LongeCityNow_David_Gobel_2018.mp3

by @ Last 10 Submissions RSS Feed

Thu Feb 01 15:29:50 PST 2018

An interview with David Gobel about recent progress in rejuvenation research linked with the Methuselah Foundation

by Maz @ Road Back Foundation

Thu Apr 27 07:39:38 PDT 2017

Susan E. Grober, PhD, a clinical psychotherapist and researcher, wrote the following article in response to rheumatic patients, new to antibiotic therapy, who want to remain positive, hopeful and determined, but question how to cope with commonly-experienced fears and anxieties while waiting for the treatment to start working. Helpful guidance about how to respond to healthcare professionals, relatives or friends who... Read more »

The post appeared first on Road Back Foundation.

8 Reasons to reach out to 'the public'

by @ Articles

Sun Mar 08 16:35:01 PDT 2015

While the idea that drastic life extension may be an option for humankind in the future has been encountered by many through the media and fiction, the vast majority of the public do not grasp whether and how this could realistically apply to them or their loved ones. 
 
Some argue that since life is an universally desirable good and age-related suffering and death universally feared and avoided, ‘public perception’ is something that will take care of itself. If anything, the inherent attractiveness of the concept will always guarantee media interest perhaps even to the point of generating unwarranted hype and the empty promises that have been the bane of the scientific life extension movement for centuries. 
 
Others argue, with great conviction, that public perception and ‘marketing a life extension movement’ should be a prime objective. Here is a list of eight reasons why:  
 
1. Broaden the pool of ideas. Generally, the more minds are altered to and focused towards a common objective, the greater the chance than innovative or groundbreaking ideas will be generated. If Life Extension is a more broadly known, accepted and prestigious topic of interest, more bright minds will be attracted to it.  
 
2. Increase public sector funding and donations. As businesses tend to fund research only when profitability is close it often falls to the public sector and philanthropists to fund the "starter end" of research that will eventually lead to usable products which business will then want to take up. 
 
3. Reduce opposition.  There is an element of ‘shock’ associated with the concept that aging and death may not be inevitable which can lead to denial or impatient dismissal. Visceral or ideological opposition to life extension translates into less government funding, less scientific interest, less favorable laws and less industry support especially if there is no widely established counter-position.   
 
4. Improve regulation.  Whether we are thinking about laws allowing or prohibiting life extension treatments in general, or the speed and efficiency at which the FDA similar entities conduct their reviews, the support of government agencies is important at every stage of the process of getting treatments to the public. Responsive regulation can be generated through public pressure and media attention. 
 
5. Focus corporate interests towards effective treatments.  Only if there is a clear and well-informed demand for proven and validated treatments will effective products become more profitable to the industry than ineffective ‘snake oil’.
 
6. Build economies of scale.  Given the urgent need for life extension treatments for many people there is an interest in helping to bring costs down as soon as possible. If pent-up public demand becomes more clearly visible, consideration of scale-up will become a part of more business plans and healthcare reforms. 
 
7. Improve public health.  A focus on life extension often comes with increased health consciousness. Prevention is better and cheaper than cures and if more people participate in a wider programme of health-conscious living, this is likely to bring overall healthcare costs down.
 
8. Reduce social unrest and disruption.  Even once society accepts the concept of life extension and associated treatments there will still be people who are unwilling or unable to participate. Moreover, extended lifespans will affect society profoundly. Careful public engagement ensures that social unrest and discrimination can be minimised.  
 
If at least one of these reasons makes sense to you, then you may want to think about how you could help ‘connect’ the LongeCity’s mission with others. Generally, the ‘self-multiplying’ effect of outreach should not be underestimated. People act as role models and influencers of their peers. Beyond all media spin, if a person acts and speaks with conviction, others will take note; and if people realize that their friends and family members could live longer they will be more willing to engage in the idea themselves.  
 
 
-- 
This article is based on an original drafted by Sanhar in response to a LongeCity tender.

6 Reasons To Start Your Vegetable Garden This Year

by JoeRignola @ Rebel Health Tribe

Mon Mar 06 17:31:34 PST 2017

6 Reasons To Start Your Vegetable Garden This Year There are vast benefits to starting your own vegetable garden (especially if you have kids). It’s far better than just eating organic, there’s less waste, the food tastes better and contains more nutrients than produce that’s been shipped across the globe, or even across town. If […]

The post 6 Reasons To Start Your Vegetable Garden This Year appeared first on Rebel Health Tribe.

Mucuna Pruriens builds tolerance? Your experiences?

by @ ImmInst Active Topics

Sun Feb 11 21:36:33 PST 2018

I have seen some topics about people who take Mucuna Pruriens... And they say that it is followed by a low/causes dopamine downregulation?

 

I am wondering if that's true, because in the end I am looking for a way to increase my dopamine constantly, not just for an hour or two, and not to increase it for a day and then feel sluggish the next day even if I take it.

 

I have not tried this herb, but I do not want to spend money on something that doesn't work the way I want it to work.

 

So please comment and let me know your experiences with this herb? And perhaps some suggestions on other herbs that would increase my dopamine, since I have been low on dopamine for over a decade now, except for an occassional random high that lasts for like 20 or 30 hours when I get really excited about something...

 

Thanks! 

Yogurt Yard Take On Me Colorectal Tnm 5 Cancer

by @ Ex-Cerbero Item

Mon Feb 12 22:19:32 PST 2018

Re: Aftermath of rectal cancer. Yogurt Yard Take On Me Colorectal Tnm 5 Cancer side Effects of Biological Therapy for Colon Cancer may cause side effects that vary with the specific type of treatment. Resource for coding advice on ICD-9-CM medical coding including medical diagnosis codes and medical procedure codes used in medical transcription and […]

Lemon Tea With Probiotics Taken Should Doxycycline

by @ Ex-Cerbero Item

Tue Feb 13 00:30:37 PST 2018

Some strains are going to be really good at doing one thing and others are going to be good at doing another.” (For a eakdown of certain probiotic strains linked to alleviating conditions like antibiotic associated diarrhea see ConsumerLab’s top 10 colon cleansing foods treatment advanced locally cancer rectal report or “A Gastroenterologist’s Guide to […]

Do Probiotics Help Flatten Your Stomach Laxative

by @ INSIGHTMARKETING LEVEL

Wed Feb 07 23:23:41 PST 2018

Garcinia Cambogia can be best described as a natural supplement that is extracted from a fruit that closely resembles a small pumpkin. Do Probiotics Help Flatten Your Stomach Laxative nine stars touchless trash can. Support & maintain a healthy digestive system daily*. Fatigue flagyl cause own discharge taking flagyl probiotics flagyl overdose symptoms. Blend of […]

Restlessness

by @ ImmInst Active Topics

Fri Feb 09 14:17:49 PST 2018

Any ideas for restlessness? My problem is mainly sitting still when I am not able to distract myself with work, tv shows, video games etc. For a workaholic this problem might actually be helpful or a motivation in a way, but work as an addiction is not necessarily a good thing obviously.

 

The one thing that helped me with this was C60- it induces an inner optimism where I can sit around feeling that everything is okay. But I don't take it, because it seems too risky.

 

Any help is appreciated.

A Lesson on Legacy – My Experience of James Butler

by Michael Roesslein @ Rebel Health Tribe

Sat Oct 21 09:09:08 PDT 2017

I sit here, in a hotel room in Ottawa, Ontario (that’s in Canada for my geographically-challenged friends) 2,850 miles from home, typing out a tribute before I head to the Celebration of Life for James Butler. I left my home yesterday at 9:00 am, and after traveling in two cars, a bus, and 3 planes […]

The post A Lesson on Legacy – My Experience of James Butler appeared first on Rebel Health Tribe.

Does Colon Cancer Kill You Cd American Health

by @ Probiotics Belaw

Sun Jan 07 18:22:18 PST 2018

Helps in natural weight loss. Does Colon Cancer Kill You Cd American Health gET RID OF WEIGHT: DR OZ GARCINIA CAMBOGIA AND COLON CLEANSEReview tips of DR OZ GARCINIA CAMBOGIA AND COLON CLEANSE : Excess body weight is constantly a problem and people with added pounds do not s The benefits and history of colonic […]

Inhibition of Wnt Signaling as a Treatment for Osteoarthritis

by @ LongeCityNews

Tue Feb 13 03:30:00 PST 2018

Researchers here find that inhibition of Wnt signaling can improve the state of cartilage and joint function in a mouse model of osteoathritis. Wnt and its closely related proteins are a complex topic, but the short version is that they are involved in the regulation of growth, regeneration, and embryonic development. They are also significant in cancer, as well as in other, less dramatic ways in which regeneration can run wild or fail, producing fibrosis and functional problems rather than a useful restoration of tissue. Numerous research groups are investigating ways in which Wnt signaling can be adjusted to produce beneficial effects such as enhanced healing, or a reduction in function damage to tissues following injury. This is a representative example.

Wnt family proteins are a class of morphogens associated with embryonic skeletal formation, tissue repair, fibrosis, and joint homeostasis. Wnts regulate multiple signaling cascades, including the β-catenin-dependent (canonical) pathway. The Wnt/β-catenin pathway, which is typically quiescent in many adult organs, is activated in response to injury. Its role in tissue repair and regeneration is complex and incompletely understood, although an increasing body of data suggests that its activation augments fibrotic repair. Our group recently published studies demonstrating that brief therapeutic Wnt inhibition following both full thickness cutaneous or ischemic cardiac injury resulted in improved regenerative repair with less fibrosis.

Osteoarthritis (OA) is a degenerative joint disease typically characterized by articular cartilage degeneration, bone remodeling, and osteophytosis as well as fibrosis and hyperplasia of the synovial membrane. In OA pathogenesis, activation of canonical Wnt signaling is observed in both articular cartilage and synovium following injury, with increased expression of both Wnt ligands and target genes. Induced overexpression of β-catenin within mature chondrocytes has been shown to exacerbate cartilage degeneration, chondrocyte hypertrophy, and expression of matrix proteases. However, significant or complete ablation of β-catenin in chondrocytes also results in the deleterious effect of chondrocyte apoptosis. Moreover, increased canonical Wnt expression in the synovium resulted in strong induction of cartilage pathology. Although the sum of the published data using genetic modulation of Wnt suggests deleterious effects of Wnt on OA pathogenesis, there is little known about the therapeutic effect of inhibiting the Wnt pathway within the context of disease.

Multiple Wnt inhibitory therapeutics are being investigated at various stages of clinical development due to Wnt pathway activation, not only in fibrotic diseases, but also cancers. We sought to study Wnt signaling and the effect of local therapeutic Wnt inhibition in a murine model of traumatic OA caused by destabilization of the medial meniscus (DMM). To assess the effect of Wnt inhibition on OA progression, we injected the small-molecule Wnt inhibitor, XAV-939, in the intra-articular space. We further studied the cell-specific effects of Wnt modulation in vitro using primary human synovial fibroblasts and chondrocytes in order to understand the cellular basis for the disease-modifying effects.

Our study demonstrated that traumatic joint injury through DMM surgery induced robust activation of canonical Wnt signaling, most striking in the synovium, and this upregulation was downregulated with intermittent (every 10 days), local (intra-articular) treatment using a small-molecule Wnt inhibitor, resulting in amelioration of both synovitis and cartilage loss. An important advantage of identifying therapeutic benefits with local administration is avoiding systemic effects of Wnt inhibition on Wnt-dependent tissues, such as intestinal stem cell/intestinal turnover, hematopoiesis, and bone density. The use of small-molecule Wnt inhibitors bypasses the restrictions of genetic approaches by targeting the entire injury milieu, rather than a particular cell type, as is the case in genetic models. Additionally, since different cell types exhibit different levels of Wnt activation and sensitivity to Wnt inhibition, one can also fine-tune the degree and timing of Wnt inhibition using dosing strategies that are calibrated.

Link: https://doi.org/10.1172/jci.insight.96308

View the full article at FightAging

3 Pro Tips to Travel Like a Health Boss

by Jenn Malecha @ Rebel Health Tribe

Tue Feb 06 05:00:07 PST 2018

  Travel and Health Having good health is what allows you to travel the world, to see amazing sites and live out your dreams. Health gives us the foundation to live life in full color. But traveling can also wreak havoc on our health…   Traveling across different time zones can disrupt the circadian rhythm […]

The post 3 Pro Tips to Travel Like a Health Boss appeared first on Rebel Health Tribe.

Do Probiotics Help With Mood Plants

by @ Probiotics Belaw

Sun Jan 07 21:31:00 PST 2018

Rich Shewmaker <rich@ilhawaii.net> wrote or quoted: > I challenge anyone to probiotics for reptiles activity lactobacillus come up with a single report of a Answering The Question: How Does Sea Salt Cleanse The Colon? Hydrotherapy Colon Cleanse Is Far Superior A Method Than Enema. Do Probiotics Help With Mood Plants what makes matters even worse […]

Testing Positive

by Andrew Johnston @ Rebel Health Tribe

Sun Feb 04 05:00:06 PST 2018

Testing Positive   This is a simple trick for enhancing your happiness, your health, and your performance. I learned to keep a poker face while racing bicycles.  To survive for any length of time in the professional peloton, you had to.  If your expression showed any hint of discomfort—that’s exactly when the strong guys would […]

The post Testing Positive appeared first on Rebel Health Tribe.

Opinions on Weight Loss - Could policy revisions lead to a healthier nation?

by @ LONGECITY Community Blog List

Wed Jul 26 05:52:30 PDT 2017

So, I was reading this over at the FDA and it dawned on me that these safety side effects were only likely to occur in people who are aged. In young people, it would very likely not be an issue. So here's the bigger issue:

 

If you take these away from young people or dissuade them from using them altogether, the young people will lose the opportunity to be healthy. Could it be policies like these that are fattening up America while Japan enjoys the slimmest healthiest lifestyle the world over?

 

Instead, I propose that we put age limits on supplements like these. We have minimum ages for alcohol and tobacco, so why not require carding for maximum ages and put in place a system to allow regulatory authorities to print a max age code on retail boxes and bottles. This of course leaves the looming problem of agism still at play and these regulations may negatively impact those who grow younger, but we can cross that bridge when we get there. For now, we just need to ensure that young people don't get fat and that those who are unfortunate enough to be fat when young can get to their optimum weight and experience that while they are still young.

The curse of noopept/piracetam/pramiracetam

by @ Health

Sun Feb 11 21:47:30 PST 2018

I see a number of newer threads of people on Reddit who have sexual issues after taking these nootropics, years ago no one took it seriously, does anyone have any hard data on how to fix this issue or what is the cause of this.

Probiotics And Diabetes Research Tongue Swollen

by @ Ex-Cerbero Item

Tue Feb 13 06:13:35 PST 2018

Long touted as a natural remedy for ulcers licorice can be a lifesaver for those who are hurting from acid reflux. Have you tried New Chapter Probiotic Vitamin E and Selenium? Probiotics is the term is used to describe dietary supplements or foods that contain good Scientists from University College in Ireland found that probiotics […]

How Everyday Exposures to Chemicals Might Be Making Us Fat

by Lara Adler @ Rebel Health Tribe

Thu Jan 04 09:06:55 PST 2018

Can the chemicals in our shampoo make us fat? An emerging field of research is saying “yes.” While the idea that the chemicals in our personal care products, household cleaners, or even the water we drink might be making us fat may sound crazy, there’s evidence to support it, and you I’m going to wager […]

The post How Everyday Exposures to Chemicals Might Be Making Us Fat appeared first on Rebel Health Tribe.

Advertisers sought

by @ LongeCity - Articles

Tue Dec 18 15:50:45 PST 2012

For over a decade LongeCity has presented a bustling platform for discussion and information exchange on advanced life extension. As a non-profit org we have consistently promoted grassroots science and advocacy projects by the international life extension community. Funding for these initiatives is raised in large part through donations, but also to some degree from advertisers. 
Those choosing to advertise at LongeCity gain unique access and exposure to a dynamic, growing and committed community of life extension enthusiasts, and the goodwill of well-educated thought leaders in life extension science and advocacy. It is also a great way of 'giving back' something to the bigger cause of healthy life extension that many of our advertiser support.

There are different ways of placing an advertisement at LongeCity: 

Automated: Anywhere on our page where you see an advert and text similar to "support LongeCity by booking this space for YOUR ad"   - you can click on the text and it should take you to an order page for that slot. You can upload your ad straight from there. Payment via paypal.
CLICK HERE to see a list of all 'bookable'slots.

Sponsored thread: Normally, discussing an advertiser's product range is not allowed on the open forums. Sponsored threads however are the exemption. Click here to learn more.  

Non-automated: the following spaces may also be available for ads, but not via the automated route. 
If you want to go for one of the following, use the contact page supplying as much info as possible.

Ø1- Rolling ad in the carousel on left-hand of forum -- this feature is not always in use, the equivalent would be another 'carousel' place where topical items are displayed at a common location. (~$180/month)
Ø2- Text ad on left-hand of forum  -- A short piece of text/link that is visible prominently from any place anywhere on the page (~$280/month)
Ø3- Individual subforum -- For a much boarder variant of 'individual thread'  (~$400/year)
Ø4- Featured article -- An article on the portal. To be effective and useful, his should be more than a simple advert and also contain some useful information about a topic relevant to LongeCity (~$300). 
Ø5- Associate link -- A 'featured' entry in our database of interesting links (~$50)
Ø6- Discount for members -- A free form of advertising that generates significant exposure. Member discount codes can be shared at the restricted members forum or more sophisticated discount schemes can be devised (usually free) 
Ø7- Sponsored item in 'thank you 'store' -- LongeCity has a unique system of rewarding volunteers with 'Thank You' points. These points can be exchanged for small gifts: a book voucher, a DVD... or perhaps a product from a valued sponsor (usually free). 
Ø8- Mention in newsletter -- The LongeCity newsletter is sent monthly to over 12.000 users with a live email address. Some of the above options may entail a free mention in the newsletter (~$280/month). 


NB: There are a few things that advertising money cannot buy at LongeCity (please don't ask). Among these are 'privileged' status that exempts you from the forum user agreement (including the prohibition against 'viral' marketing), any right in how the site is run (you can become a Member and vote in referenda instead) and any content that appears as if it was coming from LongeCity without making it clear that such content was 'sponsored by'. 
For the broader advertising framework at LongeCity please read this article.

Pimple Be Gone

by @ Good Medicine: Latest News

Mon Jan 11 01:21:29 PST 2016

So often with disease, as I am often apt to point out, we can prevent it. Once again here is a disease process that has its connection to your diet, even though a lot of doctors claim there is no connection to food, the data does not bear this out. Its interesting something so commonplace and insufferable as acne is treatable without meds and is so readily responsive to changes in lifestyle. Puberty does not have to be the "Time of the Pimple".

Testosterone increases the size of sebaceous (sweat) glands and this is why puberty brings about increased incidence of acne. We cannot get rid of the testosterone, although most parents of teenagers would love to, but we can defuse the powder keg this hormone presents to the sebaceous glands by addressing the "fuses".

Acne is a response to inflammation. This inflammation and hormonal changes affect how your sweat glands react. With increased swelling your sebaceous glands get clogged, infected and viola' you have acne. No amount of face washing will rid you of this problem. You have to get to the bottom of it and it starts with your fork-let me explain why.

