bylaw A. User Agreement (Posting Guidelines)

---

Bylaw A. User Agreement

Article 1
The following shall be the letter of the agreement that all visitors, Members and their guests will be asked to abide by when interacting with the LongeCity/ Imminst ("LongeCity") website Please read this Agreement carefully before accessing the Site.

Section01 The Nature of this Agreement
(a) The following are the terms and conditions (the "Agreement") offered to any person ("you") for access and use (including but not limited to forum user registration) of the LongeCity/Immortality Institute (LongeCity) web site and all affiliated web sites (the "Site"). The Agreement is the basis for using and interacting with the LongeCity website. By accessing the Site, you agree to abide by this Agreement.
(b) Access to the Site is a privilege and not a right. If you do not agree with this Agreement, or have no intention to follow the rules outlined herein, you may not use the Site. If you have any reason to interact with a representative of LongeCity, but you do not wish to follow these rules, please email support@LongeCity.org
© The information in this document is subject to change. These changes will be announced on the Site, but you must also agree to periodically review this document for changes. After eight (8) days of any change in the Rules, your continued use of the Site indicates your acceptance of any changes made.

Section02 Account registration
(a) Only natural persons aged 16 or above may register an account with LongeCity.
(b) Each natural person may hold one single account. Registering with multiple accounts is not allowed unless specific permission is given by LongeCity.
© You may not use the account of another person unless such use is inadvertent and infrequent (e.g. using a family members login from the same computer not noticing that the person forgot to log out).
(d) Persons whose accounts have been suspended, deleted or blocked by LongeCity may never register another account unless specific permission is given by LongeCity.
(e) Users are free to choose any alias as long as the name is not offensive and as long as there is no risk that the username may be confused with a natural person, entity, initiative or endeavour that the person using the account is not authorised to represent. Final decisions on the acceptability of any user alias are made by LongeCity leadership.
(f) An LongeCity Member who has been suspended or banned from the Site is not considered in good standing. A user who has been suspended or banned from the Site may not apply to become an LongeCity Member.
(g) Accounts may be suspended, deleted, or changed by LongeCity for a variety of reasons including but not limited to a violation of this user agreement. If you are unsure why your account is inaccessible you can email support@LongeCity.org.
You must not register a new account the without express permission from the Secretary.
(h) When an account has been suspended, Members will be notified within 8 days of suspension and may appeal to the Secretary within 8 days after receiving such notification. If no agreement can be reached with the Secretary, the Member may appeal the case to the Board. There is no right to appeal for users or other individuals who are not Members.

Section03 Content
(a) LongeCity provides an open platform for registered users to share text, video, audio, programmes, scripts, files, hyperlinks and other material on the Site ("Content") as long as such sharing is lawful and not in contravention of this Agreement. However, LongeCity does not undertake to scrutinise, evaluate, test or verify any Content prior to it being shared on the Site.
(b) Content from the Site may be downloaded solely for your own non-commercial use.
(c) You understand that by using the Site, you may be exposed to Content that you may deem offensive, indecent or objectionable.
(d) LongeCity does not control the Content contributed by users and, consequently, provides no guarantee as to the correctness, integrity or fitness of such Content.
(e) Content are the responsibility of the person from whom such Content originated. You agree that you and not LongeCity, are entirely responsible for all Content that you upload, post, email, link, transmit or otherwise make available via the Site.
(f) When contributing Content, you agree that this Content may be edited or deleted or rendered to display in a different manner at the discretion of LongeCity.
(g) LongeCity will not use Content you contribute for commercial gain without your express permission, but cannot warrant or guarantee in any way that others who you decide to share the Content with might not use it for commercial activities.
(h)LongeCity cannot be held responsible for any Content that has been contributed through its open platform. LongeCity will not react to requests to verify, redact, edit, delete or obfuscate any Content.

Section04 Intellectual Property & Privacy
(a) By contributing Content you agree that you shall have no recourse against LongeCity for any alleged or actual infringement or misappropriation of any proprietary right in relation to the Content that you have contributed.
(b) By contributing your own original Content you agree to make this Content available in perpetuity under a Creative Commons Attribution-Non-Commercial-No Derivative Works 3.0 United States License. http://creativecommo...y-nc-nd/3.0/us/unless you give express notification to the contrary at the same time that you contribute the Content.
© LongeCity will not share private data with third parties without your consent, however LongeCity may use the information it obtains as a result of your visiting and/or registering with the Site for the purpose of enforcing this Agreement or in order to save a life or prevent unlawful activity.
(d) LongeCity is not responsible if you decide to post or share private information about yourself or others on the forum. LongeCity will not normally redact, remove or alter such data if you subsequently change your mind.

Section05 Limitation of Liability
(a) In no event will LongeCity be liable for consequential or incidental damages
which may arise in connection with your use of the Site. Accordingly, you agree that LongeCity shall not be responsible to you or anyone else for any loss-of-profit, direct, indirect, incidental, special, or consequential damages
arising out of the use of the site.
(b) You acknowledge that the limitations set forth herein are integral to the amount of consideration levied in connection with the access and use of the Site and any services rendered hereunder and that, were LongeCity to assume any further liability other than as set forth herein, such consideration would of necessity be set substantially higher.
(c) You agree to defend, indemnify and hold LongeCity and its officers, directors,agents, and employees harmless against all costs, expenses, and losses, incurred from any violation of this Agreement (including negligent or wrongful conduct) by your use and access of the Site.
(d) LongeCity provides the Site and associated information "as is" and does not make any direct or indirect express or implied warranties.
(e) LongeCity does not verify the credentials of anyone contributing Content to the site and does not endorse any Content that is contributed as advice. Anyone providing advice and guidance on or in association with the site is doing this strictly in a personal capacity, whether or not this person has an official role with LongeCity, unless the advice is specifically, expressly and in each instance authorised by an LongeCity director. Users are reminded that 'Advisors' are advising the LongeCity board on policy. This does not constitute an endorsement by LongeCity of that Advisors communications with others.

Section06 Basic Prohibitions
(a) The following activities are strictly prohibited and may lead to immediate suspension or deletion of the account, court action and notification of law enforcement officials.
(b) Violating any applicable local, state, national or international law;
(c) Personal threats to anybody, whether or not that person is using the Site
(d) Misrepresenting yourself as a person who you are not.
(e) Representing yourself as affiliated with an organisation without due authorisation.
(f) Contributing Content that contains a virus, any type of malware or corrupted data;
(g) Interacting with the Site in such a way as to seriously impair the functioning or usability of the Site including but not limited to excessive contribution of irrelevant Content;
(h) Display the contents of the Site on a different web site without permission.
(i) Violate the Site's security including but not limited to accessing unauthorized data or logging into an account or attempt to log into an account for which you do not have authorization, scan or test for hardware or software
vulnerabilities, perform a denial of service attack, attempt to spread a virus or malware, or falsify TCP/IP information.
(j) Contributing any solicitation including but not limited to advertising, promotional materials, junk mail, spam, chain letters, pyramid schemes (also see section 8 below)

Section07 Content related to health
(a) Any and all advice and/or opinion provided is strictly personal and never endorsed by LongeCity, nor should it be construed to be the official policy of LongeCity to provide health advice.
(b) You must seek professional medical advice prior to embarking on any course or treatment associated with any Content on the Site.
(c) You must determine what government regulations exist associated with the procurement and use of restricted substances such that they do not contravene any laws in your country.
(d) All Information on the LongeCity Forums, including those associated with health, sciences fora are provided as an area for the open exchange of anecdotal experience and information, not as a professional source of advice.

Section08 Advertising, promotions and commercial activity
(a) Organisations or individuals seeking to advertise on the Site must first apply to LongeCity for such approval.
(b) Advertising is any Content (including private messages) that draws attention to, solicits, endorses, offers for sale, links to, critiques or otherwise relates to goods or services where one of the parties involved in initiating such Content or one of their associates stands to benefit from financial transactions that may results from such Content.
(c) LongeCity seeks to limit surreptitious advertising where users who may have a financial stake in such matters contribute Content simply to increase product desirability or brand awareness. Such Content will be censored on the basis of suspicion alone. On occasion, 'innocent' Content may inadvertently be subjected to such censure. Users should be aware of this and are kindly asked to refrain from protest in these cases, as the common aim is to increase the quality of Content on the Site.
(d) Even if a promotion has been agreed by LongeCity, this does not imply, and no-one must imply that this constitutes an official endorsement by LongeCity of the promotion, the organisation and individual conducting the promotion or the promoted products or procedures.
(e) Users must not use the Site for initiating or conducting commercial transactions, whether in private messages, or by using contact details displayed on the Site unless expressly authorised by LongeCity.

Section09 Posting Guidelines
(a) Users must agree to consider the posting guidelines as specified in Article2. Adherence to these guidelines is monitored by LongeCity Moderators, Directors and other designated Officers.
(b) Violation of a guideline will incur a warning. Repeat violation on more than three separate occasions will result in a time-limited suspension of the user account ranging from eight days to eight years.
(c) Disputes regarding the enforcement of posting guidelines should be taken up, in the first instance, with the Moderator who has issued the warning. If no resolution can be found in dialogue, the dispute can be notified to the Lead Moderator. Warnings issued by the Lead Moderator can be disputed with the Secretary. Users who have an open dispute with a Moderator cannot be warned again by the same Moderator – but the Moderator in question may still report questionable posts by that user.
(d) LongeCity has reserved a forum for the expression of free speech known as the William O'Rights Memorial Forum. LongeCity will not restrict Content in this forum even if it violates the posting guidelines as long as such Content does not violate the other provisions in this Agreement. This is a forum where users can engage in 'flame wars', ensure that posts are not interfered with by a Moderator, or complain about LongeCity without threat of censure.


Article 2 Posting Guidelines

Section01 A-- General tone of conversations
A1-- Be polite. That does not mean that you cannot try to destroy another’s argument utterly but never lose your tone or your temper while doing so. Also under no circumstances should you employ personal judgments or remarks about people themselves rather than their arguments. Aside from the fact that such judgments are more often than not ill founded, they drag down the overall quality of the discussion as well as costing time and space.
A2-- Some words are generally considered offensive terms, in polite conversation such as "fuck, "shit", "faggot" or "nigger". Causing offence rarely if ever helps to elevate the quality of a discussion. Generally, use of such words will result in a warning or ban, but discretion may be exercised depending on the context.

