Danone Oikos Contest: WIN Your Dream Date for Two

by Karla @ Canadian Freebies, Coupons, Sweepstakes Deals~ Canadianfreestuff.com

Mon Feb 12 10:25:52 PST 2018

Oikos Canada Facebook Contest OIKOS® MIX YOUR VALENTINE’S DAY CONTEST Enter to WIN your dream date for two! 1 Prize consisting of gift cards to a restaurant, spa,hotel,cinema,etc..depending on what choice you make in your entry. The approximate total and maximum retail value for the prize is three hundred dollars ($300 CAD). To enter this […]

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Twinings Tea Coupon Code for Canada

by Andria @ Canadian Freebies, Coupons, Sweepstakes Deals~ Canadianfreestuff.com

Mon Feb 12 09:11:39 PST 2018

New Twinings Tea Coupon Code for Canada. Save 10% off any Twinings Tea Product (first 100 orders) FREE Tea Samples with each order FREE Shipping This Twinings Tea Coupon Code is available online only. At Checkout, Use Coupon Promo Code TWININGS10 SHOP Twining Tea Online Here Coupon Expiry date is Unknown   Find More Grocery Coupons Here. […]

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Davids Tea Contests – Win Prize Packs

by Theresa @ Canadian Freebies, Coupons, Sweepstakes Deals~ Canadianfreestuff.com

Mon Feb 12 19:04:32 PST 2018

New David’s Tea Contest on Instagram Enter for your chance to give you and two friends the chance to win sweet prize packs including $200 worth of DT goodies and Frank And Oak $300 Gift-Cards! To enter this contest, How to enter: 1. Follow @frankandoakwomen and @davidstea 2. Tag 2 friends in the comments on Instagram Good Luck. Rules  […]

The post Davids Tea Contests – Win Prize Packs appeared first on Canadian Freebies, Coupons, Sweepstakes Deals~ Canadianfreestuff.com.

Rectal Bleeding Prostate Cancer Loss Kefir Weight Plan

by @ Probiotics Belaw

Sun Jan 07 16:40:27 PST 2018

You can learn about probiotic supplements and Probiotics NZ can advise you how to take them. Rectal Bleeding Prostate Cancer Loss Kefir Weight Plan hospitals offering this leading-edge procedure. Probiotic not as the products. Use NOW Immune Renew to help support healthy immune function throughout the year.* NOW Immune Renew delivers the natural nutrient profile […]

Keurig Coupon Code – FREE K-Cup Pods with Purchase

by Andria @ Canadian Freebies, Coupons, Sweepstakes Deals~ Canadianfreestuff.com

Mon Feb 12 09:30:29 PST 2018

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Probiotics Yogurt For Ibs Intolerance Milk Lactose

by @ Probiotics Belaw

Sun Jan 07 17:33:47 PST 2018

Die off can also occur perpetually. AVI-CULTURE-2 is the NUMBER ONE all-natural live 10-strain avian-specific Non-GMO Dairy-Free FOS-Free & Allergen-Free Now the new & improved AVI-CULTURE-2 surpasses that making IT the best avian-specific probiotic for all birds on the planet! Up to 75 percent of women will have a yeast infection in their lifetime and […]

Rexall Coupon For Canada: 100 Bonus Air Miles (Feb 13 only) + Save $5 off $25

by Andria @ Canadian Freebies, Coupons, Sweepstakes Deals~ Canadianfreestuff.com

Tue Feb 13 01:24:45 PST 2018

Rexall Coupon For Canada get 100 Air Mile Bonus Miles when you spend $50 or more Get the printable coupon from Rexall Here Rexall Coupon is valid February 13, 2018 ONLY Rexall Coupon For Canada Save $5.00 OFF when you spend $25 or more Get the printable coupon from Rexall Here Rexall Coupon expires March 6, […]

The post Rexall Coupon For Canada: 100 Bonus Air Miles (Feb 13 only) + Save $5 off $25 appeared first on Canadian Freebies, Coupons, Sweepstakes Deals~ Canadianfreestuff.com.

Old Navy Deals ~ Save up to 75% off Clearance + up to 40% off Jeans, Fleece & Outerwear

by Andria @ Canadian Freebies, Coupons, Sweepstakes Deals~ Canadianfreestuff.com

Mon Feb 12 06:02:52 PST 2018

Old Navy Deals for Canada. Save up to 75% off Clearance Save up to 50% off Storewide Save up to 50% off Old Navy Active Tees for Kids from $5 Tees for Adults from $7 Kids Jeans from $12 Adult Jeans from $15 Kids Fleece from $12 Adult Fleece from $15 and More No code […]

The post Old Navy Deals ~ Save up to 75% off Clearance + up to 40% off Jeans, Fleece & Outerwear appeared first on Canadian Freebies, Coupons, Sweepstakes Deals~ Canadianfreestuff.com.

Hello !

by @ ImmInst Active Topics

Mon Feb 05 19:13:59 PST 2018

Hi, I've come across the forum from time to time in my research of different supplements over the past couple years. Finally joined so I can add to some discussion and share my experiences as they happen. Cheers!

Cabela’s Coupons Code ~ FREE Shipping with $99 Minimum Order

by Andria @ Canadian Freebies, Coupons, Sweepstakes Deals~ Canadianfreestuff.com

Mon Feb 12 08:23:41 PST 2018

The Latest Cabela’s Coupons Codes. Get FREE Standard Shipping with $99 Minimum Order Coupon codes are valid online or with phone orders only. Use Promo Code: GEARUP at checkout Gift cards/e-gift cards do not apply towards order minimum. Cabela’s Coupons Offer end date is February 25, 2018   Find More Cabela’s Offers Here.   * indicates required Email: […]

The post Cabela’s Coupons Code ~ FREE Shipping with $99 Minimum Order appeared first on Canadian Freebies, Coupons, Sweepstakes Deals~ Canadianfreestuff.com.

WAPF’s and GAPS’ Current Response on FCLO, Years Later

by Becky Plotner @ Nourishing Plot

Tue Jan 30 05:11:44 PST 2018

The current stance on the most recent Fermented Cod Liver Oil (FCLO) findings and accusations were announced at the 2017 Annual Weston A. Price Conference in Minneapolis, Minnesota on November 19th. 

{This post may contain affiliate links which pay for this site}.

In 2015 there was a big attack on fermented cod liver oil. [...]

The post WAPF’s and GAPS’ Current Response on FCLO, Years Later appeared first on Nourishing Plot.

Jagged-1 as a More Selective Signal to Spur Bone Regrowth

by @ LongeCityNews

Mon Feb 12 03:29:05 PST 2018

Researchers here report on a more selective way to trigger the accelerated or enhanced regeneration of bone tissue, delivering jagged-1 to injuries rather than the bone morphogenetic proteins (BMPs) that have been used in the past. It appears to cause fewer issues related to inappropriate excess bone growth, as it influences mechanisms that are more closely associated with the process of regeneration in response to damage. The delivery of signals rather than cells or pharmaceuticals to produce regeneration will be a growing theme in the years ahead, and the approaches will only grow in sophistication and degree of control. The advance here is a small step in the grand scheme of the possible and the plausible; it will be interesting to see how this part of the industry evolves over the next few decades.

When a patient breaks a bone, there's a possibility the fracture won't heal properly or quickly, and use of a restorative tactic known as bone morphogenetic proteins, or BMPs, is increasingly less likely. Designed to promote spinal fusion and bone repair more than a decade ago, these molecules can overperform, causing excessive or misdirected bone growth, studies have shown. But because bone-healing biological research has often been limited, few other options exist. "Novel therapies have gone underdeveloped because of this assumption that bones heal without problem. The reality is there's a huge number of fractures that occur each year that don't heal very well."

The divide recently inspired scientists to examine a new therapeutic approach. Their method: deliver additional Jagged-1 - a potent osteoinductive protein known to activate the Notch signaling pathway that regulates bone healing - at the spot of a bone injury. "We've hypothesized for many years that by binding the Jagged-1 to a biomaterial and delivering it to a bone injury site, we could enhance healing." The results affirm that hunch: Rodents that received Jagged-1, applied via wet collagen sponge, saw improvements to skull and femoral bone injuries. Rodents treated with BMPs, by contrast, also benefited but developed the same problematic bone hypertrophy associated with human use of those proteins. Those findings suggest that the former therapy could one day benefit people.

It's not fully known why some bones don't heal the way they should - nor do scientists know whether a genetic component plays a role. What researchers have studied for years, meanwhile, is the capacity of the Jagged-1 ligand to promote bone-forming cells. The signaling is unique because this particular ligand typically binds to a delivery cell to activate bone healing in an adjacent cell - a vital trait to help ensure that a supplemental Jagged-1 dose, administered at the spot of injury, stays in place (and on task) to carry out its intended function. As a result, bone will only form where bone is supposed to form. BMPs, by comparison, are soluble, so they can migrate from the site of delivery and settle elsewhere in the body, triggering other cells that aren't supposed to form bone.

Link: https://labblog.uofmhealth.org/body-work/boosting-a-key-protein-to-help-bones-wont-heal

View the full article at FightAging

Need help making sense of blood glucose readings

by @ ImmInst Active Topics

Sun Feb 11 03:44:28 PST 2018

Hi!

I'm usually only reading at these forums but decided that I need some help to figure out what is going on with my blood glucose.

Fasting in the morning it is 75-83 mg/dL typically. After my typical breakfast (1l yogurt, some cottage cheese and a slice of bread or some oatmeal) the blood glucose looks like this:
Before breakfast 75
15 min post 75
1 hour post 65
2 hour post 65
3 hour post 84

Before lunch 80
45 min after lunch 85
75 min after lunch 78
110 min after lunch 97
2.5 hours after lunch 86

This lunch consisted of gluten free pasta (rice pasta)
Cottage cheese, meatballs

What I'm not getting is why my blood glucose drops to hypo range after breakfast, but not after lunch?

I do 16:8 IF

Supplements are:
Rhodiola,
Zinc carnosine for stomach issuer
Boron 10 mg
Lifeextension two a day multi @1 a day
B-right
Tmg
Omega 3 4g
L-tyrosine 800mg

All taken in the morning before breakfast.

I do heavy weight lifting twice a week.

Please comment and give advice to what is going on.

My suspicion so far is the high amount of dairy in the breakfast. I tried to reduce it bit with little effect. Im considering to omit it from breakfast. Other than that I dont know.

Thanks in advance

Probiotic Restore Ultra Pills For Constipation Gas Bloating

by @ projectathena probiotics composition

Tue Feb 13 02:14:43 PST 2018

Most American diets are probiotic and prebiotic foods nova is it how what get cancer low in fiber and eating less meat and more fiber through fruits and vegetables is a healthy diet step Schnell says. Product review: Arbonne – various health enhancing products. Probiotic Restore Ultra Pills youngest age of colon cancer diagnosis best […]

Supplement Review: Nicotinamide Riboside

by @ Articles - Articles

Sat Nov 19 02:04:10 PST 2016

Home Depot Free DIY Workshops – Kids- Adults – February 2018

by Theresa @ Canadian Freebies, Coupons, Sweepstakes Deals~ Canadianfreestuff.com

Mon Feb 12 18:03:55 PST 2018

Free Workshops at Home Depot – Plan a Bathroom Renovation – Saturday, February 17, 2018 Install a Vanity and a Faucet – Sunday, February 18, 2018 Install a Toilet – Saturday, February 24, 2018 Install Floor and Backsplash Tile – Sunday, February 25, 2018 NEW: Kids Kids can learn how to build their very own Periscope – March 10, 2018 […]

The post Home Depot Free DIY Workshops – Kids- Adults – February 2018 appeared first on Canadian Freebies, Coupons, Sweepstakes Deals~ Canadianfreestuff.com.

No Sugar Probiotic Yogurt Fat Stomach

by @ Probiotics Belaw

Sun Jan 07 14:17:16 PST 2018

Ingredients: Viable yogurt starter culture of nonfat milk solids and whey containing Lactobacillus bulgaricus (LB-51) and Strepococcus thermophilus bacteria (in precise Bulgarian proportions). No Sugar Probiotic Yogurt Fat Stomach help with gas and bloating. His tumor the size of a baseball was already starting to strangle the portal vein going into the liver. Activia Parfait […]

My Favorite Post-Workout Supplements to Speed Muscle Recovery

by Holly Lucille, ND, RN @ Bottom Line Inc

Sat Feb 10 06:30:38 PST 2018

Whether you hike, do strength training or intense Crossfit classes, here are my favorite supplements to keep up my energy and ensure a quick recovery.

The post My Favorite Post-Workout Supplements to Speed Muscle Recovery appeared first on Bottom Line Inc.

Chances Of Getting Colon Cancer At Age 40 Best Gnc Supplement

by @ projectathena probiotics composition

Tue Feb 13 07:03:34 PST 2018

In lab tests the Probiotic bacteria mo123: Edgar Cayce-Those who would eat 2-3 almonds each day need never fear cancer. But purchasing the cheapest and is not always the wisest course to take. Chances Of Getting Colon Cancer At Age 40 Best Gnc Supplement it is the overgrowth is typically Sintomas Fotos Candidiasis En Homes […]

Costco Weekly Savings (Feb 12 - 18)

by couponlady @ SmartCanucks.ca Flyers, Deals Canada

Mon Feb 12 08:09:40 PST 2018

*ON & Atlantic Canada: *Image: https://flyers.smartcanucks.ca/uploads/pages/98137/costco-weekly-savings-on-atlantic-canada-february-12-to-18-1.jpg ...

Old Navy Coupon Codes – Save 25% off Your Order

by Andria @ Canadian Freebies, Coupons, Sweepstakes Deals~ Canadianfreestuff.com

Tue Feb 13 05:15:23 PST 2018

Old Navy Coupon Codes for Canada. Save 30% off Your your Order This Old Navy Coupon Code is valid Online only. To get your discount, use promo code at checkout: TREAT Old Navy Coupon Codes are valid until February 13, 2018 @ 11:59 pm ET Check here for other Old Navy deals that may be on. Old […]

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Probiotic Capsule Douche Taking Leaky Gut

by @ Probiotics Belaw

Sun Jan 07 17:11:46 PST 2018

Sundown Naturals Inulin Fiber Prebiotic Mineral Supplement Capsules 90 Count $8.79 ($0.10 / count). Probiotic Capsule Douche Taking Leaky Gut seaman NEW YORK (Reuters Health) – Taking “good” bacteria known as probiotics may help prevent diarrhea ought on by a tough-to-treat infection that often results from taking antibiotics according to a fresh look at some […]

Write for LongeCity

by @ LongeCity - Articles

Tue Jan 08 11:39:43 PST 2013

There are 4 ways of writing for LongeCity:

(1) Commissioned topics 
800-1500 word (ca. 2-3 pages) articles on any of the topics listed below. 
As long as the topic is listed, it remains open for submissions.
Authors are invited to submit a finished manuscript directly to caliban@longecity.org. Responses can be expected with 14 days after submission. 
Editors may require certain alterations for style, quality or based on peer-reviewed references, but publication is guaranteed for commissioned articles if the article meets a basic quality threshold.

(2) Submit an exposé for a new topic
You can send us a 200 word article outline, accompanied with a few lines about yourself. If accepted, you will be invited to submit a full article. 
Please use the contact form. 

Reward per published article: $180 (a premium may be awarded for particularly well-researched articles)

(3) Write a blog or (4) write on the forum
You can either start a blog at LongeCity or easily synchronise a blog that you maintain elsewhere. If your blog is consistently of interest and of good quality, you will automatically be awarded ‘Thank You’ points which can be redeemed for vouchers at online stores such as amazon. We might also ask you to do a regular column.
Thank you points also accrue to forum posts, as readers 'like' your posts. 

All articles and other written contribution are subject to the general LongeCity User agreement. In short authors keep full copyright of the article, but grant a free perpetual and worldwide license to LongeCity for non-commercial use. 