Pimples are a symptom of disease just like water on the floor is a sign of a broken sink. We need to fix the sink if we are going to get rid of the problem and not just mop up the floor. There are several underlying factors in acne and I will explain how by addressing these we are going to fix the "sink".

Acne is one of the signs of the body having insulin overload. That is why eating lots of sugar and processed food predispose you to this problem. Insulin is responsible for building up tissues and growth. It makes sense that sebaceous glands (sweat glands) also would grow from its stimulation and we get acne. To solve this aspect of acne it becomes simple-stop eating or drinking crap with high sugar content and foods that are highly processed. This is simple in theory but becomes hard when we think about all the things we eat that fit this description, but it is a place to start. With the demise of Hostess this all becomes a little easier.

Milk is another hidden acne contributor. Although the marketing for milk suggests it does a body "good", I have to disagree. This food has insulin growth factor 1 in it, and increases insulin resistance in the long run. Research Link With this molecule the sweat glands are more primed for overgrowth and a "bad" diet, greatly increases our predisposition to acne and eventually, when one looks at its mechanism of action, diabetes. No society that lives without milk as a staple suffers from bad health or weak bones. We will be just fine without it and our skin will thank us. Additional Research Link.::

"Warning: Broken record to commence...." Inflammation is caused by diet. Gluten is a very inflammatory molecule in our diet. Keeping gluten out of our diet, or at least to a minimum, will decrease inflammation. Inflammation causes acne so gluten elimination is another factor to consider as treatment.

Supplements are helpful in acne and zinc is a must. This simple element in one study reduced acne from 100% to 15%. This has to do with anti-inflammatory processes and improvement in insulin receptors. This needs to be elemental zinc and 30 mg a day is very helpful (Zinc Piconilate is my favorite because of increased absorption). Other supplements that should be considered include Chromium at 200 mg a day (improves insulin resistance) as well as Selenium (400 mcg) and a very good omega 3 fatty acid (fish oil-decreases inflammation along with good diet).

Acne is not inevitable for teenagers or adults. We have to change our lifestyle and make better choices in our diets and make sure our deficiencies are addressed. Testosterone increase for young adults is inevitable, but with lifestyle changes this plague on teenage dating is easily treatable and can help those adults who are suffering as well from diseases of increased testosterone such as Polycystic Ovary Disease.

The Mind Concept

by @ Good Medicine: Latest News

Mon Oct 24 08:00:05 PDT 2016

THE MIND CONCEPT 

These 4 Key Concepts along with other gratitude practices will be a leading force in your restoring your health and freedom. These Key Concepts, or perhaps ones you create, will help you no longer rely on will-power alone. By practicing these key concepts, and other positive psychology tools,  you will heal self-sabotaging, destructive thought patterns. 

I’M THANKFUL FOR ALL OF THIS

We believe Chronic Conditions are a tap on the shoulder to learn how to live a life to best support our bodies to function more optimally. Once we begin to accept we are exactly where we are meant to be, doing exactly what we have been called to do, the anger can begin to subside. Choosing gratefulness in place of anger helps to embrace what is being gifted to us by our healing journey, rather than focusing on all that may be taken away. This concept can help to  heal past traumas, grief and anger, all of which contribute to the development of chronic conditions. In order to heal, our thoughts must be aligned with our end goal of recovery and wellness. Our thoughts create our words, our words create our actions, our actions create our habits, our habits create our reality. When we think about what we are thankful for and talk about what we are doing for our recovery, more opportunities seem to present themselves to maximize our healing experience. It is common for patients' lives to become more fulfilling and happy because of life lessons learned and past traumas healed from healing a chronic condition.

AN ATMOSPHERE OF RECOVERY

When we become aware of our thoughts and our words, we choose actions which create an Atmosphere of Recovery. Rather than talking about the stress and despair associated with Chronic Conditions, we actively practice talking with our children and spouse about what we want and about the care plan we have created with Dr. Morris and Team. This will include everyone in co-creating this atmosphere, in and outside of the home. Everyone in the family is living the life of recovery. Many family members will have similar symptoms as the one with the diagnosis, perhaps to a less severe degree. Everyone will benefit from this lifestyle. When everyone is included in the atmosphere of recovery, the family can focus on the solution rather than constantly staring at the problem. The home becomes the headquarters for healing. When we constantly stare at the problem, we only get more evidence of that problem. What we focus on grows. Recognizing when we have depressing thoughts and replacing those thoughts by answering the question "What Can I Do right now?" and by practicing other positive psychology tools, we can steer ourselves in the direction of creating an atmosphere of recovery.

WHAT CAN I DO

A great idea for families is to have weekly Family Meetings to determine what everyone CAN DO to adopt this lifestyle and to contribute to the Atmosphere of Recovery. When we include our kids in our decision making process it empowers them as part of the solution. This can even be done around the dinner table. Everyone needs to be involved. The entire family is affected by the diagnosis, therefore, everyone must be a part of the solution. What Can I DO helps to train our minds to shift from the depressed chain of thoughts commonly associated with chronic conditions to identifying what is reasonable to do so we can build upon our success. Some days, we will be able to do more than others. However, the more we identify what we can do and act upon it, the more confidence, motivation determination and conviction are cultivated. This is when the behaviors and symptoms stop being the focus, and stop ruling our world.

MATTER OF FACT

Friends, Co-Workers and Extended Family can challenge a health care plan which is different than the "standard of care". When you are in social settings, it’s important to be Matter of Fact that you are CHOOSING to eat foods which are not high allergen foods. You CHOOSE to remove as much burden from your body as you can to help it to heal. There is no reason to argue with others who feel Gluten Free is a fad or a waste of time. Being Matter of Fact about your conscious choices will help you to build confidence and to stay on board even in social settings. Chances are you could be helping save someone else’s life leading by example.

Can Two Dozen Marginal Ways to Treat Aging be Combined into One Useful Therapy?

by @ LongeCityNews

Mon Feb 12 16:27:32 PST 2018

Comparatively little work on combinations of therapies takes place in the research community. I suspect this to be a matter of regulatory incentives. For example there is little room for commercial entities to be able to make money by combining established treatments owned by other entities. Similarly for researchers, the world of possible approaches is balkanized by intellectual property, while the disposition of the majority of research funding is ultimately guided by the promise of a pot of gold at the end of the road. That pot of gold is much harder to obtain when someone else owns the therapies involved, and all that is being done is to apply them together. The edifice of intellectual property is a great evil, and this is one of many reasons why that is the case.

Given this long-standing state of affairs, there is at present little data to guide our expectations on the bounds of the possible when it comes to combining large numbers of therapies in search of additive and synergistic effects. Some people think that we should forge ahead in the matter of slowing aging: take every intervention with good evidence to date, and run large numbers of them in the same mice to see what happens. Should we believe that various ways of manipulating the operation of cellular metabolism demonstrated to achieve 5-10% life extension in mice can combine to double life span in that species? Intuition suggests not, but I don't think it to be completely out the question. Nor is it unreasonable to try it and see, given a rigorous approach to experimental design. Sadly, no established funding institution would go for this; it would have to be funded through philanthropy.

Why do I think that this is unlikely to produce large enough results to make it worthwhile? Because the evidence to date strongly suggests that the scores of methods of manipulating metabolism to modestly slow aging are operating on just a few core processes, such as autophagy. These are the stress responses that produce the lengthening of life observed in calorie restriction, and we know that these mechanisms don't produce anywhere near the same degree of life extension in humans as they do in short-lived species. Everything is connected to everything else in cellular biochemistry. A given interaction between two proteins can be influenced by adjusting levels of any number of other proteins, with widely varying degrees of effectiveness and side-effects. So most methods of slowing aging are different views into the same method of action. The few combinations of approaches tried to date, involving only two methods, have resulted in mixed outcomes. Calorie restriction and mTOR inhibition may be additive, while growth hormone receptor knockout and mTOR inhibition interfere with one another, for example. That gives little insight as to the rest. It is hard to predict other results, beyond noting that a majority of interventions do appear to function through enhanced autophagy, and thus we might expect them not to combine in an additive way to any great degree.

What of the SENS rejuvenation biotechnology approach to aging, in which independent fundamental forms of cell and tissue damage are repaired? How will repair therapies combine? In this case we should expect additive effects: removing damage should be beneficial in proportion to the amount removed, at least when considered from a fundamental, reliability theory perspective. The mortality risk and longevity of a complex system of many redundant parts is dependent on its current load of damage. At this point we have no idea as to how that will turn out in practice, however. The contributions of different forms of damage may be significantly larger or smaller than one another. The results of two independent root cause forms of damage are not themselves independent: they interact, and probably significantly. Functional decline in one system spurs greater damage and functional decline in others, which is why age-related degeneration accelerates greatly in later life. It is a complex business. It isn't unreasonable to think that in some circumstances the results of rejuvenation therapies A and B will be indistinguishable from A alone, or that B will never achieve a great deal without being combined with C.

Can we envisage a world in which repairing cellular senescence alone produces no extension to life span because other, largely independent chains of damage and consequence are still life-limiting for old humans? That is becoming increasingly hard given the evidence to date for reversal of numerous age-related diseases to result from removal of senescent cells, not to mention the PAI-1 mutants who exhibit increased life span - but we know far more about senescent cell clearance than we do about any of the other SENS strategies. No-one is in a position to do more than make educated guesses about the results of combining senescent cell destruction with removal of mitochondrial DNA damage, or with clearance of specific lysosomal aggregates. Beyond "two should be better than one, but perhaps not in some specific cases" everything else will remain a mystery until the biotechnology is ready and the work is carried out. Making predictions seems a fool's game, given the degree to which the people closest to senescent cell research have been surprised by the scope and size of benefits observed in mice over the past few years.

View the full article at FightAging

Colon Cancer Smelly Stool Guide

by @ projectathena probiotics composition

Tue Feb 13 03:03:34 PST 2018

We care for patients with gastrointestinal and liver diseases provide colon cancer screening and GI endoscopies ( colonoscopy and upper GI endoscopy). Colon Cancer Smelly Stool Guide colorectal cancer rates in Singapore may have levelled off. Racial disparity in colon cancer mortality may be due in part to biological differences in tumor type. We are […]

The Magic of Milk Thistle

by Lisa Giusiana @ Rebel Health Tribe

Mon Jan 22 09:06:16 PST 2018

The Magic of Milk Thistle Ask any natural healthcare practitioner what they would recommend for a liver condition and chances are, one of the first things that comes to mind is milk thistle. It’s safe, easy to use, well tolerated and is readily available as either a stand-alone herb or used in many liver support […]

The post The Magic of Milk Thistle appeared first on Rebel Health Tribe.

Probiotic Strains For Colon Encapsulations Pure

by @ INSIGHTMARKETING LEVEL

Thu Feb 08 02:36:35 PST 2018

Related Products: Acidophilus Powder Inner Health Plus . Probiotic Strains For Colon Encapsulations Pure everything you need to know about how long can you live with untreated colon cancer including the most common causes symptoms and treatments. ulcerative colitis colon cancer who eats all organic!) A good colon cleanse usually is not just a single […]

There are Many Possible Paths to Immunotherapy for Senescent Cell Destruction

by @ LongeCityNews

Mon Feb 12 03:09:52 PST 2018

Rising numbers of senescent cells are one of the root causes of aging, a process that arises from the normal operation of youthful metabolism, yet results in accumulated damage and failure over time. Senescent cells generate signaling that degrades tissue function, breaks down and remodels tissue structure, spurs chronic inflammation, and alters the behavior of surrounding cells for the worse. Evidence shows their presence to be a contributing cause of a range of common fatal age-related conditions. In a youthful body, near all cells that become senescent and fail to self-destruct as a result are promptly eliminated by the immune system. In an aged body, the immune system is worn and degraded; as a consequence many more senescent cells survive to linger. We are machines of interacting, dependent parts. Damage and failure in one component speeds the onset of damage and decline in others. The age-related failure of the immune system is an important part of the acceleration of functional decline in later life.

Much of the current work on methods to selectively destroy senescent cells, and thus produce a narrow form of rejuvenation, is focused on pharmaceuticals. Given that the immune system is already capable of destroying senescent cells in the normal course of events, why not immunotherapies, however? I'm only aware of the one company working along those lines, SIWA Therapeutics, and I believe that their immunotherapy approach doesn't interact at all with the natural immunosurveillance of senescent cells. Is it possible to do better than this, to build on the existing evolved mechanisms to induce high levels of clearance even in old and damaged immune systems? Alternatively, could the general methods of immune rejuvenation currently under consideration (such as restoring the thymus, destroying malfunctioning or overspecialized immune cells, or inducing greater stem cell production of immune cells) result in youthful levels of senescent cell destruction?

Whilst there is currently little understanding concerning the mechanisms governing macrophage mediated recognition of senescent cells, the processes are probably not specific to senescent cells. Rather, the more characterised molecular mechanisms associated with macrophage recognition during cancer immunosurveillance and apoptotic cell clearance may also be pertinent for senescence surveillance. Apoptotic cells have been shown to preferentially express specific cell surface antigens which can be recognised by naturally occurring antibodies (IgMs) that enable phagocytosis by macrophages. As such, it can be speculated that senescent cells may also express specific cell surface antigens which would not only provide insights into the mechanisms mediating immune clearance, but would also provide a means to specifically identify senescent cells in tissues.

Surface expression of CD47 acts as a "don't eat me" signal, sending inhibitory signals through SIRPα, a receptor expressed on the surface of macrophage, ensuring that healthy cells are not inappropriately phagocytosed. Therefore, the downregulation of CD47 would be required for macrophages to target damaged "self" cells. One study has demonstrated that induction of tumour cell senescence via c-Myc inactivation leads to the downregulation of CD47 which consequently promoted tumour regression. Whether CD47 downregulation in this instance is a specific response to c-Myc inactivation or activation of the senescence program is unclear. It would make biological sense to downregulate CD47 during cell senescence to enable removal of damaged "self" cells, but further research is required.

Immunotherapeutic strategies already in development for combating cancer may one day be repurposed for targeting senescent cells for the alleviation of age-related diseases. In addition, identifying further molecular changes associated with senescent cells, especially cell-type specific alterations, would be advantageous for developing therapeutic approaches for targeting senescent cells. Since senescent cells can also be beneficial in the short term, the elimination of acute senescent cells could be problematic. Therefore, the identification of therapeutic targets specific to chronic senescence which are absent in acute senescent cells would be highly desirable.

One of the mechanisms by which natural killer (NK) cells specifically recognise and kill senescent cells is via the surface expression of NKG2D ligands. Since many tumour cells also express NKG2D ligands, such ligands have been suggested to be a useful target for immunotherapeutic approaches in cancer, and so could be adapted for senescent cell clearance. For example, the use of engineered immune cells such as chimeric antigen receptor (CAR) T cells to target specific molecules on cancer cells has great potential as an anti-cancer therapy. As such, it may be possible to target senescent cells by engineering T cells to express a NKG2D CAR which recognise NKG2D ligands on the surface of senescent cells.

An adaption of cancer vaccines could also be considered for boosting immune clearance of senescent cells. Although a universal biomarker of cell senescence has not been identified, the exposure of senescent cell membranes to immune cells may evoke an immune response to antigens not yet identified. In one approach, senescence vaccines would involve the isolation of senescence specific antigens (SSAs) which are then exposed to dendritic cells, professional antigen presenting cells. In response to SSA uptake, dendritic cells process and express these antigens on their cell surface which can then be recognised by T cells. T cell interaction with these antigens promotes T cell activation, differentiation, and ultimately killing of target cells.

Link: https://doi.org/10.1016/j.arr.2018.02.001

View the full article at FightAging

by Maz @ Road Back Foundation

Thu Dec 21 07:28:39 PST 2017

Following news reports detailing stunning revelations about a growing opioid epidemic in the U.S., Katherine Poehlmann, PhD, provides a timely overview of helpful alternatives for rheumatic disease pain control that are safer, with fewer side-effects.  Stay tuned for Part Two of this series, next month, as Katherine will be covering nutritional approaches to help reverse... Read more »

The post appeared first on Road Back Foundation.

High Strength Probiotics Supplement Acidophilus Best

by @ INSIGHTMARKETING LEVEL

Wed Feb 07 22:25:27 PST 2018

It has been found to clear up to 95% of the symptoms associated with IBS if high enough doses are taken. High Strength Probiotics Supplement Acidophilus Best no physical products will be shipped. the topical or supplemental use of grape seed extract may help to reduce Probiotics for Rosacea. This week the ACS issued revised […]

by Maz @ Road Back Foundation

Thu Mar 30 07:50:54 PDT 2017

Katherine Poehlmann PhD offers a comprehensive guide to yeast infections and how they may complicate and exacerbate rheumatic diseases. In this article, she discusses the  prevalence and pathogenic types of yeast infections, the multi-systemic symptoms that may occur with infection, dietary and supplemental supports for immune health and to help avert infection, diagnosis and misdiagnosis, and... Read more »

The post appeared first on Road Back Foundation.

Pb8 Probiotic Canada Burping

by @ Probiotics Belaw

Sun Jan 07 16:13:41 PST 2018

Hens’ eggs are the type of egg most When there is a need to give high doses of chemotherapy to a specific area of the body it may be given by a regional method. Virtual Reality Laparoscopic Sigmoid Colectomy Virtual reality colorectal surgery is demonstrated here by medial to lateral mobilisation of the sigmoid colon […]

Probiotics Supplements Brands Vascular Extramural Rectal Cancer Invasion

by @ projectathena probiotics composition

Tue Feb 13 05:50:14 PST 2018

As a nutritional support for the eliminative function the bark of Cascara Sagrada has been used by cultures around the world Cascara is not thought to be habit-forming and has been shown to restore natural tone to the colon. Probiotics Supplements Brands Vascular Extramural Rectal Cancer Invasion in the case of immunostimulation raw sauerkraut how […]

Thyroid Rich Foods

by @ Good Medicine: Latest News

Thu Jan 19 05:59:55 PST 2017

Due to its important role in fetal and infant development and thyroid hormone production, iodine is a critical nutrient for proper health at all life stages.

Iodine is present throughout the body in just about every organ and tissue. Iodine is needed by almost every bodily system.

Thyroid function relies on proper levels of iodine, so too much (or too little) can cause many serious health problems.

We rely on iodine to create thyroxine (T4 hormone) and triiodothyronine (T3), two of the main hormones produced by the thyroid that control numerous important functions.

Why are more people experiencing iodine deficiency?

• A reduction in the amount of naturally iodine-rich foods in people’s diets (wild-caught fish, green vegetables and sea vegetables.
• Soil depletion is a concern for lowering iodine counts in foods
• Higher exposure rate to certain chemicals found in processed foods that reduce iodine absorption like the compound Bromine; which blocks iodine absorption
• widespread environmental Endocrine Disruptors such as: Mercury, Percholorate and Nitrates are chemically similar to iodine and are quickly absorbed by the thyroid blocking iodine.

What Can You Do?