Section02 B-- General writing style
B1-- Do not write excessive amounts of text. Be concise! No one has the time or the inclination to plough through a pile of superfluous rhetoric in order to discover your main points. If you really feel that you have to write an essay, then write a summary at the end as every considerate essay-writer would do.
B2-- While every caution is advised about over-using the forums design tools, please by all means DO use them, if this helps to make the text more accessible.

Section03 C-- Starting a new topic
C1-- Before starting a new topic please consider if the topic is informative, or will stimulate an interesting discourse.
C2-- Please check if the issue has been discussed before on the Site (It is not important to be a 100% sure about this – the LongeCity forums are quite large and old. But please make a quick search, especially if you have not been with the community for long. Sometimes, it may make sense to open a new topic anyway, but would be great if you could reference previous discussions.)
C3-- Please think about a good title. (This is very important. Please spend some time on considering the title. Titles like "A Question", "Hello" or "Life Extension" may lead to an otherwise interesting topic being deleted. Challenging titles may draw a lot of visitors will still incur a warning if they are not informative. Give full titles. "Vitamin E" is bad, "Vitamin E harmful?" is not as good as "Risk of Vitamin E supplements in Cancer".)
C4-- Is it a privileged topic? (LongeCity Members can create new topics over which they, as threadstarter have editorial control. This is to empower members who are willing to put in a bit of work to maximise the quality and values of a discussion thread. Other contributors must be alerted to the threadstarters intention in the first post, but cannot subsequently complain if their posts are edited.

Section04 D-- Replying to topics
D1-- Please ask yourself "Does my reply offer a significant contribution?"
D2-- It is critical that you try to keep follow-up posts on topic. Avoid going off on a different tangent. If it occurs to you that this might be another thread, open a new thread and put a link to it in the old one. The last word about relevance stays with the Moderators or the threadstarter.
D3-- As an extension of the previous point, do not derail a topic with fundamental critique even if you think that this would desirable. In particular do not question the necessity of a certain life-extension technique by referring to another method that seems more relevant to you. (Two examples: do not answer a question about the capacity of artificial intelligence to value human emotion correctly by stating that the ‘Singularity’ is a bunch of nonsense anyway; Do not intrude on an exchange about the bioavailability of resveratrol by stating that you don't care because you are signed up for cryonics)
D4-- Refrain from posting personal information unless it is inherently necessary to elaborate your views or position.
D5-- There is usually no benefit for people in reading that you agree unless you give an explanation to go with it.
D6-- You do not have to be an expert on the subject matter, but if you feel that you really don’t know enough about the subject, then ask informed questions before stepping into the ring for debate. If someone posts a link or uploads an article- read it before you go on. Also read the posts of your predecessors and be aware of related discussions elsewhere.

Section05 E-- Posting images
E1-- You are welcome to post your own images and drawings when they are relevant to sharing knowledge. Irrelevant or excessive positing of images, including emoticons (smiles) often diminishes quality of the Content and will likely incur a warning.
E2-- Showing images to illustrate a point or make a humorous quip is popular with some posters, but please consider if such posts could derail a discussion or create issues around copyright infringement.
E3-- Please be considerate about causing embarrassment when sharing images. As a rule of thumb, if you would be uncomfortable viewing it at work, do not post it.
E4-- Avatars: LongeCity encourages users to use a small portrait (passport-type) photograph as 'Avatar' of themselves, but this is not a requirement. However, the use of other peoples photographs or the LongeCity logo as Avatar is not allowed.

Section06 F-- Quotes and references
F1-- When replying to a previous post by quoting it, only quote precisely enough text as is necessary to understand your reply. Using the "reply" function in the forums will quote the entire post that you are replying to. Do not use this feature without due consideration.
F2-- If you quote, reference the quote properly, but only quote the important bits. (It is customary to put alterations to a quote in square brackets and indicate left-out bits by putting “...”) Do not quote whole articles, rather give a link or upload them. If you have to quote a substantial passage, then indicate the important passages that you want to draw attention too.
F3-- The use of references is strongly encouraged. Such references should contain enough information to find the relevant source with one or two mouse clicks. When using a link, please remember that the hypertext url may be specific to your own access and useless to others.

Spicy Watermelon Margarita Recipe

by Suja Juice @ Suja Juice

Wed Oct 04 16:27:40 PDT 2017

It’s National Taco Day and we’ve got the perfect drink to go with dinner! Just because Summer is officially over doesn’t mean you can’t still enjoy watermelon, and as far as we’re concerned, margaritas are always in season. The unique flavor of Radiate – our cold-pressed watermelon juice featuring fermented lemongrass, pairs perfectly with silver […]

GRASS Principles to Select Your Skin Care

by nayelle @ NAYELLE Probiotic Skincare – Formulated For Sensitive Skin

Tue Jan 31 21:38:54 PST 2017

So what is GRASS? It is a simple method to remind you of what to look for on labels. Each letter stands for following ingredients: Growth Factors, Retinols, Antioxidants, Specialty Products and Sun Protection. It is no longer enough to just look for skin care that avoids ‘BAD” chemicals in their formulations. Your skin [...]

The post GRASS Principles to Select Your Skin Care appeared first on NAYELLE Probiotic Skincare - Formulated For Sensitive Skin.

UP4™ PROBIOTICS DAILY FOR QUALITY and VALUE

by Rebecca @ UP4 Probiotics

Fri Oct 28 11:58:48 PDT 2016

  by Lynda Robbins, Product Education Specialist It seems to me that in the great big world of shopping- bargain and value pricing typically do not go hand in hand in with quality.  It is more the norm to find lower priced products in the “cheaply” made category or on the “marked down” shelf where […]

The post UP4™ PROBIOTICS DAILY FOR QUALITY and VALUE appeared first on UP4 Probiotics.

Getting enough protein. Is it all about timing?

by Doug Cook @ Doug Cook RD

Fri Nov 24 13:56:53 PST 2017

(DougCookRD.com) I had the pleasure of moderating a nutrition symposium by the Dairy Farmers of Canada in 2013 which focused on protein. The presenters looked at 3 principle areas of research including a review of current protein recommendations for children, adults and older adults, as well as, protein’s role in healthy aging, and weight management. Even […]

Hello !

by @ ImmInst Active Topics

Mon Feb 05 19:13:59 PST 2018

Hi, I've come across the forum from time to time in my research of different supplements over the past couple years. Finally joined so I can add to some discussion and share my experiences as they happen. Cheers!

There are Many Possible Paths to Immunotherapy for Senescent Cell Destruction

by @ LongeCityNews

Mon Feb 12 03:09:52 PST 2018

Rising numbers of senescent cells are one of the root causes of aging, a process that arises from the normal operation of youthful metabolism, yet results in accumulated damage and failure over time. Senescent cells generate signaling that degrades tissue function, breaks down and remodels tissue structure, spurs chronic inflammation, and alters the behavior of surrounding cells for the worse. Evidence shows their presence to be a contributing cause of a range of common fatal age-related conditions. In a youthful body, near all cells that become senescent and fail to self-destruct as a result are promptly eliminated by the immune system. In an aged body, the immune system is worn and degraded; as a consequence many more senescent cells survive to linger. We are machines of interacting, dependent parts. Damage and failure in one component speeds the onset of damage and decline in others. The age-related failure of the immune system is an important part of the acceleration of functional decline in later life.

Much of the current work on methods to selectively destroy senescent cells, and thus produce a narrow form of rejuvenation, is focused on pharmaceuticals. Given that the immune system is already capable of destroying senescent cells in the normal course of events, why not immunotherapies, however? I'm only aware of the one company working along those lines, SIWA Therapeutics, and I believe that their immunotherapy approach doesn't interact at all with the natural immunosurveillance of senescent cells. Is it possible to do better than this, to build on the existing evolved mechanisms to induce high levels of clearance even in old and damaged immune systems? Alternatively, could the general methods of immune rejuvenation currently under consideration (such as restoring the thymus, destroying malfunctioning or overspecialized immune cells, or inducing greater stem cell production of immune cells) result in youthful levels of senescent cell destruction?

Whilst there is currently little understanding concerning the mechanisms governing macrophage mediated recognition of senescent cells, the processes are probably not specific to senescent cells. Rather, the more characterised molecular mechanisms associated with macrophage recognition during cancer immunosurveillance and apoptotic cell clearance may also be pertinent for senescence surveillance. Apoptotic cells have been shown to preferentially express specific cell surface antigens which can be recognised by naturally occurring antibodies (IgMs) that enable phagocytosis by macrophages. As such, it can be speculated that senescent cells may also express specific cell surface antigens which would not only provide insights into the mechanisms mediating immune clearance, but would also provide a means to specifically identify senescent cells in tissues.

Surface expression of CD47 acts as a "don't eat me" signal, sending inhibitory signals through SIRPα, a receptor expressed on the surface of macrophage, ensuring that healthy cells are not inappropriately phagocytosed. Therefore, the downregulation of CD47 would be required for macrophages to target damaged "self" cells. One study has demonstrated that induction of tumour cell senescence via c-Myc inactivation leads to the downregulation of CD47 which consequently promoted tumour regression. Whether CD47 downregulation in this instance is a specific response to c-Myc inactivation or activation of the senescence program is unclear. It would make biological sense to downregulate CD47 during cell senescence to enable removal of damaged "self" cells, but further research is required.

Immunotherapeutic strategies already in development for combating cancer may one day be repurposed for targeting senescent cells for the alleviation of age-related diseases. In addition, identifying further molecular changes associated with senescent cells, especially cell-type specific alterations, would be advantageous for developing therapeutic approaches for targeting senescent cells. Since senescent cells can also be beneficial in the short term, the elimination of acute senescent cells could be problematic. Therefore, the identification of therapeutic targets specific to chronic senescence which are absent in acute senescent cells would be highly desirable.

One of the mechanisms by which natural killer (NK) cells specifically recognise and kill senescent cells is via the surface expression of NKG2D ligands. Since many tumour cells also express NKG2D ligands, such ligands have been suggested to be a useful target for immunotherapeutic approaches in cancer, and so could be adapted for senescent cell clearance. For example, the use of engineered immune cells such as chimeric antigen receptor (CAR) T cells to target specific molecules on cancer cells has great potential as an anti-cancer therapy. As such, it may be possible to target senescent cells by engineering T cells to express a NKG2D CAR which recognise NKG2D ligands on the surface of senescent cells.