G7 Canada Coupon: Instant Coffee Savings

by Theresa @ Canadian Freebies, Coupons, Sweepstakes Deals~ Canadianfreestuff.com

Mon Feb 12 18:34:52 PST 2018

New G7 Coupon for Instant Coffee Save $0.75 off on G7 Instant Coffee Available in Print Format Only Print Coupon Today ( Search G7 Vietnamese Coffee) G7 Coupon Expiry Date is unknown What is G7 Instant Coffee? G7 claims to be a gourmet instant coffee! How does that work? Well its coffee taht is full […]

The post G7 Canada Coupon: Instant Coffee Savings appeared first on Canadian Freebies, Coupons, Sweepstakes Deals~ Canadianfreestuff.com.

LongeCityNow_Neil_Thanedar_2017.mp3

by @ Last 10 Submissions RSS Feed

Wed Oct 04 10:09:09 PDT 2017

Listen in and find out how Labdoor is helping the supplement industry. Are your supplements, safe, pure, and accurately labeled?

Children’s Probiotic Yogurt Metastatic Bevacizumab-based Therapies Treatment First-line Cancer Colorectal

by @ projectathena probiotics composition

Tue Feb 13 02:41:11 PST 2018

An Organic Awakening. Cancer_Chemotherapy_in_Clinical_ DOWNLOAD PRINT. Children’s Probiotic Yogurt Metastatic Bevacizumab-based Therapies Treatment First-line Cancer Colorectal or lamb) and processed meat consumption possibly increased cancer risk. How Even Beneficial Gut Bacteria Might Spur Colon Cancer Probiotics (healthy bacteria) has over 30 I would prefer to label flora which promotes cancer The surgeon suggested that Tan […]

Sunflower lecithin causing burning lips

by @ Health

Mon Feb 12 19:23:38 PST 2018

About 45 minutes after eating anywhere from 1/4 ts to 1 1/2 tb of powdered sunflower lecithin (NOW brand) I develop a raw, tingling, burning sensation at the corner of my lips that lasts a few minutes. The higher dose caused insomnia, reflux, and migrating muscle aches/cramps, I assumed this was due to excess acetylcholine; the lower dose did not.

 

Citicoline/CDP Choline at a dose of 250 mg twice a day did not cause any symptoms or noticeable effects, though I did have vivid dreams after discontinuing it. I'm now doing a trial of alpha-GPC and have started at a very small dose of 10 mg.

 

This study found some evidence that lecithin may boost immune function: Soy lecithin supplementation alters macrophage phagocytosis and lymphocyte response to concanavalin A: a study in alloxan-induced diabetic rats:

 

Dietary soy lecithin supplementation decreases hyperlipidemia and influences lipid metabolism. Although this product is used by diabetic patients, there are no data about the effect of soy lecithin supplementation on the immune system. The addition of phosphatidylcholine, the main component of lecithin, to a culture of lymphocytes has been reported to alter their function. If phosphatidylcholine changes lymphocyte functions in vitro as previously shown, then it could also affect immune cells in vivo. In the present study, the effect of dietary soy lecithin on macrophage phagocytic capacity and on lymphocyte number in response to concanavalin A (ConA) stimulation was investigated in non-diabetic and alloxan-induced diabetic rats. Supplementation was carried out daily with 2 g kg(-1) b.w. lecithin during 7 days. After that, blood was drawn from fasting rats and peritoneal macrophages and mesenteric lymph node lymphocytes were collected to determine the phospholipid content. Plasma triacylglycerol (TAG), total and HDL cholesterol and glucose levels were also determined. Lymphocytes were stimulated by ConA. The MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) dye reduction method and flow cytometry were employed to evaluate lymphocyte metabolism and cell number, respectively. Soy lecithin supplementation significantly increased both macrophage phagocytic capacity (+29%) in non-diabetic rats and the lymphocyte number in diabetic rats (+92%). It is unlikely that plasma lipid levels indirectly affect immune cells, since plasma cholesterol, TAG, or phospholipid content was not modified by lecithin supplementation. In conclusion, lymphocyte and macrophage function were altered by lecithin supplementation, indicating an immunomodulatory effect of phosphatidylcholine.

 

I have Lyme, Bartonella, and Babesia. Is it possible that sunflower lecithin is boosting my immune system enough to cause a herxheimer reaction, could there be another explanation? 

Costco Unadvertised Deals of the week starting Feb. 5th

by Nadine @ Save Money in Winnipeg

Mon Feb 05 09:08:54 PST 2018

Lots of good deals at Costco this week, here they are from the Regent location in Winnipeg. Most will be the same store to store. Items ending in .97 are markdowns and are store specific. A lot of items with stars on them today which means they’re on their way out. If you ever see […]

The post Costco Unadvertised Deals of the week starting Feb. 5th appeared first on Save Money in Winnipeg.

Costco Canada Coupons of the week

by Nadine @ Save Money in Winnipeg

Mon Feb 05 05:25:57 PST 2018

Lots of coupons starting this week at Costco – you can get the flyer in store or check them all out online too. There’s $3 off Rice Krispie treats, $4 off french onion soup, $4 off Purex, up to $40 off mattress toppers, and a lot of health and beauty ones too, including $6.50 off […]

The post Costco Canada Coupons of the week appeared first on Save Money in Winnipeg.

Supplement Development - Great results as of late

by @ LONGECITY Community Blog List

Thu Nov 16 10:12:00 PST 2017

I've been using a bunch of supplements and improvised materials that just haven't been done yet and have been getting great results. Then two nights ago I add a half dose of an adjuvant to my existing regimen that can slowly remove glucosepane, or so it seems. I have it on good authority that this mechanism will be effective. The new ingredient is working wonders. After I shaved this morning, my face felt smoother than it had in years (I change my blades very infrequently, this one is at least a few months old and the disposable battery is about a month). The over all appearance of my skin has improved greatly in the last few weeks. At this point it looks like a pointalism painter painted some younger spots on my skin in layers and the layering is continuing. Interestingly enough, I was out walking about in the sun and overcast skies at a nearby college for several hours yesterday and was expecting my skin to look worse. I do take 4 supplements to minimize the effect of the sun on my skin as I have a somewhat mild (in cosmetic terms... medically it's atypical, basically I have a high enough adrenaline response to deal with the inflammation rapidly and systemically so I feel the effects differently and only get a few zits and a spell of anxiety) case of polymorphic light eruptions or what I refer to as sun sensitivity. The supplements virtually ameliorate the sensitivity most of the time.

 

Anyways, my skin got much better, though it was perhaps a little red and more wrinkled in areas such as that between my thumbs and pointer fingers, and I was exhausted by the end of the day. The skin returned to normal when the inflammation subsided.

 

I feel like we're getting real close for those of us who are informed enough to start defeating aging on our own.

Why do some turtles outlive humans?

by @ Articles

Wed Feb 08 16:45:06 PST 2017

(⇒ write for LongeCity )


The oldest human recorded in modernity was Jeanne Louise Calment, she died in the age of 122 years and 164 days [1] .

There are rumors that the oldest tortoise called Adwaita (Aldabra giant tortoise) died in the age of about 250 years [2] or that it was 188-year-old radiated tortoise named Tui Malila [3] , or that the highest verified age of 177 years had Galapagos giant tortoise Harriet [4] . The oldest currently living turtle is considered to be Jonathan (Seychelles giant tortoise), estimated to be over 180 years old these days [5] . Although all aforementioned numbers are estimations, it seems these turtles were older than human supercentenarians.

All previously mentioned species are terrestrial tortoises, a group with longest lifespans among turtles. The most famous of them, well-researched Galapagos giant tortoise, was observed by Charles Darwin when he was forming his well-known theory of evolution by natural selection [6] . There is only one freshwater turtle known to be able to outlive human, it is the common snapping turtle estimated to live up to more than hundred years [7] . While being considerably less researched, recorded maximal lifespan of sea turtles is usually shorter, not exceeding 80 years, however, it is believed that the green sea turtle can live up to 100 years. [8]

It is a difficult question to answer why these reptiles can outlive us because even to determine the actual age of animals with a long lifespan is complicated – partially due to the fact that it takes such a long time to study. Furthermore, many turtles are endangered species [9] so there may not be as many organisms to hand as needed for proper statistics. Nonetheless, we can still claim that turtles are among the most long-living vertebrates on earth [10] . Why?

Firstly, turtles, like all reptiles, benefit from being ectothermic organisms. They do not maintain body temperature and thus save a lot of energy. But that also means they are less flexible: it is crucial for their lifespan to be in natural temperature environment of daily cycles with night-time temperature drop [11] . If they do not live under these conditions in captivity, metabolic pathways change and turtles die much sooner. [12]

Turtles are well-adapted in other ways: their famous shell – the carapace –is good protection against natural predators. Most of hatchling turtles with a soft shell do not survive the first year [13] . A research of natural populations of freshwater turtles showed that only one per cent of them can celebrate the twentieth birthdays, but once the adulthood is reached, mortality rate drops and remains constant throughout the rest of life [14] .

Some turtles can survive under extreme environmental conditions, such as freezing [15] or lack of oxygen for months [16] . They can even undergo hibernation and anaerobic metabolism and therefore deal with hypoxia and anoxia, it was also proposed that the same genes can play a role in longevity itself [17] and also in oxidative stress resistance [18] that further promotes longer life [19] .

Turtle’s bones and shell are used as lactate buffer lowering metabolic acidosis caused by anaerobic glycolysis during the period of lack of oxygen [20] ; [21] Their organism is protected by strong innate immunity compensating slow acquired immune reactions [22] .

Because turtles have very slow metabolism as well as growth, their bodies do not need to deal with excessive metabolic heat and byproducts as mammals [23] . Their natural diet is very simple but also necessary for their longevity. [24]

According to the evolutionary theories, staying alive is less important after menopause. Galapagos giant tortoises achieve sexual maturity late (around the age of up to forty years in the wild, and between twenty and twenty-five years of life in captivity [25] ), then staying fertile until death [26] .

The Hayflick limit is said to determine how many times a cell can divide [27] . The Hayflick limit of Galapagos giant tortoise was said to be about 110 divisions [28] , approximately twice as many as 50 of human cells [29] . Studies in this context have highlighted the importance of telomeres, the protective end sequences of chromosomes, that get shorter with each cell division [30] , can play at least a partially role in life expectancy. It was observed that telomeres in European freshwater turtle’s cells are of the same length in both embryo and adult organism [31] .

Thus, it was believed that turtles are negligibly senescent organisms [32] . In other words, the cells do not age and no age-related diseases appear, which is very different cell behavior than in human bodies [33] and probably the key to any natural longevity. However, evidence now suggests that turtles may not be really negligibly senescent because of observations of survival and reproductive senescence in late age in the painted turtle population [34]

As we can see, turtles have some advantages in the lifespan field. Some of these might inspire researchers to increase lifespans in humans.

Natural Colon Cleanse Supplements Origin Leaf

by @ projectathena probiotics composition

Tue Feb 13 05:24:48 PST 2018

Flush the Pounds Away. Natural Colon Cleanse Supplements Origin Leaf i got Colothin Cleanse from my mother who is a regular user of this colon cleansing formula. This is because what this supplement does is so much more important than helping the As much as they are natural some of these products in the market […]

Supplement Review: Nicotinamide Riboside

by @ Articles

Sat Nov 19 02:04:10 PST 2016

User Agreement

by @ LongeCity - Articles

Sat Dec 17 15:11:18 PST 2011

Bylaw A. User Agreement (Posting Guidelines)

---

Bylaw A. User Agreement

Article 1
The following shall be the letter of the agreement that all visitors, Members and their guests will be asked to abide by when interacting with the LongeCity/ Imminst ("LongeCity") website Please read this Agreement carefully before accessing the Site.

Section01 The Nature of this Agreement
(a) The following are the terms and conditions (the "Agreement") offered to any person ("you") for access and use (including but not limited to forum user registration) of the LongeCity/Immortality Institute (LongeCity) web site and all affiliated web sites (the "Site"). The Agreement is the basis for using and interacting with the LongeCity website. By accessing the Site, you agree to abide by this Agreement.
(b) Access to the Site is a privilege and not a right. If you do not agree with this Agreement, or have no intention to follow the rules outlined herein, you may not use the Site. If you have any reason to interact with a representative of LongeCity, but you do not wish to follow these rules, please email support@LongeCity.org
© The information in this document is subject to change. These changes will be announced on the Site, but you must also agree to periodically review this document for changes. After eight (8) days of any change in the Rules, your continued use of the Site indicates your acceptance of any changes made.

Section02 Account registration
(a) Only natural persons aged 16 or above may register an account with LongeCity.
(b) Each natural person may hold one single account. Registering with multiple accounts is not allowed unless specific permission is given by LongeCity.
© You may not use the account of another person unless such use is inadvertent and infrequent (e.g. using a family members login from the same computer not noticing that the person forgot to log out).
(d) Persons whose accounts have been suspended, deleted or blocked by LongeCity may never register another account unless specific permission is given by LongeCity.
(e) Users are free to choose any alias as long as the name is not offensive and as long as there is no risk that the username may be confused with a natural person, entity, initiative or endeavour that the person using the account is not authorised to represent. Final decisions on the acceptability of any user alias are made by LongeCity leadership.
(f) An LongeCity Member who has been suspended or banned from the Site is not considered in good standing. A user who has been suspended or banned from the Site may not apply to become an LongeCity Member.
(g) Accounts may be suspended, deleted, or changed by LongeCity for a variety of reasons including but not limited to a violation of this user agreement. If you are unsure why your account is inaccessible you can email support@LongeCity.org.
You must not register a new account the without express permission from the Secretary.
(h) When an account has been suspended, Members will be notified within 8 days of suspension and may appeal to the Secretary within 8 days after receiving such notification. If no agreement can be reached with the Secretary, the Member may appeal the case to the Board. There is no right to appeal for users or other individuals who are not Members.

Section03 Content
(a) LongeCity provides an open platform for registered users to share text, video, audio, programmes, scripts, files, hyperlinks and other material on the Site ("Content") as long as such sharing is lawful and not in contravention of this Agreement. However, LongeCity does not undertake to scrutinise, evaluate, test or verify any Content prior to it being shared on the Site.
(b) Content from the Site may be downloaded solely for your own non-commercial use.
(c) You understand that by using the Site, you may be exposed to Content that you may deem offensive, indecent or objectionable.
(d) LongeCity does not control the Content contributed by users and, consequently, provides no guarantee as to the correctness, integrity or fitness of such Content.
(e) Content are the responsibility of the person from whom such Content originated. You agree that you and not LongeCity, are entirely responsible for all Content that you upload, post, email, link, transmit or otherwise make available via the Site.
(f) When contributing Content, you agree that this Content may be edited or deleted or rendered to display in a different manner at the discretion of LongeCity.
(g) LongeCity will not use Content you contribute for commercial gain without your express permission, but cannot warrant or guarantee in any way that others who you decide to share the Content with might not use it for commercial activities.
(h)LongeCity cannot be held responsible for any Content that has been contributed through its open platform. LongeCity will not react to requests to verify, redact, edit, delete or obfuscate any Content.

Section04 Intellectual Property & Privacy
(a) By contributing Content you agree that you shall have no recourse against LongeCity for any alleged or actual infringement or misappropriation of any proprietary right in relation to the Content that you have contributed.
(b) By contributing your own original Content you agree to make this Content available in perpetuity under a Creative Commons Attribution-Non-Commercial-No Derivative Works 3.0 United States License. http://creativecommo...y-nc-nd/3.0/us/unless you give express notification to the contrary at the same time that you contribute the Content.
© LongeCity will not share private data with third parties without your consent, however LongeCity may use the information it obtains as a result of your visiting and/or registering with the Site for the purpose of enforcing this Agreement or in order to save a life or prevent unlawful activity.
(d) LongeCity is not responsible if you decide to post or share private information about yourself or others on the forum. LongeCity will not normally redact, remove or alter such data if you subsequently change your mind.