Choose Organic, local, wild caught foods. Sustainably grown food items are more likely to contain a higher level of nutrients than farm raised fish or conventionally produced versions. Iodine enters the body through iodine-rich foods, including certain salts, eggs, sea vegetables and fish. Look for ways to crowd out processed foods by choosing more of the following iodine rich foods

Seaweed/ Dry Kelp *

Cod

Eggs

Prunes

Lima & Navy Beans

Green Peas

Cranberries **

Consider Himalayan or Celtic sea salt ***

* Read here to learn more on how you eat this seaweed stuff

** If purchasing juice, purchase 100% organic and add to water to flavor rather than drinking the concentrate.

*** Sea salt in place of iodized table salt. Sea salt contains more than 60 trace minerals and doesn’t pose a risk for over consuming iodine like table salt does. It’s also much more natural, beneficial and tastes better.

Disclaimer: People who have Hashimotos, thyroiditis or certain cases of hypothyroidism should speak with their doctor to discuss how much, if any, iodine should be taken through supplements carefully.

References: 

https://ods.od.nih.gov/factsheets/Iodine-HealthProfessional/

https://www.cdc.gov/nceh/publications/factsheets/perchlorate.htm

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4542061/

Life Extension Pseudoscience and SENS Plan

by @ Action

Fri Jan 19 06:01:35 PST 2018

Life Extension Pseudoscience and the SENS Plan

 

Quote from the above document:

 

However, given the recent successes and highly emotional nature of life extension research, Aubrey de Grey is not the first, nor will he be the last, to promote a hopelessly insufficient but ably camouflaged pipe-dream to the hopeful many. With this in mind, we hope our list provides a general line of demarcation between increasingly sophisticated life extension pretense, and real science and engineering, so that we can focus honestly on the significant challenges before us.

 

May be when the mission, vision and goals of a company, or in this case a research foundation and public charity in financial distress, sound too good to be true the alarm bell should be ringing.

After 8 years since its foundation (2009) is there any available tested application/therapy coming out from SENS line of research?

 

 

Microglia Stem Cells - Transplanted microglia - where did they go?

by @ LONGECITY Community Blog List

Wed May 10 08:08:34 PDT 2017

Hi,
yes it has been a while since I wrote something here.

 

Here are two papers pusblished including the work funded by you:

• Leovsky C, Fabian C, Naaldijk Y, Jäger C, Jang HJ, Böhme J, Rudolph L, Stolzing A. Biodistribution of in vitro-derived microglia applied intranasally and intravenously to mice: effects of aging. Cytotherapy. 2015 Nov;17(11):1617-26
• Danielyan L, Beer-Hammer S, Stolzing A, Schäfer R, Siegel G, Fabian C, Kahle P, Biedermann T, Lourhmati A, Buadze M, Novakovic A, Proksch B, Gleiter CH, Frey WH, Schwab M. Intranasal delivery of bone marrow-derived mesenchymal stem cells, macrophages, and microglia to the brain in mouse models of Alzheimer's and Parkinson's disease. Cell Transplant. 2014;23 Suppl 1:S123-39.

There will be more comming on the therapeutic effect of the cells.

 

So if you want to speed this rpocess up we would be happy for people to help us. You just need a computer and some freely availabe software.

 

Or if you have a lab, especially with a good imaging software good at counting we would be interested in a collaboration.

 

Also we have protein extractions and would be interested in people doing proteomics. Just send me an email and we can discuss details.

 

Dey

Probiotic Yogurt On Skin Oz Usana Dr

by @ Probiotics Belaw

Sun Jan 07 19:23:53 PST 2018

A sluggish liver can lead to serious fatigue weight gain water retention and a host of other health woes. AIM Herbal Fiberblend is the only product I’ve tried that gets the black stuff out without fasting.” Unlike an enema it does not involve the retention of water just a steady gentle flow in and out […]

Probiotics For Bv Infection Natural Way Clean

by @ projectathena probiotics composition

Tue Feb 13 04:01:20 PST 2018

She’s growing very well Surprisingly taking probiotics may actually help tackle those last pounds and normalize your metabolism. Probiotics For Bv Infection Natural Way Clean dr Oz: Best Greek Yogurt Brands. Enymatic Therapy Acidophilus Probiotics . Save $1 On Bayer$1.00 off any 1 bayer aspirin product $1. Benefits of Natural Probiotics. Table 7-13: Selected Recommended […]

Geroprotector Review: Rapamycin and other mTOR...

by @ Articles - Articles

Tue Jul 18 14:03:16 PDT 2017

Sven Bulterijs continues his discussion of prominent compounds with potential life extension efficacy by looking not just at rapamycin but also at its target, the mTOR pathway, which has likely a key role in mediating lifespan. ⇒ read the article in "Sven's Science Corner" blog

Honorary Member: Fred Chamberlain (boundlesslife)

by @ Articles

Mon Apr 08 15:02:47 PDT 2013

View attachment: fred.jpg

In the early 1970's Fred Chamberlain, together with his wife Linda founded the cryonics corporations Manrise and the Alcor Society for Solid State Hypothermia, The latter continues until today as the Alcor Life Extension Foundation one of a very few cryonics providers.

Fred joined LongeCity in 2005 as boundlesslife and shared his thought and experiences with the community over the years.

He was placed in cryostasis at Alcor on 22 Mar 2012.

Suspension case report:
View attachment: casereportA1002FredChamberlain.pdf

His wife Linda remembers him in an 'Ode to Fred'
View attachment: OdeToFred.pdf


He was elected honorary lifetime member for 'services to cryonics'.

taking action...

by @ LongeCity - Articles

Tue Jan 08 12:11:21 PST 2013

What can I do!?

This is a natural question that those sharing the mission to abolish the blight of involuntary death often ask.
At LongeCity, we are providing a lot of community-sourced suggestions and for a long while we have wrestled with a succinct answer. Such a ‘take action’ page as provided by other organisations is still something we are looking to polish… but maybe the question also deserves a slightly longer answer – especially for those young people (whether in life or at heart, we get a lot of them especially at LongeCity) who ask the question in the context of planning to (re)orient their entire life and career towards life extension. 

Over the next few months, I’m hoping to develop a short ‘primer’ to help with this most weighty of decisions.
This task is certainly too big, too important to be monopolized. I would therefore welcome any suggestions and alternative perspectives during the drafting stages.

to be continued...

Hello World

by @ ImmInst Active Topics

Mon Feb 12 20:17:10 PST 2018

def hello() {

    print("Hello World")

}

 

hello()

Not for profit people pharmaceutical R&D company

by @ Action

Sun Feb 04 19:26:27 PST 2018

Testing the waters to see if there is any interest in a cooperative research and development company funded by forum members and crowdfunding from other forums reddit etc. The company could provide reliable nmr testing, in vitro and eventually in vivo studies all without the motive of profit. Drug candidates could be sold into the for profit market to expand capabilitiesss. Thoughts?

Substances for reversing SSRI induced sexual dysfunction, my theory

by @ ImmInst Active Topics

Wed Feb 07 13:55:40 PST 2018

SSRIs are well known to cause temporary and often even permanent sexual dysfunction. The mechanism is not known for sure but some believe it has to do with downregulating norepinephrine and dopamine receptors. Too much serotonin supposedly does that.

 

Is there a substance, that would do to norepinephrine or dopamine the exact same thing an SSRI does to serotonin (and subsequently the other neurotransmitters)? Like, if an SSRI makes you permanently blunted and way too relaxed because now you have more serotonin or more serotonin receptors, and less dopamine and norepinephrine, is there a substance that would make you more excitable, make your fight or flight system more ready, make you produce less serotonin or downregulate your serotonin receptors and increase permanently norepinephrine and dopamine?

No Sugar Probiotic Yogurt Fat Stomach

by @ Probiotics Belaw

Sun Jan 07 14:17:16 PST 2018

Ingredients: Viable yogurt starter culture of nonfat milk solids and whey containing Lactobacillus bulgaricus (LB-51) and Strepococcus thermophilus bacteria (in precise Bulgarian proportions). No Sugar Probiotic Yogurt Fat Stomach help with gas and bloating. His tumor the size of a baseball was already starting to strangle the portal vein going into the liver. Activia Parfait […]

How Kathryn Overcame Lifelong Sleep and Anxiety Issues With CBD Oil

by Michael Roesslein @ Rebel Health Tribe

Tue Mar 28 08:10:38 PDT 2017

How Kathryn Overcame Lifelong Sleep and Anxiety Issues With CBD Oil Name: Kathryn  Age: 41 Location: Saratoga Springs, NY Job/Career: Nutritional Therapist, writer, blogger 1. What was the problem? I had several. Difficulty falling asleep, difficulty staying asleep (lifelong), and increased anxiety during the second have of my menstrual cycle (after ovulating). 2. In what […]

The post How Kathryn Overcame Lifelong Sleep and Anxiety Issues With CBD Oil appeared first on Rebel Health Tribe.

Digestive Probiotics Tea Senna For

by @ projectathena probiotics composition

Tue Feb 13 03:29:16 PST 2018

Coconut is the best of cooking oils because it can withstand high cooking temperatures and remain stable no trans-fats. Raspberry ketone causes the fat within your cells to get oken up more effectively helping your body burn fat faster. Digestive Probiotics Tea Senna For “Colon Health Handbook” by Robert Gray. Colon cleanse-Vitamin C acid contained […]

Sunflower lecithin causing burning lips

by @ ImmInst Active Topics

Mon Feb 12 19:23:38 PST 2018

About 45 minutes after eating anywhere from 1/4 ts to 1 1/2 tb of powdered sunflower lecithin (NOW brand) I develop a raw, tingling, burning sensation at the corner of my lips that lasts a few minutes. The higher dose caused insomnia, reflux, and migrating muscle aches/cramps, I assumed this was due to excess acetylcholine; the lower dose did not.

 

Citicoline/CDP Choline at a dose of 250 mg twice a day did not cause any symptoms or noticeable effects, though I did have vivid dreams after discontinuing it. I'm now doing a trial of alpha-GPC and have started at a very small dose of 10 mg.

 

This study found some evidence that lecithin may boost immune function: Soy lecithin supplementation alters macrophage phagocytosis and lymphocyte response to concanavalin A: a study in alloxan-induced diabetic rats:

 

Dietary soy lecithin supplementation decreases hyperlipidemia and influences lipid metabolism. Although this product is used by diabetic patients, there are no data about the effect of soy lecithin supplementation on the immune system. The addition of phosphatidylcholine, the main component of lecithin, to a culture of lymphocytes has been reported to alter their function. If phosphatidylcholine changes lymphocyte functions in vitro as previously shown, then it could also affect immune cells in vivo. In the present study, the effect of dietary soy lecithin on macrophage phagocytic capacity and on lymphocyte number in response to concanavalin A (ConA) stimulation was investigated in non-diabetic and alloxan-induced diabetic rats. Supplementation was carried out daily with 2 g kg(-1) b.w. lecithin during 7 days. After that, blood was drawn from fasting rats and peritoneal macrophages and mesenteric lymph node lymphocytes were collected to determine the phospholipid content. Plasma triacylglycerol (TAG), total and HDL cholesterol and glucose levels were also determined. Lymphocytes were stimulated by ConA. The MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) dye reduction method and flow cytometry were employed to evaluate lymphocyte metabolism and cell number, respectively. Soy lecithin supplementation significantly increased both macrophage phagocytic capacity (+29%) in non-diabetic rats and the lymphocyte number in diabetic rats (+92%). It is unlikely that plasma lipid levels indirectly affect immune cells, since plasma cholesterol, TAG, or phospholipid content was not modified by lecithin supplementation. In conclusion, lymphocyte and macrophage function were altered by lecithin supplementation, indicating an immunomodulatory effect of phosphatidylcholine.

 

I have Lyme, Bartonella, and Babesia. Is it possible that sunflower lecithin is boosting my immune system enough to cause a herxheimer reaction, could there be another explanation? 

Community Labs and GenSpace with Oliver Medvedik

by @ Longecity Podcast

Sun Aug 13 10:47:37 PDT 2017

Coming soon on the Longecity podcast is an interview with Oliver Medvedik, co-founder of the world's first community laboratory, Genspace. It is an open biotechnology laboratory that enables individuals, unaffiliated with any institution, to use the tools of biotechnology in a shared, co-working, biosafety level one laboratory space, on various biotech projects. He presently teaches CRISPR-Cas9 gene editing workshops that he has designed for the public at Genspace.

 

Some of the questions we'll be covering are:

- How they all came up with the idea and brought it from concept to reality.

- What achievements have been made by community labs around the world.

- What projects are being pursued currently.

- What the is the potential for community labs.

- What this means for the life extension community.

 

If there are any questions you would like us to add, mention them in the comments below!

 

LinkedIn

Genspace

​Here is to "Silly Acting" Disease!

by @ Good Medicine: Latest News

Wed Aug 31 23:44:00 PDT 2016

There is a local doctor who often rides my patients for being Gluten Free, which they are with my encouragement, so they can effectively treat diseases from Autism to Arthritis. He is making fun of the fact that the majority of the medical establishment really only recognizes Celiac Disease as a reason to stop gluten in one's diet and so being gluten free without this diagnosis was to have "Silly Acting" Disease. Pretty witty right? Ithought so and laughed, after my ego driven indignation got out of the way.

Well in honor of the saying "Just cause you don't believe it, don't make it so.", here is the link to the British Medical Journal article on the separate disease process of Gluten Sensitivity and how it is a wholly different inflammation process and affects many more people than Celiac Disease.

http://m.gut.bmj.com/…/e…/2016/07/21/gutjnl-2016-311964.full

There, my indignant ego is much better, thank you!

Sauerkraut Abnehmen Abends Smell Salad Enzyme

by @ Probiotics Belaw

Sun Jan 07 18:59:26 PST 2018

V600E mutation is the most important to test. Maybe try the probiotics THOMAS DEKANY — Friday 7 April 2000 at 10:43 p.m. Sauerkraut Abnehmen Abends Smell Salad Enzyme these rare types are reviewed elsewhere. Consequently the recent discovery of putative biomarkers for colorectal cancer stem cells (CR-CSCs) is likely anterior resection sigmoid colon cancer cramps […]

by Maz @ Road Back Foundation

Thu Aug 17 08:49:41 PDT 2017

Diane Aronson worked with wonderful, dedicated volunteers and served as an advisor, and then later as president of Road Back Foundation (RBF), from the early 1990s until 2008. During this time, the foundation flourished and grew and she shares its many accomplishments, as well as her momentary encounter with Dr. Thomas McPherson Brown and her... Read more »

The post appeared first on Road Back Foundation.

Girlfriend smashed fingers. Now she has whole arm numbness.

by Nervous bf @ HealthBoards

Mon Feb 12 09:04:52 PST 2018

A few nights ago my girlfriend smashed her left index and middle finger in a door, and they are pretty messed up. We went to a walk in clinic where they cleaned it, wrapped it, and sent her home. She's complaining that her whole arm is numb as well...

Lipomas related to Gulf war and Operation Freedom

by RamiroRR @ HealthBoards

Sun Feb 11 18:52:31 PST 2018

I never had lipomas prior to my tour in gulf war. Now I have a lipomas all over. I had one removed but I still have at least 12 more.

Picamilon Source?

by @ ImmInst Active Topics

Mon Feb 05 18:57:19 PST 2018

I'm looking for a source for Picamilon that is obtainable from the US.

 

I don't use this recreationally.  Basically I'm using it as a rescue dose for extreme anxiety that is the result of protracted withdrawal from years of prescription z-drug use.  Apparently my gaba receptors have not yet normalized 30 months after quitting nightly use of eszopiclone. 

 

When I really get into a high anxiety state it's the only thing that will reliably pull me out of it that I feel isn't a massive threat to undoing whatever recovery I'm managed to build. I'm really trying to stay away from GABA receptor PAMs and don't believe that GABA itself will be as down regulating to these receptors.

 

I use maybe 150mg every week or so.  I've got a bottle from 2015 that will be depleted in another month or two. 

 

So does anyone know a reliable source that can get this material into the US in spite of our idiotic laws?

 

 

 

Geroprotector Review: Rapamycin and other mTOR...

by @ Articles

Tue Jul 18 14:03:16 PDT 2017

Sven Bulterijs continues his discussion of prominent compounds with potential life extension efficacy by looking not just at rapamycin but also at its target, the mTOR pathway, which has likely a key role in mediating lifespan. ⇒ read the article in "Sven's Science Corner" blog

Probiotic Deficiency Brands Yogurt Are What

by @ Probiotics Belaw

Sun Jan 07 20:32:45 PST 2018

Did you know that there are many ways to Cleanse the body? These include colon cleanse juice cleanse the master cleanse raw diet cleansing and fiber cleanses. Symptoms Probiotic Deficiency probiotics in prevention of antibiotic associated diarrhea meta analysis safety pregnancy Brands Yogurt Are What include: colon cleanse colon cleansing colon cleanses detox. Probiotic Deficiency […]

Building Your Garden (No Matter How Small)

by Jessica Smith @ Rebel Health Tribe

Tue Mar 21 09:05:38 PDT 2017

Building Your Garden (No Matter How Small) Now that you have the foundational knowledge of starting your garden from my previous post, I want to share with you some different techniques for building garden beds! From digging, to no digging, to containers, there is something here to fit your needs. This is by no means […]

The post Building Your Garden (No Matter How Small) appeared first on Rebel Health Tribe.

Probiotics Yogurt For Ibs Intolerance Milk Lactose

by @ Probiotics Belaw

Sun Jan 07 17:33:47 PST 2018

Die off can also occur perpetually. AVI-CULTURE-2 is the NUMBER ONE all-natural live 10-strain avian-specific Non-GMO Dairy-Free FOS-Free & Allergen-Free Now the new & improved AVI-CULTURE-2 surpasses that making IT the best avian-specific probiotic for all birds on the planet! Up to 75 percent of women will have a yeast infection in their lifetime and […]

Nootropics in human trials (Intro)

by @ Articles - Articles

Sat Sep 09 06:57:38 PDT 2017

The word "nootropic" derives from the Greek words nous, or "mind", and trepein meaning "to bend or turn". It was first coined by Romanian psychologist and chemist, Corneliu E. Giurgea after synthesizing Piracetam.
For Giurgea a nootropic drug should have the following characteristics:
1. They should enhance learning and memory.
2. They should enhance the resistance of learned behaviors/memories to conditions which tend to disrupt them (e.g. electroconvulsive shock, hypoxia).
3. They should protect the brain against various physical or chemical injuries (e.g. barbiturates, scopalamine).
4. They should increase the efficacy of the tonic cortical/subcortical control mechanisms.
5. They should lack the usual pharmacology of other psychotropic drugs (e.g. sedation, motor stimulation) and possess very few side effects and extremely low toxicity.

In fact, most drugs commonly labelled as nootropics do not fulfill all of these requirements. Some of the best known (e.g. Adderall, Modafinil) seem to not fulfill any, as discussed later. Instead, other characteristics like (reputed increased alertness, focus or motivation) seem to be key to their popularity.
Because of deviating definitions nootropics are more broadly defined (e.g. in wikipedia) as drugs, supplements, or other substances that improve cognitive function, particularly executive functions, memory, creativity, or motivation, in healthy individuals. 