An adaption of cancer vaccines could also be considered for boosting immune clearance of senescent cells. Although a universal biomarker of cell senescence has not been identified, the exposure of senescent cell membranes to immune cells may evoke an immune response to antigens not yet identified. In one approach, senescence vaccines would involve the isolation of senescence specific antigens (SSAs) which are then exposed to dendritic cells, professional antigen presenting cells. In response to SSA uptake, dendritic cells process and express these antigens on their cell surface which can then be recognised by T cells. T cell interaction with these antigens promotes T cell activation, differentiation, and ultimately killing of target cells.

Link: https://doi.org/10.1016/j.arr.2018.02.001

View the full article at FightAging

Selecting the Right Skin Care

by nayelle @ NAYELLE Probiotic Skincare – Formulated For Sensitive Skin

Thu Jan 05 23:00:35 PST 2017

With so many options to choose from selecting the right skin care line for you could be an overwhelming task.  Knowing what goes on your skin is as important as what you put in your mouth. We all should read the labels and pay attention to marketing claims that could be misleading at times. [...]

The post Selecting the Right Skin Care appeared first on NAYELLE Probiotic Skincare - Formulated For Sensitive Skin.

Dr. Gundry’s Citrus Fennel “Winter Salad” Recipe

by Gundry MD Team @ Gundry MD

Thu Feb 01 10:20:34 PST 2018

You know, everyone seems to take the same approach to cooking meals around this time of year – it’s always winter soups, winter stews, and winter casseroles. And sure, there are some days when you just want to curl up with a mug of soup and a good book. But life can’t come to a […]

The post Dr. Gundry’s Citrus Fennel “Winter Salad” Recipe appeared first on Gundry MD.

Jagged-1 as a More Selective Signal to Spur Bone Regrowth

by @ LongeCityNews

Mon Feb 12 03:29:05 PST 2018

Researchers here report on a more selective way to trigger the accelerated or enhanced regeneration of bone tissue, delivering jagged-1 to injuries rather than the bone morphogenetic proteins (BMPs) that have been used in the past. It appears to cause fewer issues related to inappropriate excess bone growth, as it influences mechanisms that are more closely associated with the process of regeneration in response to damage. The delivery of signals rather than cells or pharmaceuticals to produce regeneration will be a growing theme in the years ahead, and the approaches will only grow in sophistication and degree of control. The advance here is a small step in the grand scheme of the possible and the plausible; it will be interesting to see how this part of the industry evolves over the next few decades.

When a patient breaks a bone, there's a possibility the fracture won't heal properly or quickly, and use of a restorative tactic known as bone morphogenetic proteins, or BMPs, is increasingly less likely. Designed to promote spinal fusion and bone repair more than a decade ago, these molecules can overperform, causing excessive or misdirected bone growth, studies have shown. But because bone-healing biological research has often been limited, few other options exist. "Novel therapies have gone underdeveloped because of this assumption that bones heal without problem. The reality is there's a huge number of fractures that occur each year that don't heal very well."

The divide recently inspired scientists to examine a new therapeutic approach. Their method: deliver additional Jagged-1 - a potent osteoinductive protein known to activate the Notch signaling pathway that regulates bone healing - at the spot of a bone injury. "We've hypothesized for many years that by binding the Jagged-1 to a biomaterial and delivering it to a bone injury site, we could enhance healing." The results affirm that hunch: Rodents that received Jagged-1, applied via wet collagen sponge, saw improvements to skull and femoral bone injuries. Rodents treated with BMPs, by contrast, also benefited but developed the same problematic bone hypertrophy associated with human use of those proteins. Those findings suggest that the former therapy could one day benefit people.

It's not fully known why some bones don't heal the way they should - nor do scientists know whether a genetic component plays a role. What researchers have studied for years, meanwhile, is the capacity of the Jagged-1 ligand to promote bone-forming cells. The signaling is unique because this particular ligand typically binds to a delivery cell to activate bone healing in an adjacent cell - a vital trait to help ensure that a supplemental Jagged-1 dose, administered at the spot of injury, stays in place (and on task) to carry out its intended function. As a result, bone will only form where bone is supposed to form. BMPs, by comparison, are soluble, so they can migrate from the site of delivery and settle elsewhere in the body, triggering other cells that aren't supposed to form bone.

Link: https://labblog.uofmhealth.org/body-work/boosting-a-key-protein-to-help-bones-wont-heal

View the full article at FightAging

4F therapy: how to apply to human

by @ Action

Mon Feb 05 15:45:29 PST 2018

Ok, I know this is quite risky, so I thought I'd ask you how we would mitigate the risks given there are some truly crazy people who are willing to play the human lab rat?

http://longevityfacts.com/regenerative-reprogramming-aging-researchers/

 

Any general or specific recommendations on how to decrease the cancer risk when extended to a human subject would be welcome.

 

Best Wishes,

 

exa

 

8 Benefits of Yarrow – And How To Use It In Your Kitchen

by Heather Dessinger and Dr. Lori Valentine Rose (PhD), Certified Nutrition Professional (CNP), Board Certified in Holistic Nutrition @ Mommypotamus

Mon Jan 22 09:18:45 PST 2018

Old Man’s Pepper. Soldier’s Herb. Knight’s Milfoil. Thousand Weed. Nose Bleed. <<– Yarrow has a colorful list of names, and an even richer and more colorful history of use in European, Native American, and Chinese medicine. The ancients called it Herbe Militaris – the Military Herb – because it was often used to staunch bleeding and […]

Continue Reading...8 Benefits of Yarrow – And How To Use It In Your Kitchen

How Digestive and Immune Systems Work Together

by Dr. Rasheed Huma @ MicroBiomePlus

Tue Jan 30 14:36:21 PST 2018

Our digestive health has a lot to do with our immune health and vice versa. Its role in maintaining our immune health and, eventually, our overall well-being cannot be underestimated. The two systems work closely to keep us in good physical shape. Here, we’ll see how the two systems partner each other and what one […]

The post How Digestive and Immune Systems Work Together appeared first on MicroBiomePlus.

LongeCity science support: quick guide/FAQ

by @ Articles

Wed Jun 12 17:36:16 PDT 2013

What is LongeCity?
LongeCity is a registered, members-based non-profit organisation.
More info here.


What THEMES of science projects does LongeCity support?
We support research into ageing and the extension of human lifespan. This means we support many types of medical research and research into basic biology, but there should be an angle that will allow people to live longer, healthier lives.


What TYPES of science projects does LongeCity support?
We support laboratory research, clinical research, bioinformatics and theoretical research in the ‘hard sciences’. We do not normally support social science research.
We do support some events, mentorship and travel to scientific conferences, but not under the ‘research budget’.


Where can the research take place?
Anywhere in the world. Laboratory research should normally be conducted in an established lab.


What does LongeCity expect in return?
Scientific integrity. Normally a written report. Interim updates for longer projects. Acknowledgement of the funding received. We may approach previous grantholders to be available as peer reviewers for future research applications.


What grant schemes are available?

a) Small Grants
Funding: up to $500
Who can apply: any LongeCity Member, it helps if you have a sponsor/supervisor with some track record
Type: typical cases are support for summer projects, internships, workshops, review paper writing, selected consumables
Next deadline: none, applications are welcome until the annual budget is exhausted
Details: http://www.longecity...s/action/grants

b) Matching Fundraiser
Funding: up to $20.000 (in total- matching fundraiser)
Who can apply: Scientists
Type: For selected projects, LongeCity will issue a call for donations and for every dollar received LongeCity will match (or better) the donation. The entire money goes to support the research project.
Next deadline: July 1^st 2013
Details: http://www.longecity...ts/research2013


Questions?
Contact us.

Save on 1st Choice Nutrition Pet Food

by Heather @ I Love Savings | Coupons | Grocery | Health | Beauty | Household

Mon Feb 12 04:42:52 PST 2018

...

The post Save on 1st Choice Nutrition Pet Food appeared first on I Love Savings | Coupons | Grocery | Health | Beauty | Household.

Health Benefits of Cantaloupe

by Suja Juice @ Suja Juice

Thu Aug 17 12:04:32 PDT 2017

Move over watermelon, there’s another cool melon in town! Cantaloupe is a unique fruit that may not be one of the most popular fruits, but there’s no reason for it not to be! Filled with so much tasty nutrition, this fruit would be perfect for a little switch-up from your normal fruits. If you want […]

Pineapple Lemon Cayenne

by admin @ Pressed Probiotic Waters – Suja Juice

Mon Jan 04 16:48:43 PST 2016

Hit your body’s reset button with this enhanced water that combines a hint of cayenne spice with citrusy lemon and pineapple plus 2 billion vegan probiotic CFUs to aid in digestive and immune health.

Hi

by @ ImmInst Active Topics

Tue Feb 06 03:24:00 PST 2018

Hi, starting the uridine / DHA / B complex stack soon and can't wait to see what happens.

LongeCity science support: quick guide/FAQ

by @ Archive - Articles

Wed Jun 12 17:36:16 PDT 2013

What is LongeCity?
LongeCity is a registered, members-based non-profit organisation.
More info here.


What THEMES of science projects does LongeCity support?
We support research into ageing and the extension of human lifespan. This means we support many types of medical research and research into basic biology, but there should be an angle that will allow people to live longer, healthier lives.


What TYPES of science projects does LongeCity support?
We support laboratory research, clinical research, bioinformatics and theoretical research in the ‘hard sciences’. We do not normally support social science research.
We do support some events, mentorship and travel to scientific conferences, but not under the ‘research budget’.


Where can the research take place?
Anywhere in the world. Laboratory research should normally be conducted in an established lab.


What does LongeCity expect in return?
Scientific integrity. Normally a written report. Interim updates for longer projects. Acknowledgement of the funding received. We may approach previous grantholders to be available as peer reviewers for future research applications.


What grant schemes are available?

a) Small Grants
Funding: up to $500
Who can apply: any LongeCity Member, it helps if you have a sponsor/supervisor with some track record
Type: typical cases are support for summer projects, internships, workshops, review paper writing, selected consumables
Next deadline: none, applications are welcome until the annual budget is exhausted
Details: http://www.longecity...s/action/grants

b) Matching Fundraiser
Funding: up to $20.000 (in total- matching fundraiser)
Who can apply: Scientists
Type: For selected projects, LongeCity will issue a call for donations and for every dollar received LongeCity will match (or better) the donation. The entire money goes to support the research project.
Next deadline: July 1^st 2013
Details: http://www.longecity...ts/research2013


Questions?
Contact us.