Section05 Limitation of Liability
(a) In no event will LongeCity be liable for consequential or incidental damages
which may arise in connection with your use of the Site. Accordingly, you agree that LongeCity shall not be responsible to you or anyone else for any loss-of-profit, direct, indirect, incidental, special, or consequential damages
arising out of the use of the site.
(b) You acknowledge that the limitations set forth herein are integral to the amount of consideration levied in connection with the access and use of the Site and any services rendered hereunder and that, were LongeCity to assume any further liability other than as set forth herein, such consideration would of necessity be set substantially higher.
(c) You agree to defend, indemnify and hold LongeCity and its officers, directors,agents, and employees harmless against all costs, expenses, and losses, incurred from any violation of this Agreement (including negligent or wrongful conduct) by your use and access of the Site.
(d) LongeCity provides the Site and associated information "as is" and does not make any direct or indirect express or implied warranties.
(e) LongeCity does not verify the credentials of anyone contributing Content to the site and does not endorse any Content that is contributed as advice. Anyone providing advice and guidance on or in association with the site is doing this strictly in a personal capacity, whether or not this person has an official role with LongeCity, unless the advice is specifically, expressly and in each instance authorised by an LongeCity director. Users are reminded that 'Advisors' are advising the LongeCity board on policy. This does not constitute an endorsement by LongeCity of that Advisors communications with others.

Section06 Basic Prohibitions
(a) The following activities are strictly prohibited and may lead to immediate suspension or deletion of the account, court action and notification of law enforcement officials.
(b) Violating any applicable local, state, national or international law;
(c) Personal threats to anybody, whether or not that person is using the Site
(d) Misrepresenting yourself as a person who you are not.
(e) Representing yourself as affiliated with an organisation without due authorisation.
(f) Contributing Content that contains a virus, any type of malware or corrupted data;
(g) Interacting with the Site in such a way as to seriously impair the functioning or usability of the Site including but not limited to excessive contribution of irrelevant Content;
(h) Display the contents of the Site on a different web site without permission.
(i) Violate the Site's security including but not limited to accessing unauthorized data or logging into an account or attempt to log into an account for which you do not have authorization, scan or test for hardware or software
vulnerabilities, perform a denial of service attack, attempt to spread a virus or malware, or falsify TCP/IP information.
(j) Contributing any solicitation including but not limited to advertising, promotional materials, junk mail, spam, chain letters, pyramid schemes (also see section 8 below)

Section07 Content related to health
(a) Any and all advice and/or opinion provided is strictly personal and never endorsed by LongeCity, nor should it be construed to be the official policy of LongeCity to provide health advice.
(b) You must seek professional medical advice prior to embarking on any course or treatment associated with any Content on the Site.
(c) You must determine what government regulations exist associated with the procurement and use of restricted substances such that they do not contravene any laws in your country.
(d) All Information on the LongeCity Forums, including those associated with health, sciences fora are provided as an area for the open exchange of anecdotal experience and information, not as a professional source of advice.

Section08 Advertising, promotions and commercial activity
(a) Organisations or individuals seeking to advertise on the Site must first apply to LongeCity for such approval.
(b) Advertising is any Content (including private messages) that draws attention to, solicits, endorses, offers for sale, links to, critiques or otherwise relates to goods or services where one of the parties involved in initiating such Content or one of their associates stands to benefit from financial transactions that may results from such Content.
(c) LongeCity seeks to limit surreptitious advertising where users who may have a financial stake in such matters contribute Content simply to increase product desirability or brand awareness. Such Content will be censored on the basis of suspicion alone. On occasion, 'innocent' Content may inadvertently be subjected to such censure. Users should be aware of this and are kindly asked to refrain from protest in these cases, as the common aim is to increase the quality of Content on the Site.
(d) Even if a promotion has been agreed by LongeCity, this does not imply, and no-one must imply that this constitutes an official endorsement by LongeCity of the promotion, the organisation and individual conducting the promotion or the promoted products or procedures.
(e) Users must not use the Site for initiating or conducting commercial transactions, whether in private messages, or by using contact details displayed on the Site unless expressly authorised by LongeCity.

Section09 Posting Guidelines
(a) Users must agree to consider the posting guidelines as specified in Article2. Adherence to these guidelines is monitored by LongeCity Moderators, Directors and other designated Officers.
(b) Violation of a guideline will incur a warning. Repeat violation on more than three separate occasions will result in a time-limited suspension of the user account ranging from eight days to eight years.
(c) Disputes regarding the enforcement of posting guidelines should be taken up, in the first instance, with the Moderator who has issued the warning. If no resolution can be found in dialogue, the dispute can be notified to the Lead Moderator. Warnings issued by the Lead Moderator can be disputed with the Secretary. Users who have an open dispute with a Moderator cannot be warned again by the same Moderator – but the Moderator in question may still report questionable posts by that user.
(d) LongeCity has reserved a forum for the expression of free speech known as the William O'Rights Memorial Forum. LongeCity will not restrict Content in this forum even if it violates the posting guidelines as long as such Content does not violate the other provisions in this Agreement. This is a forum where users can engage in 'flame wars', ensure that posts are not interfered with by a Moderator, or complain about LongeCity without threat of censure.


Article 2 Posting Guidelines

Section01 A-- General tone of conversations
A1-- Be polite. That does not mean that you cannot try to destroy another’s argument utterly but never lose your tone or your temper while doing so. Also under no circumstances should you employ personal judgments or remarks about people themselves rather than their arguments. Aside from the fact that such judgments are more often than not ill founded, they drag down the overall quality of the discussion as well as costing time and space.
A2-- Some words are generally considered offensive terms, in polite conversation such as "fuck, "shit", "faggot" or "nigger". Causing offence rarely if ever helps to elevate the quality of a discussion. Generally, use of such words will result in a warning or ban, but discretion may be exercised depending on the context.

Section02 B-- General writing style
B1-- Do not write excessive amounts of text. Be concise! No one has the time or the inclination to plough through a pile of superfluous rhetoric in order to discover your main points. If you really feel that you have to write an essay, then write a summary at the end as every considerate essay-writer would do.
B2-- While every caution is advised about over-using the forums design tools, please by all means DO use them, if this helps to make the text more accessible.

Section03 C-- Starting a new topic
C1-- Before starting a new topic please consider if the topic is informative, or will stimulate an interesting discourse.
C2-- Please check if the issue has been discussed before on the Site (It is not important to be a 100% sure about this – the LongeCity forums are quite large and old. But please make a quick search, especially if you have not been with the community for long. Sometimes, it may make sense to open a new topic anyway, but would be great if you could reference previous discussions.)
C3-- Please think about a good title. (This is very important. Please spend some time on considering the title. Titles like "A Question", "Hello" or "Life Extension" may lead to an otherwise interesting topic being deleted. Challenging titles may draw a lot of visitors will still incur a warning if they are not informative. Give full titles. "Vitamin E" is bad, "Vitamin E harmful?" is not as good as "Risk of Vitamin E supplements in Cancer".)
C4-- Is it a privileged topic? (LongeCity Members can create new topics over which they, as threadstarter have editorial control. This is to empower members who are willing to put in a bit of work to maximise the quality and values of a discussion thread. Other contributors must be alerted to the threadstarters intention in the first post, but cannot subsequently complain if their posts are edited.

Section04 D-- Replying to topics
D1-- Please ask yourself "Does my reply offer a significant contribution?"
D2-- It is critical that you try to keep follow-up posts on topic. Avoid going off on a different tangent. If it occurs to you that this might be another thread, open a new thread and put a link to it in the old one. The last word about relevance stays with the Moderators or the threadstarter.
D3-- As an extension of the previous point, do not derail a topic with fundamental critique even if you think that this would desirable. In particular do not question the necessity of a certain life-extension technique by referring to another method that seems more relevant to you. (Two examples: do not answer a question about the capacity of artificial intelligence to value human emotion correctly by stating that the ‘Singularity’ is a bunch of nonsense anyway; Do not intrude on an exchange about the bioavailability of resveratrol by stating that you don't care because you are signed up for cryonics)
D4-- Refrain from posting personal information unless it is inherently necessary to elaborate your views or position.
D5-- There is usually no benefit for people in reading that you agree unless you give an explanation to go with it.
D6-- You do not have to be an expert on the subject matter, but if you feel that you really don’t know enough about the subject, then ask informed questions before stepping into the ring for debate. If someone posts a link or uploads an article- read it before you go on. Also read the posts of your predecessors and be aware of related discussions elsewhere.

Section05 E-- Posting images
E1-- You are welcome to post your own images and drawings when they are relevant to sharing knowledge. Irrelevant or excessive positing of images, including emoticons (smiles) often diminishes quality of the Content and will likely incur a warning.
E2-- Showing images to illustrate a point or make a humorous quip is popular with some posters, but please consider if such posts could derail a discussion or create issues around copyright infringement.
E3-- Please be considerate about causing embarrassment when sharing images. As a rule of thumb, if you would be uncomfortable viewing it at work, do not post it.
E4-- Avatars: LongeCity encourages users to use a small portrait (passport-type) photograph as 'Avatar' of themselves, but this is not a requirement. However, the use of other peoples photographs or the LongeCity logo as Avatar is not allowed.

Section06 F-- Quotes and references
F1-- When replying to a previous post by quoting it, only quote precisely enough text as is necessary to understand your reply. Using the "reply" function in the forums will quote the entire post that you are replying to. Do not use this feature without due consideration.
F2-- If you quote, reference the quote properly, but only quote the important bits. (It is customary to put alterations to a quote in square brackets and indicate left-out bits by putting “...”) Do not quote whole articles, rather give a link or upload them. If you have to quote a substantial passage, then indicate the important passages that you want to draw attention too.
F3-- The use of references is strongly encouraged. Such references should contain enough information to find the relevant source with one or two mouse clicks. When using a link, please remember that the hypertext url may be specific to your own access and useless to others.

Too Much Probiotic Food Stool Hard

by @ Probiotics Belaw

Sun Jan 07 13:45:13 PST 2018

True Cleanse Complete is designed to gently eliminate waste and toxins without Did you know studies have shown your colon to have eliminate waste and toxins without making your body feel miserable. Too Much Probiotic Food Stool Hard raw Food Vegan Recipes. Airmail to Europe (EU). Growing a baby is the most wondrous thing your […]

Hi

by @ ImmInst Active Topics

Tue Feb 06 16:21:09 PST 2018

Hello forum,

   I'm 38 and line in Southern California. Supplements I take right now are:

Morning - 1 Pill Resveracel, 1 Pill Crucera-SGS, 1 Scoop BHB Salt, 1 Scoopt MCT Oil, & Veggie Smoothie (or sub spirulena pills)

Nightime - 1 Pill Meriva-SF, Glucosamine (Thorne)

My goal is to stay physically healthy as long as possible. I'm pretty tall, and we don't seem to last as long. 

Right now I'm interested in Fullerene. 

Sunflower lecithin causing burning lips

by @ ImmInst Active Topics

Mon Feb 12 19:23:38 PST 2018

About 45 minutes after eating anywhere from 1/4 ts to 1 1/2 tb of powdered sunflower lecithin (NOW brand) I develop a raw, tingling, burning sensation at the corner of my lips that lasts a few minutes. The higher dose caused insomnia, reflux, and migrating muscle aches/cramps, I assumed this was due to excess acetylcholine; the lower dose did not.

 

Citicoline/CDP Choline at a dose of 250 mg twice a day did not cause any symptoms or noticeable effects, though I did have vivid dreams after discontinuing it. I'm now doing a trial of alpha-GPC and have started at a very small dose of 10 mg.

 

This study found some evidence that lecithin may boost immune function: Soy lecithin supplementation alters macrophage phagocytosis and lymphocyte response to concanavalin A: a study in alloxan-induced diabetic rats:

 

Dietary soy lecithin supplementation decreases hyperlipidemia and influences lipid metabolism. Although this product is used by diabetic patients, there are no data about the effect of soy lecithin supplementation on the immune system. The addition of phosphatidylcholine, the main component of lecithin, to a culture of lymphocytes has been reported to alter their function. If phosphatidylcholine changes lymphocyte functions in vitro as previously shown, then it could also affect immune cells in vivo. In the present study, the effect of dietary soy lecithin on macrophage phagocytic capacity and on lymphocyte number in response to concanavalin A (ConA) stimulation was investigated in non-diabetic and alloxan-induced diabetic rats. Supplementation was carried out daily with 2 g kg(-1) b.w. lecithin during 7 days. After that, blood was drawn from fasting rats and peritoneal macrophages and mesenteric lymph node lymphocytes were collected to determine the phospholipid content. Plasma triacylglycerol (TAG), total and HDL cholesterol and glucose levels were also determined. Lymphocytes were stimulated by ConA. The MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) dye reduction method and flow cytometry were employed to evaluate lymphocyte metabolism and cell number, respectively. Soy lecithin supplementation significantly increased both macrophage phagocytic capacity (+29%) in non-diabetic rats and the lymphocyte number in diabetic rats (+92%). It is unlikely that plasma lipid levels indirectly affect immune cells, since plasma cholesterol, TAG, or phospholipid content was not modified by lecithin supplementation. In conclusion, lymphocyte and macrophage function were altered by lecithin supplementation, indicating an immunomodulatory effect of phosphatidylcholine.

 

I have Lyme, Bartonella, and Babesia. Is it possible that sunflower lecithin is boosting my immune system enough to cause a herxheimer reaction, could there be another explanation? 

Checkout 51 Cash Back Offers (Feb 15 - 21)

by couponlady @ SmartCanucks.ca Flyers, Deals Canada

Mon Feb 12 11:37:36 PST 2018

Attachment 338970 (https://forum.smartcanucks.ca/attachments/canadian-shopping-deals-flyers/338970-checkout-51-cash-back-offers-feb-15-21-1.jpg) New offers will go live at 12:00 AM February 15, 2018, and...

Nick from Bakersfield

by @ ImmInst Active Topics

Mon Feb 05 17:24:56 PST 2018

Greetings all!

 

My Name is Nick, and like the title states, I am from Bakersfield California. I've lurked around the forums here for quite some time, and my primary interest is in the area of nutrition and supplementation/nootropics. I have a little experience, primarily with Piracetam and Choline supplementation, but am looking to broaden my horizons so to speak. Anyways, just wanted to introduce myself and thank everyone in advance for their advice and contributions!

 

Regards,

Nick

Costco Weekly Coupons

by Nadine @ Save Money in Winnipeg

Mon Feb 12 05:16:50 PST 2018

Lots of coupons starting today at Costco – you can get them instore or check them out online. There’s $4.50 off Cracker Barrel cheese slices, $3 off Zavida coffee, $4 off Purex, $5 off Tide, $18 off Canon ink cartridges, $100 off queen mattress and many more! And check back in later today for the […]

The post Costco Weekly Coupons appeared first on Save Money in Winnipeg.

When Should I Take a Probiotic If I’m on Antibiotics?

by Linda Agin @ Bottom Line Inc

Mon Feb 12 03:16:44 PST 2018

QI am taking an antibiotic for an infection, and I want to take a probiotic as well to protect my stomach. Should I take it during or after my course of antibiotics? AYou should absolutely take a probiotic supplement—and you’re right to ask about timing. Antibiotics can upset the balance of beneficial bacteria in your [...]

The post When Should I Take a Probiotic If I’m on Antibiotics? appeared first on Bottom Line Inc.

Purina Canada ~ Cat and Dog Food Printable Coupons

by Andria @ Canadian Freebies, Coupons, Sweepstakes Deals~ Canadianfreestuff.com

Mon Feb 12 07:48:32 PST 2018

Purina Coupons for Cat Chow Save $3.00 on one (1) bag of Purina Cat Chow Available in Print format only. Maximum 2 prints per household. While quantities last Get Purina Cat Chow Coupon Here (via hidden smartsource) Purina Coupons Expiry is unknown **Scroll down to see all the other Purina Coupons Purina Coupons for Dog Chow Save $4.00 on one […]

The post Purina Canada ~ Cat and Dog Food Printable Coupons appeared first on Canadian Freebies, Coupons, Sweepstakes Deals~ Canadianfreestuff.com.