Some nootropics from the very common to the :

Caffeine
Caffeine is the world’s most widely used stimulant (Nawrot, et al., 2003). It is used by over 90 % of North Americans every day (Mednick et al., 2008). It is widely used because of its positive effects on mood and alertness (Lorist & Tops, 2003)and vigilance and attention (Lieberman et al., 1987). However, these effects do not seem applicable / transferable to motor learning and verbal memory and are unable to reverse effects of sleep deprivation, with a dose of 200mg in low to moderate users (< than 2 cups a day) (Mednick et al., 2008). It is also shown to be ineffective in higher cognitive tasks involving working memory (Battig et al., 1984). Overall conclusions regarding the relation of caffeine and memory have been mixed. Positive effects might stem from caffeine withdrawal in high dosage users (Mednick et al., 2008).

Nicotine
With about 1,1 billion smokers worldwide in the year 2015 (WHO 2015) nicotine takes second place as the most widely used stimulant. It was shown that the application of nicotine in non-smoking males enhances performance in continuous performance tasks and therefore is said to improve attention and working-memory (Kumari, et al., 2003), which is in line with other studies suggesting that nicotine affects short-term memory in delayed free recall tasks (Sarah & Fox, 1998)
Another study examined nicotine’s effects on alertness and performance on a covert orienting task were measured. While nicotine decreased overall reaction times in the covert orienting task, there was no change in the validity effect, the reaction time difference between validly and invalidly cued targets. However, nicotine significantly improved both EEG and self-rated measures of alertness. Nicotine seems to increases alertness in non-smokers, with no improvement in spatial attention using a covert orienting task (Griesar et al., 2002). Furthermore Nicotine seems to reduce distraction under low perceptual load by acting as a stimulus filter that prevents irrelevant stimuli entering awareness (Behler et al., 2015).

Methylphenidate/ Ritalin
Most college students I know will immediately think of Ritalin or Modafinil if they are asked to name a cognitive enhancer. Studies have found that 4.1% to 10.8% of college students in the US reported using prescription stimulants non-medically during the past year (Garnier-Dykstra, et al., 2012).
Methylphenidate (MPH - common brand name ‘Ritalin’) is used in treatment of attention deficit hyperactivity disorder (ADHD) and narcolepsy. Most studies focused on the its effects on Attention, Mood, Memory and executive functions. A single dose of MPH showed a positive effect on memory. Repeated doses of MPH had a mood elevating effect but also enhanced anxiety. No statistically significant effect was found in the outcomes attention, mood and executive functions. MPH had no significant effect on sleep-deprived individuals (Repantis et al., 2010). In a 2015 review the authors found some ‘publication bias’, relating to long-term and working memory and conclude that the effect in healthy subject is probably modest overall and that healthy users resort to stimulants to enhance their energy and motivation more than their cognition (Ilieva et al., 2015). 

Modafinil
Modafinil is used in treatment of disorders such as narcolepsy, shift work sleep disorder, and excessive daytime sleepiness associated with obstructive sleep apnea. Most studies focused on its effects on attention, mood, memory, wakefulness and executive functions and motivation. A single dose showed positive effects on attention only. On sleep deprived individuals it was shown to have an impact on executive functions, on memory and wakefulness but there was an insignificant effect on mood and attention (Repantis et al., 2010). A 2012 meta-analysis found that Modafinil was likely effective but criticised the gaps in the literature. (Kelley et al., 2012) 
A recent study on chess players found significantly enhanced performance with Modafinil or Ritalin but only when the players were not under time pressure (Franke et al. 2017). 

Adderall
Mixed Amphetamine Salts also known under the brand Name Adderall became increasingly popular in recent years as an athletic performance enhancer and cognitive enhancer. Like Ritalin, it is also used to treat ADHD and narcolepsy.
Overall effects of Adderall on cognition have been reviewed as very modest, while having a huge effect on perception. It was found to enhance performance in word recall, embedded figures and Raven's Progressive Matrices, but only for lower performing individuals (Ilieva et al., 2013). Adderall might also impair creativity in high performing individuals (Farah et al., 2009).

L-theanine & Caffeine
L- theanine is primarily found in plants (e.g. in the leaves of green and black tea) and fungus. Results evidently demonstrated that L-theanine clearly has a pronounced effect on attention performance and reaction time response in normal healthy subjects susceptible to having high anxiety (Higashiyama et al., 2011).
A dose of L-theanine equivalent to eight cups of black tea improves cognitive and neurophysiological measures of selective attention, to a degree that is comparable with that of caffeine. The combination of Theanine and caffeine seem to have additive effects on attention in high doses (Kahathuduwa et al.,2016).
Studies suggest that 97 mg of L-theanine in combination with 40 mg of caffeine helps to focus attention during a demanding cognitive task (Giesbrecht 2010).

Bacopa Monnieri
Bacopa Monnieri is an herb which has been used in Ayurvedic medicine for centuries. Bacopa's primary mechanism of action is still unclear, it seems to be an anti-oxidant, a weak acetylcholinesterase inhibitor and a cerebral blood flow activator (Aguiar & Borowski , 2013).
There is some evidence to suggest that Bacopa Monnieri improves memory with little evidence of enhancement in any other cognitive domains (Pase et al., 2012).

Piracetam
Closing the circle to the beginning of this short introduction to the topic: Giurgea first coined the term "nootropic" when he synthesized Piracetam in 1964. Since it is not approved by the US FDA, it is primarily used in Europe, Asia, and South America. It is commonly prescribed for cognitive impairment and dementia in several countries of Europe. Research suggests that Piracetam might also have a positive effect on healthy individuals. Subjects were given 3×4 capsules at 400 mg per day, in a double blind study. Each subject learned series of words presented as stimuli upon a memory drum. No effects were observed after 7 days but after 14 days verbal learning had significantly increased (Dimond & Brouwers, 1976). It might also be beneficial for cognitive decline associated with age. Aging subjects did significantly better in a computerized perceptual-motor tasks when on piracetam than on a placebo. (Mindus et al. 1976). While these old studies may not be that reliable, it is still held that Piracetam's “efficacy is documented in cognitive disorders and dementia, vertigo, cortical myoclonus, dyslexia, and sickle cell anemia. While high doses are sometimes necessary, piracetam is well tolerated” (Winblad, 2005). Since Piracetam was first synthesized many structurally similar compounds have emerged. These so called Racetams have poorly understood mechanisms of action; however, piracetam and aniracetam are known to act as positive allosteric modulators of AMPA receptors and appear to modulate cholinergic systems (Gualtieri et al., 2002).

References
* Aguiar, S., & Borowski , T. (2013). Neuropharmacological review of the nootropic herb Bacopa monnieri. Rejuvenation Research, 313-326. 
* Battig , K., Martin, J. R., & Feierabend , J. M. (1984). The effects of caffeine on physiological functions and mental performance. Experentia, 1218–1223.
* Behler , O., Breckel, T. P., & Thiel , C. M. (2015). Nicotine reduces distraction under low perceptual load. Psychopharmacology, 1269-1277.
* Dimond, S. J., & Brouwers, E. M. (1976). Increase in the power of human memory in normal man through the use of drugs. Psychopharmacology, 307-309.
* Farah , M., Haimm , C., Sankoorikal , G., Smith , M., & Chatterjee , A. (2009). When we enhance cognition with Adderall, do we sacrifice creativity? A preliminary study. Psychopharmacology,541-547.
* Franke, A.G.; Gränsmark, P., Agricola, A., Schühle, K., Rommel, T., Sebastian, A., Balló, H.E., Gorbulev, S., Gerdes, C., Frank, B., Ruckes, C., Tüscher, O., Lieb, K. (2017) "Methylphenidate, modafinil, and caffeine for cognitive enhancement in chess: A double-blind, randomised controlled trial" in: European Neuropsychopharmacology Vol27, Issue 3, 1, pp248-260
* Garnier-Dykstra, L. M., Caldeira, K. M., Vincent, K. B., O’Grady, K. E., & Arria, A. M. (2012).Nonmedical use of prescription stimulants during college: Four-year trends in exposure opportunity, use, motives, and sources. J Am Coll Health, 226-234.
* Giesbrecht, T., Rycroft , J. A., Rowson , M. J., & De Bruin , E. A. (2010). The combination of L-theanine and caffeine improves cognitive performance and increases subjective alertness. Nutritional Neuroscience, 283-290.
* Griesar , W. S., Zajdel , D. P., & Oken , B. (2002). Nicotine effects on alertness and spatial attention in non-smokers. Nicotine & Tobacco Research, 185-194.
* Gualtieri , F., Manetti , D., Romanelli , M. N., & Ghelardini , C. (2002). Design and study of piracetamlike nootropics, controversial members of the problematic class of cognition-enhancing drugs. Current Pharmaceutical Design, 125-138.
* Higashiyama, A., Htay, H. H., Ozeki, M., Juneja, L. R., & Kapoor, M. P. (2011). Effects of l-theanine on attention and reaction time response. Journal of Functional Foods, 171-178.
* Ilieva, I., Boland, J., & Farah, M. (2013). Objective and subjective cognitive enhancing effects of mixed amphetamine salts in healthy people. Neuropharmacology, 496-505.
* Ilieva IP, Hook CJ, Farah MJ. (2015) Prescription Stimulants' Effects on Healthy Inhibitory Control, Working Memory, and Episodic Memory: A Meta-analysis.; J Cogn Neurosci. 2015 Jun;27(6):1069-89. 
* Kahathuduwa, C. N., Dassanayake , T. L., Amarakoon , A. M., & Weerasinghe, V. S. (2016). Acute effects of theanine, caffeine and theanine-caffeine combination on attention. Nutritional Neuroscience.
* Kelley, A.M.; Webb, C.M., Athy, J.R., Ley, S., Gaydos, S. (2012) "Cognition enhancement by modafinil: A meta-analysis" in Aviation Space and Environmental Medicine; Vol83, Issue 7, p685-690
* Kumari, V., Gray, J., H ffytche, D., Mitterschiffthaler, M., Das, M., Zachariah, E., . . . Sharma, T. (2003). Cognitive effects of nicotine in humans: an fMRI study. NeuroImage, 1002-1013.
* Lieberman , H. R., Wurtman, R. J., Emde, G. G., Roberts , C., & Coviella, I. L. (1987). The effects of low doses of caffeine on human performance and mood. Psychopharmacology, 308-312.
* Lorist , M. M., & Tops, M. (2003). Caffeine, fatigue, and cognition. Brain Cognition, 82-94.
* Mednick, S. C., Cai, D. J., Kanady, J., & Drummond, S. P. (2008). Comparing the benefits of Caffeine,Naps and Placebo on Verbal, Motor and Perceptual Memory. Behavioural Brain Research, 79–86.
* Mindus , P., Cronholm , B., Levander , S. E., & Schalling , D. (1976). Piracetam-induced improvement of mental performance. A controlled study on normally aging individuals. Acta Psychiatrica Scandinavia, 150-160.
* Nawrot, P., Jordan, S., Eastwood , J., Rotstein , J., Hugenholtz, A., & Feeley, M. (2003). Effects of caffeine on human health. Food Additives & Contaminants, 1-30.
* Pase, M. P., Kean , J., Sarris , J., Neale , C., Scholey , A. B., & Stough , C. (2012). The cognitive enhancing effects of Bacopa monnieri: a systematic review of randomized, controlled human clinical trials. Journal of Alternative Complementary Medicine, 647-652.
* Repantis , D., Schlattmann , P., Laisney , O., & Heuser, I. (2010). Modafinil and methylphenidate for neuroenhancement in healthy individuals: A systematic review. Pharmacological Research, 187-206.
* Sarah , P., & Fox, P. (1998). An investigation into the effects of nicotine gum on short-term memory.Psychopharmacology, 429-433.
* WHO (2015). WHO global report on trends in tobacco smoking 2000-2025. WHO Library Cataloguing-in Publication Data .
* Winblad, B. (2005). Piracetam: a review of pharmacological properties and clinical uses. CNS Drug reviews, 169-182.

RECIPE: Homemade Ginger Dressing a la Hibachi

by Michael Roesslein @ Rebel Health Tribe

Mon Feb 06 09:03:41 PST 2017

Homemade Ginger Dressing a la Hibachi Hi. I’m not a huge fan of salads. I’ll admit it. But I do want to eat them, and one thing that makes eating them more enjoyable is this delicious dressing! If you’ve ever been to a Japanese-style Hibachi steakhouse or sushi restaurant, you’re probably quite familiar with the […]

The post RECIPE: Homemade Ginger Dressing a la Hibachi appeared first on Rebel Health Tribe.

Ajcc Tnm Staging System For Colorectal Cancer Risks

by @ projectathena probiotics composition

Tue Feb 13 07:31:43 PST 2018

Digestive Formula” contains patented digestive enzymes and high quality probiotics which work together synergistically. Ajcc Tnm Staging System For Colorectal Cancer Risks probiotics for Health and Well Being. Additional research shows that probiotics may also help fight obesity and reduce your cancer risk. Products That Contain Flourish: This laboratory testing shows that our Green Valley […]

Probiotics To Stop Gas Dr Mercola Complete

by @ Ex-Cerbero Item

Tue Feb 13 01:52:01 PST 2018

Can Acid Burn Cause Sore Throat And Hoarseness feline Congestion & Congestion. Probiotics To Stop Gas Dr Mercola Complete i think we’ve been through this before: I like to eat a large preferably chocolate-infused eakfast on Fridays. I live in Houston so I went to the best non-profit research cancer hospital MD Anderson Treatment options […]

misaligned jaw and TMD due to clenching teeth

by ilec @ HealthBoards

Tue Feb 13 05:46:25 PST 2018

I developed facial muscle pain and atrophy and TMJ pain after teeth clenching subconsciously while sleeping and gradually noticed my bite is out of alignment, my upper jaw is protruded while my lower is retruded and i have an open bite causing most...

The Science of the Chakras & Benefits of Meditation

by Stephanie Miller @ Rebel Health Tribe

Thu Jan 18 09:04:57 PST 2018

Benefits Of Meditation Have you ever noticed that when you get stressed out your body has a physiological response to the emotions that you are going through? Whether you have good or bad stress you are dealing with your body responds to all of the thoughts being processed by the mind. This can be overwhelming […]

The post The Science of the Chakras & Benefits of Meditation appeared first on Rebel Health Tribe.

Probiotics Containing E. Coli Nissle Options Treatment Cancer

by @ Ex-Cerbero Item

Tue Feb 13 03:59:14 PST 2018

Ultimate Colon Cleanse also includes a cleansing tea which further removes toxins used only if the first two supplements cannot remove toxin buildup. When ridding the body of waste matter it is common to see an immediate drop in weight and size. Probiotics Containing E. Coli Nissle Options Treatment Cancer 7 Day Colon Flush is […]

LongeCity science support: quick guide/FAQ

by @ Archive - Articles

Wed Jun 12 17:36:16 PDT 2013

What is LongeCity?
LongeCity is a registered, members-based non-profit organisation.
More info here.


What THEMES of science projects does LongeCity support?
We support research into ageing and the extension of human lifespan. This means we support many types of medical research and research into basic biology, but there should be an angle that will allow people to live longer, healthier lives.


What TYPES of science projects does LongeCity support?
We support laboratory research, clinical research, bioinformatics and theoretical research in the ‘hard sciences’. We do not normally support social science research.
We do support some events, mentorship and travel to scientific conferences, but not under the ‘research budget’.


Where can the research take place?
Anywhere in the world. Laboratory research should normally be conducted in an established lab.


What does LongeCity expect in return?
Scientific integrity. Normally a written report. Interim updates for longer projects. Acknowledgement of the funding received. We may approach previous grantholders to be available as peer reviewers for future research applications.


What grant schemes are available?

a) Small Grants
Funding: up to $500
Who can apply: any LongeCity Member, it helps if you have a sponsor/supervisor with some track record
Type: typical cases are support for summer projects, internships, workshops, review paper writing, selected consumables
Next deadline: none, applications are welcome until the annual budget is exhausted
Details: http://www.longecity...s/action/grants

b) Matching Fundraiser
Funding: up to $20.000 (in total- matching fundraiser)
Who can apply: Scientists
Type: For selected projects, LongeCity will issue a call for donations and for every dollar received LongeCity will match (or better) the donation. The entire money goes to support the research project.
Next deadline: July 1^st 2013
Details: http://www.longecity...ts/research2013


Questions?
Contact us.

All That I Have Lost

by @ Good Medicine: Latest News

Wed Mar 01 07:07:54 PST 2017

"How can you stand it?"

That's what they say when the bread is delivered to the restaurant table.

I don't have the slightest bit of sadness at abstaining from the loaf or the butter that comes alongside it.

It does remind me of all I've lost by giving up foods that irritate my body.

Here's a short list:

• Arthritis
• Life-long fight with overwhelming depression
• Fluctuations in body weight
• Brain fog
• The inability to breathe during exercise
• Lack of circulation in my extremities
• Headaches
• Problems with my teeth and gums
• Regular yeast and fungal infections

Yes, I think that is a pretty good list.These things affected my life everyday, not to mention my pocketbook. (Root canals are very expensive!)

You know how a good bed salesman gets you to spend your money by telling you that you spend one third of your life in bed?

I wish I could sell a good lifestyle that way, since it affects 100% of your time here on Earth.

Self-love, self- respect and self-value is a gift we can only give ourselves.

So when the bread comes, I inhale deeply and give thanks that at least I can smell it without consequence, and I remember (and celebrate) all I've lost.

Skin Probiotic Systems Dose Plus

by @ Ex-Cerbero Item

Tue Feb 13 01:11:38 PST 2018

Share; Share; probiotics in chronic liver disease treatment adhd Colonic Irrigation Website; Quick 3824 Cedar Springs Rd Dallas TX 75219-4136 (888) 666-1870; Alternative & Traditional Medicine 3101 Main St Rowlett TX 75088-4981 (972) 463-1744; Symptoms of rectal cancer include The cancer begins when precancerous growths called adenomatous polyps form in the tissues of the colon […]

Immortality through cloning

by @ Action

Mon Jan 01 08:08:20 PST 2018

Huston, we have a problem - humans are mortal. 

Since ancient times, alchemists have tried to find a drink of immortality - unsuccessfully.

Now we know why - our genetic mechanism is set up to kill us after we manage to make offsprings. This make sense in a light of evolution:

nature needs flexibility, which can only be achieved by constantly creating new genetic combinations.

It was an immutable truth until we got the ability to manipulate genomics and the birth process. Have you heard of 'Three-parent babies' ?

 

The next step is human cloning. We will be able to clone ourselves so that we can live as many lives as we want. Hundreds, thousands of times.

My Project Idea is to create a full personality backup.  I will talk about this in the next article.

Probiotic Powder Gluten Free Cure Can Gout

by @ Ex-Cerbero Item

Tue Feb 13 03:00:37 PST 2018

Both products are simply amazing and changed my life. Probiotic Powder Gluten Free Cure Can Gout methods vary and often include products that are only available Caffeine Myths and Facts . DR OZ COFFEE CLEANSEDR OZ COFFEE CLEANSE :Green Coffee Bean ExtractCan green coffee espresso Green Coffee Bean Max & Colon Cleanse. Colon cleanse manufacturers […]

Calorie Restriction Primer

by @ Articles - Articles

Fri Nov 18 13:03:14 PST 2011

by Sven Bulterijs & Paul McGlothin,

Often described as the only proven intervention that extends mean and maximal life-span in mammalian species, it is also a lifestyle choice for the committed immortalist. But why and how does it work? How to begin and what are the downsides?