Microglia Stem Cells - Transplanted microglia - where did they go?

by @ LONGECITY Community Blog List

Wed May 10 08:08:34 PDT 2017

Hi,
yes it has been a while since I wrote something here.

 

Here are two papers pusblished including the work funded by you:

• Leovsky C, Fabian C, Naaldijk Y, Jäger C, Jang HJ, Böhme J, Rudolph L, Stolzing A. Biodistribution of in vitro-derived microglia applied intranasally and intravenously to mice: effects of aging. Cytotherapy. 2015 Nov;17(11):1617-26
• Danielyan L, Beer-Hammer S, Stolzing A, Schäfer R, Siegel G, Fabian C, Kahle P, Biedermann T, Lourhmati A, Buadze M, Novakovic A, Proksch B, Gleiter CH, Frey WH, Schwab M. Intranasal delivery of bone marrow-derived mesenchymal stem cells, macrophages, and microglia to the brain in mouse models of Alzheimer's and Parkinson's disease. Cell Transplant. 2014;23 Suppl 1:S123-39.

There will be more comming on the therapeutic effect of the cells.

 

So if you want to speed this rpocess up we would be happy for people to help us. You just need a computer and some freely availabe software.

 

Or if you have a lab, especially with a good imaging software good at counting we would be interested in a collaboration.

 

Also we have protein extractions and would be interested in people doing proteomics. Just send me an email and we can discuss details.

 

Dey

Community Testing of Aging Bio-Markers

by @ Action

Wed Feb 07 15:58:56 PST 2018

Legitimate bio-marker testing is important to our community to help determine what current approaches are the best for slowing aging

 

It is 2018, and I can't believe how many anecdotal placebo-driven reports populate the LongeCity forum. Here is one egregious recent example if you want to chuckle: http://www.longecity.org/forum/topic/99447-hello-everybody-im-the-longest-continuous-user-of-hgh-in-human-history/

 

There was a budgeted effort to promote legitimate bio-marker testing last year, but it required members to pay for their first test, before embarking on an anti-aging regimen, where at the conclusion of the regimen time period, LongeCity would pay for a second test.

 

I am proposing a simpler approach. Here is the outline:

 

1. LongeCity pays for a standard aging-biomarker test. The most cost effective, easy to implement, and robust test available today is probably DNA methylation. LongeCity has a current relationship with Osiris Green and their test is the cheapest on the market, however, the standard deviation on their test is +/- 5 years. I have spoken with ZYMO and they will offer their test "at cost" for an effort such as this. ZYMO is HIPPA compliant and their standard deviation is only +/- 1.7 years.

 

2. We aim to offer this as a member benefit and to engage other communities such as the calorie restriction society.

 

3. Test subjects can opt to remain anonymous.

 

4. A simple questionnaire accompanies each test. This would ask each subject to rank their general approaches to life extension. Supplements, Diet, Exercise, Other. Depending upon the response, we could drill down further into regimens, but I would want to keep it simple at first to ensure a larger response.

 

5. We aim to complete the study before the end of Summer 2018, and present findings at RAADFest in September.

 

6. Stretch goal: Have a small number of people do DNA methylation testing at 3 different times of day. It is currently unknown if there is inter-day variability in DNA methylation.

 

7. Perhaps work in conjunction with newly formed OpenCures to complete and promote the study.

 

8. If successful, continue with testing on an annual or semi-annual basis. preferably with the same study participants.

 

Drawbacks/Objections

 

1. There are already a lot of groups (example: patients like me) that share test data, and there are many studies involving aging bio-markers. However, I am unsure that there are any studies that have easily accessible data AND focus upon longevity activists.

 

2. It is unlikely that a small study of a few dozen people will produce statistically valid results. To me, that is okay. We WILL learn something and I am certain there will be incredible marketing and community-building opportunities with such a study.

 

3. Cost. 5-10K, maybe higher if we can get some other groups to promote the study or if we can use other crowd-funding platforms. With 10K we could test between 50 and 75 people.

 

Leadership: I would be lead organizer and promoter.

 

LongeCity certainly has the budget for such a study and has enough connections to get a good number of people involved. LongeCity has not done much of consequence as of late. This could be a solid effort to help the community, not only functionally (what regimens work), but also as a promotional effort (life-extensionists are younger and healthier). 

 

 

Legitimate bio-marker testing is important to our community to help determine what current approaches are the best for slowing aging

Oh Baby! Get the Scoop on Baby Skincare

by Zoe (Social Media Manager) @ Blog – Well.ca Blog

Tue Feb 06 07:00:45 PST 2018

Welcome to the first post of Oh Baby – a monthly series where an expert shares the scoop on all you need to know for the littlest members in your family! Seanna Cohen | Skin Care Therapist | Elodie Beauty There are enough things to worry about...

The post Oh Baby! Get the Scoop on Baby Skincare appeared first on Well.ca Blog.

wellbutrin + sertraline to block DAT efficiently

by @ ImmInst Active Topics

Tue Feb 06 09:50:49 PST 2018

The occupancy of dopamine transporter (DAT) sites by bupropion and its metabolites in the human brain as measured by positron emission tomography was 26% according to GlaxoSmithKline researchers .

 

in any case, the above findings suggest that, although weak DAT occupation may occur, oral bupropion at clinically-used doses does not have the actual capacity to elevate dopamine levels in the human brain.[14] In accordance with this finding, based on analogy with serotonin reuptake inhibitors, higher than 50% inhibition of DAT would be needed for the dopamine reuptake mechanism to be a significant mechanism of the drug's action. Moreover, 65%75% DAT occupancy is necessary for euphoria and abuse potential.[82]

Ki values of sertraline at the human SERT, DAT, and NET of 0.29, 25, and 420 nM, respectively.[93] The selectivity of sertraline for the SERT over the DAT was 86-fold.[93] In any case, of the wide assortment of antidepressants assessed in the study, sertraline showed the highest affinity of them all for the DAT, even higher than the norepinephrinedopamine reuptake inhibitors (NDRIs) nomifensine (Ki = 56 nM) and BUPROPION (Ki = 520 nM).[93][104] Sertraline also has similar affinity for the DAT as the NDRI methylphenidate (Ki = 24 nM).[93][104] Tametraline (CP-24,441), a very close analogue of sertraline and the compound from which sertraline was originally derived, is an NDRI that was never marketed.[109]

 

So if wellbutrin alone is 27% on DAT and sertraline has higher affinity for dat than wellbutrin it should equal more than 50% if taken together thus block DAT efficiently and increase dopamine neurotransmission right and produce anti depressant effect?  The text say sertraline has similar affinity for the DAT as the NDRI methylphenidate (ritalin).. I dont know how much that is .But the good thing with sertraline is its long half life 26 hours and ritalin has very short 7 hours or something similar.

Québec Fresh Food Savings!! Feb 15-21

by Eliane @ I Love Savings | Coupons | Grocery | Health | Beauty | Household

Sun Feb 11 09:35:42 PST 2018

...

The post Québec Fresh Food Savings!! Feb 15-21 appeared first on I Love Savings | Coupons | Grocery | Health | Beauty | Household.

How to Meal Prep like a Boss (and only cook twice per week!)

by Zoe (Social Media Manager) @ Blog – Well.ca Blog

Thu Feb 01 07:00:41 PST 2018

Mandy King | Holistic Nutritionist | Founder of HEAL (Healthy Eating and Living) When I was first diagnosed with Celiac disease (an autoimmune disease where you have to be strictly gluten free) nine years ago, gluten free takeout just wasn’t an option like it is now....

The post How to Meal Prep like a Boss (and only cook twice per week!) appeared first on Well.ca Blog.

Why I started Obi

by ben @ Obi

Fri May 29 12:18:59 PDT 2015

I started working on the concept for Obi all the way back in early 2009 in Santa Cruz, CA. I came up with the idea while hiking at my favorite spot in Big Sur. I wanted to create something that took cutting edge concepts from the high-end niche health community and morph it into a... Read more »

Hyaluronic Acid in Skin Care

by nayelle @ NAYELLE Probiotic Skincare – Formulated For Sensitive Skin

Fri Feb 03 10:28:52 PST 2017

HYALURONIC ACID is the multitasking work horse of any quality skin care product. When we refer to “baby skin” it usually means flawless, smooth, glowing skin… or in other words perfect skin! It is not a surprise that babies’ skin has the highest levels of HYALURONIC ACID. As we age those levels lower as do [...]

The post Hyaluronic Acid in Skin Care appeared first on NAYELLE Probiotic Skincare - Formulated For Sensitive Skin.

LongeCity Affiliate Labs

by @ LongeCity - Articles

Sun Jun 19 18:16:58 PDT 2016

The Longecity “Affiliate Labs” are small, research-focused enterprises or independent academic research groups led by a scientists with strong ties to the Longecity community and a proven track record of commitment to scientific inquiry directly relevant to the Longecity mission.
These leaders and their colleagues are not just trailblazers in advancing important areas of regenerative and rejuvenation research, but also incredibly helpful when there is a community need for peer review, when providing advice and training to a young scientist, and in providing the expertise and tools to test the novel, controversial, or promising scientific leads sourced from the Longecity community and beyond.

Community Funding
There is a small support fund that the labs can draw on to flexibly support their research activities. While not a substitute for private investment and public sector grants, the ability to flexibly ‘just try’ out a new idea without needing to ‘pitch’ in lengthy proposals can be an invaluable accelerator to research progress. All Affiliates have an active link to the Longecity community, so there is a level of accountability and responsiveness beyond anything encountered in ‘traditional’ research donations.
By donating to the Affiliate Labs fund, Members can be assured that every penny goes directly to an expert personally and professionally committed to making a difference in the scientific conquest of death.
Donate HERE

Current Affiliate Labs
- Alexandra Stolzing, Loughborough University, UK & Leipzig University, Germany.
- James Clement - Betterhumans, USA
- João Pedro de Magalhães, University of Liverpool, UK
- John Schloendorn – Gene&Cell Technologies, USA
- Kelsey Moody, Ichor Therapeutics, USA.
- Kevin Perrott – Buck Institute, USA
- Matthew O’Connor – SENS Foundation, USA

Strawberry

by admin @ Pressed Probiotic Waters – Suja Juice

Sat Jan 02 13:57:23 PST 2016

Strawberry Probiotic is hydration plus gut health all in one bottle - this light and refreshing water enhanced with a hint of crushed strawberry and 2 billion vegan probiotic CFUs is great for digestive and immune health!