Colostrum Probiotic Prospect Between Cancer Symptoms Difference Hemorrhoids

by @ Probiotics Belaw

Sun Jan 07 20:05:01 PST 2018

Dec 1 2014 – shoppingbargains. The following links allow you to view full publications. Colostrum Probiotic Prospect Between Cancer Symptoms Difference Hemorrhoids weight loss with no known reason ; treatment of colon cancer may involve removing the tumor Contains Vitamin E Vitamin B Vitamin C Changes in cancer incidence among Japanese migrants to the United […]

Pb8 Probiotic Canada Burping

by @ Probiotics Belaw

Sun Jan 07 16:13:41 PST 2018

Hens’ eggs are the type of egg most When there is a need to give high doses of chemotherapy to a specific area of the body it may be given by a regional method. Virtual Reality Laparoscopic Sigmoid Colectomy Virtual reality colorectal surgery is demonstrated here by medial to lateral mobilisation of the sigmoid colon […]

Advertising Framework

by @ LongeCity - Articles

Tue Dec 18 15:30:56 PST 2012

Visitors to the forum will notice that a lot of discussion evolves around nutrition, supplements and lifestyle. We realize of course that these factors are just one element of the larger mission to conquer the blight of involuntary death, but that makes it all the more important to make sure that the strengths that LongeCity has in providing a great resource for nutritional information exchange are leveraged effectively. 

Sometimes, it may seem like there are two 'factions' at LongeCity: on the one hand the committed 'activists' who realize the truth that nutritional supplements by themselves will have very limited efficacy in extending the human lifespan and who consequently have little patience  for 'supplement pushers'. On the other hand there are the 'supplementers' who have little to no interest in 'living forever' and whose priority is a healthy lifespan and enhancing their fitness. For sure, examples of both 'camps' can be found if one looks for them, but on the whole the distinction has very little merit: firstly, nutrition, drugs, vitamins and lifestyle - even apparently peripheral topics like cognitive enhancement, are an important factor in the portfolio of life extension technologies. These are the factors that we can do for ourselves, today and for that reasons alone are worth discussing. 

This fact- that supplements are at the 'applied' end of life extension discussion also means that the information and expertise joining at LongeCity around supplements can be much more effectively leveraged for fundraising. This makes LongeCity pretty unique: we are trying to siphon some of the financial overheads from the commercial end of life extension and re-allocate them to chronically underfunded scientific research and advocacy programmes. LongeCity has been really successful in this regard: with very little funding we have made a real difference in creating pioneering information material and funding important basic research as well as supporting community projects. 

Thus 'activists' can appreciate a measure of advertising at the sitefor making an important contribution to the common cause. Ad exposure for Members is reduced but not fully eliminated not least because we think that some ads can actually be useful and interesting. There are at least four types of  advertising available: 

'Google ads' - are context-related ads. Google offers these individually based on your browser's settings and the content of the forum. Consequently please bear in mind that LongeCity has very limited control about what ads are displayed.

'Banner ads' - these paid for adverts usually leading to a sponsors website. More about LongeCity's relationship with other institutions can be found in this article. To quote: "LongeCity does not endorse any advertisers beyond the fact that they have made a donation to the community in exchange for exposure. Advertisers never influence our policy, ever. (...) Having said that, advertisers featured at LongeCity very often have a real commitment to the cause- they would not have found us otherwise". Members are invited to comment on the policy

'Links' - these are links in text and elsewhere that are monetized if the link is used to make a purchase at the external site. One well known example is Amazon.com: If you use the LongeCity 'referral' page to make a purchase, Amazon makes a small payment to LongeCity at no cost to you. We may be experimenting with other link concepts in the future. Note however, that the connections on our links page are not used in this manner. They are simply a project index interesting sources that all members can contribute to. 

'Ads by discussion' - sometimes advertising momentum is generated simply by discussing a particular product. Over the years, marketers have become very sophisticated in pursuing such 'viral' strategies - and they are generally NOT WELCOME at LongeCity. There are only two sub-forums where product-and vendor related discussions are tolerated: for supplement companies/ for other companies. Any attempts to initiate product-related discussions elsewhere will be considered a breach of the LongeCity user agreement. The limited discussion that is allowed in this context is tolerated only because we feel that some information exchange about products and providers is potentially part of the LongeCity mission. Where this link cannot be made clearly, ads by discussion -whether inadvertent or not- will not be permitted.

We have experimented a little bit and are always keen to find other ways to generate funding for life extension research and advocacy from the LongeCity website in a way that is not overly intrusive and that does not compromise our mission and values. 
Potential sponsors are invited to get in touch. 
Members with new ideas about are invited to share them in the suggestions forum . 

Digestive Probiotics Tea Senna For

by @ projectathena probiotics composition

Tue Feb 13 03:29:16 PST 2018

Coconut is the best of cooking oils because it can withstand high cooking temperatures and remain stable no trans-fats. Raspberry ketone causes the fat within your cells to get oken up more effectively helping your body burn fat faster. Digestive Probiotics Tea Senna For “Colon Health Handbook” by Robert Gray. Colon cleanse-Vitamin C acid contained […]

Cryonics

by @ Articles - Articles

Tue Feb 21 13:06:47 PST 2012

The following is a quick overview on Cryonics.

 

NB: The information below is periodically reviewed for accuracy, but LongeCity makes no representations or gives any warranties whatsoever that the following information is accurate and complete at any point in time. LongeCity accepts no responsibility or liability for information contained on this page. The discussion of cryonics service providers and services in no way entails any endorsement on part of LongeCity. The lead author of this page, its editors and other contributors from time to time may be affiliated with one of the service providers mentioned below. Without qualification to the foregoing disclaimers, LongeCity strives to present the following information in an objective and balanced manner. If you feel that information on this page is inaccurate or imbalanced please contact the LongeCity Support Email.

 

INDEX

• Cryonics Overview
• Existing Cryonics Organizations
• Cryonics Services Offered
• Sizes of the Organizations
• Whole Body/Neuro Options
• Cryopreservation and Yearly Fees
• Human Cryopreservation Procedures
• Funding Cryonics by Insurance

Cryonics Overview

 

Cryonics is based on the idea that future medicine will have capabilities well beyond those of current medicine, including the ability to cure all diseases, rejuvenate and repair damage incurred in the cryopreservation process — through the use of nanotechnology and other technologies. Cryonics can be an ambulance or time capsule to future medicine which can allow us to live many thousands of years or longer in youth and good health. Stored at very low temperatures there will be very little molecular motion in cryonics patients for tens of thousands of years, although most of us do not believe that we will have to wait anywhere near so long for future medicine.

 

Although cryonics patients must be legally dead before cryonics procedures to reduce or eliminate ischemic damage and ice formation can be applied, cryonicists do not believe that cryonics patients are dead in an ultimate sense. Nearly all the cells of the body are alive for quite some time after the heart stops — including neurons. A standby team can be used to minimize the time between pronouncement of death and cooling, cardiopulmonary support, etc. Cryonicists believe that the anatomical basis of mind can survive much longer than six minutes after stoppage of the heart in the absence of cooling — despite the inability of current medicine to revive patients without neurological damage after more than six minutes of cardiac arrest. (See Quantifying Ischemic Damage for Cryonics Rescue for more details.)

 

Existing Cryonics Organizations

 

For most of cryonics history (which began in the mid-1960s), all of the cryonics organizations offering cryonics services have been in the United States. In 2005 a cryonics organization was created in Russia (just northwest of Moscow) and there are plans for another cryonics organization in Australia to offer perfusion and storage of cryonics patients within a few years. LongeCity does not endorse any particular cryonics organization. The data below is taken from the cryonics organizations without LongeCity attempting to verify the accuracy of their claims or the extent of the services they claim to provide. If you are considering utilizing any of these organizations, you should conduct your own investigation.

 

NAME	LOCATION	INCORPORATED	NON-PROFIT ?
Alcor Life Extension Foundation	Scottsdale, Arizona	1972	Yes
American Cryonics Society (ACS)	Cupertino, California	1969	Yes
Cryonics Institute (CI)	Clinton Township, Michigan	1976	Yes
KrioRus	Moscow, Russia	2005	No
Oregon Cryonics	Salem, Oregon	2005*	No
Suspended Animation, Inc (SA)	Boynton Beach, Florida	2002	No
Trans Time, Inc.	San Leandro, California	1972	No

 

Alcor Life Extension Foundation and the American Cryonics Society (ACS) are organized as 501©3 charitable organizations, whereas the Cryonics Institute (CI) is simply a non-profit corporation. Although Suspended Animation, Inc. (SA) is ostensibly a for-profit company, it is mainly engaged in research and development of cryonics capabilities financed by the principals of the Life Extension Foundation. By 2012 KrioRus had relocated to a facility closer to Moscow, but a newer facility is being built midway between Moscow and St. Petersburg.

 

Oregon Cryonics was incorporated in 2005, but accepted its first patient (a pet patient) in May, 2014. Jordan Sparks is the owner/operator, but he has plans for a Board of Directors or other mechanism to out-live him (to allow for the organization to continue).

 

Cryonics Services Offered

 

Not all cryonics services are offered by all cryonics organizations. Patient administration service is offered by cryonics organizations that sign-up Members who are to be cryopreserved upon legal death and maintain responsibility for those Members while they are Patient's in cryopreservation storage. Perfusion is the replacement of normal body fluid with cryoprotective solutions to reduce or prevent ice formation at cryogenic temperatures. Storage is the storage of a cryonics patient in liquid nitrogen. Standby/Stabilization/Transport (SST) involves standing by the bedside of a medically terminal patient destined to be cryopreserved, the application of a heart-lung resuscitator and ice-water cooling as soon as possible after declaration of death,and transport to a perfusion facility while tissues are still being stabilized at low temperature.

 

The following table represents the services which cryonics organizations say they provide.

 

*=simplification, see explanation

NAME	PATIENT ADMINISTRATION	PERFUSION	STORAGE	SST
Alcor	Yes	Yes	Yes	Yes
ACS	Yes	Yes*	No*	Yes*
CI	Yes	Yes	Yes	No*
KrioRus	Yes	Yes	Yes	No
Oregon Cryonics	Yes	Yes	Yes	No
SA	No*	No	No	Yes
Trans Time	Yes	No	Yes	No

 

All standby cases done for Alcor Foundation outside of Arizona, but inside the continental United States are handled by Suspended Animation, Inc (SA). Alcor does standby for Alcor Members who are terminal in Arizona, Hawaii, and Alaska as well as in Canada. SA does not provide SST services outside the continental United States for any organization.

 

The American Cryonics Society (ACS) states that it mainly contracts with Suspended Animation,Inc. (SA) for perfusion and standby/transport, and contracts with the Cryonics Institute (CI) for storage. ACS also states that it has equipment, contractors and volunteers which are available for use in perfusion and standby in California should the need arise, although this is far less sophisticated and formal than what SA provides. ACS creates and manages individual charitable trusts for its patients. ACS regards these trusts as an important feature of the benefit gained by being an ACS Member.

 

Cryonics Institute (CI) Members who reside in the continental United States have the option of contracting directly with SA if they desire professional SST.In some cases volunteers or paid funeral directors have provided these services to CI Members. SA will keep records of CI Members who have arranged to have SA SST, but does not continue any administrative responsibility after the patient has been cryopreserved.

 

Trans Time is currently storing patients, but (despite what their website says) is not currently seeking new Members or Patients.

 

Sizes of the Organizations

 

There are various ways by which organization size could be measured, but for the purposes of this section size is represented by the number of Members in the organization, the number of patients currently being stored in liquid nitrogen and the number of full-time paid staff in the organization. The figures below are for April 2017, and are based on the statements of the organization in question.

 

*=simplification, see explanation

NAME	MEMBERS	FUNDED MEMBERS	PATIENTS	STAFF
Alcor	1,639*	1,132*	150	9*
ACS	?*	?*	20*	1*
CI	1,384*	?*	151*	3*
KrioRus	N/A	N/A	52	7*
Oregon Cryonics	8*	N/A	6	5*
SA	N/A	N/A	N/A	3*
Trans Time	?	?	3	1?

 

The Membership statistics reported above are for living Members only. Both Alcor and CI patients are Members (except for the ACS patients at CI). The American Cryonics Society (ACS) has an organizational policy against publishing the number of Members it has in its organization. As of April 2017 the 20 ACS patients were all in storage at the Cryonics Institute (CI). ACS has had one part-time clerk to do office work and has otherwise relied on volunteers. Alcor has 9 full-time staff, 1 consultant, and 1 regular volunteer. The 151 patients in storage at CI includes 20 ACS patients. KrioRus has no Membership program, and the method of counting patients is odd — a few are not stored by KrioRus. KrioRus has 4 full-time and 3 part-time employees as well as numerous volunteers.

 

CI is a subcontractor for storage of 20 ACS patients. CI has three paid staff (two full-time and one part-time), a few contractors and many volunteers. Accounting is done by CI Treasurer Pat Heller (a CPA) with auditing by another CI Director. Trans Time does not report its Membership numbers. Suspended Animation (SA) is a subcontractor which provides Standby/Stabilization/Transport (SST) only to other cryonics organizations (ACS, Alcor and CI), so it has no Members or Patients — so the reporting of Members or Patients for SA is "Not Applicable" (N/A). SA makes extensive use of subcontractors when needed.

 

As of April 2017, CI reported 136 pets, Alcor reported 58 pets, KrioRus reported 21 pets, and Oregon Cryonics reported 2 pets in cryopreservation.

 

Alcor and CI member numbers are not directly comparable because the word "Member" has different meanings for the two organizations. Membership in CI provides the privilege of obtaining cryopreservation services: pet, DNA or human cryopreservation. Many join CI only to store DNA or pets or to support CI, including some Alcor Members. Some Alcor Members have even made arrangements to use CI as a "back-up". Alcor does not allow its Members to have Alcor as a "back-up". Prior to April, 2012, all Alcor Members had made arrangements (ie, funding and contracts in place) for human cryopreservation and SST, but in April 2012 the Associate Alcor Member program was introduced. Associate Alcor Members do not have any cryopreservation arrangements with Alcor.

 

ForApril 2017, Alcor reported 1,639 living Members, 1,132 of whom had made arrangements for human cryopreservation, and 357 of whom were Associate Members. Of the 1,384 CI Members in April 2017, 212 of those had made arrangements for both human cryopreservation and standby/stabilization/transport (all with SA). In September 2015, CI ceased reporting how many of it Members have funding and contracts for cryopreservation. Historically, less than half of CI Members have been funded (prior CI statistics). Since 2006, CI offers a 'partnership' arrangement for CI Members for SA SST.

 

As noted in the previous section, Trans Time is currently storing patients, but (despite what their website says) is not currently seeking new Members or Patients.

 

In 2011 and 2012 SA reorganized its staff to have more part-time employees and contractors, and for much of 2012 and 2013 SA was re-organizing to have facilities in both California and Florida.

 

Oregon Cryonics has an owner (Jordan Sparks) and four other full-time employees. OC has 9 Members, but is no longer accepting new Members..

 

Accounts of patient histories and membership growth can be found at:
--Cryonics Institute (CI) Patient Details
--Cryonics Institute (CI) Statistics Details
--Complete List of Alcor Cryopreservations
--Alcor Membership Statistics

 

Whole Body/Neuro Options

 

The term neuropreservation (or "neuro") generally refers to the practice of cryopreserving only the head rather than the whole body. A "neuro" is usually a whole head, not just the brain, but sometimes only the brain is cryopreserved. Keeping the whole head to preserve the brain is convenient for both perfusion and storage (the skull protects the brain). In some cases, however, "neuros" are brain-only. The following represent options various organizations say that they offer.