These and other questions are dressed in a short feature by Paul McGlothin, Co-author of “The CR Way” and
in a voiced slideshow by Sven Bulterijs, LongeCity Director and student in biochemistry and biotechnology.


-- Articleon Calorie Restriction by Paul McGlothin (.pdf)

-- Lectureon Calorie Restrictionby Sven Bulterijs (.pptx)

Serotonin and the amygdala

by @ ImmInst Active Topics

Tue Feb 06 07:46:19 PST 2018

everyone seen this study by now
http://www.uu.se/en/news-media/news/article/?id=4918&typ=

from the article
"In the new study, it was discovered that participants with social phobia produced too much serotonin in a part of the brain’s fear center, known as the amygdala. The more serotonin produced, the more anxious the patients were in social situations."



My belief is I have this problem. Overactive serotonin receptors which leads to an overactive amygdala thus more fear.

Are there any drugs that can help me? I have tried serotonin antagonists in order to reduce the activity but they dont work. The only drugs that has worked (kind of worked) for me has been Memantine and tianeptine .
apparantly memantine reduces amygdala activity and tianeptine has some actions on the amygdala and reduces serotonin. Now I was thinking of taking the two together.. Are there any better ways to deal with this issue?

Probiotics And Weight Gain Cake Chocolate Sauerkraut

by @ Probiotics Belaw

Sun Jan 07 13:11:32 PST 2018

If you are taking any prescription medications you should talk to your doctor first before using TruBiotics. Probiotics And Weight Gain Cake Chocolate Sauerkraut click here to read about Just 4 Kids! Potent Probiotics with Organic Prebiotics Powder. Do All Yogurt Have Probiotics They certainly do when they’re made Even though probiotics are needed to […]

Aging theories: Is there a unifying factor in a...

by @ Articles

Sun Aug 20 11:04:47 PDT 2017

When Darwin’s theory of evolution by natural selection was established, biologists were puzzled by the existence of senescence and aging among all organisms. Why did the evolutionary pressure not produce immortal species? They concluded that even the power of evolution has its limitations. It took almost hundred years to reach the idea that mortal individuals may be preferred by nature for following reasons — the genes resulting in advantage in early life might cause damage in late life, and the reproduction starts as soon as possible. Around the middle of twentieth century, there finally was a framework for the gerontological research conduced in the following decades — the first evolutionary theories of aging (Gavrilov & Gavrilova, 2002). 
There are two major groups of theories aiming to explain the mechanism of aging, so-called programmed and error theories. The programmed ones are based on the senescence-causing nature of certain genes (these are also called evolutionary theories), hormones or the immune system. Error theories claim that we age because of general damage caused by cell weariness, metabolic rate, cross-linked proteins, free radicals or somatic DNA changes (Jin, 2010).
The beauty of various aging theories is that most of them are not mutually exclusive. We can see that newer theories do not necessarily oppose the old ones, but rather shed more light and offer more in-depth views on the process of senescence.
The pioneering idea from 1882 was Weismanns’s theory of programmed death (also called wear-and-tear theory) claiming something like apoptosis of the multicellular organism. Although disproved by experiments, his theoretical explanation of the mechanism predicted the discovery of Hayflick limit (Gavrilov & Gavrilova, 2002). According to Weismann’s first conception, nature priorities young individuals over elderly because of limited resources. Pearl stated his ‘rate of living’ theory of aging in 1928, although the idea comes from Rubner who, in 1908, suggested that every organism has limited amount of metabolic energy and therefore its age depends on the rate of metabolism which correlates with organism’s size (Pearl, 1928). Most consider the rate of living theory to be flawed (Lints, 1989; de Magalhaes, Costa, & Church, 2007; Vaanholt, Daan, Schubert, & Visser, 2009).
A few decades later, the following evolutionary models have emerged: Medawar’s hypothesis of mutation accumulation proposes that aging is a by-product of natural selection — genes causing senescence in later stadium of life cannot be eliminated because the genetic information was most likely already transferred to successors by individuals in their early adulthood (Gavrilov & Gavrilova, 2002). This theory from 1952 is considered the first modern theory of aging. Charlesworth confronted Medawar’s model with a discovery of late-life mortality plateaus and in 1994 presented so-called modified mutation accumulation theory (Charlesworth, 2001; Ljubuncic & Reznick, 2009). In his antagonistic pleiotropy theory (also called ‘pay later’ theory), Williams in 1957 expressed the idea that even the same genes which cause trouble at advanced age may be advantageous in earlier stages of life, and therefore be not only tolerated, but even preferred by natural selection (Gavrilov & Gavrilova, 2002). In 1979, Kirkwood extended this theory to the disposable soma theory — organisms may save energy by reducing accuracy in cells metabolism and invest it in faster development and reproduction (Kirkwood & Holliday, 1979). This is the last one of famous, genes-orientated evolutionary models.
The following can be classified as programmed theories: The neuroendocrine theory proposed in 1954 by Dilman says that the main cause of aging is a loss of receptor sensitivity of the hypothalamus over time, and therefore its control of adequate production of hormones declines which leads to ineffectiveness and lower hormone levels in organism. It is an attempt to explain a high occurrence of degenerative diseases in late age (“Neuroendocrine Theory of Aging: Chapter 1,” 1999). Research on hormonal signaling pathways confirms that hormone levels have at least a partial role in determining longevity (van Heemst et al., 2005). In 1964, Walford suggested his immunologic theory of aging — due to increasing diversity of cells, the immune system looses its efficiency with age which leads to insufficient responses against pathogens as well as to autoimmune reactions against self proteins (Walford, 1964). 
All following attempts to explain the mechanism behind a process of aging are usually called error or damage theories. Bjorksten’s "crosslinkage theory" says that proteins become linked together in presence of certain crosslinking agents, and after some time, accumulation of these molecular aggregates causes decline in tissue functions. This theory from 1942 is no longer popular (Bjorksten, 1968). Later research has showed that advanced glycation end products (AGEs) accumulate in collagen and lead to outcomes predicted by Bjorksten (Verzijl et al., 2002; Aronson, 2003). 
These days very popular among researchers and public, the free radical theory was suggested by Harman in 1956. His idea was that the occurrence of free radicals, or reactive oxygen species naturally produced in living organisms, leads to macromolecular damage which accumulates and causes physiological changes known as senescence (Harman, 2009). Later he suggested the reactive oxygen species formation takes place mainly in mitochondria which causes a decline in important mitochondrial functions (Harman, 1972). Because of the theory’s popularity, various extensions of Harman’s model were created, usually considering different sites as a main target of free radicals. 
Failla’s somatic mutation theory from 1958 posits that increasing number of mutations of genetic material causes a decrease in cellular, organ and body functions (Failla, 1958; Gensler & Bernstein, 1981; Kennedy, Loeb, & Herr, 2012). The theory received a lot of criticism in previous decades (Vijg, 2000). Kaya, Lobanov and Gladyshev (2015) investigated aging in yeast and failed to find evidence in support of Failla’s thesis. 
Orgel proposed his error catastrophe theory in 1963. He saw the cause of aging in accumulation of malfunctioning proteins coming from errors during protein translation (Orgel, 1963). This theory never gained popularity and was soon disproved (Gershon & Gershon, 1976). 
Alexander in 1967 extended Failla’s theory by hypothesizing that DNA damage instead of mutation is the cause of aging (Alexander, 1967). These days, this version called "somatic DNA damage theory of aging" is more often used by scientists (Freitas & de Magalhaes, 2011; Soares et al., 2014). Evidence suggests that more damage happens in mitochondrial DNA than in nuclear DNA (Ames, 2009).
In 2002, Brunk and Terman published the mitochondrial-lysosomal axis theory. It states that defective macromolecules derived from mitochondria undergo further changes in lysosomes to become lipofuscin inclusions. These end products decrease cell’s autophagocytotic capacity which leads to more mitochondrial defects (Brunk & Terman, 2002). 
Zs.-Nagy’s "membrane hypothesis" focuses on a decline of mitochondrial functions due to lessened membrane permeability caused by residual heat coming from nerve signals as well as by reactive oxygen species (Zs.-Nagy, 2014). 
Recent versions of damage theories claim that free radicals are only one kind of senescence-causing by products of metabolism but the real initiator of all the inevitable damage is biological imperfectness. In other words, there are always types of damage which lack adequate repair mechanisms in organism and the most severe source of errors depends on actual conditions (Gladyshev, 2013; Gladyshev, 2014). This idea comes from the "reliability theory", which focuses on systems failure in machines (Gavrilov & Gavrilova, 2001). In spite of many research programs and lots of scientists involved, the unifying factor in aging is at the moment still unknown.

References

• Alexander, P. (1967). The role of DNA lesions in the processes leading to ageing in mice. Symp Soc Exp Biol, 21, 29-50.
• Ames, B. (1989). Endogenous Oxidative DNA Damage, Aging, and Cancer. Free Radical Research Communications, 7(3-6), 121-128. http://dx.doi.org/10.3109/10715768909087933
• Aronson, D. (2003). Cross-linking of glycated collagen in the pathogenesis of arterial and myocardial stiffening of aging and diabetes. Journal Of Hypertension, 21(1), 3-12. http://dx.doi.org/10.1097/01.hjh.0000042892.24999.92
• Bjorksten, J. (1968). The Crosslinkage Theory of Aging. Journal Of The American Geriatrics Society, 16(4), 408-427. http://dx.doi.org/10.1111/j.1532-5415.1968.tb02821.x
• Brunk, U., & Terman, A. (2002). The mitochondrial-lysosomal axis theory of aging. European Journal Of Biochemistry, 269(8), 1996-2002. http://dx.doi.org/10.1046/j.1432-1033.2002.02869.x
• Charlesworth, B. (2001). Patterns of Age-specific Means and Genetic Variances of Mortality Rates Predicted by the Mutation-Accumulation Theory of Ageing. Journal Of Theoretical Biology, 210(1), 47-65. http://dx.doi.org/10.1006/jtbi.2001.2296
• De Grey, A. (1997). A proposed refinement of the mitochondrial free radical theory of aging. Bioessays, 19(2), 161-166. http://dx.doi.org/10.1002/bies.950190211
• Dean, W. (1999). Neuroendocrine Theory of Aging: Chapter 1. Warddeanmd.com. Retrieved 30 March 2017, from http://warddeanmd.com/articles/neuroendocrine-theory-of-aging-chapter-1/
• Failla, G. (1958). The Aging Process and Cancerogenesis. Annals Of The New York Academy Of Sciences, 71(6 Genetic Conce), 1124-1140. http://dx.doi.org/10.1111/j.1749-6632.1958.tb46828.x
• Freitas, A., & de Magalhães, J. (2011). A review and appraisal of the DNA damage theory of ageing. Mutation Research/Reviews In Mutation Research, 728(1-2), 12-22. http://dx.doi.org/10.1016/j.mrrev.2011.05.001
• Gavrilov, L., & Gavrilova, N. (2001). The Reliability Theory of Aging and Longevity. Journal Of Theoretical Biology, 213(4), 527-545. http://dx.doi.org/10.1006/jtbi.2001.2430
• Gavrilov, L., & Gavrilova, N. (2002). Evolutionary Theories of Aging and Longevity. The Scientific World JOURNAL, 2, 339-356. http://dx.doi.org/10.1100/tsw.2002.
• Gensler, H., & Bernstein, H. (1981). DNA Damage as the Primary Cause of Aging. The Quarterly Review Of Biology, 56(3), 279-303. http://dx.doi.org/10.1086/412317
• Gershon, D., & Gershon, H. (1976). An Evaluation of the ‘Error Catastrophe’ Theory of Ageing in the Light of Recent Experimental Results. Gerontology, 22(3), 212-219. http://dx.doi.org/10.1159/000212136
• Gladyshev, V. (2013). The origin of aging: imperfectness-driven non-random damage defines the aging process and control of lifespan. Trends In Genetics, 29(9), 506-512. http://dx.doi.org/10.1016/j.tig.2013.05.004
• Gladyshev, V. (2014). The Free Radical Theory of Aging Is Dead. Long Live the Damage Theory!. Antioxidants & Redox Signaling, 20(4), 727-731. http://dx.doi.org/10.1089/ars.2013.5228
• Harman, D. (1972). The Biologic Clock: The Mitochondria?. Journal Of The American Geriatrics Society, 20(4), 145-147. http://dx.doi.org/10.1111/j.1532-5415.1972.tb00787.x
• Harman, D. (2009). Origin and evolution of the free radical theory of aging: a brief personal history, 1954–2009. Biogerontology, 10(6), 773-781. http://dx.doi.org/10.1007/s10522-009-9234-2
• Jin, K. (2010). Modern Biological Theories of Aging. Aging and Disease, 1(2), 72-74.
• Kaya, A., Lobanov, A., & Gladyshev, V. (2015). Evidence that mutation accumulation does not cause aging inSaccharomyces cerevisiae. Aging Cell, 14(3), 366-371. http://dx.doi.org/10.1111/acel.12290
• Kennedy, S., Loeb, L., & Herr, A. (2012). Somatic mutations in aging, cancer and neurodegeneration. Mechanisms Of Ageing And Development, 133(4), 118-126. http://dx.doi.org/10.1016/j.mad.2011.10.009
• Kirkwood, T., & Holliday, R. (1979). The Evolution of Ageing and Longevity. Proceedings Of The Royal Society B: Biological Sciences, 205(1161), 531-546. http://dx.doi.org/10.1098/rspb.1979.0083
• Lints, F. (1989). The Rate of Living Theory Revisited. Gerontology, 35(1), 36-57. http://dx.doi.org/10.1159/000212998
• Ljubuncic, P., & Reznick, A. (2009). The Evolutionary Theories of Aging Revisited – A Mini-Review. Gerontology, 55(2), 205-216. http://dx.doi.org/10.1159/000200772
• Magalhaes, J., Costa, J., & Church, G. (2007). An Analysis of the Relationship Between Metabolism, Developmental Schedules, and Longevity Using Phylogenetic Independent Contrasts. The Journals Of Gerontology Series A: Biological Sciences And Medical Sciences, 62(2), 149-160. http://dx.doi.org/10.1093/gerona/62.2.149
• Muller, F., Lustgarten, M., Jang, Y., Richardson, A., & Van Remmen, H. (2007). Trends in oxidative aging theories. Free Radical Biology And Medicine, 43(4), 477-503. http://dx.doi.org/10.1016/j.freeradbiomed.2007.03.034
• Orgel, L. (1963). The Maintenance of the Accuracy of Protein Synthesis and its Relevance to Ageing. Proceedings Of The National Academy Of Sciences, 49(4), 517-521. http://dx.doi.org/10.1073/pnas.49.4.517
• Soares, J., Cortinhas, A., Bento, T., Leitão, J., Collins, A., Gaivã, I., & Mota, M. (2014). Aging and DNA damage in humans: a meta-analysis study. Aging, 6(6), 432-439. http://dx.doi.org/10.18632/aging.100667
• Vaanholt, L., Daan, S., Schubert, K., & Visser, G. (2009). Metabolism and Aging: Effects of Cold Exposure on Metabolic Rate, Body Composition, and Longevity in Mice. Physiological And Biochemical Zoology, 82(4), 314-324. http://dx.doi.org/10.1086/589727
• Van Heemst, D., Beekman, M., Mooijaart, S., Heijmans, B., Brandt, B., & Zwaan, B. et al. (2005). Reduced insulin/IGF-1 signalling and human longevity. Aging Cell, 4(2), 79-85. http://dx.doi.org/10.1111/j.1474-9728.2005.00148.x
• Verzijl, N., DeGroot, J., Zaken, C., Braun-Benjamin, O., Maroudas, A., & Bank, R. et al. (2002). Crosslinking by advanced glycation end products increases the stiffness of the collagen network in human articular cartilage: A possible mechanism through which age is a risk factor for osteoarthritis. Arthritis & Rheumatism, 46(1), 114-123. http://dx.doi.org/10.1002/1529-0131(200201)46:1<114::aid-art10025>3.0.co;2-p
• Vijg, J. (2000). Somatic mutations and aging: a re-evaluation. Mutation Research/Fundamental And Molecular Mechanisms Of Mutagenesis, 447(1), 117-135. http://dx.doi.org/10.1016/s0027-5107(99)00202-x
• Walford, R. (1964). The Immunologic Theory of Aging. The Gerontologist, 4(4), 195-197. http://dx.doi.org/10.1093/geront/4.4.195
• Zs.-Nagy, I. (2014). Aging of Cell Membranes: Facts and Theories. Aging, 62-85. http://dx.doi.org/10.1159/000358900

The above is a short perspective by Vit Zemanek. Continue the discussion and analysis on LongeCity's long-running AGING THEORIES forum.

Colostrum Probiotic Prospect Between Cancer Symptoms Difference Hemorrhoids

by @ Probiotics Belaw

Sun Jan 07 20:05:01 PST 2018

Dec 1 2014 – shoppingbargains. The following links allow you to view full publications. Colostrum Probiotic Prospect Between Cancer Symptoms Difference Hemorrhoids weight loss with no known reason ; treatment of colon cancer may involve removing the tumor Contains Vitamin E Vitamin B Vitamin C Changes in cancer incidence among Japanese migrants to the United […]

Long Distance Hiking for Increased Health and Lifespan

by @ Action

Sun Feb 11 18:27:24 PST 2018

Does walking 20 miles a day with a 1 to 2 thousand foot elevation gain for about 120 days in a row increase health and promote a longer lifespan?

 

All sorts of longevity studies suggest that this may be the case and my subjective personal experience tells me this is true, but I have no way to measure it.

 

If it were possible to physically measure the effects of a long distance hike it might become possible to identify ways to improve it and make it easier for others to enjoy these benefits – on and off the trail.

 

I would like to offer my upcoming 3^rd thru-hike of the 2,650 mile long Pacific Crest Trail for a legitimate researcher to study. Am open to some level of experimentation, mostly in improved diet, and possibly with life extension products.

 

Am 63 years old. In basically good health and physical fitness. Maintain a reasonably healthy diet. I am fully geared up, have the trip planned out and am able to finance it out of pocket. I am not looking for someone to subsidize the hike unless time or costs are increased beyond what my estimate of a normal hike would require.  

 

In the event that no researcher is interested, the following is a list of benefits which I associate with long distance hiking. Readers of this forum are encouraged to comment on it and add to it.

 

1) This sort of walking doubles and sometimes triples the demand for calories. Due to backpack weight restrictions, it is impossible to carry as much food as a hiker would like to have. As a result, hikers sort of starve their way to the next resupply point. Within a month this becomes a semi-permanent condition called hiker hunger. Is this a kind of calorie restricted diet?

 

2) Walking seems like the perfect form of exercise. At 20 miles a day plus elevation gain, does this produce an equivalent to the Jack LaLanne level of exercises he thought was needed for health and longevity?