Comcast Xfinity Review

by Philip Palermo @ Reviews.com

Thu Feb 01 13:02:38 PST 2018

Assessing the effects of c60 on human cancer pr...

by @ Articles - Articles

Mon Sep 08 08:12:36 PDT 2014

 View attachment: c60re02.png 

 

"Assessing the effects of c60 on human cancer proliferation in vivo"

is led by life-extension trailblazer Kelsey Moody. It is interesting that he turns the attention of his new venture Ichor Therapeutics to the potential health effects of 'buckyballs' - a topic that has received significant attention on LongeCity ever since it was claimed in a scientific report that rats fed on olive oil infused with these structures experience dramatically increased maximal lifespans. (Review here). 
True to it mission, LongeCity hosts the leading international discussion forum on this topic. Previously, the LongeCity community has come together to fund further grassroots research on C60 in mice and these studies are on-going.

Meanwhile though, in keeping with the pioneer spirit often found on the LongeCity forums, reports have come in from people trialing C60 in olive oil on themselves. As Kelsey points out, the long-term safety of this has yet to be established, and this project is particularly interested in whether C60 in olive oil has any cancer-inducing properties. Conversely, it may be the case that the compound has a tumor–suppressing function. 
To investigate this, the team  plans to infuse a total of 25 mice with C60-olive oil of various strengths or with an inert ‘control’ solution, graft a human cancer cell line to the mice and study the results. (Full research proposal here) 
 
If the fundraiser succeeds it will further support the revolutionary notion of stakeholder-oriented, grass-roots science which complements, challenges and enriches academic research at those junctures that the community actually cares about. Moreover and perhaps even more importantly the fundraiser will help to built capacity and community interface at a dedicated life-extension research facility. Already, Ichor has housed an intern on a LongeCity stipend (Report here- Members only). Ultimately, we hope to create a network of such community-friendly labs around the globe, to provide aspiring young scientists
with training and networking and all members with easily accessible sources of expert advice.

LongeCity has facilitated 'crowdfunding' well before many other platforms in use today. This year, we have decided to try to tap into the potential of these external sites, but to add something to the process: This project is the first one to run on an external fundraising page that has received an official ‘stamp of endorsement’ from LongeCity.
The team has mooted the project at LongeCity, submitted for formal peer review and informal members comments and the board looked into the ability of the team to use the donated money responsibly and to deliver success (Internal link here).  In the end, the project received a high rating of 3 stars and LongeCity decided to match each dollar donation from our general funds. And, awesomely, a generous Member immediately stepped forward to match them as well!
 
This means we only need to raise $6.000 via the external crowdfunding page at indigogo. Please give generously and spread the word!

For any queries about the project to Kelsey and the team, please post below.

Why You Should Embrace Ground Flaxseed – And 6 Ways To Eat It

by Gundry MD Team @ Gundry MD

Wed Jan 17 05:54:51 PST 2018

There’s a teeny, tiny seed out there that has actually been causing a stir in the health and nutrition world since 3000 BC. That’s right, flaxseed has been around forever. And it’s been considered a superfood since then too. In fact, in the 700s – that’s right, the 700s (not the 1700s) – the king […]

The post Why You Should Embrace Ground Flaxseed – And 6 Ways To Eat It appeared first on Gundry MD.

Community Labs and GenSpace with Oliver Medvedik

by @ Longecity Podcast

Sun Aug 13 10:47:37 PDT 2017

Coming soon on the Longecity podcast is an interview with Oliver Medvedik, co-founder of the world's first community laboratory, Genspace. It is an open biotechnology laboratory that enables individuals, unaffiliated with any institution, to use the tools of biotechnology in a shared, co-working, biosafety level one laboratory space, on various biotech projects. He presently teaches CRISPR-Cas9 gene editing workshops that he has designed for the public at Genspace.

 

Some of the questions we'll be covering are:

- How they all came up with the idea and brought it from concept to reality.

- What achievements have been made by community labs around the world.

- What projects are being pursued currently.

- What the is the potential for community labs.

- What this means for the life extension community.

 

If there are any questions you would like us to add, mention them in the comments below!

 

LinkedIn

Genspace

crowdsourced multivitamin

by @ Articles - Articles

Tue Dec 18 17:41:21 PST 2012

Extending maximum human lifespan will likely require a wide range of new biotechnology. Powerful interventions such as pharmaceuticals, stem cell technology, and gene therapy are in development but could be years or decades away from widespread implementation. During the intervening time the best way to ward off the ravages of disease and aging is to take care of yourself.

Members of LongeCity are keenly aware of this reality. That is why LongeCity forum discussions about exercise, nutrition, and supplements are very active and comprehensive. Members are constantly on the lookout for the latest research lending insight into which supplements are beneficial, cost-effective, and readily available.
Much has been made of the deficiencies of current multivitamin formulations and this has led to a community effort to design the “perfect multivitamin”.


In a long process of collaborative discussion, Members designed what in their view comes closer to the 'perfect' anti-aging supplement than any other product on the market.
LongeCity then found a partner in RevGenetics Ltd (FDA RegNo: 12757922694) to produce it.

Under the brand name VIMMORTAL the formula was promoted during 2011.Many members enjoyed the heavy discount that RevGenetics generously provided to LongeCity members.

After over a year of sales, members decided to revisit the formula. The inclusion of choline in particular proved controversial in light of current research. VIMMORTAL was stopped and a new group convened to collate suggested tweaks and improvements. The revised formula was relayed to the previous partner Revgenetics.

After many delays and extensions throughout 2012, it became clear eventually that Revgenetics was not going to take the second generation of the crowdsourced supplement further.
This is a setback for the project, in which LongeCity was at the forefront of connecting supplement sellers and consumers in an innovative dialogue at the cutting edge of nutritional supplement design. However, we are proud of this effort and the experience and data generated by it.

The VIMMORTAL formula is 'open source' and we are optimistic that another manufacturer/seller will see the opportunities of connecting directly with the life extension community to provide the 'ideal' supplement solution.

Check the Vimmortal project forum.

Dr. Gundry’s Sautéed Cabbage Recipe (with walnuts & prosciutto!)

by Dr. Steven Gundry @ Gundry MD

Sat Jan 13 12:37:01 PST 2018

It’s the beginning of a new year. You’ve probably made a few health goals, including losing some weight. But just because you’re eating healthier doesn’t mean you have to eat bland, boring meals. You can still cook great meals that your whole family will love while you’re dropping unwanted pounds. This cabbage recipe is one […]

The post Dr. Gundry’s Sautéed Cabbage Recipe (with walnuts & prosciutto!) appeared first on Gundry MD.

Restlessness

by @ ImmInst Active Topics

Fri Feb 09 14:17:49 PST 2018

Any ideas for restlessness? My problem is mainly sitting still when I am not able to distract myself with work, tv shows, video games etc. For a workaholic this problem might actually be helpful or a motivation in a way, but work as an addiction is not necessarily a good thing obviously.

 

The one thing that helped me with this was C60- it induces an inner optimism where I can sit around feeling that everything is okay. But I don't take it, because it seems too risky.

 

Any help is appreciated.

Your Top 5 Health Questions Answered by a Naturopath

by Zoe (Social Media Manager) @ Blog – Well.ca Blog

Sat Feb 03 07:00:37 PST 2018

Dr. Laura Belus, ND  Want to improve your health but don’t know what vitamin or supplement you need to be taking for maximum results? The best way to get started is with the basics, which is exactly why I put them all together in the...

The post Your Top 5 Health Questions Answered by a Naturopath appeared first on Well.ca Blog.

Honorary Member: Fred Chamberlain (boundlesslife)

by @ Articles - Articles

Mon Apr 08 15:02:47 PDT 2013

View attachment: fred.jpg

In the early 1970's Fred Chamberlain, together with his wife Linda founded the cryonics corporations Manrise and the Alcor Society for Solid State Hypothermia, The latter continues until today as the Alcor Life Extension Foundation one of a very few cryonics providers.

Fred joined LongeCity in 2005 as boundlesslife and shared his thought and experiences with the community over the years.

He was placed in cryostasis at Alcor on 22 Mar 2012.

Suspension case report:
View attachment: casereportA1002FredChamberlain.pdf

His wife Linda remembers him in an 'Ode to Fred'
View attachment: OdeToFred.pdf


He was elected honorary lifetime member for 'services to cryonics'.

BACK TO SCHOOL WITH UP4™ KIDS CUBES Probiotics

by Rebecca @ UP4 Probiotics

Fri Jul 29 11:26:49 PDT 2016

By Lynda Robbins, UP4™ Probiotics Education Specialist In many regions throughout the country, it’s still the middle of summer sizzle.  Most folks aren’t in the mood yet for back to school mania; however, it’s never too early to be taking action to strengthen kids’ immune systems in preparation for the onslaught of germs that tend to […]

The post BACK TO SCHOOL WITH UP4™ KIDS CUBES Probiotics appeared first on UP4 Probiotics.

Honorary Member: Fred Chamberlain (boundlesslife)

by @ Articles

Mon Apr 08 15:02:47 PDT 2013

View attachment: fred.jpg

In the early 1970's Fred Chamberlain, together with his wife Linda founded the cryonics corporations Manrise and the Alcor Society for Solid State Hypothermia, The latter continues until today as the Alcor Life Extension Foundation one of a very few cryonics providers.

Fred joined LongeCity in 2005 as boundlesslife and shared his thought and experiences with the community over the years.

He was placed in cryostasis at Alcor on 22 Mar 2012.

Suspension case report:
View attachment: casereportA1002FredChamberlain.pdf

His wife Linda remembers him in an 'Ode to Fred'
View attachment: OdeToFred.pdf


He was elected honorary lifetime member for 'services to cryonics'.

The DivaCup – Challenge the Menstrual Status Quo

by Zoe (Social Media Manager) @ Blog – Well.ca Blog

Thu Feb 01 09:00:42 PST 2018

Sponsored by DivaCup Let’s talk tampons (and pads. And periods). The average North American woman uses around 20-25 tampons (or pads/plus pads) during each menstrual period that she has. Many girls begin menstruating around age 11 and continue, like clockwork (barring things like pregnancy), until...

The post The DivaCup – Challenge the Menstrual Status Quo appeared first on Well.ca Blog.