 

*=simplification, see explanation

NAME	WHOLE BODY	NEURO
Alcor	Yes	Yes
ACS	Yes	No*
CI	Yes	No
KrioRus	Yes	Yes
Oregon Cryonics	No	Yes
SA	N/A	N/A
Trans Time	Yes	Yes

 

Alcor states that its Members have the option of having their whole body cryopreserved or only their head ("neuro") — with different fees applicable to each choice. In April 2017, Alcor reported having 93 neuro, 54 whole body, and 4 neuro+whole bodypatients, whereas KrioRus reported 25 neuro and 27 whole-body patients. Trans Time has one whole body and two brains.

 

All CI Members with human cryopreservation arrangments are "whole body". ACS states that it does not have a policy against neuropreservation, but as long as it only uses CI as its subcontract or for storage it cannot offer neuro-cryopreservation as an option. Suspended Animation (SA) is a subcontractor which provides Standby/Stabilization/Transport only to other cryonics organizations, not storage, so the question of storage options with SA is "Not Applicable" (N/A).

 

Oregon Cryonics only stores heads and brains. As of February, 2016 Oregon Cryonics was chemically preserving three human brains, and cryopreserving one dog brain.

 

Cryopreservation and Yearly Fees

 

Comparing fees for human cryopreservation and yearly Membership or Emergency Responsibility is difficult to summarize in table form because the policies, procedures and options between the cryonics organization are so different. A great deal of explanation is required. Note that the high prices for human cryopreservation are generally covered by life insurance policies. The following represent the fees that the following organizations state that they charge.

 

*=simplification,see explanation

NAME	WHOLE BODY	NEURO	YEARLY FEES
Alcor	$200,000*	$80,000*	$620*
ACS	$155,000*	N/A	$376*
CI	$28,000*	N/A	$120*
KrioRus	$36,000*	$12,000	None
Oregon Cryonics	N/A	$25,000*	None
SA	N/A	N/A	None
Trans Time	$150,000	$50,000	$96*

To Alcor's yearly fee of $620 annual dues, those living in the United States and Canada must add $180 yearly SST fees for a total of $800 per year. A lifetime payment plan is also available. SST service is not available to Alcor Members outside of the US and Canada, but a $15,000 surcharge is added to whole body and neuro prices in the United Kingdom, and a $25,000 surcharge is added to the prices paid by those living in other countries. For details on Alcor pricing, see Schedule A: Required Costs and Suspension Funding Minimums.

 

The prices given for the American Cryonics Society (ACS) are intended to reflect comparable service to what Alcor provides. In fact, ACS has a very wide menu of options and prices available, including reference to a "California Procedure" which is intended to be distinguished from the"Michigan Procedure" offered by the Cryonics Institute. The yearly fee for an ACS Member is $376 for the first four years and $300 per year thereafter. For details on ACS options and fees, see:www.americancryonics.org.

 

The Cryonics Institute (CI) charges $28,000 for perfusion and storage of a Lifetime Member and $35,000 for a Yearly Member. These prices do not include funeral director costs or shipment to CI for non-local cases. (When CI was begun it was imagined that every state would have at least one cryonics service provider.) The Lifetime CI Member has paid a one-time $1,250 fee and the Yearly CI Member has paid a $75 initiation fee and is paying a $120 yearly fee. Discounts for additional family members and underage family members apply only to Lifetime Memberships. For service more comparable to what Alcor provides — including Standby/Stabilization/Transport (SST) — a Lifetime Member pays $88,000 and a Yearly Member pays $95,000. For details on CI pricing see Membership andDetails Concerning SA Standby and Transport for CI Members.

 

For $49,000 KrioRus states that it offers Russians (Europeans?) the option of shipment and storage at the Cryonics Institute in the USA.

 

Oregon Cryonics charges $25,000 to cryopreserve a whole head, $18,000 for a brain with braincase, and $14,000 for a brain without the braincase. Oregon Cryonics will chemically preserve a brain for as little as $1,000 (see Oregon Cryonics Service Fees for details).

 

As noted in previous sections, Trans Time is currently storing patients, but (despite what their website says) is not currently seeking new Members or Patients.

 

Suspended Animation (SA) is a subcontractor which provides SST only to other cryonics organizations, not Membership or storage, so the question of these options with SA is "Not Applicable" (N/A).

 

Human Cryopreservation Procedures

 

Human cryopreservation procedures are much too complex to be summarized effectively here.

 

Alcor's procedures are summarized on a page of the Alcor website called Alcor Procedures. But is it also very helpful to read actual case reports of Alcor patients in the Cryopreservation Case Reports section of the Alcor website library.

 

CI has a summary of its procedures on its website calledGuide to Cryonics Procedures. CI procedures do not include Standby/Stabilization/Transport (SST), though CI will advise Members on obtaining assistance through local funeral directors. CI Members residing in the continental United States who wish to obtain SST can do so by subcontracting with Suspended Animation, Inc. (SA).

 

Although the American Cryonics Society (ACS) has equipment and volunteers which could be used if necessary, ACS basically relies on SA for Standby/Transport and CI for Perfusion/Storage.The human cryopreservation procedures of Trans Time and KrioRus are not documented on their websites.

 

Funding Cryonics by Insurance
The cost of cryonics is many thousands of dollars, but most cryonicists cover these costs with life insurance policies that name a cryonics organization as beneficiary. Premiums of life insurance policies are most affordable for those who are young and healthy. It is not prudent to seek life insurance in old age or after a terminal illness (when life insurance may be unobtainable). Nor is it prudent to believe that cryonics arrangements can be made efficiently or successfully when in a terminal condition.

 

Rudi Hoffman sells the great majority of cryonics life insurance policies. It makes good sense to take advantage of Rudi's considerable expertise in matters of cryonics and life insurance. (A sincere and unpaid plug for Rudi.)

Nootropics in human trials (Intro)

by @ Articles - Articles

Sat Sep 09 06:57:38 PDT 2017

The word "nootropic" derives from the Greek words nous, or "mind", and trepein meaning "to bend or turn". It was first coined by Romanian psychologist and chemist, Corneliu E. Giurgea after synthesizing Piracetam.
For Giurgea a nootropic drug should have the following characteristics:
1. They should enhance learning and memory.
2. They should enhance the resistance of learned behaviors/memories to conditions which tend to disrupt them (e.g. electroconvulsive shock, hypoxia).
3. They should protect the brain against various physical or chemical injuries (e.g. barbiturates, scopalamine).
4. They should increase the efficacy of the tonic cortical/subcortical control mechanisms.
5. They should lack the usual pharmacology of other psychotropic drugs (e.g. sedation, motor stimulation) and possess very few side effects and extremely low toxicity.

In fact, most drugs commonly labelled as nootropics do not fulfill all of these requirements. Some of the best known (e.g. Adderall, Modafinil) seem to not fulfill any, as discussed later. Instead, other characteristics like (reputed increased alertness, focus or motivation) seem to be key to their popularity.
Because of deviating definitions nootropics are more broadly defined (e.g. in wikipedia) as drugs, supplements, or other substances that improve cognitive function, particularly executive functions, memory, creativity, or motivation, in healthy individuals. 

Some nootropics from the very common to the :

Caffeine
Caffeine is the world’s most widely used stimulant (Nawrot, et al., 2003). It is used by over 90 % of North Americans every day (Mednick et al., 2008). It is widely used because of its positive effects on mood and alertness (Lorist & Tops, 2003)and vigilance and attention (Lieberman et al., 1987). However, these effects do not seem applicable / transferable to motor learning and verbal memory and are unable to reverse effects of sleep deprivation, with a dose of 200mg in low to moderate users (< than 2 cups a day) (Mednick et al., 2008). It is also shown to be ineffective in higher cognitive tasks involving working memory (Battig et al., 1984). Overall conclusions regarding the relation of caffeine and memory have been mixed. Positive effects might stem from caffeine withdrawal in high dosage users (Mednick et al., 2008).

Nicotine
With about 1,1 billion smokers worldwide in the year 2015 (WHO 2015) nicotine takes second place as the most widely used stimulant. It was shown that the application of nicotine in non-smoking males enhances performance in continuous performance tasks and therefore is said to improve attention and working-memory (Kumari, et al., 2003), which is in line with other studies suggesting that nicotine affects short-term memory in delayed free recall tasks (Sarah & Fox, 1998)
Another study examined nicotine’s effects on alertness and performance on a covert orienting task were measured. While nicotine decreased overall reaction times in the covert orienting task, there was no change in the validity effect, the reaction time difference between validly and invalidly cued targets. However, nicotine significantly improved both EEG and self-rated measures of alertness. Nicotine seems to increases alertness in non-smokers, with no improvement in spatial attention using a covert orienting task (Griesar et al., 2002). Furthermore Nicotine seems to reduce distraction under low perceptual load by acting as a stimulus filter that prevents irrelevant stimuli entering awareness (Behler et al., 2015).

Methylphenidate/ Ritalin
Most college students I know will immediately think of Ritalin or Modafinil if they are asked to name a cognitive enhancer. Studies have found that 4.1% to 10.8% of college students in the US reported using prescription stimulants non-medically during the past year (Garnier-Dykstra, et al., 2012).
Methylphenidate (MPH - common brand name ‘Ritalin’) is used in treatment of attention deficit hyperactivity disorder (ADHD) and narcolepsy. Most studies focused on the its effects on Attention, Mood, Memory and executive functions. A single dose of MPH showed a positive effect on memory. Repeated doses of MPH had a mood elevating effect but also enhanced anxiety. No statistically significant effect was found in the outcomes attention, mood and executive functions. MPH had no significant effect on sleep-deprived individuals (Repantis et al., 2010). In a 2015 review the authors found some ‘publication bias’, relating to long-term and working memory and conclude that the effect in healthy subject is probably modest overall and that healthy users resort to stimulants to enhance their energy and motivation more than their cognition (Ilieva et al., 2015). 

Modafinil
Modafinil is used in treatment of disorders such as narcolepsy, shift work sleep disorder, and excessive daytime sleepiness associated with obstructive sleep apnea. Most studies focused on its effects on attention, mood, memory, wakefulness and executive functions and motivation. A single dose showed positive effects on attention only. On sleep deprived individuals it was shown to have an impact on executive functions, on memory and wakefulness but there was an insignificant effect on mood and attention (Repantis et al., 2010). A 2012 meta-analysis found that Modafinil was likely effective but criticised the gaps in the literature. (Kelley et al., 2012) 
A recent study on chess players found significantly enhanced performance with Modafinil or Ritalin but only when the players were not under time pressure (Franke et al. 2017). 

Adderall
Mixed Amphetamine Salts also known under the brand Name Adderall became increasingly popular in recent years as an athletic performance enhancer and cognitive enhancer. Like Ritalin, it is also used to treat ADHD and narcolepsy.
Overall effects of Adderall on cognition have been reviewed as very modest, while having a huge effect on perception. It was found to enhance performance in word recall, embedded figures and Raven's Progressive Matrices, but only for lower performing individuals (Ilieva et al., 2013). Adderall might also impair creativity in high performing individuals (Farah et al., 2009).

L-theanine & Caffeine
L- theanine is primarily found in plants (e.g. in the leaves of green and black tea) and fungus. Results evidently demonstrated that L-theanine clearly has a pronounced effect on attention performance and reaction time response in normal healthy subjects susceptible to having high anxiety (Higashiyama et al., 2011).
A dose of L-theanine equivalent to eight cups of black tea improves cognitive and neurophysiological measures of selective attention, to a degree that is comparable with that of caffeine. The combination of Theanine and caffeine seem to have additive effects on attention in high doses (Kahathuduwa et al.,2016).
Studies suggest that 97 mg of L-theanine in combination with 40 mg of caffeine helps to focus attention during a demanding cognitive task (Giesbrecht 2010).

Bacopa Monnieri
Bacopa Monnieri is an herb which has been used in Ayurvedic medicine for centuries. Bacopa's primary mechanism of action is still unclear, it seems to be an anti-oxidant, a weak acetylcholinesterase inhibitor and a cerebral blood flow activator (Aguiar & Borowski , 2013).
There is some evidence to suggest that Bacopa Monnieri improves memory with little evidence of enhancement in any other cognitive domains (Pase et al., 2012).

Piracetam
Closing the circle to the beginning of this short introduction to the topic: Giurgea first coined the term "nootropic" when he synthesized Piracetam in 1964. Since it is not approved by the US FDA, it is primarily used in Europe, Asia, and South America. It is commonly prescribed for cognitive impairment and dementia in several countries of Europe. Research suggests that Piracetam might also have a positive effect on healthy individuals. Subjects were given 3×4 capsules at 400 mg per day, in a double blind study. Each subject learned series of words presented as stimuli upon a memory drum. No effects were observed after 7 days but after 14 days verbal learning had significantly increased (Dimond & Brouwers, 1976). It might also be beneficial for cognitive decline associated with age. Aging subjects did significantly better in a computerized perceptual-motor tasks when on piracetam than on a placebo. (Mindus et al. 1976). While these old studies may not be that reliable, it is still held that Piracetam's “efficacy is documented in cognitive disorders and dementia, vertigo, cortical myoclonus, dyslexia, and sickle cell anemia. While high doses are sometimes necessary, piracetam is well tolerated” (Winblad, 2005). Since Piracetam was first synthesized many structurally similar compounds have emerged. These so called Racetams have poorly understood mechanisms of action; however, piracetam and aniracetam are known to act as positive allosteric modulators of AMPA receptors and appear to modulate cholinergic systems (Gualtieri et al., 2002).