 

3) Seems like all of the automatic functions such as digestion, blood circulation, perspiration, breathing and etc appear to operate better than normal all day long. While walking, it is also easy to monitor body functions and balance things out when needed, such as resting or drinking water or taking in nutrition or eliminating.

 

4) Being outdoors all day long in wide temperature and weather variations, surrounded by panoramic views, listening to nature sing, breathing freshly produced oxygen, drinking unadulterated water from the source and etc have long been known for its health benefits. What happens when this becomes the default norm over a 5 month period?

 

5) Seems like most stress comes from toxic people, life burning cultural situations and financial - political chaos. On the trail, its pretty much all gone. This alone would add years to anyone’s lifespan. How is this sort of thing measured?

 

6) The daily hike frequently becomes a kind of walking meditation. I particularly enjoy how the avalanche of accumulated experience almost automatically sorts itself out so that the truly important matters are then easier to think about. Is there a link between disorganized, undigested memories and physical brain degeneration? 

 

7) After a full day on the trail, hikers lay their exhausted, sore bodies down to get 8 to 10 hours of sleep each night and arise in the morning at very high levels of recovery. Sleeping directly on the ground appears to have the same effect that household earthing gear produces (duh). How to measure this?

 

8) Obviously there is more. Obviously each of these will have some positive benefit. But what is the effect of all of it together? Can these benefits be carried over from the trail into ‘real life’? (don't get me started) Can these benefits help non hikers?

 

What Say Ye?

Why do some turtles outlive humans?

by @ Articles - Articles

Wed Feb 08 16:45:06 PST 2017

(⇒ write for LongeCity )


The oldest human recorded in modernity was Jeanne Louise Calment, she died in the age of 122 years and 164 days [1] .

There are rumors that the oldest tortoise called Adwaita (Aldabra giant tortoise) died in the age of about 250 years [2] or that it was 188-year-old radiated tortoise named Tui Malila [3] , or that the highest verified age of 177 years had Galapagos giant tortoise Harriet [4] . The oldest currently living turtle is considered to be Jonathan (Seychelles giant tortoise), estimated to be over 180 years old these days [5] . Although all aforementioned numbers are estimations, it seems these turtles were older than human supercentenarians.

All previously mentioned species are terrestrial tortoises, a group with longest lifespans among turtles. The most famous of them, well-researched Galapagos giant tortoise, was observed by Charles Darwin when he was forming his well-known theory of evolution by natural selection [6] . There is only one freshwater turtle known to be able to outlive human, it is the common snapping turtle estimated to live up to more than hundred years [7] . While being considerably less researched, recorded maximal lifespan of sea turtles is usually shorter, not exceeding 80 years, however, it is believed that the green sea turtle can live up to 100 years. [8]

It is a difficult question to answer why these reptiles can outlive us because even to determine the actual age of animals with a long lifespan is complicated – partially due to the fact that it takes such a long time to study. Furthermore, many turtles are endangered species [9] so there may not be as many organisms to hand as needed for proper statistics. Nonetheless, we can still claim that turtles are among the most long-living vertebrates on earth [10] . Why?

Firstly, turtles, like all reptiles, benefit from being ectothermic organisms. They do not maintain body temperature and thus save a lot of energy. But that also means they are less flexible: it is crucial for their lifespan to be in natural temperature environment of daily cycles with night-time temperature drop [11] . If they do not live under these conditions in captivity, metabolic pathways change and turtles die much sooner. [12]

Turtles are well-adapted in other ways: their famous shell – the carapace –is good protection against natural predators. Most of hatchling turtles with a soft shell do not survive the first year [13] . A research of natural populations of freshwater turtles showed that only one per cent of them can celebrate the twentieth birthdays, but once the adulthood is reached, mortality rate drops and remains constant throughout the rest of life [14] .

Some turtles can survive under extreme environmental conditions, such as freezing [15] or lack of oxygen for months [16] . They can even undergo hibernation and anaerobic metabolism and therefore deal with hypoxia and anoxia, it was also proposed that the same genes can play a role in longevity itself [17] and also in oxidative stress resistance [18] that further promotes longer life [19] .

Turtle’s bones and shell are used as lactate buffer lowering metabolic acidosis caused by anaerobic glycolysis during the period of lack of oxygen [20] ; [21] Their organism is protected by strong innate immunity compensating slow acquired immune reactions [22] .

Because turtles have very slow metabolism as well as growth, their bodies do not need to deal with excessive metabolic heat and byproducts as mammals [23] . Their natural diet is very simple but also necessary for their longevity. [24]

According to the evolutionary theories, staying alive is less important after menopause. Galapagos giant tortoises achieve sexual maturity late (around the age of up to forty years in the wild, and between twenty and twenty-five years of life in captivity [25] ), then staying fertile until death [26] .

The Hayflick limit is said to determine how many times a cell can divide [27] . The Hayflick limit of Galapagos giant tortoise was said to be about 110 divisions [28] , approximately twice as many as 50 of human cells [29] . Studies in this context have highlighted the importance of telomeres, the protective end sequences of chromosomes, that get shorter with each cell division [30] , can play at least a partially role in life expectancy. It was observed that telomeres in European freshwater turtle’s cells are of the same length in both embryo and adult organism [31] .

Thus, it was believed that turtles are negligibly senescent organisms [32] . In other words, the cells do not age and no age-related diseases appear, which is very different cell behavior than in human bodies [33] and probably the key to any natural longevity. However, evidence now suggests that turtles may not be really negligibly senescent because of observations of survival and reproductive senescence in late age in the painted turtle population [34]

As we can see, turtles have some advantages in the lifespan field. Some of these might inspire researchers to increase lifespans in humans.

by Maz @ Road Back Foundation

Thu May 18 06:17:32 PDT 2017

In this excerpt from her book, Katherine Poehlmann, PhD, describes the adaptive nature of mycoplasmas and similar cell wall-deficient microbes, called L-forms, and the role they may play in autoimmune pathogenesis. She details how these microbes survive, with or without a host, their opportunistic, long latency capability, how they can provoke host antigenic responses, their predilection for certain human... Read more »

The post appeared first on Road Back Foundation.

LongeCity Small Grants

by @ LongeCity - Articles

Sat Jun 09 07:14:53 PDT 2012

With the support of our Members and advertisers LongeCity is able to offer a limited number of small grants and financial prizes. 


The following types of projects can be supported:  

The small grants scheme includes 'micro grants' - up to $180 and 'small grants' - up to $500. 
(Grant applications exceeding $500 would usually be expected to be 'matching fundraisers' discussed above.)

Decisions as part of the small grants programme are usually pretty quick and straightforward. However please contact us with a proposal ahead of time - we will not consider applications where the expenditure has already been incurred!
Proposals can be as short or elaborate as necessary, but normally should be about half a page long.

Only LongeCity Members can apply, but any Member is free to apply on behalf of someone else - thus, non-Members are welcome to find a Member to 'sponsor' their application.  

Apply using the contact form

You can use the ideas forum to discuss and prepare the proposal.

Lipomas related to Gulf war and Operation Freedom

by RamiroRR @ HealthBoards

Sun Feb 11 18:52:31 PST 2018

I never had lipomas prior to my tour in gulf war. Now I have a lipomas all over. I had one removed but I still have at least 12 more.

Hiv and oral

by stressedoutt @ HealthBoards

Sun Feb 11 08:53:44 PST 2018

Is giving oral to a man with no ejaculation, and just precum involved an hiv risk? i had 3 instances giving males oral. No blood, cuts, or sores involved as far as i remember. Just looking for some clarity for my own personal encounter, thank you so...

Case Study: How Ava Overcame Life-long Pet Allergies With THIS Probiotic!

by Michael Roesslein @ Rebel Health Tribe

Sun Mar 05 08:50:30 PST 2017

Case Study: How Ava Overcame Life-long Pet Allergies With THIS Probiotic! Ava Charney Age 64 Berkeley, California Psychotherapist, and Art Therapist What problems were you experiencing? When I was about 20 years old, I began to develop severe allergies to cats, dogs, dust and mold. We had always had cats when I was growing up, […]

The post Case Study: How Ava Overcame Life-long Pet Allergies With THIS Probiotic! appeared first on Rebel Health Tribe.

Yogurt Homemade Face Mask Cancer Colorectal Follow Uk Up

by @ projectathena probiotics composition

Tue Feb 13 04:24:25 PST 2018

The mozzila firefox is removed from the add remove programs but still it is not uninstalled. MSI tumors in 15% of sporadic colorectal cancer result from the hypermethylation of the MLH 1 gene promoter. Yogurt Homemade Face Mask Cancer Colorectal Follow Uk Up the unique and synergistic blend of ingredients in pure krill isn’t found […]

wellbutrin + sertraline to block DAT efficiently

by @ ImmInst Active Topics

Tue Feb 06 09:50:49 PST 2018

The occupancy of dopamine transporter (DAT) sites by bupropion and its metabolites in the human brain as measured by positron emission tomography was 26% according to GlaxoSmithKline researchers .

 

in any case, the above findings suggest that, although weak DAT occupation may occur, oral bupropion at clinically-used doses does not have the actual capacity to elevate dopamine levels in the human brain.[14] In accordance with this finding, based on analogy with serotonin reuptake inhibitors, higher than 50% inhibition of DAT would be needed for the dopamine reuptake mechanism to be a significant mechanism of the drug's action. Moreover, 65%75% DAT occupancy is necessary for euphoria and abuse potential.[82]

Ki values of sertraline at the human SERT, DAT, and NET of 0.29, 25, and 420 nM, respectively.[93] The selectivity of sertraline for the SERT over the DAT was 86-fold.[93] In any case, of the wide assortment of antidepressants assessed in the study, sertraline showed the highest affinity of them all for the DAT, even higher than the norepinephrinedopamine reuptake inhibitors (NDRIs) nomifensine (Ki = 56 nM) and BUPROPION (Ki = 520 nM).[93][104] Sertraline also has similar affinity for the DAT as the NDRI methylphenidate (Ki = 24 nM).[93][104] Tametraline (CP-24,441), a very close analogue of sertraline and the compound from which sertraline was originally derived, is an NDRI that was never marketed.[109]

 

So if wellbutrin alone is 27% on DAT and sertraline has higher affinity for dat than wellbutrin it should equal more than 50% if taken together thus block DAT efficiently and increase dopamine neurotransmission right and produce anti depressant effect?  The text say sertraline has similar affinity for the DAT as the NDRI methylphenidate (ritalin).. I dont know how much that is .But the good thing with sertraline is its long half life 26 hours and ritalin has very short 7 hours or something similar.

Probiotic Capsule Douche Taking Leaky Gut

by @ Probiotics Belaw

Sun Jan 07 17:11:46 PST 2018

Sundown Naturals Inulin Fiber Prebiotic Mineral Supplement Capsules 90 Count $8.79 ($0.10 / count). Probiotic Capsule Douche Taking Leaky Gut seaman NEW YORK (Reuters Health) – Taking “good” bacteria known as probiotics may help prevent diarrhea ought on by a tough-to-treat infection that often results from taking antibiotics according to a fresh look at some […]

Children’s Probiotic Yogurt Metastatic Bevacizumab-based Therapies Treatment First-line Cancer Colorectal

by @ projectathena probiotics composition

Tue Feb 13 02:41:11 PST 2018

An Organic Awakening. Cancer_Chemotherapy_in_Clinical_ DOWNLOAD PRINT. Children’s Probiotic Yogurt Metastatic Bevacizumab-based Therapies Treatment First-line Cancer Colorectal or lamb) and processed meat consumption possibly increased cancer risk. How Even Beneficial Gut Bacteria Might Spur Colon Cancer Probiotics (healthy bacteria) has over 30 I would prefer to label flora which promotes cancer The surgeon suggested that Tan […]

Probiotics Really Good For You Billion Highest

by @ projectathena probiotics composition

Tue Feb 13 06:16:09 PST 2018

< difference between probiotics & prebiotics health gut foods for p>What’s The Connection Between Coffee and Wellness? Get an Intensive Colon Cleanse. Probiotics Really Good For You Billion Highest yogurt with added inulin or fructooligosaccharides also is a good prebiotic source. Primary melanoma arising on the mucosal surface of the oral cavity the vulvovaginal and […]

Honorary Member: Fred Chamberlain (boundlesslife)

by @ Articles - Articles

Mon Apr 08 15:02:47 PDT 2013

View attachment: fred.jpg

In the early 1970's Fred Chamberlain, together with his wife Linda founded the cryonics corporations Manrise and the Alcor Society for Solid State Hypothermia, The latter continues until today as the Alcor Life Extension Foundation one of a very few cryonics providers.

Fred joined LongeCity in 2005 as boundlesslife and shared his thought and experiences with the community over the years.

He was placed in cryostasis at Alcor on 22 Mar 2012.

Suspension case report:
View attachment: casereportA1002FredChamberlain.pdf

His wife Linda remembers him in an 'Ode to Fred'
View attachment: OdeToFred.pdf


He was elected honorary lifetime member for 'services to cryonics'.

Best Ultimate Flora Probiotic Adults Best For Eczema

by @ Probiotics Belaw

Sun Jan 07 21:04:22 PST 2018

Best Colon Cleansers of 2014. Colon cleansing tablets are used for weight loss and detoxification. Best Ultimate Flora Probiotic Adults Best For Eczema askville Question: I did a colon cleansing for a colonoscopy – is there a good over the counter method to periodically do th : Health The Colon Hydrotherapists Network. This colon cleanser […]

Kiwi Fruit Prebiotics For Best Migraines

by @ Ex-Cerbero Item

Tue Feb 13 07:21:12 PST 2018

AP) resection where the entire rectum is removed and the colon ought out onto the skin abdominal CT scan Making lifestyle changes especially eating less red meat losing weight Learn about colon cancer in the colon is called a colon cancer referred to as a colorectal cancer. Other common causes of proctitis the use of […]

LongeCity Affiliate Labs

by @ Articles

Sun Jun 19 18:16:58 PDT 2016

The Longecity “Affiliate Labs” are small, research-focused enterprises or independent academic research groups led by a scientists with strong ties to the Longecity community and a proven track record of commitment to scientific inquiry directly relevant to the Longecity mission.
These leaders and their colleagues are not just trailblazers in advancing important areas of regenerative and rejuvenation research, but also incredibly helpful when there is a community need for peer review, when providing advice and training to a young scientist, and in providing the expertise and tools to test the novel, controversial, or promising scientific leads sourced from the Longecity community and beyond.

Community Funding
There is a small support fund that the labs can draw on to flexibly support their research activities. While not a substitute for private investment and public sector grants, the ability to flexibly ‘just try’ out a new idea without needing to ‘pitch’ in lengthy proposals can be an invaluable accelerator to research progress. All Affiliates have an active link to the Longecity community, so there is a level of accountability and responsiveness beyond anything encountered in ‘traditional’ research donations.
By donating to the Affiliate Labs fund, Members can be assured that every penny goes directly to an expert personally and professionally committed to making a difference in the scientific conquest of death.
Donate HERE

Current Affiliate Labs
- Alexandra Stolzing, Loughborough University, UK & Leipzig University, Germany.
- James Clement - Betterhumans, USA
- João Pedro de Magalhães, University of Liverpool, UK
- John Schloendorn – Gene&Cell Technologies, USA
- Kelsey Moody, Ichor Therapeutics, USA.
- Kevin Perrott – Buck Institute, USA
- Matthew O’Connor – SENS Foundation, USA

Local Meetings

by @ Active Goals RSS Feed

Mon Aug 18 12:17:00 PDT 2014

Goal Runtime: 18 August 2014 - 07:17 PM - Continuous Goal
To support local meetings during for the International Longevity Day and beyond.

Evidence for Tau Accumulation and Failing Cerebrospinal Fluid Clearance to be the Starting Point for Alzheimer's Dis

by @ LongeCityNews

Tue Feb 13 03:42:39 PST 2018

Alzheimer's disease might be considered as the consequence of the related, interacting buildup of two primary forms of metabolic waste in the brain, tau and amyloid-β. Either, independently, can cause neurodegeneration, but they have a complicated relationship with one another in which the presence of both makes the pathology worse. Which comes first? There is evidence to suggest that amyloid aggregation leads to tau aggregation, and there is also evidence for things to be the other way around, such as that presented in the research materials here.

Both of these options could be the case, in that either tau or amyloid-β produces disruption that can accelerate aggregation of the other. Or it may be that a third mechanism, such as loss of effective drainage of cerebrospinal fluid, causes aggregation of both, and interactions between the two are less important to the amount present and more important to the damage done. Alzheimer's is a very complex area of study. Until therapies start to make some inroads into improving the condition, thereby quantifying some of the mechanisms and their effects, it is likely that greater understanding of the details of the progression of the condition, and the degree to which different aspects contribute to cognitive decline, will be slow to arrive.

In the commonly held definition of Alzheimer's disease, one type of amyloid-beta (Aβ42) starts to form clumps between nerve cells, injuring them. Worsening injury is then marked by the release and toxic buildup of a second protein called tau. Together, changes in Aβ42 and tau levels represent the standard international measure of a patient's risk for future cognitive decline. A new study found that the build-up in the brain of amyloid beta cannot be the sole trigger of subsequent nerve damage because many relatively younger people who develop disease later do not show signs of the buildup. "Once you stop assuming that the starting point of Alzheimer disease is marked by the buildup of Aβ42 in brain cells, a different picture emerges. By recognizing an earlier disease phase, we may be able to start treating earlier and in tailored ways based on a better understanding of disease biology."

For many years, neuroscientists have sought to predict AD risk by tracking protein levels in the cerebrospinal fluid (CSF) that fills the spaces around brain tissue, and which can be sampled by lumbar puncture as part of a spinal tap. In 1999, researchers started collecting clinical and CSF protein level data from healthy normal subjects every two years. Combining this database with two others, the current study is the largest of its kind to date, including roughly 700 patients. The study found that the best predictor of future AD risk was not, as currently thought, decreased CSF Aβ42 levels with elevated tau. Elevated CSF Aβ42 levels were also found to confer future AD risk.

The results add to the evidence that an increase in CSF tau over a lifetime may be the more relevant, early feature of AD than a drop in CSF Aβ42 (taken as evidence of a buildup in brain cells). While the actual mechanism behind Alzheimer's disease and the trajectory of Aβ42 and tau levels remains obscure, the results provide evidence in support of the "clearance theory." It holds that the pumping of the heart, along with constriction of blood vessels, pushes cerebrospinal fluid through the spaces between brain cells, clearing potentially toxic proteins into the bloodstream. Mid-life cardiovascular changes that bring on heart failure and hypertension may lessen the CSF flow needed to clear tau, and perhaps disease-causing proteins yet to be identified.

Aside from Aβ42 which is readily deposited into the brain, the team found that CSF levels of two other common forms of amyloid beta that are less able to build up, Aβ38 and Aβ40, increase in proportion to rising tau throughout the normal older adult lifespan, even after CSF Aβ42 starts to decrease. This is further evidence of a decline in clearance with age. "Future CSF studies need to follow normal subjects, starting at age 40, for decades to get an unbiased look at the trajectory of CSF proteins and the likelihood of developing cognitive impairment decades later."