Antibiotic Therapy & Probiotics: When You’re on Antibiotics & Need “THE BEST” Probiotic, Think SPORE Probiotics…

by Chris @ Thrive Probiotic

Mon Jan 22 11:35:14 PST 2018

The cold and flu epidemic has reached an all-time high this season. It’s even been reported that the occurrence of flu this season alone has doubled. Visits to the ER due to cold/flu instances have risen from 5% to over 11%. But it’s not just common flu or bacterial illnesses that are causing issues…there are […]

The post Antibiotic Therapy & Probiotics: When You’re on Antibiotics & Need “THE BEST” Probiotic, Think SPORE Probiotics… appeared first on Thrive Probiotic.

Movie Screening: “Food Evolution” & Interview With Canadian Farmer Greg Hannam

by Doug Cook @ Doug Cook RD

Mon Feb 05 21:43:25 PST 2018

(DougCookRD.com) I had the great pleasure of attending a screening of the movie Food Evolution presented by CropLife Canada, Life Sciences Ontario, UofW Faculty of Science Foundation, Partners in Research, Ontario Agri-Food Technologies, Food Starter, Royal Canadian Institute of Science and narrated by none other than scientist extraordinaire Niel deGrasse Tyson which tackles the hotly debated […]

Geroprotector Review: Rapamycin and other mTOR...

by @ Articles - Articles

Tue Jul 18 14:03:16 PDT 2017

Sven Bulterijs continues his discussion of prominent compounds with potential life extension efficacy by looking not just at rapamycin but also at its target, the mTOR pathway, which has likely a key role in mediating lifespan. ⇒ read the article in "Sven's Science Corner" blog

Featured on Healing Quest: Kiran Krishnan

by Chris @ Thrive Probiotic

Fri Jan 19 14:14:35 PST 2018

Check out Just Thrive Probiotic microbiologist Kiran Krishnan’s latest radio interview on Healing Quest radio! The Just Thrive segment starts 8 minutes in! CLICK HERE TO LISTEN >> http://bit.ly/2Dv2TEM

The post Featured on Healing Quest: Kiran Krishnan appeared first on Thrive Probiotic.

Article Management

by @ New Features - Media Demo

Sun Aug 28 09:49:50 PDT 2011

This video shows off some of the user interface you can expect to see in the article management area of the ACP.

Aging theories: Is there a unifying factor in a...

by @ Articles

Sun Aug 20 11:04:47 PDT 2017

When Darwin’s theory of evolution by natural selection was established, biologists were puzzled by the existence of senescence and aging among all organisms. Why did the evolutionary pressure not produce immortal species? They concluded that even the power of evolution has its limitations. It took almost hundred years to reach the idea that mortal individuals may be preferred by nature for following reasons — the genes resulting in advantage in early life might cause damage in late life, and the reproduction starts as soon as possible. Around the middle of twentieth century, there finally was a framework for the gerontological research conduced in the following decades — the first evolutionary theories of aging (Gavrilov & Gavrilova, 2002). 
There are two major groups of theories aiming to explain the mechanism of aging, so-called programmed and error theories. The programmed ones are based on the senescence-causing nature of certain genes (these are also called evolutionary theories), hormones or the immune system. Error theories claim that we age because of general damage caused by cell weariness, metabolic rate, cross-linked proteins, free radicals or somatic DNA changes (Jin, 2010).
The beauty of various aging theories is that most of them are not mutually exclusive. We can see that newer theories do not necessarily oppose the old ones, but rather shed more light and offer more in-depth views on the process of senescence.
The pioneering idea from 1882 was Weismanns’s theory of programmed death (also called wear-and-tear theory) claiming something like apoptosis of the multicellular organism. Although disproved by experiments, his theoretical explanation of the mechanism predicted the discovery of Hayflick limit (Gavrilov & Gavrilova, 2002). According to Weismann’s first conception, nature priorities young individuals over elderly because of limited resources. Pearl stated his ‘rate of living’ theory of aging in 1928, although the idea comes from Rubner who, in 1908, suggested that every organism has limited amount of metabolic energy and therefore its age depends on the rate of metabolism which correlates with organism’s size (Pearl, 1928). Most consider the rate of living theory to be flawed (Lints, 1989; de Magalhaes, Costa, & Church, 2007; Vaanholt, Daan, Schubert, & Visser, 2009).
A few decades later, the following evolutionary models have emerged: Medawar’s hypothesis of mutation accumulation proposes that aging is a by-product of natural selection — genes causing senescence in later stadium of life cannot be eliminated because the genetic information was most likely already transferred to successors by individuals in their early adulthood (Gavrilov & Gavrilova, 2002). This theory from 1952 is considered the first modern theory of aging. Charlesworth confronted Medawar’s model with a discovery of late-life mortality plateaus and in 1994 presented so-called modified mutation accumulation theory (Charlesworth, 2001; Ljubuncic & Reznick, 2009). In his antagonistic pleiotropy theory (also called ‘pay later’ theory), Williams in 1957 expressed the idea that even the same genes which cause trouble at advanced age may be advantageous in earlier stages of life, and therefore be not only tolerated, but even preferred by natural selection (Gavrilov & Gavrilova, 2002). In 1979, Kirkwood extended this theory to the disposable soma theory — organisms may save energy by reducing accuracy in cells metabolism and invest it in faster development and reproduction (Kirkwood & Holliday, 1979). This is the last one of famous, genes-orientated evolutionary models.
The following can be classified as programmed theories: The neuroendocrine theory proposed in 1954 by Dilman says that the main cause of aging is a loss of receptor sensitivity of the hypothalamus over time, and therefore its control of adequate production of hormones declines which leads to ineffectiveness and lower hormone levels in organism. It is an attempt to explain a high occurrence of degenerative diseases in late age (“Neuroendocrine Theory of Aging: Chapter 1,” 1999). Research on hormonal signaling pathways confirms that hormone levels have at least a partial role in determining longevity (van Heemst et al., 2005). In 1964, Walford suggested his immunologic theory of aging — due to increasing diversity of cells, the immune system looses its efficiency with age which leads to insufficient responses against pathogens as well as to autoimmune reactions against self proteins (Walford, 1964). 
All following attempts to explain the mechanism behind a process of aging are usually called error or damage theories. Bjorksten’s "crosslinkage theory" says that proteins become linked together in presence of certain crosslinking agents, and after some time, accumulation of these molecular aggregates causes decline in tissue functions. This theory from 1942 is no longer popular (Bjorksten, 1968). Later research has showed that advanced glycation end products (AGEs) accumulate in collagen and lead to outcomes predicted by Bjorksten (Verzijl et al., 2002; Aronson, 2003). 
These days very popular among researchers and public, the free radical theory was suggested by Harman in 1956. His idea was that the occurrence of free radicals, or reactive oxygen species naturally produced in living organisms, leads to macromolecular damage which accumulates and causes physiological changes known as senescence (Harman, 2009). Later he suggested the reactive oxygen species formation takes place mainly in mitochondria which causes a decline in important mitochondrial functions (Harman, 1972). Because of the theory’s popularity, various extensions of Harman’s model were created, usually considering different sites as a main target of free radicals. 
Failla’s somatic mutation theory from 1958 posits that increasing number of mutations of genetic material causes a decrease in cellular, organ and body functions (Failla, 1958; Gensler & Bernstein, 1981; Kennedy, Loeb, & Herr, 2012). The theory received a lot of criticism in previous decades (Vijg, 2000). Kaya, Lobanov and Gladyshev (2015) investigated aging in yeast and failed to find evidence in support of Failla’s thesis. 
Orgel proposed his error catastrophe theory in 1963. He saw the cause of aging in accumulation of malfunctioning proteins coming from errors during protein translation (Orgel, 1963). This theory never gained popularity and was soon disproved (Gershon & Gershon, 1976). 
Alexander in 1967 extended Failla’s theory by hypothesizing that DNA damage instead of mutation is the cause of aging (Alexander, 1967). These days, this version called "somatic DNA damage theory of aging" is more often used by scientists (Freitas & de Magalhaes, 2011; Soares et al., 2014). Evidence suggests that more damage happens in mitochondrial DNA than in nuclear DNA (Ames, 2009).
In 2002, Brunk and Terman published the mitochondrial-lysosomal axis theory. It states that defective macromolecules derived from mitochondria undergo further changes in lysosomes to become lipofuscin inclusions. These end products decrease cell’s autophagocytotic capacity which leads to more mitochondrial defects (Brunk & Terman, 2002). 
Zs.-Nagy’s "membrane hypothesis" focuses on a decline of mitochondrial functions due to lessened membrane permeability caused by residual heat coming from nerve signals as well as by reactive oxygen species (Zs.-Nagy, 2014). 
Recent versions of damage theories claim that free radicals are only one kind of senescence-causing by products of metabolism but the real initiator of all the inevitable damage is biological imperfectness. In other words, there are always types of damage which lack adequate repair mechanisms in organism and the most severe source of errors depends on actual conditions (Gladyshev, 2013; Gladyshev, 2014). This idea comes from the "reliability theory", which focuses on systems failure in machines (Gavrilov & Gavrilova, 2001). In spite of many research programs and lots of scientists involved, the unifying factor in aging is at the moment still unknown.