References
* Aguiar, S., & Borowski , T. (2013). Neuropharmacological review of the nootropic herb Bacopa monnieri. Rejuvenation Research, 313-326. 
* Battig , K., Martin, J. R., & Feierabend , J. M. (1984). The effects of caffeine on physiological functions and mental performance. Experentia, 1218–1223.
* Behler , O., Breckel, T. P., & Thiel , C. M. (2015). Nicotine reduces distraction under low perceptual load. Psychopharmacology, 1269-1277.
* Dimond, S. J., & Brouwers, E. M. (1976). Increase in the power of human memory in normal man through the use of drugs. Psychopharmacology, 307-309.
* Farah , M., Haimm , C., Sankoorikal , G., Smith , M., & Chatterjee , A. (2009). When we enhance cognition with Adderall, do we sacrifice creativity? A preliminary study. Psychopharmacology,541-547.
* Franke, A.G.; Gränsmark, P., Agricola, A., Schühle, K., Rommel, T., Sebastian, A., Balló, H.E., Gorbulev, S., Gerdes, C., Frank, B., Ruckes, C., Tüscher, O., Lieb, K. (2017) "Methylphenidate, modafinil, and caffeine for cognitive enhancement in chess: A double-blind, randomised controlled trial" in: European Neuropsychopharmacology Vol27, Issue 3, 1, pp248-260
* Garnier-Dykstra, L. M., Caldeira, K. M., Vincent, K. B., O’Grady, K. E., & Arria, A. M. (2012).Nonmedical use of prescription stimulants during college: Four-year trends in exposure opportunity, use, motives, and sources. J Am Coll Health, 226-234.
* Giesbrecht, T., Rycroft , J. A., Rowson , M. J., & De Bruin , E. A. (2010). The combination of L-theanine and caffeine improves cognitive performance and increases subjective alertness. Nutritional Neuroscience, 283-290.
* Griesar , W. S., Zajdel , D. P., & Oken , B. (2002). Nicotine effects on alertness and spatial attention in non-smokers. Nicotine & Tobacco Research, 185-194.
* Gualtieri , F., Manetti , D., Romanelli , M. N., & Ghelardini , C. (2002). Design and study of piracetamlike nootropics, controversial members of the problematic class of cognition-enhancing drugs. Current Pharmaceutical Design, 125-138.
* Higashiyama, A., Htay, H. H., Ozeki, M., Juneja, L. R., & Kapoor, M. P. (2011). Effects of l-theanine on attention and reaction time response. Journal of Functional Foods, 171-178.
* Ilieva, I., Boland, J., & Farah, M. (2013). Objective and subjective cognitive enhancing effects of mixed amphetamine salts in healthy people. Neuropharmacology, 496-505.
* Ilieva IP, Hook CJ, Farah MJ. (2015) Prescription Stimulants' Effects on Healthy Inhibitory Control, Working Memory, and Episodic Memory: A Meta-analysis.; J Cogn Neurosci. 2015 Jun;27(6):1069-89. 
* Kahathuduwa, C. N., Dassanayake , T. L., Amarakoon , A. M., & Weerasinghe, V. S. (2016). Acute effects of theanine, caffeine and theanine-caffeine combination on attention. Nutritional Neuroscience.
* Kelley, A.M.; Webb, C.M., Athy, J.R., Ley, S., Gaydos, S. (2012) "Cognition enhancement by modafinil: A meta-analysis" in Aviation Space and Environmental Medicine; Vol83, Issue 7, p685-690
* Kumari, V., Gray, J., H ffytche, D., Mitterschiffthaler, M., Das, M., Zachariah, E., . . . Sharma, T. (2003). Cognitive effects of nicotine in humans: an fMRI study. NeuroImage, 1002-1013.
* Lieberman , H. R., Wurtman, R. J., Emde, G. G., Roberts , C., & Coviella, I. L. (1987). The effects of low doses of caffeine on human performance and mood. Psychopharmacology, 308-312.
* Lorist , M. M., & Tops, M. (2003). Caffeine, fatigue, and cognition. Brain Cognition, 82-94.
* Mednick, S. C., Cai, D. J., Kanady, J., & Drummond, S. P. (2008). Comparing the benefits of Caffeine,Naps and Placebo on Verbal, Motor and Perceptual Memory. Behavioural Brain Research, 79–86.
* Mindus , P., Cronholm , B., Levander , S. E., & Schalling , D. (1976). Piracetam-induced improvement of mental performance. A controlled study on normally aging individuals. Acta Psychiatrica Scandinavia, 150-160.
* Nawrot, P., Jordan, S., Eastwood , J., Rotstein , J., Hugenholtz, A., & Feeley, M. (2003). Effects of caffeine on human health. Food Additives & Contaminants, 1-30.
* Pase, M. P., Kean , J., Sarris , J., Neale , C., Scholey , A. B., & Stough , C. (2012). The cognitive enhancing effects of Bacopa monnieri: a systematic review of randomized, controlled human clinical trials. Journal of Alternative Complementary Medicine, 647-652.
* Repantis , D., Schlattmann , P., Laisney , O., & Heuser, I. (2010). Modafinil and methylphenidate for neuroenhancement in healthy individuals: A systematic review. Pharmacological Research, 187-206.
* Sarah , P., & Fox, P. (1998). An investigation into the effects of nicotine gum on short-term memory.Psychopharmacology, 429-433.
* WHO (2015). WHO global report on trends in tobacco smoking 2000-2025. WHO Library Cataloguing-in Publication Data .
* Winblad, B. (2005). Piracetam: a review of pharmacological properties and clinical uses. CNS Drug reviews, 169-182.

Probiotics For Bv Infection Natural Way Clean

by @ projectathena probiotics composition

Tue Feb 13 04:01:20 PST 2018

She’s growing very well Surprisingly taking probiotics may actually help tackle those last pounds and normalize your metabolism. Probiotics For Bv Infection Natural Way Clean dr Oz: Best Greek Yogurt Brands. Enymatic Therapy Acidophilus Probiotics . Save $1 On Bayer$1.00 off any 1 bayer aspirin product $1. Benefits of Natural Probiotics. Table 7-13: Selected Recommended […]

Flamingo Chicken Coupons – Save $1.00 Print Today

by Theresa @ Canadian Freebies, Coupons, Sweepstakes Deals~ Canadianfreestuff.com

Mon Feb 12 18:16:07 PST 2018

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Sun Jan 07 15:46:37 PST 2018

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Genes Associated With Familial Colon Cancer Female Health

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This test evaluates for parasitic infection leaky gut syndrome and candida while measuring dysbiotic bacteria digestive enzymes digestion capability and even a count of all probiotics! What are Probiotics? What Can They do for you? The literal meaning of “Probiotics” comes from the Greek meaning “For Life” Probiotics are living bacteria cultures which when consumed […]

Well.ca Contest: WIN a beautiful Amped & Co LED Heart Wall Light

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Mon Feb 12 16:11:40 PST 2018

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Alysena Birth Control Pills Recall

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Mon Feb 12 17:57:00 PST 2018

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Probiotics Supplements Brands Vascular Extramural Rectal Cancer Invasion

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by @ Probiotics Belaw

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Nootropics in human trials (Intro)

by @ Articles

Sat Sep 09 06:57:38 PDT 2017

The word "nootropic" derives from the Greek words nous, or "mind", and trepein meaning "to bend or turn". It was first coined by Romanian psychologist and chemist, Corneliu E. Giurgea after synthesizing Piracetam.
For Giurgea a nootropic drug should have the following characteristics:
1. They should enhance learning and memory.
2. They should enhance the resistance of learned behaviors/memories to conditions which tend to disrupt them (e.g. electroconvulsive shock, hypoxia).
3. They should protect the brain against various physical or chemical injuries (e.g. barbiturates, scopalamine).
4. They should increase the efficacy of the tonic cortical/subcortical control mechanisms.
5. They should lack the usual pharmacology of other psychotropic drugs (e.g. sedation, motor stimulation) and possess very few side effects and extremely low toxicity.

In fact, most drugs commonly labelled as nootropics do not fulfill all of these requirements. Some of the best known (e.g. Adderall, Modafinil) seem to not fulfill any, as discussed later. Instead, other characteristics like (reputed increased alertness, focus or motivation) seem to be key to their popularity.
Because of deviating definitions nootropics are more broadly defined (e.g. in wikipedia) as drugs, supplements, or other substances that improve cognitive function, particularly executive functions, memory, creativity, or motivation, in healthy individuals. 

Some nootropics from the very common to the :

Caffeine
Caffeine is the world’s most widely used stimulant (Nawrot, et al., 2003). It is used by over 90 % of North Americans every day (Mednick et al., 2008). It is widely used because of its positive effects on mood and alertness (Lorist & Tops, 2003)and vigilance and attention (Lieberman et al., 1987). However, these effects do not seem applicable / transferable to motor learning and verbal memory and are unable to reverse effects of sleep deprivation, with a dose of 200mg in low to moderate users (< than 2 cups a day) (Mednick et al., 2008). It is also shown to be ineffective in higher cognitive tasks involving working memory (Battig et al., 1984). Overall conclusions regarding the relation of caffeine and memory have been mixed. Positive effects might stem from caffeine withdrawal in high dosage users (Mednick et al., 2008).

Nicotine
With about 1,1 billion smokers worldwide in the year 2015 (WHO 2015) nicotine takes second place as the most widely used stimulant. It was shown that the application of nicotine in non-smoking males enhances performance in continuous performance tasks and therefore is said to improve attention and working-memory (Kumari, et al., 2003), which is in line with other studies suggesting that nicotine affects short-term memory in delayed free recall tasks (Sarah & Fox, 1998)
Another study examined nicotine’s effects on alertness and performance on a covert orienting task were measured. While nicotine decreased overall reaction times in the covert orienting task, there was no change in the validity effect, the reaction time difference between validly and invalidly cued targets. However, nicotine significantly improved both EEG and self-rated measures of alertness. Nicotine seems to increases alertness in non-smokers, with no improvement in spatial attention using a covert orienting task (Griesar et al., 2002). Furthermore Nicotine seems to reduce distraction under low perceptual load by acting as a stimulus filter that prevents irrelevant stimuli entering awareness (Behler et al., 2015).

Methylphenidate/ Ritalin
Most college students I know will immediately think of Ritalin or Modafinil if they are asked to name a cognitive enhancer. Studies have found that 4.1% to 10.8% of college students in the US reported using prescription stimulants non-medically during the past year (Garnier-Dykstra, et al., 2012).
Methylphenidate (MPH - common brand name ‘Ritalin’) is used in treatment of attention deficit hyperactivity disorder (ADHD) and narcolepsy. Most studies focused on the its effects on Attention, Mood, Memory and executive functions. A single dose of MPH showed a positive effect on memory. Repeated doses of MPH had a mood elevating effect but also enhanced anxiety. No statistically significant effect was found in the outcomes attention, mood and executive functions. MPH had no significant effect on sleep-deprived individuals (Repantis et al., 2010). In a 2015 review the authors found some ‘publication bias’, relating to long-term and working memory and conclude that the effect in healthy subject is probably modest overall and that healthy users resort to stimulants to enhance their energy and motivation more than their cognition (Ilieva et al., 2015). 

Modafinil
Modafinil is used in treatment of disorders such as narcolepsy, shift work sleep disorder, and excessive daytime sleepiness associated with obstructive sleep apnea. Most studies focused on its effects on attention, mood, memory, wakefulness and executive functions and motivation. A single dose showed positive effects on attention only. On sleep deprived individuals it was shown to have an impact on executive functions, on memory and wakefulness but there was an insignificant effect on mood and attention (Repantis et al., 2010). A 2012 meta-analysis found that Modafinil was likely effective but criticised the gaps in the literature. (Kelley et al., 2012) 
A recent study on chess players found significantly enhanced performance with Modafinil or Ritalin but only when the players were not under time pressure (Franke et al. 2017). 

Adderall
Mixed Amphetamine Salts also known under the brand Name Adderall became increasingly popular in recent years as an athletic performance enhancer and cognitive enhancer. Like Ritalin, it is also used to treat ADHD and narcolepsy.
Overall effects of Adderall on cognition have been reviewed as very modest, while having a huge effect on perception. It was found to enhance performance in word recall, embedded figures and Raven's Progressive Matrices, but only for lower performing individuals (Ilieva et al., 2013). Adderall might also impair creativity in high performing individuals (Farah et al., 2009).

L-theanine & Caffeine
L- theanine is primarily found in plants (e.g. in the leaves of green and black tea) and fungus. Results evidently demonstrated that L-theanine clearly has a pronounced effect on attention performance and reaction time response in normal healthy subjects susceptible to having high anxiety (Higashiyama et al., 2011).
A dose of L-theanine equivalent to eight cups of black tea improves cognitive and neurophysiological measures of selective attention, to a degree that is comparable with that of caffeine. The combination of Theanine and caffeine seem to have additive effects on attention in high doses (Kahathuduwa et al.,2016).
Studies suggest that 97 mg of L-theanine in combination with 40 mg of caffeine helps to focus attention during a demanding cognitive task (Giesbrecht 2010).

Bacopa Monnieri
Bacopa Monnieri is an herb which has been used in Ayurvedic medicine for centuries. Bacopa's primary mechanism of action is still unclear, it seems to be an anti-oxidant, a weak acetylcholinesterase inhibitor and a cerebral blood flow activator (Aguiar & Borowski , 2013).
There is some evidence to suggest that Bacopa Monnieri improves memory with little evidence of enhancement in any other cognitive domains (Pase et al., 2012).

Piracetam
Closing the circle to the beginning of this short introduction to the topic: Giurgea first coined the term "nootropic" when he synthesized Piracetam in 1964. Since it is not approved by the US FDA, it is primarily used in Europe, Asia, and South America. It is commonly prescribed for cognitive impairment and dementia in several countries of Europe. Research suggests that Piracetam might also have a positive effect on healthy individuals. Subjects were given 3×4 capsules at 400 mg per day, in a double blind study. Each subject learned series of words presented as stimuli upon a memory drum. No effects were observed after 7 days but after 14 days verbal learning had significantly increased (Dimond & Brouwers, 1976). It might also be beneficial for cognitive decline associated with age. Aging subjects did significantly better in a computerized perceptual-motor tasks when on piracetam than on a placebo. (Mindus et al. 1976). While these old studies may not be that reliable, it is still held that Piracetam's “efficacy is documented in cognitive disorders and dementia, vertigo, cortical myoclonus, dyslexia, and sickle cell anemia. While high doses are sometimes necessary, piracetam is well tolerated” (Winblad, 2005). Since Piracetam was first synthesized many structurally similar compounds have emerged. These so called Racetams have poorly understood mechanisms of action; however, piracetam and aniracetam are known to act as positive allosteric modulators of AMPA receptors and appear to modulate cholinergic systems (Gualtieri et al., 2002).

References
* Aguiar, S., & Borowski , T. (2013). Neuropharmacological review of the nootropic herb Bacopa monnieri. Rejuvenation Research, 313-326. 
* Battig , K., Martin, J. R., & Feierabend , J. M. (1984). The effects of caffeine on physiological functions and mental performance. Experentia, 1218–1223.
* Behler , O., Breckel, T. P., & Thiel , C. M. (2015). Nicotine reduces distraction under low perceptual load. Psychopharmacology, 1269-1277.
* Dimond, S. J., & Brouwers, E. M. (1976). Increase in the power of human memory in normal man through the use of drugs. Psychopharmacology, 307-309.
* Farah , M., Haimm , C., Sankoorikal , G., Smith , M., & Chatterjee , A. (2009). When we enhance cognition with Adderall, do we sacrifice creativity? A preliminary study. Psychopharmacology,541-547.
* Franke, A.G.; Gränsmark, P., Agricola, A., Schühle, K., Rommel, T., Sebastian, A., Balló, H.E., Gorbulev, S., Gerdes, C., Frank, B., Ruckes, C., Tüscher, O., Lieb, K. (2017) "Methylphenidate, modafinil, and caffeine for cognitive enhancement in chess: A double-blind, randomised controlled trial" in: European Neuropsychopharmacology Vol27, Issue 3, 1, pp248-260
* Garnier-Dykstra, L. M., Caldeira, K. M., Vincent, K. B., O’Grady, K. E., & Arria, A. M. (2012).Nonmedical use of prescription stimulants during college: Four-year trends in exposure opportunity, use, motives, and sources. J Am Coll Health, 226-234.
* Giesbrecht, T., Rycroft , J. A., Rowson , M. J., & De Bruin , E. A. (2010). The combination of L-theanine and caffeine improves cognitive performance and increases subjective alertness. Nutritional Neuroscience, 283-290.
* Griesar , W. S., Zajdel , D. P., & Oken , B. (2002). Nicotine effects on alertness and spatial attention in non-smokers. Nicotine & Tobacco Research, 185-194.
* Gualtieri , F., Manetti , D., Romanelli , M. N., & Ghelardini , C. (2002). Design and study of piracetamlike nootropics, controversial members of the problematic class of cognition-enhancing drugs. Current Pharmaceutical Design, 125-138.
* Higashiyama, A., Htay, H. H., Ozeki, M., Juneja, L. R., & Kapoor, M. P. (2011). Effects of l-theanine on attention and reaction time response. Journal of Functional Foods, 171-178.
* Ilieva, I., Boland, J., & Farah, M. (2013). Objective and subjective cognitive enhancing effects of mixed amphetamine salts in healthy people. Neuropharmacology, 496-505.
* Ilieva IP, Hook CJ, Farah MJ. (2015) Prescription Stimulants' Effects on Healthy Inhibitory Control, Working Memory, and Episodic Memory: A Meta-analysis.; J Cogn Neurosci. 2015 Jun;27(6):1069-89. 
* Kahathuduwa, C. N., Dassanayake , T. L., Amarakoon , A. M., & Weerasinghe, V. S. (2016). Acute effects of theanine, caffeine and theanine-caffeine combination on attention. Nutritional Neuroscience.
* Kelley, A.M.; Webb, C.M., Athy, J.R., Ley, S., Gaydos, S. (2012) "Cognition enhancement by modafinil: A meta-analysis" in Aviation Space and Environmental Medicine; Vol83, Issue 7, p685-690
* Kumari, V., Gray, J., H ffytche, D., Mitterschiffthaler, M., Das, M., Zachariah, E., . . . Sharma, T. (2003). Cognitive effects of nicotine in humans: an fMRI study. NeuroImage, 1002-1013.
* Lieberman , H. R., Wurtman, R. J., Emde, G. G., Roberts , C., & Coviella, I. L. (1987). The effects of low doses of caffeine on human performance and mood. Psychopharmacology, 308-312.
* Lorist , M. M., & Tops, M. (2003). Caffeine, fatigue, and cognition. Brain Cognition, 82-94.
* Mednick, S. C., Cai, D. J., Kanady, J., & Drummond, S. P. (2008). Comparing the benefits of Caffeine,Naps and Placebo on Verbal, Motor and Perceptual Memory. Behavioural Brain Research, 79–86.
* Mindus , P., Cronholm , B., Levander , S. E., & Schalling , D. (1976). Piracetam-induced improvement of mental performance. A controlled study on normally aging individuals. Acta Psychiatrica Scandinavia, 150-160.
* Nawrot, P., Jordan, S., Eastwood , J., Rotstein , J., Hugenholtz, A., & Feeley, M. (2003). Effects of caffeine on human health. Food Additives & Contaminants, 1-30.
* Pase, M. P., Kean , J., Sarris , J., Neale , C., Scholey , A. B., & Stough , C. (2012). The cognitive enhancing effects of Bacopa monnieri: a systematic review of randomized, controlled human clinical trials. Journal of Alternative Complementary Medicine, 647-652.
* Repantis , D., Schlattmann , P., Laisney , O., & Heuser, I. (2010). Modafinil and methylphenidate for neuroenhancement in healthy individuals: A systematic review. Pharmacological Research, 187-206.
* Sarah , P., & Fox, P. (1998). An investigation into the effects of nicotine gum on short-term memory.Psychopharmacology, 429-433.
* WHO (2015). WHO global report on trends in tobacco smoking 2000-2025. WHO Library Cataloguing-in Publication Data .
* Winblad, B. (2005). Piracetam: a review of pharmacological properties and clinical uses. CNS Drug reviews, 169-182.