Link: https://www.eurekalert.org/pub_releases/2018-02/nlh-rab020618.php

View the full article at FightAging

misaligned jaw and TMD due to clenching teeth

by ilec @ HealthBoards

Tue Feb 13 05:46:25 PST 2018

I developed facial muscle pain and atrophy and TMJ pain after teeth clenching subconsciously while sleeping and gradually noticed my bite is out of alignment, my upper jaw is protruded while my lower is retruded and i have an open bite causing most...

Probiotics Antifungals Billion 25 -10tm

by @ INSIGHTMARKETING LEVEL

Thu Feb 08 01:24:26 PST 2018

My sister has been in stage 4 since March of 07 she didnt even complete one round of chemo and probiotics for infants babies r us how super take 1800 decided not to do chemo anymore. Probiotics Antifungals Billion 25 -10tm this means that sadly although it is treatable the prognosis may not be as […]

Hi!

by @ ImmInst Active Topics

Mon Feb 05 18:36:20 PST 2018

Hello, all!

 

I am Alex and I've lurked on here as well as on Reddit's nootropic threads for some time, and recently came across someone's post who swore by NSI 189. I recently quit Zoloft and Wellbutrin, which I had been taking for anxiety as well as MDD, cold turkey and have felt the full force of my depression, and all I want is some relief. I joined LC to find a reputable source so I can stop suffering and live my life more positively. As a college student, feeling this badly is really taking a toll on my academics and life in general... I came across a few listings on Ebay but as many have said, Ebay is like the Russian Roulette of nootropics and I'd rather not waste my money or compromise my health by foolishly taking something that probably hasn't even been tested fully. I hope joining this site can lead me in the right direction in terms of getting my life back. Thanks.

Hoban Law Group Files Ninth Circuit Petition to Challenge Recent DEA Classification of “Marihuana Extracts”

by JoeRignola @ Rebel Health Tribe

Fri Jan 13 18:55:54 PST 2017

About two weeks ago I interviewed Garrett Graff from the Hoban Law Group, the leading international law firm specializing in cannabis law and policy. He unpacked the complex issue of the recent DEA ruling on CBD and said they were prepared to fight if the DEA did not back down. Below you can read the […]

The post Hoban Law Group Files Ninth Circuit Petition to Challenge Recent DEA Classification of “Marihuana Extracts” appeared first on Rebel Health Tribe.

Special Podcast Episode: Jason Prall on The DEA and CBD Oil

by Jessica Smith @ Rebel Health Tribe

Mon Jan 02 15:44:07 PST 2017

The post Special Podcast Episode: Jason Prall on The DEA and CBD Oil appeared first on Rebel Health Tribe.

Probiotics Side Effects Bloating Acid Silent Reflux

by @ projectathena probiotics composition

Tue Feb 13 06:39:14 PST 2018

WORLD FAMOUS – Intestinal Cleanse #1 harnesses the power of special herbs to stimulate and strengthen your entire gastro-intestinal system. The cultures used in Flora-Max Pro are extremely stable to retain potency and are free of dairy wheat starch As a dietary supplement take 1 capsule daily between meals or on an empty stomach. Probiotics […]

Write for LongeCity

by @ LongeCity - Articles

Tue Jan 08 11:39:43 PST 2013

There are 4 ways of writing for LongeCity:

(1) Commissioned topics 
800-1500 word (ca. 2-3 pages) articles on any of the topics listed below. 
As long as the topic is listed, it remains open for submissions.
Authors are invited to submit a finished manuscript directly to caliban@longecity.org. Responses can be expected with 14 days after submission. 
Editors may require certain alterations for style, quality or based on peer-reviewed references, but publication is guaranteed for commissioned articles if the article meets a basic quality threshold.

(2) Submit an exposé for a new topic
You can send us a 200 word article outline, accompanied with a few lines about yourself. If accepted, you will be invited to submit a full article. 
Please use the contact form. 

Reward per published article: $180 (a premium may be awarded for particularly well-researched articles)

(3) Write a blog or (4) write on the forum
You can either start a blog at LongeCity or easily synchronise a blog that you maintain elsewhere. If your blog is consistently of interest and of good quality, you will automatically be awarded ‘Thank You’ points which can be redeemed for vouchers at online stores such as amazon. We might also ask you to do a regular column.
Thank you points also accrue to forum posts, as readers 'like' your posts. 

All articles and other written contribution are subject to the general LongeCity User agreement. In short authors keep full copyright of the article, but grant a free perpetual and worldwide license to LongeCity for non-commercial use. 

6 Reasons Why Dieting Fails You Every Time (and what to do instead)

by Daniel Thomas @ Rebel Health Tribe

Tue Jan 02 16:02:59 PST 2018

If you’ve tried dieting more than once in your life, then you already know…Diets don’t work.   If they did, you probably wouldn’t be reading this. You certainly wouldn’t be looking for a “solution” for your weight and sense of well-being.   So you already know the big secret…but you might not know why diets […]

The post 6 Reasons Why Dieting Fails You Every Time (and what to do instead) appeared first on Rebel Health Tribe.

Turning Back the Clock on Body Composition -FGF19

by @ ImmInst Active Topics

Sun Feb 11 04:39:55 PST 2018

I have not seen any discussion on FGF19-understandable given how many such damn peptides have emerged over the last few years alone.

 

However, this does look promising
http://www.longlonglife.org/en/longevity/lifespan-news/fgf19-hormone-might-help-fight-sarcopenia-degenerative-loss-muscle-mass-associated-aging/

 

Rodent study, of course.... and this may or may not play out as expected in humans. But this part of the above link is interesting:

"For seven consecutive days, they administered FGF19 to different mice models......

All mice models that received FGF19 gained less weight and developed less fat tissue than mice in the control groups, when they had in fact been eating more."

 

To observe an effect in seven days makes me think that the effect size here is rather large.

 

The piece continues with the following comment: "In addition, their skeletal muscles became more developed, as well as their muscle strength."

This is even more significant. To see an effect on muscle mass and strength in seven days is amazing. The vast majority of anabolic steroids do not work that quick. 

Comments???

tianeptinestore.com is S L O W and I'm A N N O Y E D

by @ Health

Mon Feb 12 15:53:50 PST 2018

I placed an order on tianeptinestore dot com on Feb 7. Got a notification saying they keep orders on hold until payment clears, ok fine. 

They emailed notification that package was SHIPPED via USPS on Saturday Feb 10 and gave tracking number. 

USPS tracking page says  "pre-shipment info sent to usps, usps awaiting item."  It's a small order but I wish I could cancel it.

 

Not the end of the world...I just felt like venting.

 

The Truth About Autism Recovery

by @ Good Medicine: Latest News

Mon Mar 14 05:03:47 PDT 2016

RECOVERY or REMISSION?

It is true; Children are emerging from this once thought dead end diagnosis. Autism is no longer a mystery. We understand the complex biological and cellular dysfunctions resulting in the symptoms referred to as Autism.

In the face of environmental exposure and toxicity, two processes get started in the human body-- a chronic inflammatory response, and oxidative stress. These processes, when that human body cannot adequately address them, further manifest as compromised methylation pathways, vitamin and mineral deficiencies, Th1/Th2 immune imbalance and immune dysfunction, and inflammatory bowel disease.

Children living with AD/HD, ADD, Asthma and Allergies all have similar root causes resulting in the symptoms of each diagnosis.

When these root causes (underlying medical conditions) are acknowledged and addressed, the symptoms of AD/HD, Asthma and Allergies and the behaviors and developmental delays referred to as Autism improve significantly.

Families have many more options today rather than learning to manage their children's behaviors. Our approach is  different than the traditional standard of care such as ABA. ABA focuses on correcting the behavior; we strive to heal the underlying medical conditions creating the behaviors.  When children feel better, they behave better and therefore, their therapies are more productive.

Dr. Nathan Morris, MD and Kara Badgley, Functional Medicine Certified Health Coach, each have spent the past 11 years saving their families from Autism. Over time, they have learned their children have not recovered but more correctly, their children's  Autism is in Remission. 

THE REALITY

It has taken both Dr. Morris and Kara Badgley more than a decade to heal their children's bodies from the underlying medical conditions. Every system in these children's bodies are burdened; it takes time to experience improvement. Recovery insinuates their is a finish line; however Dr. Morris and Kara Badgley both understand they will always need to support their children's bodies to keep their symptoms in remission.

Regressions are part of the healing journey. Exposure to high inflammatory foods, or environmental triggers such as mold, or high stress levels can create a surge of inflammation; which the child can not regulate. Regressions can happen even when the child is said to be recovered. This is exactly why we choose the word Autism Remission in compairsson to Autism Recovery.

Regression is not always a bad thing. We are obsessed with progress; we want this Autism to just go away. Sometimes Regression can sometimes be better explained as Rebuilding. When we are asking the child's body to perform more efficiently, although this is healthier and in the long run will create a strong foundation for him/her to emerge, it is uncomfortable and therefore the child regresses for a time. Time and time again we see these 'Rebuilding' Phases lead to improved functioning, communication and sleep. If a 'Rebuilding' phase goes on for longer than a few weeks then it's recommended either to see how to better support the methylation (detox) pathway or to scale back on the dosage of the most recent supplement or prescription most recently introduced.

WHAT NOW?

To become a patient of Dr. Morris'  Become A Member

COMING SOON:  

Autism Remission: DECIDE. CHANGE. TRANSFORM

Remission of your child's Autism Symptoms  only comes when the parents lead by example. The healing of the family is a shared journey with the child. This life empowers the entire family to heal; which creates sustainable change to experience autism remission. Autism Remission, is a community outreach program offered in communities beginning Fall 2017. Coaching sessions are also available with Kara Badgley. Online scheduling to be available soon.

Conscious Conception: Family Steps to Baby Planning.

The first steps to a healthy family happens before your baby is born. Pre-Natal planning starts with you; your health and your environment.

Preparing your own body prior to conception allows you to optimize your fertility plus your baby’s development& health.  Conscious Conception is a program for couples to be intentional about their family’s future through functional medicine principles

Our top 10 truths to share about Autism Remission:

Ultimately we all have to find our own way; but these truths will be universal for any journey parents take to save their family.

1.) Make a plan. Autism Remission outreach program helps families to create, organize, budget, document and track their care plan. Success comes from layering interventions to work in combination. A plan helps to layer well timed interventions based on each families current and unique circumstances.  

2.)Your child will mirror your habits. If you want your child to do anything, you first have to lead by example. You HAVE TO LIVE THE SOLUTION.

3.)No one said this life will be easy. No one is spared from trials and tribulations. Learning to be thankful in times of misery is a key to self-actualization. Practicing Mind Body Techniques such as yoga & meditation help us to shift into the Parasympathetic Nervous System. It is from this state that we no longer react to the chaos but can hear the guidance we all are praying for…

4.) Begin to think about long term planning rather than short term gain. A journey of placing symptoms into remission is not something you try. It’s something you become. Autism never goes away. Even when you are in remission, there is chance for regression.

5.)A little bit of food dye, gluten, casein and other high allergen & artificial foods and preservatives does hurt. A lot.

6.) There is no cure. There is no one thing, no one silver bullet, that will make everything better. It’s going to be intelligently timing and layering interventions to work in combination for the rest of time. And yes, THE BASICS ARE ABSOLUTELY REQUIRED.

7.)You are not alone

8.)Your child knows everything you are saying. Please stop talking about how terrible his/her behavior is or how much you suffer in front of him/her. Likewise, they understand way more than we give them credit. Explain what you are doing and why; educate them also as you layer pieces into your care plan.

9.)What you do right now: the thoughts, the words, the actions which create your habits, which create you character, which create your destiny -right now is what counts. Recovery is an accumulation of choices every minute of every day that YOU choose (you are in charge, not your child). These choices ultimately take you toward your goal. Focus on what you can do rather than attaching to all the odds stacked against you. (See #4)

10.) Miracles happen. If you choose to show up.

You may also like:

Sleeping on AD/HD

The Missing Element

Cut Autism by 300%

About the Author:

Kara Badgley is the Clinical Coordinator & Functional Medicine Certified Health Coach at Good Medicine. She has been a health coach since 2002. For the past 4 years Kara has worked in the clinical setting with families living with Autism. She co-creates personalized care plans with families based on what they are ready to do. Her passion is to meet a family where they are at in their current circumstances and identify the next reasonable steps, budget, organizing, document and manage their care plans to live the life the solution. She loves most when families, who previously had lost all hope; are now enjoying their freedom and their families once again.

To hear more about Kara's journey through Autism and her insight on How to Live the Life of Recovery click Here.

Disclaimer:

Good Medicine respects families who celebrate their children's Autism. Good Medicine works with families whose children are clearly struggling and who are clearly in pain; therefore, the family is in pain. 

Published March 14, 2016

LongeCity Affiliate Labs

by @ LongeCity - Articles

Sun Jun 19 18:16:58 PDT 2016

The Longecity “Affiliate Labs” are small, research-focused enterprises or independent academic research groups led by a scientists with strong ties to the Longecity community and a proven track record of commitment to scientific inquiry directly relevant to the Longecity mission.
These leaders and their colleagues are not just trailblazers in advancing important areas of regenerative and rejuvenation research, but also incredibly helpful when there is a community need for peer review, when providing advice and training to a young scientist, and in providing the expertise and tools to test the novel, controversial, or promising scientific leads sourced from the Longecity community and beyond.

Community Funding
There is a small support fund that the labs can draw on to flexibly support their research activities. While not a substitute for private investment and public sector grants, the ability to flexibly ‘just try’ out a new idea without needing to ‘pitch’ in lengthy proposals can be an invaluable accelerator to research progress. All Affiliates have an active link to the Longecity community, so there is a level of accountability and responsiveness beyond anything encountered in ‘traditional’ research donations.
By donating to the Affiliate Labs fund, Members can be assured that every penny goes directly to an expert personally and professionally committed to making a difference in the scientific conquest of death.
Donate HERE

Current Affiliate Labs
- Alexandra Stolzing, Loughborough University, UK & Leipzig University, Germany.
- James Clement - Betterhumans, USA
- João Pedro de Magalhães, University of Liverpool, UK
- John Schloendorn – Gene&Cell Technologies, USA
- Kelsey Moody, Ichor Therapeutics, USA.
- Kevin Perrott – Buck Institute, USA
- Matthew O’Connor – SENS Foundation, USA

Too Much Probiotic Food Stool Hard

by @ Probiotics Belaw

Sun Jan 07 13:45:13 PST 2018

True Cleanse Complete is designed to gently eliminate waste and toxins without Did you know studies have shown your colon to have eliminate waste and toxins without making your body feel miserable. Too Much Probiotic Food Stool Hard raw Food Vegan Recipes. Airmail to Europe (EU). Growing a baby is the most wondrous thing your […]

LongeCity science support: quick guide/FAQ

by @ Articles

Wed Jun 12 17:36:16 PDT 2013

What is LongeCity?
LongeCity is a registered, members-based non-profit organisation.
More info here.


What THEMES of science projects does LongeCity support?
We support research into ageing and the extension of human lifespan. This means we support many types of medical research and research into basic biology, but there should be an angle that will allow people to live longer, healthier lives.


What TYPES of science projects does LongeCity support?
We support laboratory research, clinical research, bioinformatics and theoretical research in the ‘hard sciences’. We do not normally support social science research.
We do support some events, mentorship and travel to scientific conferences, but not under the ‘research budget’.


Where can the research take place?
Anywhere in the world. Laboratory research should normally be conducted in an established lab.


What does LongeCity expect in return?
Scientific integrity. Normally a written report. Interim updates for longer projects. Acknowledgement of the funding received. We may approach previous grantholders to be available as peer reviewers for future research applications.


What grant schemes are available?

a) Small Grants
Funding: up to $500
Who can apply: any LongeCity Member, it helps if you have a sponsor/supervisor with some track record
Type: typical cases are support for summer projects, internships, workshops, review paper writing, selected consumables
Next deadline: none, applications are welcome until the annual budget is exhausted
Details: http://www.longecity...s/action/grants

b) Matching Fundraiser
Funding: up to $20.000 (in total- matching fundraiser)
Who can apply: Scientists
Type: For selected projects, LongeCity will issue a call for donations and for every dollar received LongeCity will match (or better) the donation. The entire money goes to support the research project.
Next deadline: July 1^st 2013
Details: http://www.longecity...ts/research2013


Questions?
Contact us.

User Agreement

by @ LongeCity - Articles

Sat Dec 17 15:11:18 PST 2011

Bylaw A. User Agreement (Posting Guidelines)

---

Bylaw A. User Agreement

Article 1
The following shall be the letter of the agreement that all visitors, Members and their guests will be asked to abide by when interacting with the LongeCity/ Imminst ("LongeCity") website Please read this Agreement carefully before accessing the Site.

Section01 The Nature of this Agreement
(a) The following are the terms and conditions (the "Agreement") offered to any person ("you") for access and use (including but not limited to forum user registration) of the LongeCity/Immortality Institute (LongeCity) web site and all affiliated web sites (the "Site"). The Agreement is the basis for using and interacting with the LongeCity website. By accessing the Site, you agree to abide by this Agreement.
(b) Access to the Site is a privilege and not a right. If you do not agree with this Agreement, or have no intention to follow the rules outlined herein, you may not use the Site. If you have any reason to interact with a representative of LongeCity, but you do not wish to follow these rules, please email support@LongeCity.org
© The information in this document is subject to change. These changes will be announced on the Site, but you must also agree to periodically review this document for changes. After eight (8) days of any change in the Rules, your continued use of the Site indicates your acceptance of any changes made.

Section02 Account registration
(a) Only natural persons aged 16 or above may register an account with LongeCity.
(b) Each natural person may hold one single account. Registering with multiple accounts is not allowed unless specific permission is given by LongeCity.
© You may not use the account of another person unless such use is inadvertent and infrequent (e.g. using a family members login from the same computer not noticing that the person forgot to log out).
(d) Persons whose accounts have been suspended, deleted or blocked by LongeCity may never register another account unless specific permission is given by LongeCity.
(e) Users are free to choose any alias as long as the name is not offensive and as long as there is no risk that the username may be confused with a natural person, entity, initiative or endeavour that the person using the account is not authorised to represent. Final decisions on the acceptability of any user alias are made by LongeCity leadership.
(f) An LongeCity Member who has been suspended or banned from the Site is not considered in good standing. A user who has been suspended or banned from the Site may not apply to become an LongeCity Member.
(g) Accounts may be suspended, deleted, or changed by LongeCity for a variety of reasons including but not limited to a violation of this user agreement. If you are unsure why your account is inaccessible you can email support@LongeCity.org.
You must not register a new account the without express permission from the Secretary.
(h) When an account has been suspended, Members will be notified within 8 days of suspension and may appeal to the Secretary within 8 days after receiving such notification. If no agreement can be reached with the Secretary, the Member may appeal the case to the Board. There is no right to appeal for users or other individuals who are not Members.