References

• Alexander, P. (1967). The role of DNA lesions in the processes leading to ageing in mice. Symp Soc Exp Biol, 21, 29-50.
• Ames, B. (1989). Endogenous Oxidative DNA Damage, Aging, and Cancer. Free Radical Research Communications, 7(3-6), 121-128. http://dx.doi.org/10.3109/10715768909087933
• Aronson, D. (2003). Cross-linking of glycated collagen in the pathogenesis of arterial and myocardial stiffening of aging and diabetes. Journal Of Hypertension, 21(1), 3-12. http://dx.doi.org/10.1097/01.hjh.0000042892.24999.92
• Bjorksten, J. (1968). The Crosslinkage Theory of Aging. Journal Of The American Geriatrics Society, 16(4), 408-427. http://dx.doi.org/10.1111/j.1532-5415.1968.tb02821.x
• Brunk, U., & Terman, A. (2002). The mitochondrial-lysosomal axis theory of aging. European Journal Of Biochemistry, 269(8), 1996-2002. http://dx.doi.org/10.1046/j.1432-1033.2002.02869.x
• Charlesworth, B. (2001). Patterns of Age-specific Means and Genetic Variances of Mortality Rates Predicted by the Mutation-Accumulation Theory of Ageing. Journal Of Theoretical Biology, 210(1), 47-65. http://dx.doi.org/10.1006/jtbi.2001.2296
• De Grey, A. (1997). A proposed refinement of the mitochondrial free radical theory of aging. Bioessays, 19(2), 161-166. http://dx.doi.org/10.1002/bies.950190211
• Dean, W. (1999). Neuroendocrine Theory of Aging: Chapter 1. Warddeanmd.com. Retrieved 30 March 2017, from http://warddeanmd.com/articles/neuroendocrine-theory-of-aging-chapter-1/
• Failla, G. (1958). The Aging Process and Cancerogenesis. Annals Of The New York Academy Of Sciences, 71(6 Genetic Conce), 1124-1140. http://dx.doi.org/10.1111/j.1749-6632.1958.tb46828.x
• Freitas, A., & de Magalhães, J. (2011). A review and appraisal of the DNA damage theory of ageing. Mutation Research/Reviews In Mutation Research, 728(1-2), 12-22. http://dx.doi.org/10.1016/j.mrrev.2011.05.001
• Gavrilov, L., & Gavrilova, N. (2001). The Reliability Theory of Aging and Longevity. Journal Of Theoretical Biology, 213(4), 527-545. http://dx.doi.org/10.1006/jtbi.2001.2430
• Gavrilov, L., & Gavrilova, N. (2002). Evolutionary Theories of Aging and Longevity. The Scientific World JOURNAL, 2, 339-356. http://dx.doi.org/10.1100/tsw.2002.
• Gensler, H., & Bernstein, H. (1981). DNA Damage as the Primary Cause of Aging. The Quarterly Review Of Biology, 56(3), 279-303. http://dx.doi.org/10.1086/412317
• Gershon, D., & Gershon, H. (1976). An Evaluation of the ‘Error Catastrophe’ Theory of Ageing in the Light of Recent Experimental Results. Gerontology, 22(3), 212-219. http://dx.doi.org/10.1159/000212136
• Gladyshev, V. (2013). The origin of aging: imperfectness-driven non-random damage defines the aging process and control of lifespan. Trends In Genetics, 29(9), 506-512. http://dx.doi.org/10.1016/j.tig.2013.05.004
• Gladyshev, V. (2014). The Free Radical Theory of Aging Is Dead. Long Live the Damage Theory!. Antioxidants & Redox Signaling, 20(4), 727-731. http://dx.doi.org/10.1089/ars.2013.5228
• Harman, D. (1972). The Biologic Clock: The Mitochondria?. Journal Of The American Geriatrics Society, 20(4), 145-147. http://dx.doi.org/10.1111/j.1532-5415.1972.tb00787.x
• Harman, D. (2009). Origin and evolution of the free radical theory of aging: a brief personal history, 1954–2009. Biogerontology, 10(6), 773-781. http://dx.doi.org/10.1007/s10522-009-9234-2
• Jin, K. (2010). Modern Biological Theories of Aging. Aging and Disease, 1(2), 72-74.
• Kaya, A., Lobanov, A., & Gladyshev, V. (2015). Evidence that mutation accumulation does not cause aging inSaccharomyces cerevisiae. Aging Cell, 14(3), 366-371. http://dx.doi.org/10.1111/acel.12290
• Kennedy, S., Loeb, L., & Herr, A. (2012). Somatic mutations in aging, cancer and neurodegeneration. Mechanisms Of Ageing And Development, 133(4), 118-126. http://dx.doi.org/10.1016/j.mad.2011.10.009
• Kirkwood, T., & Holliday, R. (1979). The Evolution of Ageing and Longevity. Proceedings Of The Royal Society B: Biological Sciences, 205(1161), 531-546. http://dx.doi.org/10.1098/rspb.1979.0083
• Lints, F. (1989). The Rate of Living Theory Revisited. Gerontology, 35(1), 36-57. http://dx.doi.org/10.1159/000212998
• Ljubuncic, P., & Reznick, A. (2009). The Evolutionary Theories of Aging Revisited – A Mini-Review. Gerontology, 55(2), 205-216. http://dx.doi.org/10.1159/000200772
• Magalhaes, J., Costa, J., & Church, G. (2007). An Analysis of the Relationship Between Metabolism, Developmental Schedules, and Longevity Using Phylogenetic Independent Contrasts. The Journals Of Gerontology Series A: Biological Sciences And Medical Sciences, 62(2), 149-160. http://dx.doi.org/10.1093/gerona/62.2.149
• Muller, F., Lustgarten, M., Jang, Y., Richardson, A., & Van Remmen, H. (2007). Trends in oxidative aging theories. Free Radical Biology And Medicine, 43(4), 477-503. http://dx.doi.org/10.1016/j.freeradbiomed.2007.03.034
• Orgel, L. (1963). The Maintenance of the Accuracy of Protein Synthesis and its Relevance to Ageing. Proceedings Of The National Academy Of Sciences, 49(4), 517-521. http://dx.doi.org/10.1073/pnas.49.4.517
• Soares, J., Cortinhas, A., Bento, T., Leitão, J., Collins, A., Gaivã, I., & Mota, M. (2014). Aging and DNA damage in humans: a meta-analysis study. Aging, 6(6), 432-439. http://dx.doi.org/10.18632/aging.100667
• Vaanholt, L., Daan, S., Schubert, K., & Visser, G. (2009). Metabolism and Aging: Effects of Cold Exposure on Metabolic Rate, Body Composition, and Longevity in Mice. Physiological And Biochemical Zoology, 82(4), 314-324. http://dx.doi.org/10.1086/589727
• Van Heemst, D., Beekman, M., Mooijaart, S., Heijmans, B., Brandt, B., & Zwaan, B. et al. (2005). Reduced insulin/IGF-1 signalling and human longevity. Aging Cell, 4(2), 79-85. http://dx.doi.org/10.1111/j.1474-9728.2005.00148.x
• Verzijl, N., DeGroot, J., Zaken, C., Braun-Benjamin, O., Maroudas, A., & Bank, R. et al. (2002). Crosslinking by advanced glycation end products increases the stiffness of the collagen network in human articular cartilage: A possible mechanism through which age is a risk factor for osteoarthritis. Arthritis & Rheumatism, 46(1), 114-123. http://dx.doi.org/10.1002/1529-0131(200201)46:1<114::aid-art10025>3.0.co;2-p
• Vijg, J. (2000). Somatic mutations and aging: a re-evaluation. Mutation Research/Fundamental And Molecular Mechanisms Of Mutagenesis, 447(1), 117-135. http://dx.doi.org/10.1016/s0027-5107(99)00202-x
• Walford, R. (1964). The Immunologic Theory of Aging. The Gerontologist, 4(4), 195-197. http://dx.doi.org/10.1093/geront/4.4.195
• Zs.-Nagy, I. (2014). Aging of Cell Membranes: Facts and Theories. Aging, 62-85. http://dx.doi.org/10.1159/000358900

The above is a short perspective by Vit Zemanek. Continue the discussion and analysis on LongeCity's long-running AGING THEORIES forum.

A Few Recent Advances in Tissue Engineering and Regenerative Medicine

by @ LongeCityNews

Fri Feb 09 16:00:03 PST 2018

The tissue engineering and regenerative medicine communities are too large and energetic to do more than sample their output, or note the most interesting advances that stand out from the pack. The publicity materials I'll point out here are a recent selection of items that caught my eye as they went past. Dozens more, each of which would have merited worldwide attention ten or fifteen years ago, drift by with little comment every year. The state of the art is progressing rapidly towards both the ability to build complex tissues from a cell sample, such as patient-matched organs for transplantation, and the ability to control regeneration and growth inside the body. Ultimately we may not need transplantation if native organs can be persuaded to repair themselves ... but this will likely also require significant progress towards repairing the cell and tissue damage of aging, the forms of molecular breakage that degrade regenerative capacity.

Even though the research community has progressed a long way past the capabilities of even a decade ago, there remains a longer road ahead. Transplants of cell populations are still very challenging; only a small fraction of those cells survive to take up residence and contribute over the long term. The best technology demonstrations manage 10% survival or thereabouts. Standard approaches to finding the best methodology for each cell type and situation have yet to arise. There is a lot of trial and error. Yet replacement of cell populations, reliably, and with high quality, youthful, undamaged cells, is needed to treat many of the consequences of aging. Consider the loss of dopamine-generating neurons in Parkinson's disease, for example, or the wearing down of the stem cell population responsible for generating the immune system, or the structural remodeling and weakening of the heart in response to hypertension. Removing the damage that caused those issues will not automatically restore all of the losses.

Researchers report first lung stem cell transplantation clinical trial

For the first time, researchers have regenerated patients' damaged lungs using autologous lung stem cell transplantation in a pilot clinical trial. In 2015, the researchers identified p63+/Krt5+ adult stem cells in a mouse lung, which had potential to regenerate pulmonary structures including bronchioles and alveoli. Now they are focusing on lung stem cells in humans rather than mice. The researchers found that a population of basal cells labeled with an SOX9+ marker had the potential to serve as lung stem cells in humans. They used lung bronchoscopy to brush off and amplify these lung stem cells from tiny samples.

In order to test the capacity of lung stem cells to regenerate lung tissue in vivo, the team transplanted the human lung stem cells into damaged lungs of immunodeficient mice. Histological analysis showed that stem cell transplantation successfully regenerated human bronchial and alveolar structures in the lungs of mice. Also, the fibrotic area in the injured lungs of the mice was replaced by new human alveoli after receiving stem cell transplantation. Arterial blood gas analysis showed that the lung function of the mice was significantly recovered.

The team launched the first clinical trial based on autologous lung stem cell transplantation for the treatment of bronchiectasis. The first two patients were recruited in March 2016. Their own lung stem cells were delivered into the patients' lung through bronchoscopy. One year after transplantation, two patients described relief of multiple respiratory symptoms such as coughing and dyspnea. CT imaging showed regional recovery of the dilated structure. Patient lung function began to recover three months after transplantation, which maintained for one year.

Scientists create functioning kidney tissue

Kidney glomeruli - constituent microscopic parts of the organ - were generated from human embryonic stem cells grown in plastic laboratory culture dishes containing a nutrient broth known as culture medium, containing molecules to promote kidney development. They were combined with a gel like substance, which acted as natural connective tissue - and then injected as a tiny clump under the skin of mice. After three months, an examination of the tissue revealed that nephrons: the microscopic structural and functional units of the kidney - had formed.