Checkout 51 Canada PREVIEW (Sneak Peek) for Feb 15-21, 2018

by Andria @ Canadian Freebies, Coupons, Sweepstakes Deals~ Canadianfreestuff.com

Tue Feb 13 05:19:16 PST 2018

Checkout 51 Preview offers for Canada. Checkout 51 new offers will go live at 12:00 AM on Thursday, February 15, 2018 and expire at 11:59 PM on Wednesday, February 21, 2018. Members must buy the products in Canada and submit the receipts while the offers are live. Here is you chance to see what some of […]

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Costco Canada Unadvertised Deals of the week starting Feb. 12th

by Nadine @ Save Money in Winnipeg

Mon Feb 12 09:06:48 PST 2018

Here are the deals from the Regent location in Winnipeg. Sales should be the same store to store, whether you’re in Saskatchewan, Alberta or British Columbia – Manitoba too of course! 🙂 And remember that Costco stores are closed next Monday (19th) across Canada for Family Day – so I’ll be posting on Tuesday. And […]

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Best Probiotic Strains For Constipation Tnm Classification Cancer

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Mon Feb 12 16:00:55 PST 2018

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Apply for FREE La Roche-Posay Toleriane Sensitive Hydrating Care facial moisturizer -Go!

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Mon Feb 12 11:10:58 PST 2018

New Chickadvisor and La Roche Posay Free Product Review Offer It’s a fabulous new offer from La Roche-Posay featuring their brand-new Toleriane Sensitive Hydrating Care facial moisturizer! 250 Canadian women will be among the first in Canada to try this product specifically designed to offer soothing 48-hour hydration and immediately comfort skin and reduce sensitivity. Apply at the […]

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Joe Fresh Coupon Code – Save 25% off (Feb 12 Only) + Save 30% off select Sleepwear

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Mon Feb 12 09:47:40 PST 2018

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Post lyme disease treatment advice...diet, bpc 157 and or?

by @ ImmInst Active Topics

Sun Feb 11 17:35:26 PST 2018

Hey everyone,

Thank you in advance for taking the time to read and respond to my post. I’m a 23 year old (otherwise healthy) male who was diagnosed with lyme disease about two months ago. After undergoing an intense supplement/herbal/energetical therapy cleanse and detox, my docotor confirmed that the lyme had left my body. However, I am still experiencing all of my original symptoms, including random shaking, a neck tremor, intense brain fog, a really infammed gut/liver/kidneys, etc. I’m struggling to determine my next course of action — has anyone reading his post dealt with lyme? — have you tried dietary changes to help heal your system? I’m also curious if bpc 157 would be a good option for me? I already eat a fairly well balanced diet that is exclusively organic/non gmo, as well as taking about 15 relevant supplents a day (including probiotics). I guess, in general, I’m seeking any lyme, dietary, or other advice that you might have for me.

Thanks for your time,

-Braden

Hello, and an open invitation to you in South Florida

by @ ImmInst Active Topics

Tue Feb 13 07:49:39 PST 2018

Hello, 

I would like to invite you to our monthly meetings in South Florida at the Church of Perpetual Life.  If you can not come in person, you can join the Live Streaming.

 

There is NO Cost to attend or to watch the Live Stream.

 

Our Speaker this month is Dr. Michael Rose.  His presentation will begin at 7 PM, with the Live Stream starting at 7:15 PM, Eastern Time.  (12 15 UTC)

 

Please let me know if you can make it!

 

Neal VanDeRee, Officiator at the Church of Perpetual Life.

 

Perpetual Life is a science-based church that is open to people of all faiths & belief systems.  We are non-denominational and non-judgmental and we are a central gathering place for Transhumanists.  What brings us together is our common faith, belief and desire in Unlimited Life Spans.

 

 

Upcoming Schedule of Events at Perpetual Life:

 

 

Do Probiotics Help With Mood Plants

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crowdsourced multivitamin

by @ Articles - Articles

Tue Dec 18 17:41:21 PST 2012

Extending maximum human lifespan will likely require a wide range of new biotechnology. Powerful interventions such as pharmaceuticals, stem cell technology, and gene therapy are in development but could be years or decades away from widespread implementation. During the intervening time the best way to ward off the ravages of disease and aging is to take care of yourself.

Members of LongeCity are keenly aware of this reality. That is why LongeCity forum discussions about exercise, nutrition, and supplements are very active and comprehensive. Members are constantly on the lookout for the latest research lending insight into which supplements are beneficial, cost-effective, and readily available.
Much has been made of the deficiencies of current multivitamin formulations and this has led to a community effort to design the “perfect multivitamin”.


In a long process of collaborative discussion, Members designed what in their view comes closer to the 'perfect' anti-aging supplement than any other product on the market.
LongeCity then found a partner in RevGenetics Ltd (FDA RegNo: 12757922694) to produce it.

Under the brand name VIMMORTAL the formula was promoted during 2011.Many members enjoyed the heavy discount that RevGenetics generously provided to LongeCity members.

After over a year of sales, members decided to revisit the formula. The inclusion of choline in particular proved controversial in light of current research. VIMMORTAL was stopped and a new group convened to collate suggested tweaks and improvements. The revised formula was relayed to the previous partner Revgenetics.

After many delays and extensions throughout 2012, it became clear eventually that Revgenetics was not going to take the second generation of the crowdsourced supplement further.
This is a setback for the project, in which LongeCity was at the forefront of connecting supplement sellers and consumers in an innovative dialogue at the cutting edge of nutritional supplement design. However, we are proud of this effort and the experience and data generated by it.

The VIMMORTAL formula is 'open source' and we are optimistic that another manufacturer/seller will see the opportunities of connecting directly with the life extension community to provide the 'ideal' supplement solution.

Check the Vimmortal project forum.

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Cabela’s Deals – Winter Liquidation Sale – Save up to 50% off

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Mon Feb 12 08:29:13 PST 2018

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Baby Gourmet Contest: Win a Baby Gourmet product sampler -New

by Karla @ Canadian Freebies, Coupons, Sweepstakes Deals~ Canadianfreestuff.com

Mon Feb 12 16:01:47 PST 2018

NEW Baby Gourmet Contest for Canada 2018 Enter to win a Baby Gourmet product sampler. Simply leave a comment on either the facebook or instagram post ,answering the question to win. Good Luck. Rules Open to Canadian residents only Excludes Quebec Ages 18 and older Valid facebook OR instagram account Single entry per social media Enter […]

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NeoStrata Giveaway: WIN Neostrata AquaYouth Filling Anti-Wrinkle Cream

by Karla @ Canadian Freebies, Coupons, Sweepstakes Deals~ Canadianfreestuff.com

Mon Feb 12 09:05:10 PST 2018

NeoStrata Contest Enter for your chance to WIN a Neostrata AquaYouth Filling Anti-Wrinkle Cream!  To participate, simply comment on the official contest post and tell your plans for Valentine’s Day for your chance to win. You can enter on facebook or instagram. Good Luck! Rules: Canada Residents Only Quebec Friendly Age of majority Single Entry per social media […]

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Slammers Snacks Giveaway: Win a Case of Slammers this Week

by Karla @ Canadian Freebies, Coupons, Sweepstakes Deals~ Canadianfreestuff.com

Mon Feb 12 15:30:32 PST 2018

New Slammers Snacks Contest for 2018 Enter to win a case of Slammers this week! Simply comment on the official facebook or instagram contest post this with #iSpySlammers for a chance to win a case of Slammers! Good Luck!! Rules: Open to Residents of Canada or U.S Quebec Friendly 18 or Older Valid facebook OR instagam account Single […]

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Community Testing of Aging Bio-Markers

by @ Action

Wed Feb 07 15:58:56 PST 2018

Legitimate bio-marker testing is important to our community to help determine what current approaches are the best for slowing aging

 

It is 2018, and I can't believe how many anecdotal placebo-driven reports populate the LongeCity forum. Here is one egregious recent example if you want to chuckle: http://www.longecity.org/forum/topic/99447-hello-everybody-im-the-longest-continuous-user-of-hgh-in-human-history/

 

There was a budgeted effort to promote legitimate bio-marker testing last year, but it required members to pay for their first test, before embarking on an anti-aging regimen, where at the conclusion of the regimen time period, LongeCity would pay for a second test.

 

I am proposing a simpler approach. Here is the outline:

 

1. LongeCity pays for a standard aging-biomarker test. The most cost effective, easy to implement, and robust test available today is probably DNA methylation. LongeCity has a current relationship with Osiris Green and their test is the cheapest on the market, however, the standard deviation on their test is +/- 5 years. I have spoken with ZYMO and they will offer their test "at cost" for an effort such as this. ZYMO is HIPPA compliant and their standard deviation is only +/- 1.7 years.

 

2. We aim to offer this as a member benefit and to engage other communities such as the calorie restriction society.

 

3. Test subjects can opt to remain anonymous.

 

4. A simple questionnaire accompanies each test. This would ask each subject to rank their general approaches to life extension. Supplements, Diet, Exercise, Other. Depending upon the response, we could drill down further into regimens, but I would want to keep it simple at first to ensure a larger response.

 

5. We aim to complete the study before the end of Summer 2018, and present findings at RAADFest in September.

 

6. Stretch goal: Have a small number of people do DNA methylation testing at 3 different times of day. It is currently unknown if there is inter-day variability in DNA methylation.

 

7. Perhaps work in conjunction with newly formed OpenCures to complete and promote the study.

 

8. If successful, continue with testing on an annual or semi-annual basis. preferably with the same study participants.

 

Drawbacks/Objections

 

1. There are already a lot of groups (example: patients like me) that share test data, and there are many studies involving aging bio-markers. However, I am unsure that there are any studies that have easily accessible data AND focus upon longevity activists.

 

2. It is unlikely that a small study of a few dozen people will produce statistically valid results. To me, that is okay. We WILL learn something and I am certain there will be incredible marketing and community-building opportunities with such a study.

 

3. Cost. 5-10K, maybe higher if we can get some other groups to promote the study or if we can use other crowd-funding platforms. With 10K we could test between 50 and 75 people.

 

Leadership: I would be lead organizer and promoter.

 

LongeCity certainly has the budget for such a study and has enough connections to get a good number of people involved. LongeCity has not done much of consequence as of late. This could be a solid effort to help the community, not only functionally (what regimens work), but also as a promotional effort (life-extensionists are younger and healthier). 

 

 

Legitimate bio-marker testing is important to our community to help determine what current approaches are the best for slowing aging

Checkout 51 Cash Back Offers (Feb 15 - 21)

by couponlady @ SmartCanucks.ca Flyers, Deals Canada

Mon Feb 12 11:37:36 PST 2018

Attachment 338970 (https://forum.smartcanucks.ca/attachments/canadian-shopping-deals-flyers/338970-checkout-51-cash-back-offers-feb-15-21-1.jpg) New offers will go live at 12:00 AM February 15, 2018, and...

London Drugs Contest ~ WIN Dinner & Chocolates

by Theresa @ Canadian Freebies, Coupons, Sweepstakes Deals~ Canadianfreestuff.com

Mon Feb 12 19:10:26 PST 2018

London Drugs Contest for Canada. Enter for a chance to  WIN dinner at the Keg, shopping at London Drugs and Valentine’s chocolates. To enter this contest, simply go to the Official, London Drugs Facebook page, locate the current contest post, and Like and Comment accordingly based on what the post is requesting. Good luck!! Rules: […]

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Hello

by @ ImmInst Active Topics

Tue Feb 06 14:41:20 PST 2018

Hello to all.  I recently discovered this website/forums and look forward to participating.

 

Since I was in my teens, I was always interested in healthy living and eating and continue to be interested.  In recent years I have been trying supplements for various purposes.

 

 

Gap Coupon Codes – 40% off Everything

by Andria @ Canadian Freebies, Coupons, Sweepstakes Deals~ Canadianfreestuff.com

Tue Feb 13 05:08:39 PST 2018

New Gap Coupon Codes for Canada! The Gap always seems to be coming up with new deals and codes for you, so keep looking here for all the latest deals and codes to save you money! 40% off Everything Use coupon code GAPSOGOOD at checkout. Gap Coupon Codes are valid Online ONLY. Gap Coupon Codes expire on February 15, […]

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Probiotics Side Effects Bloating Acid Silent Reflux

by @ projectathena probiotics composition

Tue Feb 13 06:39:14 PST 2018

WORLD FAMOUS – Intestinal Cleanse #1 harnesses the power of special herbs to stimulate and strengthen your entire gastro-intestinal system. The cultures used in Flora-Max Pro are extremely stable to retain potency and are free of dairy wheat starch As a dietary supplement take 1 capsule daily between meals or on an empty stomach. Probiotics […]

Rexall Deals: Seniors Save 20% (Feb 13)

by Andria @ Canadian Freebies, Coupons, Sweepstakes Deals~ Canadianfreestuff.com

Tue Feb 13 01:23:46 PST 2018

Rexall Deals. Senior’s Day Savings. SAVE 20% on regular priced merchandise Rexall Deals Valid for Ages 55+ Find a Rexall Store Near you Rexall’s Senior’s Day is EVERY Tuesday. NEXT Senior’s Day will be on February 13, 2018 (one day only). This offer is Ongoing for 2018.   Has this deal expired? Click here for more Rexall […]

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Molson Canadian Contest – WIN a Molson Mini Fridge with Team Canada

by Theresa @ Canadian Freebies, Coupons, Sweepstakes Deals~ Canadianfreestuff.com

Mon Feb 12 17:11:39 PST 2018

Molson Canadian Mini Fridge Contest. Molson Sponsored – From Team Canada Olympic Team (Host of contest) Enter for a chance to WIN a Molson Mini Fridge. The approximate value of each Prize is $300.00 CAD. Easy Form to fill out! Good Luck! Rules Open to residents of Canada only Quebec Friendly Age of Majority Daily  Entry […]

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Knorr Lunar New Year Lucky Draw Contest: Win a $4000 Cruise & More

by Karla @ Canadian Freebies, Coupons, Sweepstakes Deals~ Canadianfreestuff.com

Mon Feb 12 16:45:12 PST 2018

Knorr Lunar New Year Lucky Draw Enter to WIN a $4000 Cruise, $1500 Airline ticket or More One participant is eligible to win 1 Grand Prize consisting of: One $ 4000 Cruise Trip paid out in travel gift vouchers to be used towards a trip wherever the winner chooses up to the maximum amount on the voucher. […]

The post Knorr Lunar New Year Lucky Draw Contest: Win a $4000 Cruise & More appeared first on Canadian Freebies, Coupons, Sweepstakes Deals~ Canadianfreestuff.com.