Section03 Content
(a) LongeCity provides an open platform for registered users to share text, video, audio, programmes, scripts, files, hyperlinks and other material on the Site ("Content") as long as such sharing is lawful and not in contravention of this Agreement. However, LongeCity does not undertake to scrutinise, evaluate, test or verify any Content prior to it being shared on the Site.
(b) Content from the Site may be downloaded solely for your own non-commercial use.
(c) You understand that by using the Site, you may be exposed to Content that you may deem offensive, indecent or objectionable.
(d) LongeCity does not control the Content contributed by users and, consequently, provides no guarantee as to the correctness, integrity or fitness of such Content.
(e) Content are the responsibility of the person from whom such Content originated. You agree that you and not LongeCity, are entirely responsible for all Content that you upload, post, email, link, transmit or otherwise make available via the Site.
(f) When contributing Content, you agree that this Content may be edited or deleted or rendered to display in a different manner at the discretion of LongeCity.
(g) LongeCity will not use Content you contribute for commercial gain without your express permission, but cannot warrant or guarantee in any way that others who you decide to share the Content with might not use it for commercial activities.
(h)LongeCity cannot be held responsible for any Content that has been contributed through its open platform. LongeCity will not react to requests to verify, redact, edit, delete or obfuscate any Content.

Section04 Intellectual Property & Privacy
(a) By contributing Content you agree that you shall have no recourse against LongeCity for any alleged or actual infringement or misappropriation of any proprietary right in relation to the Content that you have contributed.
(b) By contributing your own original Content you agree to make this Content available in perpetuity under a Creative Commons Attribution-Non-Commercial-No Derivative Works 3.0 United States License. http://creativecommo...y-nc-nd/3.0/us/unless you give express notification to the contrary at the same time that you contribute the Content.
© LongeCity will not share private data with third parties without your consent, however LongeCity may use the information it obtains as a result of your visiting and/or registering with the Site for the purpose of enforcing this Agreement or in order to save a life or prevent unlawful activity.
(d) LongeCity is not responsible if you decide to post or share private information about yourself or others on the forum. LongeCity will not normally redact, remove or alter such data if you subsequently change your mind.

Section05 Limitation of Liability
(a) In no event will LongeCity be liable for consequential or incidental damages
which may arise in connection with your use of the Site. Accordingly, you agree that LongeCity shall not be responsible to you or anyone else for any loss-of-profit, direct, indirect, incidental, special, or consequential damages
arising out of the use of the site.
(b) You acknowledge that the limitations set forth herein are integral to the amount of consideration levied in connection with the access and use of the Site and any services rendered hereunder and that, were LongeCity to assume any further liability other than as set forth herein, such consideration would of necessity be set substantially higher.
(c) You agree to defend, indemnify and hold LongeCity and its officers, directors,agents, and employees harmless against all costs, expenses, and losses, incurred from any violation of this Agreement (including negligent or wrongful conduct) by your use and access of the Site.
(d) LongeCity provides the Site and associated information "as is" and does not make any direct or indirect express or implied warranties.
(e) LongeCity does not verify the credentials of anyone contributing Content to the site and does not endorse any Content that is contributed as advice. Anyone providing advice and guidance on or in association with the site is doing this strictly in a personal capacity, whether or not this person has an official role with LongeCity, unless the advice is specifically, expressly and in each instance authorised by an LongeCity director. Users are reminded that 'Advisors' are advising the LongeCity board on policy. This does not constitute an endorsement by LongeCity of that Advisors communications with others.

Section06 Basic Prohibitions
(a) The following activities are strictly prohibited and may lead to immediate suspension or deletion of the account, court action and notification of law enforcement officials.
(b) Violating any applicable local, state, national or international law;
(c) Personal threats to anybody, whether or not that person is using the Site
(d) Misrepresenting yourself as a person who you are not.
(e) Representing yourself as affiliated with an organisation without due authorisation.
(f) Contributing Content that contains a virus, any type of malware or corrupted data;
(g) Interacting with the Site in such a way as to seriously impair the functioning or usability of the Site including but not limited to excessive contribution of irrelevant Content;
(h) Display the contents of the Site on a different web site without permission.
(i) Violate the Site's security including but not limited to accessing unauthorized data or logging into an account or attempt to log into an account for which you do not have authorization, scan or test for hardware or software
vulnerabilities, perform a denial of service attack, attempt to spread a virus or malware, or falsify TCP/IP information.
(j) Contributing any solicitation including but not limited to advertising, promotional materials, junk mail, spam, chain letters, pyramid schemes (also see section 8 below)

Section07 Content related to health
(a) Any and all advice and/or opinion provided is strictly personal and never endorsed by LongeCity, nor should it be construed to be the official policy of LongeCity to provide health advice.
(b) You must seek professional medical advice prior to embarking on any course or treatment associated with any Content on the Site.
(c) You must determine what government regulations exist associated with the procurement and use of restricted substances such that they do not contravene any laws in your country.
(d) All Information on the LongeCity Forums, including those associated with health, sciences fora are provided as an area for the open exchange of anecdotal experience and information, not as a professional source of advice.

Section08 Advertising, promotions and commercial activity
(a) Organisations or individuals seeking to advertise on the Site must first apply to LongeCity for such approval.
(b) Advertising is any Content (including private messages) that draws attention to, solicits, endorses, offers for sale, links to, critiques or otherwise relates to goods or services where one of the parties involved in initiating such Content or one of their associates stands to benefit from financial transactions that may results from such Content.
(c) LongeCity seeks to limit surreptitious advertising where users who may have a financial stake in such matters contribute Content simply to increase product desirability or brand awareness. Such Content will be censored on the basis of suspicion alone. On occasion, 'innocent' Content may inadvertently be subjected to such censure. Users should be aware of this and are kindly asked to refrain from protest in these cases, as the common aim is to increase the quality of Content on the Site.
(d) Even if a promotion has been agreed by LongeCity, this does not imply, and no-one must imply that this constitutes an official endorsement by LongeCity of the promotion, the organisation and individual conducting the promotion or the promoted products or procedures.
(e) Users must not use the Site for initiating or conducting commercial transactions, whether in private messages, or by using contact details displayed on the Site unless expressly authorised by LongeCity.

Section09 Posting Guidelines
(a) Users must agree to consider the posting guidelines as specified in Article2. Adherence to these guidelines is monitored by LongeCity Moderators, Directors and other designated Officers.
(b) Violation of a guideline will incur a warning. Repeat violation on more than three separate occasions will result in a time-limited suspension of the user account ranging from eight days to eight years.
(c) Disputes regarding the enforcement of posting guidelines should be taken up, in the first instance, with the Moderator who has issued the warning. If no resolution can be found in dialogue, the dispute can be notified to the Lead Moderator. Warnings issued by the Lead Moderator can be disputed with the Secretary. Users who have an open dispute with a Moderator cannot be warned again by the same Moderator – but the Moderator in question may still report questionable posts by that user.
(d) LongeCity has reserved a forum for the expression of free speech known as the William O'Rights Memorial Forum. LongeCity will not restrict Content in this forum even if it violates the posting guidelines as long as such Content does not violate the other provisions in this Agreement. This is a forum where users can engage in 'flame wars', ensure that posts are not interfered with by a Moderator, or complain about LongeCity without threat of censure.


Article 2 Posting Guidelines

Section01 A-- General tone of conversations
A1-- Be polite. That does not mean that you cannot try to destroy another’s argument utterly but never lose your tone or your temper while doing so. Also under no circumstances should you employ personal judgments or remarks about people themselves rather than their arguments. Aside from the fact that such judgments are more often than not ill founded, they drag down the overall quality of the discussion as well as costing time and space.
A2-- Some words are generally considered offensive terms, in polite conversation such as "fuck, "shit", "faggot" or "nigger". Causing offence rarely if ever helps to elevate the quality of a discussion. Generally, use of such words will result in a warning or ban, but discretion may be exercised depending on the context.

Section02 B-- General writing style
B1-- Do not write excessive amounts of text. Be concise! No one has the time or the inclination to plough through a pile of superfluous rhetoric in order to discover your main points. If you really feel that you have to write an essay, then write a summary at the end as every considerate essay-writer would do.
B2-- While every caution is advised about over-using the forums design tools, please by all means DO use them, if this helps to make the text more accessible.

Section03 C-- Starting a new topic
C1-- Before starting a new topic please consider if the topic is informative, or will stimulate an interesting discourse.
C2-- Please check if the issue has been discussed before on the Site (It is not important to be a 100% sure about this – the LongeCity forums are quite large and old. But please make a quick search, especially if you have not been with the community for long. Sometimes, it may make sense to open a new topic anyway, but would be great if you could reference previous discussions.)
C3-- Please think about a good title. (This is very important. Please spend some time on considering the title. Titles like "A Question", "Hello" or "Life Extension" may lead to an otherwise interesting topic being deleted. Challenging titles may draw a lot of visitors will still incur a warning if they are not informative. Give full titles. "Vitamin E" is bad, "Vitamin E harmful?" is not as good as "Risk of Vitamin E supplements in Cancer".)
C4-- Is it a privileged topic? (LongeCity Members can create new topics over which they, as threadstarter have editorial control. This is to empower members who are willing to put in a bit of work to maximise the quality and values of a discussion thread. Other contributors must be alerted to the threadstarters intention in the first post, but cannot subsequently complain if their posts are edited.

Section04 D-- Replying to topics
D1-- Please ask yourself "Does my reply offer a significant contribution?"
D2-- It is critical that you try to keep follow-up posts on topic. Avoid going off on a different tangent. If it occurs to you that this might be another thread, open a new thread and put a link to it in the old one. The last word about relevance stays with the Moderators or the threadstarter.
D3-- As an extension of the previous point, do not derail a topic with fundamental critique even if you think that this would desirable. In particular do not question the necessity of a certain life-extension technique by referring to another method that seems more relevant to you. (Two examples: do not answer a question about the capacity of artificial intelligence to value human emotion correctly by stating that the ‘Singularity’ is a bunch of nonsense anyway; Do not intrude on an exchange about the bioavailability of resveratrol by stating that you don't care because you are signed up for cryonics)
D4-- Refrain from posting personal information unless it is inherently necessary to elaborate your views or position.
D5-- There is usually no benefit for people in reading that you agree unless you give an explanation to go with it.
D6-- You do not have to be an expert on the subject matter, but if you feel that you really don’t know enough about the subject, then ask informed questions before stepping into the ring for debate. If someone posts a link or uploads an article- read it before you go on. Also read the posts of your predecessors and be aware of related discussions elsewhere.

Section05 E-- Posting images
E1-- You are welcome to post your own images and drawings when they are relevant to sharing knowledge. Irrelevant or excessive positing of images, including emoticons (smiles) often diminishes quality of the Content and will likely incur a warning.
E2-- Showing images to illustrate a point or make a humorous quip is popular with some posters, but please consider if such posts could derail a discussion or create issues around copyright infringement.
E3-- Please be considerate about causing embarrassment when sharing images. As a rule of thumb, if you would be uncomfortable viewing it at work, do not post it.
E4-- Avatars: LongeCity encourages users to use a small portrait (passport-type) photograph as 'Avatar' of themselves, but this is not a requirement. However, the use of other peoples photographs or the LongeCity logo as Avatar is not allowed.

Section06 F-- Quotes and references
F1-- When replying to a previous post by quoting it, only quote precisely enough text as is necessary to understand your reply. Using the "reply" function in the forums will quote the entire post that you are replying to. Do not use this feature without due consideration.
F2-- If you quote, reference the quote properly, but only quote the important bits. (It is customary to put alterations to a quote in square brackets and indicate left-out bits by putting “...”) Do not quote whole articles, rather give a link or upload them. If you have to quote a substantial passage, then indicate the important passages that you want to draw attention too.
F3-- The use of references is strongly encouraged. Such references should contain enough information to find the relevant source with one or two mouse clicks. When using a link, please remember that the hypertext url may be specific to your own access and useless to others.

Lyric Hijacking - Neffex: Watch Me (LongeCity Version?)

by @ LONGECITY Community Blog List

Tue Oct 17 13:57:00 PDT 2017

This song has become a favorite, but I'm I'm a lyrical hijacker, so here's my version:

 

I never take doubt as a lesson
I never second guess it
Take negativity and reject it
I got my mind blind to rejection
So I'll be just fine don't be wasting any time with discretion

 

I run this campaign like I'm running an election
I pop this champagne like we're not in a recession
I feel no damn pain rejuvenation is a blessing
Feel it pumping through my veins got me feeling like I'm finessing yea

 

I'm in motion I'm obsessive
Like the ocean I'm relentless
No promotion still progressing
Overdosing on these lessons

 

And these words my only weapon
Cut aging deep oh yea I threaten
Feel the heat and all the tension
Feel relief from this whole session

 

And I keep myself progressing
Cuz I creep around suppressants
I don't sleep enough you guessed it
Every second is a blessing

 

Got no time to be depressed
On this grind your always stressed
So I work harder than the rest
Dad always said to do my best

 

I don't ever doubt myself
Can't count on pharma, or else
And I do not need their help
I was told to show not tell
So watch me

 

Man this beat got me aggressive
Got me on the straight offensive
You can't stop this trains direction
Cuz it runs on rejuvenation

 

Oh and did I fail to mention
That I need all your attention
Cuz we're failing in retention
Listen up or just forget it

 

I ain't here to spit perfection
I embrace my imperfections
I just want all that's neglected
To hear something they connect with

 

So I use my only method
All this words that I've invested
I don't hope that they're impressive
I just hope that they're effective

 

I swear to God if you want it then you got to get it
Cuz when your on your death bed you will regret it
You only got one life one shot don't let it
Slip away today get up and make a big change
Huh?
You decide your own future
A winner or a loser
A headline or a rumor
On the bench or a shooter?
Superstar or recruiter
Defense or prosecutor?
Just livin' a consumer or will you be a producer

 

If you think you have a dream go capture it
Go act a bit
Get off ya ass and take some action bitch
Start acting like you want this shit

 

Cuz passion ain't compassionate
Too many people want this shit
It's not enough your talented
You have to fuckin' grab at it

 

I'm sick of aging adequate
Another college graduate
Just looking for an advocate
To pack my urn and get paid for it

 

You want it? Take a stab at it
You need it then go after it
These people they don't matter kid
Just block them out and capture it

 

I don't ever doubt myself
I can count on no one else
And I do not need their help
I was told to show not tell
So watch me

 

The sped up nightcore/nightstep version sounds best, but could be faster:

 

Original:

Advertising Framework

by @ LongeCity - Articles

Tue Dec 18 15:30:56 PST 2012

Visitors to the forum will notice that a lot of discussion evolves around nutrition, supplements and lifestyle. We realize of course that these factors are just one element of the larger mission to conquer the blight of involuntary death, but that makes it all the more important to make sure that the strengths that LongeCity has in providing a great resource for nutritional information exchange are leveraged effectively. 

Sometimes, it may seem like there are two 'factions' at LongeCity: on the one hand the committed 'activists' who realize the truth that nutritional supplements by themselves will have very limited efficacy in extending the human lifespan and who consequently have little patience  for 'supplement pushers'. On the other hand there are the 'supplementers' who have little to no interest in 'living forever' and whose priority is a healthy lifespan and enhancing their fitness. For sure, examples of both 'camps' can be found if one looks for them, but on the whole the distinction has very little merit: firstly, nutrition, drugs, vitamins and lifestyle - even apparently peripheral topics like cognitive enhancement, are an important factor in the portfolio of life extension technologies. These are the factors that we can do for ourselves, today and for that reasons alone are worth discussing. 

This fact- that supplements are at the 'applied' end of life extension discussion also means that the information and expertise joining at LongeCity around supplements can be much more effectively leveraged for fundraising. This makes LongeCity pretty unique: we are trying to siphon some of the financial overheads from the commercial end of life extension and re-allocate them to chronically underfunded scientific research and advocacy programmes. LongeCity has been really successful in this regard: with very little funding we have made a real difference in creating pioneering information material and funding important basic research as well as supporting community projects. 

Thus 'activists' can appreciate a measure of advertising at the sitefor making an important contribution to the common cause. Ad exposure for Members is reduced but not fully eliminated not least because we think that some ads can actually be useful and interesting. There are at least four types of  advertising available: 

'Google ads' - are context-related ads. Google offers these individually based on your browser's settings and the content of the forum. Consequently please bear in mind that LongeCity has very limited control about what ads are displayed.

'Banner ads' - these paid for adverts usually leading to a sponsors website. More about LongeCity's relationship with other institutions can be found in this article. To quote: "LongeCity does not endorse any advertisers beyond the fact that they have made a donation to the community in exchange for exposure. Advertisers never influence our policy, ever. (...) Having said that, advertisers featured at LongeCity very often have a real commitment to the cause- they would not have found us otherwise". Members are invited to comment on the policy

'Links' - these are links in text and elsewhere that are monetized if the link is used to make a purchase at the external site. One well known example is Amazon.com: If you use the LongeCity 'referral' page to make a purchase, Amazon makes a small payment to LongeCity at no cost to you. We may be experimenting with other link concepts in the future. Note however, that the connections on our links page are not used in this manner. They are simply a project index interesting sources that all members can contribute to. 

'Ads by discussion' - sometimes advertising momentum is generated simply by discussing a particular product. Over the years, marketers have become very sophisticated in pursuing such 'viral' strategies - and they are generally NOT WELCOME at LongeCity. There are only two sub-forums where product-and vendor related discussions are tolerated: for supplement companies/ for other companies. Any attempts to initiate product-related discussions elsewhere will be considered a breach of the LongeCity user agreement. The limited discussion that is allowed in this context is tolerated only because we feel that some information exchange about products and providers is potentially part of the LongeCity mission. Where this link cannot be made clearly, ads by discussion -whether inadvertent or not- will not be permitted.

We have experimented a little bit and are always keen to find other ways to generate funding for life extension research and advocacy from the LongeCity website in a way that is not overly intrusive and that does not compromise our mission and values. 
Potential sponsors are invited to get in touch. 
Members with new ideas about are invited to share them in the suggestions forum . 

Research funding 2013: Expression of interest s...

by @ Archive - Articles

Mon Aug 29 16:46:25 PDT 2011

LongeCity continues to support small-scale, high-impact life extension research with community crowdfunding.
(For a review of previous projects see here)

Projects should:
- aim to make a scientific contribution to the extension of the human lifespan
- be applied research or basic research with some potential for applied development
- present short updates for LongeCity Members with interim data, photos from the facility etc at agreed intervals
- be led or overseen by a person with a postgraduate qualification in the relevant field or by a person with demonstrable equivalent experience
- have a flexible project structure that can be adjusted according to the amount of money raised
- be small in scale - one or two key workers
- be short in duration - approx 6 months maximum
- not be confidential. LongeCity will expect open and public presentation and discussion of research results. However, confidentiality will be accepted where a manuscript or patent is in preparation.

In 2013, we are not just matching, but trebling donations
LongeCity will launch a call for donations. Every donation received will be trebled. Projects can have a total budget of $3.000- $21.000. (Hence needing to raise only $1.000-$7.000)

Interested applicants should send
- a project outline of no more than 1000 words written in lay language (can be supported by up to 10 literature references)
- a curriculum vitae of the project leader
to research@longecity.org


Deadline: July 1st 2013 (or until further notice).