Tiny human blood vessels - known as capillaries - had developed inside the mice which nourished the new kidney structures. However, the mini-kidneys lack a large artery, and without that the organ's function will only be a fraction of normal. So, the researchers are working with surgeons to put in an artery that will bring more blood the new kidney. "We have proved beyond any doubt these structures function as kidney cells by filtering blood and producing urine - though we can't yet say what percentage of function exists. What is particularly exciting is that the structures are made of human cells which developed an excellent capillary blood supply, becoming linked to the vasculature of the mouse. Though this structure was formed from several hundred glomeruli, and humans have about a million in their kidneys - this is clearly a major advance. It constitutes a proof of principle - but much work is yet to be done."

New tissue-engineered blood vessel replacements closer to human trials

Researchers have created a new lab-grown blood vessel replacement that is composed completely of biological materials, but surprisingly doesn't contain any living cells at implantation. The vessel, that could be used as an "off the shelf" graft for kidney dialysis patients, performed well in a recent study with nonhuman primates. It is the first-of-its-kind nonsynthetic, decellularized graft that becomes repopulated with cells by the recipient's own cells when implanted.

The researchers generated vessel-like tubes in the lab from post-natal human skin cells that were embedded in a gel-like material made of cow fibrin, a protein involved in blood clotting. Researchers put the cell-populated gel in a bioreactor and grew the tube for seven weeks and then washed away the cells over the final week. What remained was the collagen and other proteins secreted by the cells, making an all-natural, but non-living tube for implantation.

To test the vessels, the researchers implanted the 15-centimeter-long (about 5 inches) lab-grown grafts into adult baboons. Six months after implantation, the grafts grossly appeared like a blood vessel and the researchers observed healthy cells from the recipients taking up residence within the walls of the tubes. None of the grafts calcified and only one ruptured, which was attributed to inadvertent mechanical damage with handling. The grafts after six months were shown to withstand almost 30 times the average human blood pressure without bursting. The implants showed no immune response and resisted infection.

View the full article at FightAging

What is Integrative Dermatology

by nayelle @ NAYELLE Probiotic Skincare – Formulated For Sensitive Skin

Thu Feb 01 16:46:27 PST 2018

We were wondering ourselves about all the concepts that influence "integrative dermatology" and received some great advice from Dr.V (a boardcertified dermatologist) to help answer the question of "What is Integrative Dermatology?Integrative Dermatology - It’s SO MUCH more than SKIN DEEP!We are entering a new era of health & wellness. It is no secret that [...]

The post What is Integrative Dermatology appeared first on NAYELLE Probiotic Skincare - Formulated For Sensitive Skin.

Why do some turtles outlive humans?

by @ Articles

Wed Feb 08 16:45:06 PST 2017

(⇒ write for LongeCity )


The oldest human recorded in modernity was Jeanne Louise Calment, she died in the age of 122 years and 164 days [1] .

There are rumors that the oldest tortoise called Adwaita (Aldabra giant tortoise) died in the age of about 250 years [2] or that it was 188-year-old radiated tortoise named Tui Malila [3] , or that the highest verified age of 177 years had Galapagos giant tortoise Harriet [4] . The oldest currently living turtle is considered to be Jonathan (Seychelles giant tortoise), estimated to be over 180 years old these days [5] . Although all aforementioned numbers are estimations, it seems these turtles were older than human supercentenarians.

All previously mentioned species are terrestrial tortoises, a group with longest lifespans among turtles. The most famous of them, well-researched Galapagos giant tortoise, was observed by Charles Darwin when he was forming his well-known theory of evolution by natural selection [6] . There is only one freshwater turtle known to be able to outlive human, it is the common snapping turtle estimated to live up to more than hundred years [7] . While being considerably less researched, recorded maximal lifespan of sea turtles is usually shorter, not exceeding 80 years, however, it is believed that the green sea turtle can live up to 100 years. [8]

It is a difficult question to answer why these reptiles can outlive us because even to determine the actual age of animals with a long lifespan is complicated – partially due to the fact that it takes such a long time to study. Furthermore, many turtles are endangered species [9] so there may not be as many organisms to hand as needed for proper statistics. Nonetheless, we can still claim that turtles are among the most long-living vertebrates on earth [10] . Why?

Firstly, turtles, like all reptiles, benefit from being ectothermic organisms. They do not maintain body temperature and thus save a lot of energy. But that also means they are less flexible: it is crucial for their lifespan to be in natural temperature environment of daily cycles with night-time temperature drop [11] . If they do not live under these conditions in captivity, metabolic pathways change and turtles die much sooner. [12]

Turtles are well-adapted in other ways: their famous shell – the carapace –is good protection against natural predators. Most of hatchling turtles with a soft shell do not survive the first year [13] . A research of natural populations of freshwater turtles showed that only one per cent of them can celebrate the twentieth birthdays, but once the adulthood is reached, mortality rate drops and remains constant throughout the rest of life [14] .

Some turtles can survive under extreme environmental conditions, such as freezing [15] or lack of oxygen for months [16] . They can even undergo hibernation and anaerobic metabolism and therefore deal with hypoxia and anoxia, it was also proposed that the same genes can play a role in longevity itself [17] and also in oxidative stress resistance [18] that further promotes longer life [19] .

Turtle’s bones and shell are used as lactate buffer lowering metabolic acidosis caused by anaerobic glycolysis during the period of lack of oxygen [20] ; [21] Their organism is protected by strong innate immunity compensating slow acquired immune reactions [22] .

Because turtles have very slow metabolism as well as growth, their bodies do not need to deal with excessive metabolic heat and byproducts as mammals [23] . Their natural diet is very simple but also necessary for their longevity. [24]

According to the evolutionary theories, staying alive is less important after menopause. Galapagos giant tortoises achieve sexual maturity late (around the age of up to forty years in the wild, and between twenty and twenty-five years of life in captivity [25] ), then staying fertile until death [26] .

The Hayflick limit is said to determine how many times a cell can divide [27] . The Hayflick limit of Galapagos giant tortoise was said to be about 110 divisions [28] , approximately twice as many as 50 of human cells [29] . Studies in this context have highlighted the importance of telomeres, the protective end sequences of chromosomes, that get shorter with each cell division [30] , can play at least a partially role in life expectancy. It was observed that telomeres in European freshwater turtle’s cells are of the same length in both embryo and adult organism [31] .

Thus, it was believed that turtles are negligibly senescent organisms [32] . In other words, the cells do not age and no age-related diseases appear, which is very different cell behavior than in human bodies [33] and probably the key to any natural longevity. However, evidence now suggests that turtles may not be really negligibly senescent because of observations of survival and reproductive senescence in late age in the painted turtle population [34]

As we can see, turtles have some advantages in the lifespan field. Some of these might inspire researchers to increase lifespans in humans.

4 Key Tips for Choosing a Probiotic

by Rebecca @ UP4 Probiotics

Mon Jan 25 06:37:40 PST 2016

With so many probiotic supplements on the market today, it can be difficult navigating the sea of products to choose from. Luckily, we are here to help with our 4 key tips of what to look for when picking a probiotic supplement that is right for you.  1) CFUs Probiotics are measured in CFUs (Colony Forming […]

The post 4 Key Tips for Choosing a Probiotic appeared first on UP4 Probiotics.

Turning Back the Clock on Body Composition -FGF19

by @ ImmInst Active Topics

Sun Feb 11 04:39:55 PST 2018

I have not seen any discussion on FGF19-understandable given how many such damn peptides have emerged over the last few years alone.

 

However, this does look promising
http://www.longlonglife.org/en/longevity/lifespan-news/fgf19-hormone-might-help-fight-sarcopenia-degenerative-loss-muscle-mass-associated-aging/

 

Rodent study, of course.... and this may or may not play out as expected in humans. But this part of the above link is interesting:

"For seven consecutive days, they administered FGF19 to different mice models......

All mice models that received FGF19 gained less weight and developed less fat tissue than mice in the control groups, when they had in fact been eating more."

 

To observe an effect in seven days makes me think that the effect size here is rather large.

 

The piece continues with the following comment: "In addition, their skeletal muscles became more developed, as well as their muscle strength."

This is even more significant. To see an effect on muscle mass and strength in seven days is amazing. The vast majority of anabolic steroids do not work that quick. 

Comments???

50% off Toys on Amazon

by Heather @ I Love Savings | Coupons | Grocery | Health | Beauty | Household

Sun Feb 11 03:02:48 PST 2018

...

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A Sincere Introduction

by @ ImmInst Active Topics

Thu Feb 08 22:00:00 PST 2018

Hello those of you interested in a non-woo-woo way to longevity and increased cognition! I am a similar soul. I have been interested in how science, diet, medicinal practices, and psychology can alter the way I currently transgress this solemn world; this has lead me in the direction of all sorts of different experiences, some of which, admittedly, have been quasi-rational. So, it is in my docket, it is my modus operandi, my purpose to encourage rational, evidence based discussion in a community whose goals I admire a great deal. Cheers, to those of you who are here, and to those who are not--they may still benefit from our discussion and progress.

 

On an unrelated tangential note my interests are as follows: Literature, Medicine, Film, Art, Philosophy (unstructured unfortunately, I know who Hegel, Wittgenstein, Kant etc. is, though I can't really sustain conversation on their ideas.)  

 

I'll welcome any conversation on those topics, and conversations not on those topics-- though I can't promise I'll be too much use!

LongeCity Connect

by @ LongeCity - Articles

Sat Jun 08 11:42:27 PDT 2013

Database of Experts, Advocates and Volunteers  
LongeCity has been 'the' forum for information exchange on life extension for over a decade. Over the years, many of the 'who is who' in the scene have visited the site, newcomers have used the site to educate themselves or as a springboard for new projects,  and many initiatives and rallying efforts have brought people together. 
However, in all that time we did not have a well-coordinated approach to networking. From time to time different efforts to reach out and connect were made but there were few tools in place to support such  initiatives, and they had to start from scratch each time. There was no database that can be searched for the right skills set, no 'register of interests' that can be used to connect volunteers around the globe... until we realized that the simplest and most effective way of  creating and maintain such a register was lying right in from of us in our database of users.
To leverage that resource and turn it into a powerful tool for networking, we have added new data fields. 
You can find these by here under 'volunteering'. As a privacy protection measure, the entries in these fields will be *viewable by members only* -at the very moment, you can only see your own entries.

Please update your profile here: if you have ever shared information this kind of information elsewhere on LongeCity, (i.e. in a forum thread or in a PM to the Members Secretary/Volunteer Coordinator) then please take a minute to enter the information in this register. We will look at doing some conversions manually, you yourself know best whether the info you supplied is still up-to date.  

This initiative is still very much in its infancy and we are looking forward to suggestions over the next few weeks and months how to make this into a powerfully effective networking tool.