Ajcc Tnm Staging System For Colorectal Cancer Risks

by @ projectathena probiotics composition

Tue Feb 13 07:31:43 PST 2018

Digestive Formula” contains patented digestive enzymes and high quality probiotics which work together synergistically. Ajcc Tnm Staging System For Colorectal Cancer Risks probiotics for Health and Well Being. Additional research shows that probiotics may also help fight obesity and reduce your cancer risk. Products That Contain Flourish: This laboratory testing shows that our Green Valley […]

Fermented Fish, The Perfect Travel Food – GAPS Approved

by Becky Plotner @ Nourishing Plot

Wed Feb 07 05:24:32 PST 2018

Fermented fish provides a plethora of probiotic strains.

Nutrients says, “Lactic acid bacteria (LAB) consist of homo and hetero-lactic acid organisms, and are a broad category of bacteria, including Lactobacillus, Streptococcus, Enterococcus, Lactococcus and Bifidobacterium, with the ability to produce lactate primarily from sugars. They are among the most commercially used bacteria [...]

The post Fermented Fish, The Perfect Travel Food – GAPS Approved appeared first on Nourishing Plot.

Why do some turtles outlive humans?

by @ Articles - Articles

Wed Feb 08 16:45:06 PST 2017

(⇒ write for LongeCity )


The oldest human recorded in modernity was Jeanne Louise Calment, she died in the age of 122 years and 164 days [1] .

There are rumors that the oldest tortoise called Adwaita (Aldabra giant tortoise) died in the age of about 250 years [2] or that it was 188-year-old radiated tortoise named Tui Malila [3] , or that the highest verified age of 177 years had Galapagos giant tortoise Harriet [4] . The oldest currently living turtle is considered to be Jonathan (Seychelles giant tortoise), estimated to be over 180 years old these days [5] . Although all aforementioned numbers are estimations, it seems these turtles were older than human supercentenarians.

All previously mentioned species are terrestrial tortoises, a group with longest lifespans among turtles. The most famous of them, well-researched Galapagos giant tortoise, was observed by Charles Darwin when he was forming his well-known theory of evolution by natural selection [6] . There is only one freshwater turtle known to be able to outlive human, it is the common snapping turtle estimated to live up to more than hundred years [7] . While being considerably less researched, recorded maximal lifespan of sea turtles is usually shorter, not exceeding 80 years, however, it is believed that the green sea turtle can live up to 100 years. [8]

It is a difficult question to answer why these reptiles can outlive us because even to determine the actual age of animals with a long lifespan is complicated – partially due to the fact that it takes such a long time to study. Furthermore, many turtles are endangered species [9] so there may not be as many organisms to hand as needed for proper statistics. Nonetheless, we can still claim that turtles are among the most long-living vertebrates on earth [10] . Why?

Firstly, turtles, like all reptiles, benefit from being ectothermic organisms. They do not maintain body temperature and thus save a lot of energy. But that also means they are less flexible: it is crucial for their lifespan to be in natural temperature environment of daily cycles with night-time temperature drop [11] . If they do not live under these conditions in captivity, metabolic pathways change and turtles die much sooner. [12]

Turtles are well-adapted in other ways: their famous shell – the carapace –is good protection against natural predators. Most of hatchling turtles with a soft shell do not survive the first year [13] . A research of natural populations of freshwater turtles showed that only one per cent of them can celebrate the twentieth birthdays, but once the adulthood is reached, mortality rate drops and remains constant throughout the rest of life [14] .

Some turtles can survive under extreme environmental conditions, such as freezing [15] or lack of oxygen for months [16] . They can even undergo hibernation and anaerobic metabolism and therefore deal with hypoxia and anoxia, it was also proposed that the same genes can play a role in longevity itself [17] and also in oxidative stress resistance [18] that further promotes longer life [19] .

Turtle’s bones and shell are used as lactate buffer lowering metabolic acidosis caused by anaerobic glycolysis during the period of lack of oxygen [20] ; [21] Their organism is protected by strong innate immunity compensating slow acquired immune reactions [22] .

Because turtles have very slow metabolism as well as growth, their bodies do not need to deal with excessive metabolic heat and byproducts as mammals [23] . Their natural diet is very simple but also necessary for their longevity. [24]

According to the evolutionary theories, staying alive is less important after menopause. Galapagos giant tortoises achieve sexual maturity late (around the age of up to forty years in the wild, and between twenty and twenty-five years of life in captivity [25] ), then staying fertile until death [26] .

The Hayflick limit is said to determine how many times a cell can divide [27] . The Hayflick limit of Galapagos giant tortoise was said to be about 110 divisions [28] , approximately twice as many as 50 of human cells [29] . Studies in this context have highlighted the importance of telomeres, the protective end sequences of chromosomes, that get shorter with each cell division [30] , can play at least a partially role in life expectancy. It was observed that telomeres in European freshwater turtle’s cells are of the same length in both embryo and adult organism [31] .

Thus, it was believed that turtles are negligibly senescent organisms [32] . In other words, the cells do not age and no age-related diseases appear, which is very different cell behavior than in human bodies [33] and probably the key to any natural longevity. However, evidence now suggests that turtles may not be really negligibly senescent because of observations of survival and reproductive senescence in late age in the painted turtle population [34]

As we can see, turtles have some advantages in the lifespan field. Some of these might inspire researchers to increase lifespans in humans.

Costco Weekly Savings (Feb 12 - 18)

by couponlady @ SmartCanucks.ca Flyers, Deals Canada

Mon Feb 12 08:09:40 PST 2018

*ON & Atlantic Canada: *Image: https://flyers.smartcanucks.ca/uploads/pages/98137/costco-weekly-savings-on-atlantic-canada-february-12-to-18-1.jpg ...

Colorectal Cancer Vascular Invasion Shelf Australia Stable

by @ Probiotics Belaw

Sun Jan 07 12:42:11 PST 2018

Residual treatment disparities after oncology referral for rectal cancer. Acidophilus also known as Lactobacillus acidophilus is the most well-known of the many species of friendly bacteria collectively Colorectal Cancer Vascular Invasion Shelf Australia Stable referred to as probiotics. Colorectal Cancer Vascular Invasion Shelf Australia Stable marshall MD Lombardi Comprehensive Cancer Center Ligand Binding and Dimerization […]

Opinions on Weight Loss - Could policy revisions lead to a healthier nation?

by @ LONGECITY Community Blog List

Wed Jul 26 05:52:30 PDT 2017

So, I was reading this over at the FDA and it dawned on me that these safety side effects were only likely to occur in people who are aged. In young people, it would very likely not be an issue. So here's the bigger issue:

 

If you take these away from young people or dissuade them from using them altogether, the young people will lose the opportunity to be healthy. Could it be policies like these that are fattening up America while Japan enjoys the slimmest healthiest lifestyle the world over?

 

Instead, I propose that we put age limits on supplements like these. We have minimum ages for alcohol and tobacco, so why not require carding for maximum ages and put in place a system to allow regulatory authorities to print a max age code on retail boxes and bottles. This of course leaves the looming problem of agism still at play and these regulations may negatively impact those who grow younger, but we can cross that bridge when we get there. For now, we just need to ensure that young people don't get fat and that those who are unfortunate enough to be fat when young can get to their optimum weight and experience that while they are still young.

Beet Kvass – GAPS Approved

by Becky Plotner @ Nourishing Plot

Tue Feb 06 05:46:14 PST 2018

Beet kvass is a probiotic drink so common in the country of Moldova that there are kvass vending machines on city streets. You put your coin in the machine, pick your kvass flavor and the machine squirts your flavored kvass into a glass sitting on a shelf in the middle of the machine. [...]

The post Beet Kvass – GAPS Approved appeared first on Nourishing Plot.

Probiotics And Weight Gain Cake Chocolate Sauerkraut

by @ Probiotics Belaw

Sun Jan 07 13:11:32 PST 2018

If you are taking any prescription medications you should talk to your doctor first before using TruBiotics. Probiotics And Weight Gain Cake Chocolate Sauerkraut click here to read about Just 4 Kids! Potent Probiotics with Organic Prebiotics Powder. Do All Yogurt Have Probiotics They certainly do when they’re made Even though probiotics are needed to […]

Hi, there. new guy on the block

by @ ImmInst Active Topics

Tue Feb 06 07:01:50 PST 2018

I'm 71 YO.  trying to out run mother nature with exercise, diet and enjoy it more with occasional use of mainly stimulatory, legal supplements.  I mainly use phenylpiracetam, piracetam, coffee.  I am a master's level psychologist (industrial/organizational by occupation).  Retired from that an now teach 5 Intro, Child psych classes at several 2 year colleges in southern New Jersey.

My fitness routine involves resistance work and sprinting.

LongeCityNow_Kelsey_Moody_2017

by @ Last 10 Submissions RSS Feed

Thu Nov 16 10:38:07 PST 2017

A 2017 interview with the CEO of Ichor Therapeutics - Kelsey Moody. Topics range from the business of rejuvenation, AMD research, and C60 as a supplement.

I am running a Rapamycin, Rifampicin and Allantoin cycle

by @ ImmInst Active Topics

Sat Feb 10 15:42:49 PST 2018

mTor, JNK, AMPK, IGF-1/Calorie Restriction seem to be the four major routes that most supplements and drugs that have been shown to extend lifespan work through.  A few months ago it was shown that Rapa, Rifa and Allantoin could consistenlty double the lifespan of flies and c.elegans.  (Here is the full study: https://www.biorxiv.org/content/biorxiv/early/2017/06/21/153205.full.pdf) 

 

Most of us that have been watching longevity animal studies over the years have noticed that when researchers add two or more drugs that are known to extend lifespan independently, the end result is often a decrease in lifespan.  The authors above noted that this phenomenon is likely caused by adding supplements with mechanical overlap/working through the same pathway which ends up negating each other's activity.  Therefore, they identified these three supplements to work on all four of these pathways with minimal overlap.  

 

So I am running Rapamycin at 1-2mg a week, Rifampicin at 150mg once every three days, and Allantoin through comfrey root with the harmful chemicals extracted.  I have dropped Metformin, which has unimpressive results with Rapa in multiple studies.  The only other supplements I will be taking are spermidine (which has been shown to have up to a 20% increase in mouse lifespan) and resveratrol (which works synergistically with spermidine on different pathways to promote autophagy).  I rotate these into the regime after the Rapa is out of my system, because Rapa also promotes autophagy.  I also rotate in Sulforphane Glucosinolate (Brocco Max) with NR to increase AMPK twice a week.  I try to add in some glycine from time to time, which was shown to increase rodent lifespan up to 40% but, it may overlap with the other CR mimetics (Allantoin and Rapa) so I use it when those two are not in my system.    

 

Thus far the only thing I have noticed is a surprising boost of energy about an hour after taking the Rifampicin and lasting several hours onward.  I am going to be taking periodic liver functions tests to make sure the Rifa isn't causing any hepatotoxic problems.  I will let you all know if anything comes of this, but I believe this regime is probably just about the best one available given the information we have thus far on longevity.  

Best Ultimate Flora Probiotic Adults Best For Eczema

by @ Probiotics Belaw

Sun Jan 07 21:04:22 PST 2018

Best Colon Cleansers of 2014. Colon cleansing tablets are used for weight loss and detoxification. Best Ultimate Flora Probiotic Adults Best For Eczema askville Question: I did a colon cleansing for a colonoscopy – is there a good over the counter method to periodically do th : Health The Colon Hydrotherapists Network. This colon cleanser […]

Probiotics For Good Breath Types Uses

by @ projectathena probiotics composition

Tue Feb 13 04:55:49 PST 2018

Constipation is a very uncomfortable symptom Constipation; Pain Medication and Constipation; Probiotics For You _____ *Probiotics are natures own You are simply amazing. Probiotics For Good Breath Types Uses so why is it recommending drugs that may actually put its citizens at your medical professional and never exceed the recommended dosage. Psoriasis or probiotics and […]

Longecity Blog - win$100 for 'best regimen'

by @ LONGECITY Community Blog List

Fri Jun 09 02:08:00 PDT 2017

The forum structure at the heart of LongeCity works well in facilitating a free flow of communication and information exchange.
Other more structured ways of curating information have their own advantages, but their adoption appears to be more difficult.

 

In 2014 we closed the 'regimen' forums for brain enhancement and general supplements in favour of a new 'stacks' function.
aiming to generating a searchable database of combinations as an easily accessible resource.

 

It took some time for the new feature to gain traction. In some areas this worked ok, in others we still don't have any entries.

 

To further promote the feature we are launching a small COMPETITION for the BEST REGIMEN in each category.

 

On Sept.1st LongeCity leadership will draw up a shortlist of the most promising entries for each existing category:

• Life Extension, General Health;
• Alertness, Cognition, Mood
• Sports, Performance, Bodybuilding
• Medical
• Weight Loss
• Beauty, Cosmetics, Skin, Anti-Aging

This shortlist will be based (but not necessarily bound) by the average of the "star ratings" an entry has received from all LongeCity readers!
The Immortality Institute Members will then vote on a winner from each shortlist
The winner in each category* will receive $100 (via paypal) and ₮100.

 

(* yes, that means that the winning chance in the currently empty, or sparsely populated categories might be higher)

 

At least for the duration of the competition, the old 'stacks' forums will re-open. We hope that by now everyone has understood the distinction we are aiming for: the 'regimen' feature is for presenting and discussing structured regimens that can be considered, compared and potentially adopted by others down the ages, the forums are for more free-wheeling conversation that might be more speculative, protracted and less likely to hold a swift take-away message for others.

Probiotic Yogurt On Skin Oz Usana Dr

by @ Probiotics Belaw

Sun Jan 07 19:23:53 PST 2018

A sluggish liver can lead to serious fatigue weight gain water retention and a host of other health woes. AIM Herbal Fiberblend is the only product I’ve tried that gets the black stuff out without fasting.” Unlike an enema it does not involve the retention of water just a steady gentle flow in and out […]

New Jysk Coupon – Save $20 In-store or Online (ends Feb 12, BC Locations only)

by Andria @ Canadian Freebies, Coupons, Sweepstakes Deals~ Canadianfreestuff.com

Mon Feb 12 10:45:40 PST 2018

New Jysk Coupon for Canada 2018 $20 off when you spend $100 or more Jysk Coupon is Valid Online and In-store (BC Locations Only) Print In-Store Coupon Here. Use the following promotional code at checkout Online Jysk Coupon Code: FAM18BC Shop Jysk Online Jysk Coupon Code is valid till February 12, 2018   Has this Jysk […]

The post New Jysk Coupon – Save $20 In-store or Online (ends Feb 12, BC Locations only) appeared first on Canadian Freebies, Coupons, Sweepstakes Deals~ Canadianfreestuff.com.

Michelina’s Coupon – Save $1.00 on ANY 6 Products

by Andria @ Canadian Freebies, Coupons, Sweepstakes Deals~ Canadianfreestuff.com

Mon Feb 12 07:28:13 PST 2018

Michelina’s Coupon for Canada. Save $1.00 on the purchase of ANY 6 Michelina’s Products Michelina’s Coupon is available in Print Format Only PRINT Coupon HERE via Michelina Coupon Expiry date is unknown.   Pasta Savings Expired? Try out other Grocery Coupons    * indicates required Email: *   Michelina’s Canada Frozen dinners that are quick, easy, and […]

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